Published in Aging (Albany NY) on January 28, 2009
Extending healthy life span--from yeast to humans. Science (2010) 12.12
Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab (2011) 3.13
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
Growth and aging: a common molecular mechanism. Aging (Albany NY) (2009) 2.13
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. Aging (Albany NY) (2010) 1.76
Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging (Albany NY) (2011) 1.74
mTOR's role in ageing: protein synthesis or autophagy? Aging (Albany NY) (2009) 1.59
Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet (2010) 1.59
NCI's provocative questions on cancer: some answers to ignite discussion. Oncotarget (2011) 1.42
Polyamines in aging and disease. Aging (Albany NY) (2011) 1.36
Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence. Aging (Albany NY) (2010) 1.33
TOR and ageing: a complex pathway for a complex process. Philos Trans R Soc Lond B Biol Sci (2011) 1.25
The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging (Albany NY) (2009) 1.21
Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet (2012) 1.20
Mitochondrial membrane lipidome defines yeast longevity. Aging (Albany NY) (2013) 1.14
Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions. Oncotarget (2012) 1.11
Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY) (2011) 1.10
TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast. Aging Cell (2013) 1.08
Geroconversion: irreversible step to cellular senescence. Cell Cycle (2014) 1.07
Progeria, rapamycin and normal aging: recent breakthrough. Aging (Albany NY) (2011) 1.06
Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes? Aging Cell (2009) 1.04
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00
Chronological aging in Saccharomyces cerevisiae. Subcell Biochem (2012) 0.98
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High glucose-mediated oxidative stress impairs cell migration. PLoS One (2011) 0.98
The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Mol Biol Cell (2013) 0.97
Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR. Aging Dis (2010) 0.95
mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo) (2013) 0.94
Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell (2014) 0.94
Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p. PLoS One (2011) 0.93
Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. Cell Cycle (2012) 0.91
Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis. Aging (Albany NY) (2013) 0.90
Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan. Aging Cell (2013) 0.90
The sweet taste of death: glucose triggers apoptosis during yeast chronological aging. Aging (Albany NY) (2010) 0.89
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY) (2016) 0.89
Predicting the fission yeast protein interaction network. G3 (Bethesda) (2012) 0.87
Mechanisms by which different functional states of mitochondria define yeast longevity. Int J Mol Sci (2015) 0.87
Conserved role of medium acidification in chronological senescence of yeast and mammalian cells. Aging (Albany NY) (2011) 0.86
Longevity of U cells of differentiated yeast colonies grown on respiratory medium depends on active glycolysis. Cell Cycle (2015) 0.85
DNA replication stress-induced loss of reproductive capacity in S. cerevisiae and its inhibition by caloric restriction. Cell Cycle (2013) 0.84
Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan. Cell Cycle (2014) 0.83
Effects of calorie restriction on life span of microorganisms. Appl Microbiol Biotechnol (2010) 0.82
The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae. Aging (Albany NY) (2011) 0.82
Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration. Front Genet (2012) 0.82
A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology. Redox Biol (2014) 0.82
Crosstalk between mitochondrial stress signals regulates yeast chronological lifespan. Mech Ageing Dev (2013) 0.80
Dysfunctional mitochondria modulate cAMP-PKA signaling and filamentous and invasive growth of Saccharomyces cerevisiae. Genetics (2012) 0.80
Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations. Protein Cell (2014) 0.80
Alzheimer's disease promotion by obesity: induced mechanisms-molecular links and perspectives. Curr Gerontol Geriatr Res (2012) 0.79
Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae. PLoS One (2013) 0.78
Breathing lessons: Tor tackles the mitochondria. Aging (Albany NY) (2009) 0.78
Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates. NPJ Aging Mech Dis (2015) 0.77
Reprogramming of energy metabolism as a driver of aging. Oncotarget (2016) 0.77
Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Mol Microbiol (2013) 0.77
Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes. Oncotarget (2016) 0.77
Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60. J Aging Res (2012) 0.77
Dietary restriction and lifespan: Lessons from invertebrate models. Ageing Res Rev (2016) 0.77
Sch9 regulates intracellular protein ubiquitination by controlling stress responses. Redox Biol (2015) 0.76
Stressed-out mitochondria get MAD. Cell Metab (2010) 0.76
Affected chromosome homeostasis and genomic instability of clonal yeast cultures. Curr Genet (2015) 0.75
Slm35 links mitochondrial stress response and longevity through TOR signaling pathway. Aging (Albany NY) (2016) 0.75
Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation. Microb Cell (2016) 0.75
Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae. Microb Cell (2014) 0.75
The longevity of tor1Δ, sch9Δ, and ras2Δ mutants depends on actin dynamics in Saccharomyces cerevisiae. Cell Biosci (2015) 0.75
Caloric restriction extends yeast chronological lifespan by optimizing the Snf1 (AMPK) signaling pathway. Mol Cell Biol (2017) 0.75
Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing. Microb Cell (2014) 0.75
Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging. Microb Cell (2014) 0.75
Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging. Front Genet (2016) 0.75
Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity. Curr Genet (2017) 0.75
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TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
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Mitochondria, oxidants, and aging. Cell (2005) 16.11
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol (2004) 9.96
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Genetics: influence of TOR kinase on lifespan in C. elegans. Nature (2003) 7.55
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab (2007) 7.07
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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell (1993) 6.44
Rates of behavior and aging specified by mitochondrial function during development. Science (2002) 6.28
Regulation of longevity and stress resistance by Sch9 in yeast. Science (2001) 5.93
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell (2007) 5.67
Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem (2008) 5.22
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab (2007) 4.59
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The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem (2006) 4.28
Mitochondrial retrograde signaling. Annu Rev Genet (2006) 3.75
Mitochondria--a nexus for aging, calorie restriction, and sirtuins? Cell (2008) 3.38
Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. Mol Cell (2006) 3.16
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Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol (2004) 2.42
Isolation of yeast mitochondria. Methods Mol Biol (2006) 2.09
Model organisms as a guide to mammalian aging. Dev Cell (2002) 1.96
Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. J Biol Chem (2004) 1.95
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Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem (2000) 1.58
Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span. Mol Cell Biol (2006) 1.47
The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.45
Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. J Biol Chem (2003) 1.38
Preadaptation to efficient respiratory maintenance is essential both for maximal longevity and the retention of replicative potential in chronologically ageing yeast. Mech Ageing Dev (2006) 1.37
Mitochondrial transcription is regulated via an ATP "sensing" mechanism that couples RNA abundance to respiration. Mol Cell (2006) 1.28
Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span. Eukaryot Cell (2008) 1.23
Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Genetics (2002) 1.22
Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle (2007) 1.07
Rethinking the mitochondrial theory of aging: the role of mitochondrial gene expression in lifespan determination. Cell Cycle (2007) 1.05
Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis. PLoS One (2008) 0.95
Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes. Aging Cell (2007) 0.94
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab (2007) 4.59
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci U S A (2009) 3.84
Mitochondria in innate immune responses. Nat Rev Immunol (2011) 3.31
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Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab (2011) 3.13
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab (2010) 3.07
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J Clin Invest (2007) 2.03
Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab (2013) 2.03
Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. Nat Genet (2002) 1.89
A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Mol Cell Biol (2002) 1.85
Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol Cell Biol (2003) 1.80
Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim Biophys Acta (2009) 1.67
Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Res (2002) 1.64
Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression. Nucleic Acids Res (2007) 1.60
Ancient mtDNA genetic variants modulate mtDNA transcription and replication. PLoS Genet (2009) 1.58
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol (2008) 1.56
Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness. Cell (2012) 1.56
Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. J Biol Chem (2007) 1.54
Revisiting the TCA cycle: signaling to tumor formation. Trends Mol Med (2011) 1.51
Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span. Mol Cell Biol (2006) 1.47
The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.45
Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction. Cell Metab (2012) 1.41
Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. J Biol Chem (2003) 1.38
Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins. Mol Cell Biol (2002) 1.35
Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc Natl Acad Sci U S A (2010) 1.34
A compendium of human mitochondrial gene expression machinery with links to disease. Environ Mol Mutagen (2010) 1.26
Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2. J Mol Evol (2006) 1.23
Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Genetics (2002) 1.22
Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation. Mitochondrion (2007) 1.21
Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae. Mol Cell Biol (2005) 1.21
Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol (2011) 1.18
A novel mitochondrial protein, Tar1p, is encoded on the antisense strand of the nuclear 25S rDNA. Genes Dev (2002) 1.16
Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA. Nucleic Acids Res (2011) 1.15
Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors. Crit Care Med (2009) 1.10
Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability. Gene (2005) 1.08
Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle (2007) 1.07
Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness. Hum Mol Genet (2009) 1.07
Rethinking the mitochondrial theory of aging: the role of mitochondrial gene expression in lifespan determination. Cell Cycle (2007) 1.05
LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. J Biol Chem (2011) 1.03
Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress. Biochem Pharmacol (2006) 1.03
Accessorizing the human mitochondrial transcription machinery. Trends Biochem Sci (2013) 1.03
Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription. Proc Natl Acad Sci U S A (2011) 1.02
Mitochondrial stress signals revise an old aging theory. Cell (2011) 0.97
Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis. Nucleic Acids Res (2013) 0.96
Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Proc Natl Acad Sci U S A (2012) 0.93
Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p. PLoS One (2011) 0.93
Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. Mol Ther (2012) 0.92
The core human mitochondrial transcription initiation complex: It only takes two to tango. Transcription (2011) 0.87
Suppression of NLRX1 in chronic obstructive pulmonary disease. J Clin Invest (2015) 0.85
Genomic imprinting at a boundary element flanking the SDHD locus. Hum Mol Genet (2011) 0.84
Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. Am J Pathol (2011) 0.84
Expression of the rDNA-encoded mitochondrial protein Tar1p is stringently controlled and responds differentially to mitochondrial respiratory demand and dysfunction. Curr Genet (2008) 0.84
MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2014) 0.83
Alternative mitochondrial fuel extends life span. Cell Metab (2012) 0.80
Expanding the mitochondrial interactome. Genome Biol (2007) 0.79
Multi-faceted regulation of mitochondria by TOR. Cell Cycle (2009) 0.79
Checkpoint kinase phosphorylation in response to endogenous oxidative DNA damage in repair-deficient stationary-phase Saccharomyces cerevisiae. Mech Ageing Dev (2009) 0.79
Mitochondrial DNA oxidative damage and mutagenesis in Saccharomyces cerevisiae. Methods Mol Biol (2009) 0.76
A "radical" mitochondrial view of autophagy-related pathology. Aging (Albany NY) (2009) 0.76
Stressed-out mitochondria get MAD. Cell Metab (2010) 0.76
Debut of MitoMatters. Mitochondrion (2008) 0.75
Into the wild frontier of mitochondrial disease and aging. Methods (2008) 0.75