PubRank

Gerald S Shadel

Author PubWeight™ 94.13‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab 2007 4.59
2 TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 2011 4.16
3 Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci U S A 2009 3.84
4 Mitochondria in innate immune responses. Nat Rev Immunol 2011 3.31
5 Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. Mol Cell 2006 3.16
6 Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab 2011 3.13
7 Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab 2010 3.07
8 Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab 2012 2.56
9 Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J Clin Invest 2007 2.03
10 Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab 2013 2.03
11 Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. Nat Genet 2002 1.89
12 A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Mol Cell Biol 2002 1.85
13 Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging (Albany NY) 2009 1.82
14 Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol Cell Biol 2003 1.80
15 Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim Biophys Acta 2009 1.67
16 Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Res 2002 1.64
17 Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression. Nucleic Acids Res 2007 1.60
18 Ancient mtDNA genetic variants modulate mtDNA transcription and replication. PLoS Genet 2009 1.58
19 Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol 2008 1.56
20 Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness. Cell 2012 1.56
21 Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. J Biol Chem 2007 1.54
22 Revisiting the TCA cycle: signaling to tumor formation. Trends Mol Med 2011 1.51
23 Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span. Mol Cell Biol 2006 1.47
24 The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae. Mol Biol Cell 2005 1.45
25 Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction. Cell Metab 2012 1.41
26 Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. J Biol Chem 2003 1.38
27 Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins. Mol Cell Biol 2002 1.35
28 Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc Natl Acad Sci U S A 2010 1.34
29 A compendium of human mitochondrial gene expression machinery with links to disease. Environ Mol Mutagen 2010 1.26
30 Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2. J Mol Evol 2006 1.23
31 Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Genetics 2002 1.22
32 Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation. Mitochondrion 2007 1.21
33 Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae. Mol Cell Biol 2005 1.21
34 Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol 2011 1.18
35 A novel mitochondrial protein, Tar1p, is encoded on the antisense strand of the nuclear 25S rDNA. Genes Dev 2002 1.16
36 Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA. Nucleic Acids Res 2011 1.15
37 Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors. Crit Care Med 2009 1.10
38 Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability. Gene 2005 1.08
39 Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle 2007 1.07
40 Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness. Hum Mol Genet 2009 1.07
41 Rethinking the mitochondrial theory of aging: the role of mitochondrial gene expression in lifespan determination. Cell Cycle 2007 1.05
42 LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. J Biol Chem 2011 1.03
43 Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress. Biochem Pharmacol 2006 1.03
44 Accessorizing the human mitochondrial transcription machinery. Trends Biochem Sci 2013 1.03
45 Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription. Proc Natl Acad Sci U S A 2011 1.02
46 Mitochondrial stress signals revise an old aging theory. Cell 2011 0.97
47 Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis. Nucleic Acids Res 2013 0.96
48 Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Proc Natl Acad Sci U S A 2012 0.93
49 Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p. PLoS One 2011 0.93
50 Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. Mol Ther 2012 0.92
51 The core human mitochondrial transcription initiation complex: It only takes two to tango. Transcription 2011 0.87
52 Suppression of NLRX1 in chronic obstructive pulmonary disease. J Clin Invest 2015 0.85
53 Genomic imprinting at a boundary element flanking the SDHD locus. Hum Mol Genet 2011 0.84
54 Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. Am J Pathol 2011 0.84
55 Expression of the rDNA-encoded mitochondrial protein Tar1p is stringently controlled and responds differentially to mitochondrial respiratory demand and dysfunction. Curr Genet 2008 0.84
56 MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2014 0.83
57 Alternative mitochondrial fuel extends life span. Cell Metab 2012 0.80
58 Checkpoint kinase phosphorylation in response to endogenous oxidative DNA damage in repair-deficient stationary-phase Saccharomyces cerevisiae. Mech Ageing Dev 2009 0.79
59 Expanding the mitochondrial interactome. Genome Biol 2007 0.79
60 Multi-faceted regulation of mitochondria by TOR. Cell Cycle 2009 0.79
61 A "radical" mitochondrial view of autophagy-related pathology. Aging (Albany NY) 2009 0.76
62 Mitochondrial DNA oxidative damage and mutagenesis in Saccharomyces cerevisiae. Methods Mol Biol 2009 0.76
63 Stressed-out mitochondria get MAD. Cell Metab 2010 0.76
64 Debut of MitoMatters. Mitochondrion 2008 0.75
65 Into the wild frontier of mitochondrial disease and aging. Methods 2008 0.75