Published in Aging (Albany NY) on November 13, 2009
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY) (2010) 3.27
Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging. Aging (Albany NY) (2011) 1.35
Regulation of Drosophila lifespan by JNK signaling. Exp Gerontol (2010) 1.27
Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY) (2011) 1.10
Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation. Cell Death Differ (2012) 1.02
Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat Genet (2007) 12.62
p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05
Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell (2009) 5.57
Modulation of mammalian life span by the short isoform of p53. Genes Dev (2004) 4.52
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J (2002) 4.17
Delayed ageing through damage protection by the Arf/p53 pathway. Nature (2007) 3.87
Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell (2008) 2.85
Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev (2006) 2.35
Drosophila germ-line modulation of insulin signaling and lifespan. Proc Natl Acad Sci U S A (2008) 2.31
Cancer and ageing: convergent and divergent mechanisms. Nat Rev Mol Cell Biol (2007) 2.27
Identification and characterization of a p53 homologue in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 2.04
20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer (2009) 2.00
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol (2005) 1.78
dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster. Aging (Albany NY) (2009) 1.71
Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. Proc Natl Acad Sci U S A (2007) 1.51
Does p53 affect organismal aging? J Cell Physiol (2002) 1.37
p53: guardian AND suppressor of longevity? Exp Gerontol (2005) 1.36
Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. Aging (Albany NY) (2009) 1.19
The price of tumour suppression? Nature (2002) 1.10
New tricks of an old molecule: lifespan regulation by p53. Aging Cell (2006) 1.03
Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. Exp Gerontol (2009) 0.93
Sir2 and longevity: the p53 connection. Cell Cycle (2009) 0.83
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell (2005) 4.64
JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell (2008) 3.04
JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell (2003) 2.86
Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet (2010) 2.39
Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell (2011) 1.81
EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development (2011) 1.76
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Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. EMBO J (2006) 1.63
Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc Natl Acad Sci U S A (2005) 1.51
Regulation of Drosophila lifespan by JNK signaling. Exp Gerontol (2010) 1.27
Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. PLoS Genet (2009) 1.25
Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. Dev Cell (2011) 1.24
JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Dev Dyn (2006) 1.21
Insulin and JNK: optimizing metabolic homeostasis and lifespan. Trends Endocrinol Metab (2009) 1.19
Dpp signaling determines regional stem cell identity in the regenerating adult Drosophila gastrointestinal tract. Cell Rep (2013) 1.09
14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell (2008) 1.09
JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell (2009) 1.06
Promoting longevity by maintaining metabolic and proliferative homeostasis. J Exp Biol (2014) 1.05
DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs. Mol Cell Biol (2005) 1.02
Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genet (2012) 0.99
Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Dev Cell (2011) 0.93
Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons. BMC Neurosci (2005) 0.91
Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila. Cell Rep (2013) 0.90
Metabolic homeostasis: HDACs take center stage. Cell (2011) 0.86
Schnurri regulates hemocyte function to promote tissue recovery after DNA damage. J Cell Sci (2012) 0.84
Aging: seeking mitonuclear balance. Cell (2013) 0.75