Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells.

PubWeight™: 2.59‹?› | Rank: Top 1%

🔗 View Article (PMC 2885227)

Published in J Biol Chem on April 09, 2010

Authors

Lei Liu1, Guan-Zheng Luo, Wei Yang, Xiaoyang Zhao, Qinyuan Zheng, Zhuo Lv, Wei Li, Hua-Jun Wu, Liu Wang, Xiu-Jie Wang, Qi Zhou

Author Affiliations

1: State Key Laboratory of Reproductive Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China.

Articles citing this

Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13

Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89

Induced pluripotent stem cells--opportunities for disease modelling and drug discovery. Nat Rev Drug Discov (2011) 2.58

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet (2012) 2.35

Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci. Cell Stem Cell (2011) 2.09

Molecular analyses of human induced pluripotent stem cells and embryonic stem cells. Cell Stem Cell (2010) 1.81

Genetic and epigenetic variations in iPSCs: potential causes and implications for application. Cell Stem Cell (2013) 1.63

Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells. Mol Psychiatry (2011) 1.59

Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells. Dev Biol (2010) 1.47

Totipotent embryonic stem cells arise in ground-state culture conditions. Cell Rep (2013) 1.43

DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival. J Biol Chem (2011) 1.40

Ascorbic acid improves pluripotency of human parthenogenetic embryonic stem cells through modifying imprinted gene expression in the Dlk1-Dio3 region. Stem Cell Res Ther (2015) 1.38

Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. Nat Med (2013) 1.34

Dlk1 is necessary for proper skeletal muscle development and regeneration. PLoS One (2010) 1.28

Genomic imprinting in development, growth, behavior and stem cells. Development (2014) 1.23

MicroRNAs in the imprinted DLK1-DIO3 region repress the epithelial-to-mesenchymal transition by targeting the TWIST1 protein signaling network. J Biol Chem (2012) 1.23

Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles. RNA (2011) 1.13

Silencing of a large microRNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor. Mol Cancer (2012) 1.12

microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. Cell Res (2012) 1.12

Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective. Cell Res (2012) 1.12

miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer. Clin Cancer Res (2014) 1.11

Small regulatory RNAs controlled by genomic imprinting and their contribution to human disease. Epigenetics (2012) 1.10

Zscan4 restores the developmental potency of embryonic stem cells. Nat Commun (2013) 1.10

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver. Nucleic Acids Res (2013) 1.07

Vitamin C improves the quality of somatic cell reprogramming. Nat Genet (2012) 1.07

Genomic approaches to deconstruct pluripotency. Annu Rev Genomics Hum Genet (2011) 1.06

Comparison of human induced pluripotent and embryonic stem cells: fraternal or identical twins? Mol Ther (2011) 1.05

miR-154* and miR-379 in the DLK1-DIO3 microRNA mega-cluster regulate epithelial to mesenchymal transition and bone metastasis of prostate cancer. Clin Cancer Res (2014) 1.02

Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. J Clin Invest (2011) 1.01

Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging. Cell Mol Life Sci (2010) 1.01

Suppression of the imprinted gene NNAT and X-chromosome gene activation in isogenic human iPS cells. PLoS One (2011) 1.01

Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells. PLoS One (2012) 0.98

Cellular reprogramming: a small molecule perspective. Curr Opin Cell Biol (2012) 0.97

Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor. J Biol Chem (2010) 0.95

Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation. Asian J Androl (2012) 0.95

MicroRNA profiling of rhesus macaque embryonic stem cells. BMC Genomics (2011) 0.94

Meat Science and Muscle Biology Symposium: stem cell niche and postnatal muscle growth. J Anim Sci (2011) 0.92

Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors. Oncogene (2011) 0.91

Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells. BMC Neurosci (2011) 0.90

Concise review: Human cell engineering: cellular reprogramming and genome editing. Stem Cells (2012) 0.90

iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery. Acta Pharmacol Sin (2013) 0.89

iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. Cell Res (2011) 0.89

The functions of microRNAs and long non-coding RNAs in embryonic and induced pluripotent stem cells. Genomics Proteomics Bioinformatics (2013) 0.87

Epigenetic landscape of pluripotent stem cells. Antioxid Redox Signal (2012) 0.86

Generating pluripotent stem cells: differential epigenetic changes during cellular reprogramming. FEBS Lett (2012) 0.86

Thyroid hormone signaling and adult neurogenesis in mammals. Front Endocrinol (Lausanne) (2014) 0.86

The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J (2014) 0.85

Spatiotemporal expression pattern of Mirg, an imprinted non-coding gene, during mouse embryogenesis. J Mol Histol (2011) 0.85

Mouse cloning and somatic cell reprogramming using electrofused blastomeres. Cell Res (2010) 0.84

A focused microarray for screening rat embryonic stem cell lines. Stem Cells Dev (2012) 0.83

Staged miRNA re-regulation patterns during reprogramming. Genome Biol (2013) 0.82

Pluripotency of induced pluripotent stem cells. J Anim Sci Biotechnol (2012) 0.82

The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas. Int J Oncol (2013) 0.82

Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines. Stem Cell Res Ther (2015) 0.82

Somatic donor cell type correlates with embryonic, but not extra-embryonic, gene expression in postimplantation cloned embryos. PLoS One (2013) 0.81

Epigenetic silencing of genes and microRNAs within the imprinted Dlk1-Dio3 region at human chromosome 14.32 in giant cell tumor of bone. BMC Cancer (2014) 0.81

Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. Epigenomics (2016) 0.81

Characterization of the imprinting signature of mouse embryo fibroblasts by RNA deep sequencing. Nucleic Acids Res (2013) 0.81

Switching cell fate, ncRNAs coming to play. Cell Death Dis (2013) 0.81

Restoration of Dlk1 and Rtl1 is necessary but insufficient to rescue lethality in intergenic differentially methylated region (IG-DMR)-deficient mice. J Biol Chem (2010) 0.80

Ground-state conditions promote robust Prdm14 reactivation and maintain an active Dlk1-Dio3 region during reprogramming. Mol Cells (2014) 0.80

Rapid transcriptional pulsing dynamics of high expressing retroviral transgenes in embryonic stem cells. PLoS One (2012) 0.80

Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting. Nat Commun (2015) 0.80

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell (2016) 0.80

Expression and imprinting analysis of AK044800, a transcript from the Dlk1-Dio3 imprinted gene cluster during mouse embryogenesis. Mol Cells (2013) 0.79

Reprogramming somatic cells by fusion with embryonic stem cells does not cause silencing of the Dlk1-Dio3 region in mice. World J Stem Cells (2012) 0.79

Overexpression of SNORD114-3 marks acute promyelocytic leukemia. Leukemia (2013) 0.79

Molecular mechanisms of pluripotency and reprogramming. Stem Cell Res Ther (2010) 0.79

Genomic imprinting is variably lost during reprogramming of mouse iPS cells. Stem Cell Res (2013) 0.78

Roles of small molecules in somatic cell reprogramming. Acta Pharmacol Sin (2013) 0.78

MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells. J Biol Chem (2013) 0.78

MicroRNAs targeting prostate cancer stem cells. Exp Biol Med (Maywood) (2015) 0.78

Looking into the black box: insights into the mechanisms of somatic cell reprogramming. Genes (Basel) (2011) 0.76

Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma. Oncotarget (2016) 0.76

Time to reconsider stem cell induction strategies. Cells (2012) 0.76

A reporter model to visualize imprinting stability at the Dlk1 locus during mouse development and in pluripotent cells. Development (2016) 0.76

Continuous passages accelerate the reprogramming of mouse induced pluripotent stem cells. Cell Reprogram (2014) 0.76

Progress and bottleneck in induced pluripotency. Cell Regen (Lond) (2012) 0.76

Pluripotency of induced pluripotent stem cells. Genomics Proteomics Bioinformatics (2013) 0.76

Differential genomic imprinting and expression of imprinted microRNAs in testes-derived male germ-line stem cells in mouse. PLoS One (2011) 0.76

Distinct MicroRNA Expression Signatures of Porcine Induced Pluripotent Stem Cells under Mouse and Human ESC Culture Conditions. PLoS One (2016) 0.75

miR-127 enhances myogenic cell differentiation by targeting S1PR3. Cell Death Dis (2017) 0.75

A non-invasive method to determine the pluripotent status of stem cells by culture medium microRNA expression detection. Sci Rep (2016) 0.75

Synergetic effects of DNA methylation and histone modification during mouse induced pluripotent stem cell generation. Sci Rep (2017) 0.75

microRNAs and Prostate Cancer. Adv Exp Med Biol (2015) 0.75

Present and future challenges of induced pluripotent stem cells. Philos Trans R Soc Lond B Biol Sci (2015) 0.75

Sex and age differences in the expression of liver microRNAs during the life span of F344 rats. Biol Sex Differ (2017) 0.75

Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. Cell Discov (2015) 0.75

Gene Signature of Human Oral Mucosa Fibroblasts: Comparison with Dermal Fibroblasts and Induced Pluripotent Stem Cells. Biomed Res Int (2015) 0.75

Epigenetic mechanisms of induced pluripotency. Contemp Oncol (Pozn) (2015) 0.75

Deleting maternal Gtl2 leads to growth enhancement and decreased expression of stem cell markers in teratoma. J Reprod Dev (2014) 0.75

miR-410 and miR-495 Are Dynamically Regulated in Diverse Cardiomyopathies and Their Inhibition Attenuates Pathological Hypertrophy. PLoS One (2016) 0.75

Are embryonic stem and induced pluripotent stem cells the same or different? Implications for their potential therapeutic use. Cell Cycle (2012) 0.75

Integrated analysis of hematopoietic differentiation outcomes and molecular characterization reveals unbiased differentiation capacity and minor transcriptional memory in HPC/HSC-iPSCs. Stem Cell Res Ther (2017) 0.75

Cell Pluripotency Levels Associated with Imprinted Genes in Human. Comput Math Methods Med (2015) 0.75

Cardiac Thyroid Hormone Metabolism and Heart Failure. Eur Thyroid J (2017) 0.75

An imprinted long noncoding RNA located between genes Meg8 and Meg9 in the cattle Dlk1-Dio3 domain. Genetica (2016) 0.75

Articles cited by this

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24

Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A (1993) 20.33

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08

Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04

Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62

Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55

Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A (2010) 7.31

GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis. Nucleic Acids Res (2008) 6.91

iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51

Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res (2008) 6.46

A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain. Genome Res (2004) 5.77

A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature (2009) 5.46

Capturing pluripotency. Cell (2008) 5.08

Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90

Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency. Stem Cells (2008) 3.81

The evolution of the DLK1-DIO3 imprinted domain in mammals. PLoS Biol (2008) 2.05

Pluripotency and nuclear reprogramming. Philos Trans R Soc Lond B Biol Sci (2008) 1.82

High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12. Genomics (2005) 1.60

Molecular framework underlying pluripotency. Cell Cycle (2008) 1.42

Articles by these authors

Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63

A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78

Genome-wide analysis of estrogen receptor binding sites. Nat Genet (2006) 18.63

Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell (2005) 14.32

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell (2008) 14.18

Model-based analysis of tiling-arrays for ChIP-chip. Proc Natl Acad Sci U S A (2006) 13.68

Genome-wide association studies of 14 agronomic traits in rice landraces. Nat Genet (2010) 8.75

The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci U S A (2005) 8.60

Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43

H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science (2008) 7.89

Model-based analysis of two-color arrays (MA2C). Genome Biol (2007) 7.28

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell (2009) 7.09

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00

GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis. Nucleic Acids Res (2008) 6.91

PlasmoDB: a functional genomic database for malaria parasites. Nucleic Acids Res (2008) 6.73

High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56

iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51

Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA (2008) 6.39

Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. Lancet (2013) 6.10

A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell (2007) 5.99

Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90

Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA (2011) 5.86

BSMAP: whole genome bisulfite sequence MAPping program. BMC Bioinformatics (2009) 5.67

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell (2005) 5.43

Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules. Mol Biol Cell (2002) 5.20

Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med (2003) 4.98

A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95

Cardiovascular risk and events in 17 low-, middle-, and high-income countries. N Engl J Med (2014) 4.88

Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med (2014) 4.86

Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet (2011) 4.85

Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature (2006) 4.68

Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA (2010) 4.64

A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. JAMA (2011) 4.63

A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Science (2007) 4.61

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35

RSeQC: quality control of RNA-seq experiments. Bioinformatics (2012) 4.31

Productivity is a poor predictor of plant species richness. Science (2011) 4.21

A novel influenza A (H1N1) vaccine in various age groups. N Engl J Med (2009) 4.20

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell (2012) 4.18

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97

Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med (2014) 3.96

A broadly implementable research course in phage discovery and genomics for first-year undergraduate students. MBio (2014) 3.93

TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79

Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host Microbe (2010) 3.73

Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature (2005) 3.67

Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat Biotechnol (2013) 3.65

UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke. Cell (2006) 3.65

Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses. Am Heart J (2008) 3.52

Meta-analysis of traditional Chinese patent medicine for ischemic stroke. Stroke (2007) 3.46

Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. Nat Genet (2009) 3.46

Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars. Nat Genet (2013) 3.41

Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis. Ann Intern Med (2015) 3.41

Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis. BMJ (2009) 3.39

The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients. J Hypertens (2005) 3.27

Naturopathic medicine for the prevention of cardiovascular disease: a randomized clinical trial. CMAJ (2013) 3.25

Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis. BMJ (2009) 3.22

CEAS: cis-regulatory element annotation system. Nucleic Acids Res (2006) 3.15

Analysis of the human endogenous coregulator complexome. Cell (2011) 2.97

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci U S A (2009) 2.95

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95

CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model. Nucleic Acids Res (2013) 2.88

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization. Nature (2008) 2.88

Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol (2002) 2.87

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87

Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol (2008) 2.84

Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med (2006) 2.83

Function annotation of the rice transcriptome at single-nucleotide resolution by RNA-seq. Genome Res (2010) 2.73

Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Mol Cell (2007) 2.71

Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid. J Clin Epidemiol (2011) 2.69

The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration. Cell Stem Cell (2012) 2.69

Structure and mechanism of human DNA polymerase eta. Nature (2010) 2.69

A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. Cell (2006) 2.68

Prediction and identification of herpes simplex virus 1-encoded microRNAs. J Virol (2006) 2.67

Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. Am J Hum Genet (2008) 2.65

Genome-wide genetic changes during modern breeding of maize. Nat Genet (2012) 2.60

A complete sequence of the T. tengcongensis genome. Genome Res (2002) 2.60

A new Mycobacterium species causing diffuse lepromatous leprosy. Am J Clin Pathol (2008) 2.59

Random walk in orthogonal space to achieve efficient free-energy simulation of complex systems. Proc Natl Acad Sci U S A (2008) 2.56

Prevalence of a healthy lifestyle among individuals with cardiovascular disease in high-, middle- and low-income countries: The Prospective Urban Rural Epidemiology (PURE) study. JAMA (2013) 2.55

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci U S A (2007) 2.53

Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol (2004) 2.49

DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression. Genome Res (2008) 2.48

Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease. Kidney Int (2013) 2.48

Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I. Science (2011) 2.47

Inflammatory breast cancer: the disease, the biology, the treatment. CA Cancer J Clin (2010) 2.45

A drinking water crisis in Lake Taihu, China: linkage to climatic variability and lake management. Environ Manage (2010) 2.45

Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes (2002) 2.44

Early use of noninvasive positive pressure ventilation for acute lung injury: a multicenter randomized controlled trial. Crit Care Med (2012) 2.43

Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2012) 2.42

Use of abdominopelvic computed tomography in emergency departments and rates of urgent diagnoses in Crohn's disease. Clin Gastroenterol Hepatol (2011) 2.40

Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J (2005) 2.37

GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis. Nucleic Acids Res (2008) 2.35

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other. Immunity (2003) 2.34

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet (2009) 2.34