PubRank

Michael B Kastan

Author PubWeight™ 115.97‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003 20.13
2 Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 2006 6.52
3 The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010 5.12
4 Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 2002 4.27
5 Initiating cellular stress responses. Cell 2004 4.18
6 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 2005 4.16
7 Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 2007 4.14
8 Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev 2002 4.12
9 Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 2004 3.76
10 Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell 2002 3.71
11 ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab 2006 3.38
12 ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 2010 3.03
13 Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 2008 2.83
14 Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell 2008 2.46
15 ATM activation in normal human tissues and testicular cancer. Cell Cycle 2005 2.25
16 The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol 2004 2.23
17 Autophagy links inflammasomes to atherosclerotic progression. Cell Metab 2012 2.08
18 Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett 2010 1.99
19 Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol 2002 1.96
20 A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol 2013 1.96
21 Mitochondrial dysfunction in ataxia-telangiectasia. Blood 2011 1.93
22 Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res 2002 1.71
23 5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage. Genes Dev 2010 1.64
24 Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene 2004 1.58
25 Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res 2008 1.58
26 Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites. Nat Protoc 2008 1.49
27 BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. Mol Cell Biol 2004 1.45
28 The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev 2005 1.37
29 Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov 2013 1.25
30 Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer Res 2007 1.18
31 Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. Mol Cancer Res 2007 1.16
32 Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol Cancer Res 2003 1.15
33 The DNA damage response: implications for tumor responses to radiation and chemotherapy. Annu Rev Med 2014 1.13
34 Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. Cancer Res 2004 1.12
35 A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. Mol Cell Biol 2008 1.04
36 Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair. Proc Natl Acad Sci U S A 2013 1.02
37 Analyzing cell cycle checkpoints after ionizing radiation. Methods Mol Biol 2004 1.01
38 Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. J Biol Chem 2012 1.01
39 Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. J Virol 2008 0.98
40 Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. Mol Cancer Res 2004 0.96
41 p53: a two-faced cancer gene. Nat Cell Biol 2007 0.96
42 Molecular cross-talk among chromosome fragility syndromes. Genes Dev 2004 0.96
43 A new role for ATM: regulating mitochondrial function and mitophagy. Autophagy 2012 0.94
44 Phosphatases join kinases in DNA-damage response pathways. Trends Cell Biol 2004 0.91
45 Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks. EMBO J 2014 0.91
46 Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia. Cancer Epidemiol 2010 0.87
47 NAD+ modulates p53 DNA binding specificity and function. Mol Cell Biol 2004 0.85
48 A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Cancer Genet Cytogenet 2006 0.83
49 Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. J Biomol Screen 2014 0.83
50 Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. Int J Radiat Oncol Biol Phys 2012 0.78
51 A message from the Editor-in-Chief. Mol Cancer Res 2012 0.75
52 Cell biology: A BID for the pathway. Nature 2005 0.75