Published in Cell Cycle on March 15, 2010
Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology (2011) 1.08
Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Mol Biol Cell (2012) 1.06
Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis. Cold Spring Harb Perspect Biol (2011) 1.02
Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc Natl Acad Sci U S A (2010) 1.01
Modulation of microtubule dynamics by a TIR domain protein from the intracellular pathogen Brucella melitensis. Biochem J (2011) 0.98
Ubiquitin C-terminal hydrolase l1 in tumorigenesis. Biochem Res Int (2012) 0.93
The Ubiquitin Proteome of Toxoplasma gondii Reveals Roles for Protein Ubiquitination in Cell-Cycle Transitions. Cell Host Microbe (2015) 0.86
Proteomic survey of ubiquitin-linked nuclear proteins in interferon-stimulated macrophages. J Interferon Cytokine Res (2011) 0.82
Urea transporter UT-B deletion induces DNA damage and apoptosis in mouse bladder urothelium. PLoS One (2013) 0.81
PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development. Histochem Cell Biol (2011) 0.80
Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction. Biochem J (2016) 0.79
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation. Virology (2013) 0.77
Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation. Cell Death Dis (2014) 0.77
Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy. Front Cell Neurosci (2015) 0.77
Recent progress in histochemistry and cell biology. Histochem Cell Biol (2012) 0.76
UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression. Oncotarget (2015) 0.75
Defining the human deubiquitinating enzyme interaction landscape. Cell (2009) 11.39
Tubulin modifications and their cellular functions. Curr Opin Cell Biol (2008) 3.52
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell (2002) 3.21
The tubulin code. Cell Cycle (2007) 2.80
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol (2004) 2.46
Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. Proc Natl Acad Sci U S A (1977) 2.41
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet (2003) 2.24
Protein partners of deubiquitinating enzymes. Biochem J (2008) 2.15
Post-translational modifications of tau protein in Alzheimer's disease. J Neural Transm (Vienna) (2004) 1.78
The functions of UCH-L1 and its relation to neurodegenerative diseases. Neurochem Int (2007) 1.77
DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors. Cell Cycle (2009) 1.77
Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. J Neurosci (2003) 1.75
Microtubule-associated protein tau in development, degeneration and protection of neurons. Prog Neurobiol (2008) 1.74
Gamma-tubulin complexes and microtubule organization. Curr Opin Cell Biol (2006) 1.64
Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues. Biochemistry (1996) 1.61
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A (2004) 1.59
Ubiquitin-proteasome system and Parkinson's diseases. Exp Neurol (2005) 1.47
Post-translational modifications of tubulin in the nervous system. J Neurochem (2009) 1.44
Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control. Biol Reprod (2003) 1.38
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer. Am J Pathol (1999) 1.36
Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. Mol Cell Biol (2005) 1.33
Parkin stabilizes microtubules through strong binding mediated by three independent domains. J Biol Chem (2005) 1.25
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis. Oncogene (2008) 1.23
The ubiquitin conjugation system is involved in the disassembly of cilia and flagella. J Cell Biol (2009) 1.23
The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders. Drug News Perspect (2007) 1.21
PGP9.5 as a prognostic factor in pancreatic cancer. Clin Cancer Res (2000) 1.18
BRCA1 regulates gamma-tubulin binding to centrosomes. Cancer Biol Ther (2007) 1.15
Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies. Curr Alzheimer Res (2008) 1.14
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1. Hum Mol Genet (2008) 1.08
The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes. Environ Mol Mutagen (2009) 1.06
Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling. PLoS One (2009) 1.06
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes. PLoS One (2009) 1.02
Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells. Br J Haematol (2004) 1.02
High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer. Cancer Sci (2006) 0.99
Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease. Mol Neurobiol (1991) 0.98
Control at the cell center: the role of spindle poles in cytoskeletal organization and cell cycle regulation. Cell Cycle (2007) 0.98
A new function of microtubule-associated protein tau: involvement in chromosome stability. Cell Cycle (2008) 0.98
Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells. Int J Oncol (2008) 0.95
The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase. Biochem J (1990) 0.94
The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation. J Cell Mol Med (2009) 0.90
The BRCA1 E3 ubiquitin ligase controls centrosome dynamics. Cell Cycle (2006) 0.90
Post-translational modifications of tau protein. Bratisl Lek Listy (2006) 0.89
Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation. Biochem Biophys Res Commun (2009) 0.87
Characterization of genes associated with different phenotypes of human bladder cancer cells. Acta Biochim Biophys Sin (Shanghai) (2006) 0.84
Stimulation of the murine Uchl1 gene promoter by the B-Myb transcription factor. Lung Cancer (2003) 0.84
Gefitinib-responsive EGFR-positive colorectal cancers have different proteome profiles from non-responsive cell lines. Eur J Cancer (2005) 0.83
Hyperphosphorylation of microtubule-associated tau protein plays dual role in neurodegeneration and neuroprotection. Pathophysiology (2009) 0.83
Tubulin folding pathways: implication in the regulation of microtubule dynamics. Curr Cancer Drug Targets (2007) 0.78
The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends. Mol Cell (2003) 4.03
Delivery of multiple siRNAs using lipid-coated PLGA nanoparticles for treatment of prostate cancer. Nano Lett (2011) 1.92
Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res (2007) 1.69
Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res (2006) 1.55
Structure and function of IRF-7. J Interferon Cytokine Res (2002) 1.53
The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors. Cancer Res (2004) 1.50
The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2004) 1.46
Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis. J Biol Chem (2009) 1.46
Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling. J Biol Chem (2005) 1.45
Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit. J Virol (2003) 1.42
Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Mol Pharmacol (2004) 1.39
Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha. Mol Cell Biol (2004) 1.33
EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells. Cancer Res (2006) 1.31
Phosphorylation of the Epstein-Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBV-encoded protein kinase and effects of the L-riboside benzimidazole 1263W94. J Virol (2002) 1.30
Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway. Cancer Res (2007) 1.26
TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1. Mol Cell Biol (2008) 1.25
Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles. J Am Chem Soc (2012) 1.23
Epstein-Barr virus-encoded protein kinase (BGLF4) is involved in production of infectious virus. J Virol (2007) 1.23
Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination. Mol Cell Biol (2007) 1.23
Conserved herpesvirus protein kinases. Biochim Biophys Acta (2007) 1.17
Hyperphosphorylation of EBNA2 by Epstein-Barr virus protein kinase suppresses transactivation of the LMP1 promoter. J Virol (2005) 1.15
Targeting of host-cell ubiquitin pathways by viruses. Essays Biochem (2005) 1.14
The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production. J Virol (2010) 1.12
Tissue regeneration in vivo within recombinant spidroin 1 scaffolds. Biomaterials (2012) 1.12
Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines. J Virol (2011) 1.11
Epstein-Barr virus activates beta-catenin in type III latently infected B lymphocyte lines: association with deubiquitinating enzymes. Proc Natl Acad Sci U S A (2003) 1.08
Epstein-Barr virus infections: prospects for treatment. J Antimicrob Chemother (2005) 1.08
The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity. J Virol (2009) 1.06
Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling. PLoS One (2009) 1.06
Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties. J Virol (2004) 1.05
New associations of human papillomavirus, Simian virus 40, and Epstein-Barr virus with human cancer. J Natl Cancer Inst (2002) 1.03
Tumor viruses and cell signaling pathways: deubiquitination versus ubiquitination. Mol Cell Biol (2004) 1.02
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes. PLoS One (2009) 1.02
Multiple signal transducers and activators of transcription are induced by EBV LMP-1. Virology (2004) 1.01
Up-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells. Proc Natl Acad Sci U S A (2005) 1.00
Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers. Biochemistry (2011) 1.00
Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma. Int J Cancer (2005) 1.00
MUC1 induced by Epstein-Barr virus latent membrane protein 1 causes dissociation of the cell-matrix interaction and cellular invasiveness via STAT signaling. J Virol (2006) 0.99
Epstein-barr virus latent membrane protein 1 induces and causes release of fibroblast growth factor-2. Cancer Res (2002) 0.98
Interferon regulatory factor 5 represses expression of the Epstein-Barr virus oncoprotein LMP1: braking of the IRF7/LMP1 regulatory circuit. J Virol (2005) 0.98
Epstein-Barr virus latent membrane protein 1 promotes concentration in multivesicular bodies of fibroblast growth factor 2 and its release through exosomes. Int J Cancer (2007) 0.98
FALS mutations in Cu, Zn superoxide dismutase destabilize the dimer and increase dimer dissociation propensity: a large-scale thermodynamic analysis. Amyloid (2006) 0.98
Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication. J Virol (2009) 0.97
Interferon regulatory factor 7 is negatively regulated by the Epstein-Barr virus immediate-early gene, BZLF-1. J Virol (2005) 0.96
The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7. J Virol (2010) 0.96
Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites. J Virol (2012) 0.94
Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol (2004) 0.93
Effects of maribavir and selected indolocarbazoles on Epstein-Barr virus protein kinase BGLF4 and on viral lytic replication. Antimicrob Agents Chemother (2004) 0.90
Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9. J Virol (2011) 0.90
Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA. J Bacteriol (2010) 0.90
Epstein-Barr virus induces invasion and metastasis factors. Anticancer Res (2003) 0.90
Upregulation of special AT-rich-binding protein 1 by Epstein-Barr virus latent membrane protein 1 in human nasopharyngeal cells and nasopharyngeal cancer. J Gen Virol (2012) 0.89
Mitosis-specific hyperphosphorylation of Epstein-Barr virus nuclear antigen 2 suppresses its function. J Virol (2004) 0.87
Is Epstein-Barr virus transmitted sexually? J Infect Dis (2007) 0.86
Epstein-Barr virus latent membrane protein 1 regulates the function of interferon regulatory factor 7 by inducing its sumoylation. J Virol (2012) 0.86
Epstein-Barr virus BRLF1 inhibits transcription of IRF3 and IRF7 and suppresses induction of interferon-beta. Virology (2010) 0.85
Non-native soluble oligomers of Cu/Zn superoxide dismutase (SOD1) contain a conformational epitope linked to cytotoxicity in amyotrophic lateral sclerosis (ALS). Biochemistry (2014) 0.85
PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells. Leuk Lymphoma (2011) 0.83
Ribonucleotide reductase inhibitors enhance cidofovir-induced apoptosis in EBV-positive nasopharyngeal carcinoma xenografts. Int J Cancer (2005) 0.81
Role of the ubiquitin system and tumor viruses in AIDS-related cancer. BMC Biochem (2007) 0.80
Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase. J Virol (2013) 0.80
cdc2/cyclin B1-dependent phosphorylation of EBNA2 at Ser243 regulates its function in mitosis. J Virol (2006) 0.79
The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity. J Virol (2014) 0.78
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation. Virology (2013) 0.77