Published in Nat Methods on February 14, 2010
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell (2013) 2.22
An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship. EMBO J (2010) 2.01
Ras trafficking, localization and compartmentalized signalling. Semin Cell Dev Biol (2011) 1.48
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi. J Cell Biol (2014) 1.31
An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier. J Cell Biol (2013) 1.31
A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity. J Am Chem Soc (2010) 1.29
Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology. Pflugers Arch (2013) 1.27
Spatial positive feedback at the onset of mitosis. Cell (2012) 1.26
Rapid and orthogonal logic gating with a gibberellin-induced dimerization system. Nat Chem Biol (2012) 1.20
A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast. Mol Biol Cell (2013) 1.19
Chemically inducible diffusion trap at cilia reveals molecular sieve-like barrier. Nat Chem Biol (2013) 1.17
Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization. Sci Signal (2011) 1.10
Sensitive and high resolution localization and tracking of membrane proteins in live cells with BRET. Traffic (2012) 1.00
Cellular and molecular interactions of phosphoinositides and peripheral proteins. Chem Phys Lipids (2014) 0.89
Rapidly relocating molecules between organelles to manipulate small GTPase activity. ACS Chem Biol (2012) 0.88
Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization. Mol Cell Biol (2015) 0.86
Conditionally controlling nuclear trafficking in yeast by chemical-induced protein dimerization. Nat Protoc (2010) 0.83
Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization. Sci Rep (2015) 0.83
Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells. Sci Rep (2014) 0.82
Spatio-temporal manipulation of small GTPase activity at subcellular level and on timescale of seconds in living cells. J Vis Exp (2012) 0.82
Cell-permeant and photocleavable chemical inducer of dimerization. Angew Chem Int Ed Engl (2014) 0.82
How to understand and outwit adaptation. Dev Cell (2014) 0.82
Phosphoinositides differentially regulate protrudin localization through the FYVE domain. J Biol Chem (2012) 0.82
Endosomal sorting of VAMP3 is regulated by PI4K2A. J Cell Sci (2014) 0.81
Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function. ACS Synth Biol (2015) 0.80
Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides. J Cell Biol (2016) 0.80
Small-molecule-based nanoassemblies as inducible nanoprobes for monitoring dynamic molecular interactions inside live cells. Angew Chem Int Ed Engl (2011) 0.79
Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. PLoS Biol (2016) 0.79
Organomatics and organometrics: Novel platforms for long-term whole-organ culture. Technology (Singap World Sci) (2014) 0.79
Chemical tools for studying directed cell migration. ACS Chem Biol (2011) 0.79
Comparative proteomic analysis of compartmentalised Ras signalling. Sci Rep (2015) 0.78
Visualizing mitochondrial lipids and fusion events in Mammalian cells. Methods Cell Biol (2012) 0.78
Rapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activation. Sci Signal (2014) 0.77
Acute manipulation of phosphoinositide levels in cells. Methods Cell Biol (2012) 0.77
Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement. Mol Biol Cell (2016) 0.76
Biological constraints limit the use of rapamycin-inducible FKBP12-Inp54p for depleting PIP2 in dorsal root ganglia neurons. J Negat Results Biomed (2013) 0.76
Effective molarity redux: Proximity as a guiding force in chemistry and biology. Isr J Chem (2013) 0.76
Cellular signaling circuits interfaced with synthetic, post-translational, negating Boolean logic devices. ACS Synth Biol (2014) 0.76
Molecular tools for acute spatiotemporal manipulation of signal transduction. Curr Opin Chem Biol (2016) 0.75
A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nat Chem Biol (2016) 0.75
Calcineurin β protects brain after injury by activating the unfolded protein response. Neurobiol Dis (2016) 0.75
Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells. ACS Cent Sci (2016) 0.75
Non-contact intracellular binding of chloroplasts in vivo. Sci Rep (2015) 0.75
Using a kinase-inducible bimolecular switch to control enzyme activity in living cells. Curr Protoc Chem Biol (2013) 0.75
Optical control of membrane tethering and interorganellar communication at nanoscales. Chem Sci (2017) 0.75
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell (1995) 21.15
Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature (2008) 9.66
Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol (2006) 5.37
Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science (2006) 5.10
MAM: more than just a housekeeper. Trends Cell Biol (2009) 4.27
An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nat Methods (2005) 4.23
Compartmentalized Ras/MAPK signaling. Annu Rev Immunol (2006) 3.03
Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 Complex. J Biol Chem (2007) 3.02
Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons. Neuron (2005) 2.26
Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Mol Cell (2003) 2.20
Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. Trends Cell Biol (2007) 1.73
Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting. Proc Natl Acad Sci U S A (2006) 1.43
Interrelationships of endoplasmic reticulum, mitochondria, intermediate filaments, and microtubules--a quadruple fluorescence labeling study. Biochem Cell Biol (1993) 1.11
Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem (2007) 1.10
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science (2006) 6.25
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci U S A (2007) 5.31
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell (2010) 5.14
Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science (2006) 5.10
Mitochondrial fusion intermediates revealed in vitro. Science (2004) 4.52
Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell (2007) 4.30
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A (2002) 4.27
Structural basis of mitochondrial tethering by mitofusin complexes. Science (2004) 4.21
Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol (2005) 3.75
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci U S A (2008) 3.46
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A (2007) 3.39
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. J Biol Chem (2009) 3.29
Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1. Cell (2006) 3.25
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell (2006) 3.22
PNPASE regulates RNA import into mitochondria. Cell (2010) 2.54
Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Mol Biol Cell (2009) 2.49
Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell (2003) 2.48
The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Mol Cell (2011) 2.43
Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol (2004) 2.42
UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J (2011) 2.36
Evolution of fluorescein as a platform for finely tunable fluorescence probes. J Am Chem Soc (2005) 2.35
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev (2004) 2.30
TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem (2004) 2.25
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech (2009) 2.16
Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons. J Cell Biol (2009) 1.97
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One (2011) 1.93
Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins. J Cell Biol (2006) 1.83
Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia. Nat Methods (2013) 1.76
Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci U S A (2002) 1.69
Modular domain structure in the Candida glabrata adhesin Epa1p, a beta1,6 glucan-cross-linked cell wall protein. Mol Microbiol (2002) 1.65
The cytoskeleton of Giardia lamblia. Int J Parasitol (2003) 1.60
A nanoparticle formulation that selectively transfects metastatic tumors in mice. Proc Natl Acad Sci U S A (2013) 1.55
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. J Cell Biol (2011) 1.52
Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae. Biotechnol Biofuels (2010) 1.51
Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast. J Cell Biol (2008) 1.50
Robust neuronal symmetry breaking by Ras-triggered local positive feedback. Curr Biol (2007) 1.49
Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proc Natl Acad Sci U S A (2010) 1.43
Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow. Am J Physiol Cell Physiol (2002) 1.43
Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion. J Cell Biol (2011) 1.43
Development of a highly selective fluorescence probe for hydrogen sulfide. J Am Chem Soc (2011) 1.43
Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria. Proc Natl Acad Sci U S A (2003) 1.34
The Ran GTPase cycle is required for yeast nuclear pore complex assembly. J Cell Biol (2003) 1.33
The cardiolipin transacylase, tafazzin, associates with two distinct respiratory components providing insight into Barth syndrome. Mol Biol Cell (2008) 1.30
A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity. J Am Chem Soc (2010) 1.29
Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. J Cell Biol (2003) 1.27
Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology. Pflugers Arch (2013) 1.27
An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol (2007) 1.25
Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev Cell (2003) 1.23
tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre. J Cell Sci (2005) 1.22
The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway. J Cell Sci (2009) 1.21
Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis. Mol Cell Biol (2003) 1.21
Rapid and orthogonal logic gating with a gibberellin-induced dimerization system. Nat Chem Biol (2012) 1.20
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nat Chem Biol (2009) 1.19
A striking quality control subcompartment in Saccharomyces cerevisiae: the endoplasmic reticulum-associated compartment. Mol Biol Cell (2003) 1.18
Mining the Giardia lamblia genome for new cyst wall proteins. J Biol Chem (2003) 1.17
Functional analysis of the triplex proteins (VP19C and VP23) of herpes simplex virus type 1. J Virol (2006) 1.15
Drosophila E-cadherin is essential for proper germ cell-soma interaction during gonad morphogenesis. Development (2003) 1.15
Caveolin-1 interacts directly with dynamin-2. J Mol Biol (2005) 1.14
Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14
Highly activatable and rapidly releasable caged fluorescein derivatives. J Am Chem Soc (2007) 1.12
Characterisation of alpha-1 giardin: an immunodominant Giardia lamblia annexin with glycosaminoglycan-binding activity. Int J Parasitol (2003) 1.11
Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization. Sci Signal (2011) 1.10
Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor. J Cell Sci (2008) 1.10
Mitochondrial outer and inner membrane fusion requires a modified carrier protein. J Cell Biol (2009) 1.09
Red fluorescent probe for monitoring the dynamics of cytoplasmic calcium ions. Angew Chem Int Ed Engl (2013) 1.08
Tunable design strategy for fluorescence probes based on 4-substituted BODIPY chromophore: improvement of highly sensitive fluorescence probe for nitric oxide. Anal Bioanal Chem (2006) 1.07
Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol (2008) 1.07
Mouse lines with photo-activatable mitochondria to study mitochondrial dynamics. Genesis (2012) 1.07
Development of a far-red to near-infrared fluorescence probe for calcium ion and its application to multicolor neuronal imaging. J Am Chem Soc (2011) 1.06
The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J Cell Biol (2014) 1.06
Conventional and immunoelectron microscopy of mitochondria. Methods Mol Biol (2007) 1.04
Vesicle trafficking maintains nuclear shape in Saccharomyces cerevisiae during membrane proliferation. J Cell Biol (2010) 1.04
Hyaline cartilage engineered by chondrocytes in pellet culture: histological, immunohistochemical and ultrastructural analysis in comparison with cartilage explants. J Anat (2004) 1.00
Synthesizing biomolecule-based Boolean logic gates. ACS Synth Biol (2013) 1.00
A role for GRIP domain proteins and/or their ligands in structure and function of the trans Golgi network. J Cell Sci (2003) 0.99
Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor. Traffic (2006) 0.99
The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast. Mol Biol Cell (2006) 0.99
Development of luciferin analogues bearing an amino group and their application as BRET donors. Chem Asian J (2010) 0.99
Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition. Mol Biol Cell (2006) 0.99
Unremodeled and remodeled cardiolipin are functionally indistinguishable in yeast. J Biol Chem (2013) 0.98
The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Mol Biol Cell (2008) 0.98
Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci (2011) 0.97
Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method. J Am Chem Soc (2011) 0.97
Trivalent arsenic inhibits the functions of chaperonin complex. Genetics (2010) 0.95
Spore coat architecture of Clostridium novyi NT spores. J Bacteriol (2007) 0.95
Development of azo-based fluorescent probes to detect different levels of hypoxia. Angew Chem Int Ed Engl (2013) 0.92
Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer. Proc Natl Acad Sci U S A (2008) 0.91
Development of hypoxia-sensitive Gd3+-based MRI contrast agents. Bioorg Med Chem Lett (2012) 0.91
Growth and integration of neocartilage with native cartilage in vitro. J Orthop Res (2005) 0.89
Rapidly relocating molecules between organelles to manipulate small GTPase activity. ACS Chem Biol (2012) 0.88
Rapidly reversible manipulation of molecular activity with dual chemical dimerizers. Angew Chem Int Ed Engl (2013) 0.86
Giardia lamblia: identification and characterization of Rab and GDI proteins in a genome survey of the ER to Golgi endomembrane system. Exp Parasitol (2002) 0.85
Modification of intracellular Ca2+ dynamics by laser inactivation of inositol 1,4,5-trisphosphate receptor using membrane-permeant probes. Chem Biol (2004) 0.85
RNA interference effector proteins localize to mobile cytoplasmic puncta in Schizosaccharomyces pombe. Traffic (2006) 0.85
Interactions of the Kaposi's Sarcoma-associated herpesvirus nuclear egress complex: ORF69 is a potent factor for remodeling cellular membranes. J Virol (2013) 0.84