SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.

PubWeight™: 4.27‹?› | Rank: Top 1%

🔗 View Article (PMC 129731)

Published in Proc Natl Acad Sci U S A on October 08, 2002

Authors

Patrick Onyango1, Ivana Celic, J Michael McCaffery, Jef D Boeke, Andrew P Feinberg

Author Affiliations

1: Institute of Genetic Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, 1064 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA.

Articles citing this

(truncated to the top 100)

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14

Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A (2006) 7.00

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell (2005) 6.79

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell (2010) 5.40

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell (2010) 4.19

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23

SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol (2008) 3.15

Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev (2007) 2.77

SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Circulation (2016) 2.71

Retracted Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. J Cell Sci (2010) 2.56

Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria. Biochemistry (2010) 2.48

Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One (2010) 2.44

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci (2010) 2.37

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging (Albany NY) (2009) 2.32

SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24

SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12

Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies. PLoS One (2014) 2.02

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99

Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85

Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A (2004) 1.80

Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev (2003) 1.78

Altered sirtuin expression is associated with node-positive breast cancer. Br J Cancer (2006) 1.73

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol Cell Biol (2004) 1.73

The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci (2009) 1.62

Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem (2009) 1.60

The SirT3 divining rod points to oxidative stress. Mol Cell (2011) 1.58

Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol (2008) 1.57

NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity. AAPS J (2006) 1.57

The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther (2013) 1.57

Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54

Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One (2007) 1.50

Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine. Biochemistry (2006) 1.49

Retracted The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners. BMC Physiol (2010) 1.47

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci (2009) 1.46

The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem (2008) 1.45

The dual role of sirtuins in cancer. Genes Cancer (2011) 1.45

Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44

NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem (2009) 1.43

Acetylation goes global: the emergence of acetylation biology. Sci Signal (2009) 1.41

Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms. J Cell Biochem (2010) 1.38

Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions. Mol Cell Biol (2004) 1.37

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer (2010) 1.32

Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase. Biochem J (2008) 1.31

Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization. Mech Ageing Dev (2010) 1.30

SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28

Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest (2010) 1.27

Mitochondria and endothelial function. Circ Res (2013) 1.27

SIRT1 in neurodevelopment and brain senescence. Neuron (2014) 1.22

The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases. Proc Natl Acad Sci U S A (2006) 1.21

Histone deacetylase inhibition with valproic acid downregulates osteocalcin gene expression in human dental pulp stem cells and osteoblasts: evidence for HDAC2 involvement. Stem Cells (2014) 1.19

Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture. PLoS One (2011) 1.18

p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One (2010) 1.18

Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17

SIRT3 substrate specificity determined by peptide arrays and machine learning. ACS Chem Biol (2010) 1.17

SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. Mol Cell Biol (2013) 1.15

SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol (2012) 1.12

NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol (2012) 1.12

Mitochondrial longevity pathways. Biochim Biophys Acta (2011) 1.11

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. Cell Death Dis (2013) 1.09

Mitochondrial SIRT3 and heart disease. Cardiovasc Res (2010) 1.09

Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res (2013) 1.09

Evolution of the arginase fold and functional diversity. Cell Mol Life Sci (2008) 1.09

Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix. Mol Cell Biol (2007) 1.08

Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates. J Biomed Biotechnol (2010) 1.08

NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab (2012) 1.05

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. Mol Cell Proteomics (2015) 1.02

Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation. Handb Exp Pharmacol (2011) 1.02

Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions. PLoS One (2012) 1.01

Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol Life Sci (2010) 1.00

Mediterranean diet and cardioprotection: the role of nitrite, polyunsaturated fatty acids, and polyphenols. Nutrition (2011) 1.00

The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology. Circ Res (2009) 1.00

Human longevity and 11p15.5: a study in 1321 centenarians. Eur J Hum Genet (2009) 1.00

Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes. J Biol Chem (2015) 0.99

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci (2013) 0.97

Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer. Cell Death Dis (2014) 0.96

Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. PLoS One (2012) 0.96

Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart. Am J Physiol Heart Circ Physiol (2011) 0.94

SIRT3: as simple as it seems? Gerontology (2013) 0.94

2-cys peroxiredoxins: emerging hubs determining redox dependency of Mammalian signaling networks. Int J Cell Biol (2014) 0.93

Characterization of murine SIRT3 transcript variants and corresponding protein products. J Cell Biochem (2010) 0.93

Mitochondrial acetylation and diseases of aging. J Aging Res (2011) 0.91

The human sirtuin family: evolutionary divergences and functions. Hum Genomics (2011) 0.90

Deacetylase inhibitors - focus on non-histone targets and effects. World J Biol Chem (2010) 0.90

Sirtuins: from metabolic regulation to brain aging. Front Aging Neurosci (2013) 0.90

Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria. Front Physiol (2014) 0.89

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts. Biochem J (2013) 0.89

Mitochondrial-nuclear epistasis: implications for human aging and longevity. Ageing Res Rev (2010) 0.89

The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients. Biomed Res Int (2014) 0.88

Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer (2013) 0.88

SIRT3 regulates progression and development of diseases of aging. Trends Endocrinol Metab (2015) 0.88

Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle. J Physiol (2015) 0.88

Sirtuins, bioageing, and cancer. J Aging Res (2011) 0.86

Sirtuins and pyridine nucleotides. Circ Res (2012) 0.86

Articles cited by this

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97

Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43

A knowledge base for predicting protein localization sites in eukaryotic cells. Genomics (1992) 11.85

At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol (1987) 9.21

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell (1997) 8.61

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92

Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays (1998) 7.79

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell (1991) 7.17

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A (2000) 6.49

An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev (1997) 6.00

Sir2 links chromatin silencing, metabolism, and aging. Genes Dev (2000) 5.95

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun (1999) 5.83

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev (1995) 5.55

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature (1997) 4.57

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell (1999) 4.07

Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell (1999) 3.98

PRINTS prepares for the new millennium. Nucleic Acids Res (1999) 3.58

Localization of Sir2p: the nucleolus as a compartment for silent information regulators. EMBO J (1997) 3.55

Pch2 links chromatin silencing to meiotic checkpoint control. Cell (1999) 2.45

CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2. J Biol Chem (1998) 2.37

A fine-structure deletion map of human chromosome 11p: analysis of J1 series hybrids. Somat Cell Mol Genet (1989) 2.29

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J (2001) 2.24

The conserved core of a human SIR2 homologue functions in yeast silencing. Mol Biol Cell (1999) 2.07

Localization of GTPases by indirect immunofluorescence and immunoelectron microscopy. Methods Enzymol (1995) 2.00

Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. Gene (1999) 1.95

A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast. EMBO J (2001) 1.95

Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. Science (1993) 1.31

Deciphering NAD-dependent deacetylases. Cell (2001) 1.11

Articles by these authors

Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature (2002) 9.40

Increased methylation variation in epigenetic domains across cancer types. Nat Genet (2011) 8.92

Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res (2008) 8.62

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature (2008) 7.64

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science (2003) 6.85

Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nat Genet (2006) 6.74

A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell (2006) 6.61

Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17

Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics (2014) 5.93

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89

Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nat Genet (2009) 5.52

Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes. Nature (2004) 5.15

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell (2010) 5.14

An integrated epigenetic and genetic approach to common human disease. Trends Genet (2004) 4.89

Human l1 retrotransposition is associated with genetic instability in vivo. Cell (2002) 4.79

A robust toolkit for functional profiling of the yeast genome. Mol Cell (2004) 4.69

Mitochondrial fusion intermediates revealed in vitro. Science (2004) 4.52

The biochemistry of sirtuins. Annu Rev Biochem (2006) 4.32

Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell (2007) 4.30

Structural basis of mitochondrial tethering by mitofusin complexes. Science (2004) 4.21

DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray. Nat Genet (2003) 4.14

An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science (2007) 4.00

Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet (2002) 3.93

Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol (2005) 3.75

Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. Int J Epidemiol (2012) 3.62

Mobile interspersed repeats are major structural variants in the human genome. Cell (2010) 3.60

Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet (2004) 3.56

Human L1 element target-primed reverse transcription in vitro. EMBO J (2002) 3.54

A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res (2002) 3.50

DNA methylation signatures within the human brain. Am J Hum Genet (2007) 3.50

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci U S A (2008) 3.46

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A (2007) 3.39

The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation. Curr Biol (2006) 3.37

Total synthesis of a functional designer eukaryotic chromosome. Science (2014) 3.31

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. J Biol Chem (2009) 3.29

Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1. Cell (2006) 3.25

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25

Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell (2006) 3.22

Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res (2002) 3.21

Mighty Piwis defend the germline against genome intruders. Cell (2007) 3.06

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol (2011) 3.00

Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell (2009) 2.99

Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature (2011) 2.81

Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Genome Res (2006) 2.81

Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol (2004) 2.76

Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. Am J Hum Genet (2002) 2.73

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell (2004) 2.73

Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science (2005) 2.72

A core nucleosome surface crucial for transcriptional silencing. Nat Genet (2002) 2.67

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62

PNPASE regulates RNA import into mitochondria. Cell (2010) 2.54

Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity. Cancer Res (2002) 2.52

A highly active synthetic mammalian retrotransposon. Nature (2004) 2.51

Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Mol Biol Cell (2009) 2.49

Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell (2003) 2.48

Reversible switching between epigenetic states in honeybee behavioral subcastes. Nat Neurosci (2012) 2.44

The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Mol Cell (2011) 2.43

Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol (2004) 2.42

Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer (2013) 2.41

Epigenetics and assisted reproductive technology: a call for investigation. Am J Hum Genet (2004) 2.41

Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell (2008) 2.39

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J (2011) 2.36

Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae. Mol Cell Biol (2005) 2.33

SNP-specific array-based allele-specific expression analysis. Genome Res (2008) 2.30

Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev (2004) 2.30

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem (2004) 2.25

LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression? Bioessays (2005) 2.24

The emerging science of epigenomics. Hum Mol Genet (2006) 2.22

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech (2009) 2.16

Molecular archeology of L1 insertions in the human genome. Genome Biol (2002) 2.14

Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12

Accurate genome-scale percentage DNA methylation estimates from microarray data. Biostatistics (2010) 2.11

Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell (2011) 2.10

Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe (2008) 2.08

Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition. Gastroenterology (2004) 2.06

Gene function prediction from congruent synthetic lethal interactions in yeast. Mol Syst Biol (2005) 2.04

Redefining CpG islands using hidden Markov models. Biostatistics (2010) 2.03

A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation. Genes Dev (2008) 2.01

Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol Cell (2002) 2.00

Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants. Cell (2008) 1.99

Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons. J Cell Biol (2009) 1.97

Transposon-mediated genome manipulation in vertebrates. Nat Methods (2009) 1.96

Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics (2012) 1.95

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One (2011) 1.93

Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant. Genes Dev (2005) 1.92

GeneDesign: rapid, automated design of multikilobase synthetic genes. Genome Res (2006) 1.87

Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertil Steril (2005) 1.87

Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins. J Cell Biol (2006) 1.83

Global synthetic-lethality analysis and yeast functional profiling. Trends Genet (2005) 1.82

Human transposon tectonics. Cell (2012) 1.81

Regulated noise in the epigenetic landscape of development and disease. Cell (2012) 1.79

A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript. Proc Natl Acad Sci U S A (2011) 1.77

Genome-wide consequences of deleting any single gene. Mol Cell (2013) 1.76

Significance analysis and statistical dissection of variably methylated regions. Biostatistics (2011) 1.74

Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics (2003) 1.73