Published in Mol Cell on March 12, 2004
Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat Rev Mol Cell Biol (2012) 3.43
What a difference a decade makes: insights into translesion DNA synthesis. Proc Natl Acad Sci U S A (2007) 3.32
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res (2008) 3.15
Structure and mechanism of human DNA polymerase eta. Nature (2010) 2.69
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J (2005) 2.37
Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin. EMBO J (2006) 2.25
Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release. EMBO J (2006) 2.23
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion. PLoS Biol (2006) 1.89
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure (2009) 1.59
Structural insight into translesion synthesis by DNA Pol II. Cell (2009) 1.39
Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota. EMBO J (2009) 1.33
A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment. Proc Natl Acad Sci U S A (2007) 1.33
Translesion DNA polymerases. Cold Spring Harb Perspect Biol (2013) 1.33
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". J Biol Chem (2009) 1.25
An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η. Biochemistry (2014) 1.23
A comprehensive comparison of DNA replication past 2-deoxyribose and its tetrahydrofuran analog in Escherichia coli. Nucleic Acids Res (2004) 1.22
Replication through an abasic DNA lesion: structural basis for adenine selectivity. EMBO J (2010) 1.16
Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase. J Mol Biol (2006) 1.14
Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. J Mol Biol (2010) 1.12
Base excision repair intermediates are mutagenic in mammalian cells. Nucleic Acids Res (2005) 1.11
Structural diversity of the Y-family DNA polymerases. Biochim Biophys Acta (2010) 1.10
DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics. Nucleic Acids Res (2007) 1.08
Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence. J Biol Chem (2008) 1.06
DNA synthesis across an abasic lesion by human DNA polymerase iota. Structure (2009) 1.04
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. J Biol Chem (2008) 1.03
Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions. J Am Chem Soc (2006) 1.02
A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Nucleic Acids Res (2006) 1.00
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Res (2009) 1.00
Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Chem Res Toxicol (2010) 0.99
Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4. EMBO J (2010) 0.98
A mechanism of nucleotide misincorporation during transcription due to template-strand misalignment. Mol Cell (2006) 0.96
DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions. Curr Opin Struct Biol (2011) 0.96
Replication of an oxidized abasic site in Escherichia coli by a dNTP-stabilized misalignment mechanism that reads upstream and downstream nucleotides. Biochemistry (2006) 0.96
Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization. J Am Chem Soc (2008) 0.95
Novel thermostable Y-family polymerases: applications for the PCR amplification of damaged or ancient DNAs. Nucleic Acids Res (2006) 0.95
DNA adduct structure-function relationships: comparing solution with polymerase structures. Chem Res Toxicol (2007) 0.94
Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase. J Biol Chem (2009) 0.93
Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) may accommodate lesion bypass. Protein Sci (2005) 0.93
Multiple solutions to inefficient lesion bypass by T7 DNA polymerase. DNA Repair (Amst) (2006) 0.92
Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases. Chem Res Toxicol (2006) 0.91
Structural and kinetic analysis of nucleoside triphosphate incorporation opposite an abasic site by human translesion DNA polymerase η. J Biol Chem (2015) 0.91
Translesion synthesis of abasic sites by yeast DNA polymerase epsilon. J Biol Chem (2009) 0.90
The Y-family DNA polymerase Dpo4 uses a template slippage mechanism to create single-base deletions. J Bacteriol (2011) 0.90
DNA sequence modulates the conformation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme. Biochemistry (2007) 0.90
Biochemical analysis of active site mutations of human polymerase η. Mutat Res (2013) 0.89
Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. J Mol Biol (2009) 0.89
UmuD(2) inhibits a non-covalent step during DinB-mediated template slippage on homopolymeric nucleotide runs. J Biol Chem (2010) 0.87
Ubiquitin mediates the physical and functional interaction between human DNA polymerases η and ι. Nucleic Acids Res (2012) 0.86
Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4. J Biol Chem (2009) 0.86
Contribution of partial charge interactions and base stacking to the efficiency of primer extension at and beyond abasic sites in DNA. Biochemistry (2012) 0.86
Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana. J Nucleic Acids (2010) 0.85
Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.85
DNA synthesis across an abasic lesion by yeast REV1 DNA polymerase. J Mol Biol (2010) 0.85
Translesion DNA polymerases are required for spontaneous deletion formation in Salmonella typhimurium. Proc Natl Acad Sci U S A (2009) 0.85
Mechanisms of mutagenesis: DNA replication in the presence of DNA damage. Mutat Res Rev Mutat Res (2016) 0.84
Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies. Nucleic Acids Res (2006) 0.84
Y-family polymerase conformation is a major determinant of fidelity and translesion specificity. Structure (2012) 0.83
Dynamic conformational change regulates the protein-DNA recognition: an investigation on binding of a Y-family polymerase to its target DNA. PLoS Comput Biol (2014) 0.82
RNA aptamers selected against DNA polymerase beta inhibit the polymerase activities of DNA polymerases beta and kappa. Nucleic Acids Res (2006) 0.82
Structural mechanism of replication stalling on a bulky amino-polycyclic aromatic hydrocarbon DNA adduct by a y family DNA polymerase. J Mol Biol (2013) 0.81
Roles of the Y-family DNA polymerase Dbh in accurate replication of the Sulfolobus genome at high temperature. DNA Repair (Amst) (2012) 0.81
Quantitative analysis of the mutagenic potential of 1-aminopyrene-DNA adduct bypass catalyzed by Y-family DNA polymerases. Mutat Res (2012) 0.81
Differential temperature-dependent multimeric assemblies of replication and repair polymerases on DNA increase processivity. Biochemistry (2012) 0.80
Mechanistic investigation of the bypass of a bulky aromatic DNA adduct catalyzed by a Y-family DNA polymerase. DNA Repair (Amst) (2014) 0.80
Amino acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase. J Biol Chem (2012) 0.80
Translesion DNA Synthesis. Ecosal Plus (2012) 0.80
Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation. J Biol Chem (2009) 0.80
Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions. Structure (2011) 0.79
Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase. Biochemistry (2009) 0.79
Formation of purine-purine mispairs by Sulfolobus solfataricus DNA polymerase IV. Biochemistry (2008) 0.79
Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase η and Sulfolobus solfataricus P2 Polymerase IV. J Am Chem Soc (2015) 0.78
Identification of an unfolding intermediate for a DNA lesion bypass polymerase. Chem Res Toxicol (2012) 0.77
Effects of N(2)-alkylguanine, O(6)-alkylguanine, and abasic lesions on DNA binding and bypass synthesis by the euryarchaeal B-family DNA polymerase vent (exo(-)). Chem Res Toxicol (2012) 0.77
Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling. PLoS Genet (2016) 0.77
Cytosine unstacking and strand slippage at an insertion-deletion mutation sequence in an overhang-containing DNA duplex. Biochemistry (2014) 0.76
Hypermutation signature reveals a slippage and realignment model of translesion synthesis by Rev3 polymerase in cisplatin-treated yeast. Proc Natl Acad Sci U S A (2017) 0.75
A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases. Theor Biol Med Model (2011) 0.75
Lesion-Induced Mutation in the Hyperthermophilic Archaeon Sulfolobus acidocaldarius and Its Avoidance by the Y-Family DNA Polymerase Dbh. Genetics (2015) 0.75
Translesion Synthesis DNA Polymerase Kappa Is Indispensable for DNA Repair Synthesis in Cisplatin Exposed Dorsal Root Ganglion Neurons. Mol Neurobiol (2017) 0.75
Mutagenic potential of hypoxanthine in live human cells. Mutat Res (2017) 0.75
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science (2008) 7.89
Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA (2011) 5.86
Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell (2005) 5.43
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. JAMA (2011) 4.63
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature (2005) 3.67
UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke. Cell (2006) 3.65
Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat Rev Mol Cell Biol (2012) 3.43
What a difference a decade makes: insights into translesion DNA synthesis. Proc Natl Acad Sci U S A (2007) 3.32
Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol Cell (2005) 3.16
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87
Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol (2008) 2.84
Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Mol Cell (2007) 2.71
Structure and mechanism of human DNA polymerase eta. Nature (2010) 2.69
Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J Biol Chem (2010) 2.59
Random walk in orthogonal space to achieve efficient free-energy simulation of complex systems. Proc Natl Acad Sci U S A (2008) 2.56
The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci U S A (2007) 2.53
Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol (2004) 2.49
Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease. Kidney Int (2013) 2.48
Inflammatory breast cancer: the disease, the biology, the treatment. CA Cancer J Clin (2010) 2.45
Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2012) 2.42
Use of abdominopelvic computed tomography in emergency departments and rates of urgent diagnoses in Crohn's disease. Clin Gastroenterol Hepatol (2011) 2.40
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J (2005) 2.37
Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other. Immunity (2003) 2.34
Gamma-secretase gene mutations in familial acne inversa. Science (2010) 2.30
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. J Exp Med (2003) 2.26
Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis (2011) 2.25
Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin. EMBO J (2006) 2.25
Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release. EMBO J (2006) 2.23
The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2. J Cell Biol (2004) 2.22
Delays in primary surgical treatment are not associated with significant tumor size progression in breast cancer patients. Ann Surg (2011) 2.16
Gene transfer to plants by diverse species of bacteria. Nature (2005) 2.11
Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis (2013) 2.09
Replication of a cis-syn thymine dimer at atomic resolution. Nature (2003) 2.07
Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res (2009) 2.07
Chimpanzee adenovirus antibodies in humans, sub-Saharan Africa. Emerg Infect Dis (2006) 1.99
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc Natl Acad Sci U S A (2010) 1.96
Black soot and the survival of Tibetan glaciers. Proc Natl Acad Sci U S A (2009) 1.93
Multidisciplinary considerations in the implementation of the findings from the American College of Surgeons Oncology Group (ACOSOG) Z0011 study: a practice-changing trial. Ann Surg Oncol (2011) 1.93
Watching DNA polymerase η make a phosphodiester bond. Nature (2012) 1.92
Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways. Radiology (2010) 1.84
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. J Exp Med (2005) 1.80
Fibroblast growth factor-23 and cardiovascular events in CKD. J Am Soc Nephrol (2013) 1.78
Brain tissue oxygen and outcome after severe traumatic brain injury: a systematic review. Crit Care Med (2009) 1.75
Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol (2012) 1.75
118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects. BMC Med Genet (2009) 1.74
Reduced risks of neural tube defects and orofacial clefts with higher diet quality. Arch Pediatr Adolesc Med (2011) 1.73
A multilevel adaptive finite element algorithm for bioluminescence tomography. Opt Express (2006) 1.71
Association of cardiac troponin T with left ventricular structure and function in CKD. Am J Kidney Dis (2013) 1.67
Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase. Proc Natl Acad Sci U S A (2004) 1.66
Large liver tumors: protocol for radiofrequency ablation and its clinical application in 110 patients--mathematic model, overlapping mode, and electrode placement process. Radiology (2004) 1.65
Adherence to a healthy lifestyle and all-cause mortality in CKD. Clin J Am Soc Nephrol (2013) 1.64
Molecular breeding of polymerases for amplification of ancient DNA. Nat Biotechnol (2007) 1.63
Predicting the extent of nodal disease in early-stage breast cancer. Ann Surg Oncol (2014) 1.63
Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J (2004) 1.61
Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases. Curr Opin Genet Dev (2004) 1.61
High-affinity peptide against MT1-MMP for in vivo tumor imaging. J Control Release (2011) 1.59
Crystal structure of T4 endonuclease VII resolving a Holliday junction. Nature (2007) 1.59
Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations. Cancer Res (2007) 1.56
H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells. J Biol Chem (2007) 1.56
Orofacial clefts in the National Birth Defects Prevention Study, 1997-2004. Am J Med Genet A (2009) 1.55
In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination. DNA Repair (Amst) (2003) 1.55
A structure-based model for the synthesis and hydrolysis of ATP by F1-ATPase. Cell (2005) 1.55
Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. Cancer (2006) 1.54
An enzymatic atavist revealed in dual pathways for water activation. PLoS Biol (2008) 1.52
Mid-pregnancy cotinine and risks of orofacial clefts and neural tube defects. J Pediatr (2008) 1.52
The draft genome of a socially polymorphic halictid bee, Lasioglossum albipes. Genome Biol (2013) 1.52
The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. Nucleic Acids Res (2006) 1.51
Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med (2012) 1.51
History-adjusted marginal structural analysis of the association between hemoglobin variability and mortality among chronic hemodialysis patients. Clin J Am Soc Nephrol (2008) 1.49
Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication. J Biol Chem (2004) 1.48
Xeroderma pigmentosum-variant patients from America, Europe, and Asia. J Invest Dermatol (2008) 1.46
Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells. Stem Cells (2005) 1.46
A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients. Virology (2008) 1.45
Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication. Mol Cell Biol (2009) 1.45
Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin. Proc Natl Acad Sci U S A (2012) 1.44
The active form of DNA polymerase V is UmuD'(2)C-RecA-ATP. Nature (2009) 1.43
Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations. J Am Chem Soc (2011) 1.42
Brain hyperthermia after traumatic brain injury does not reduce brain oxygen. Neurosurgery (2008) 1.42
Development of new cancers in patients with DCIS: the M.D. Anderson experience. Ann Surg Oncol (2007) 1.42
Inflammatory breast cancer: what we know and what we need to learn. Oncologist (2012) 1.41
Air pollution and birth weight in northern Nevada, 1991-1999. Inhal Toxicol (2002) 1.41
Systematic identification of microRNA and messenger RNA profiles in hepatitis C virus-infected human hepatoma cells. Virology (2009) 1.40
Structural insight into translesion synthesis by DNA Pol II. Cell (2009) 1.39
Mutations in PRRT2 result in paroxysmal dyskinesias with marked variability in clinical expression. J Med Genet (2011) 1.38
Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese. J Biol Chem (2007) 1.38
Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota. J Biol Chem (2004) 1.37
PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells (2011) 1.37
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. EMBO J (2002) 1.36
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat Immunol (2010) 1.35
Synergistic approach to improve "alchemical" free energy calculation in rugged energy surface. J Chem Phys (2007) 1.35