Published in Mol Cell Biol on October 01, 2005
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature (2011) 3.30
Evolutionary pathways in BRCA1-associated breast tumors. Cancer Discov (2012) 2.01
Aurora A kinase (AURKA) in normal and pathological cell division. Cell Mol Life Sci (2012) 1.84
A clinical overview of centrosome amplification in human cancers. Int J Biol Sci (2011) 1.71
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J Exp Med (2013) 1.30
SADB phosphorylation of gamma-tubulin regulates centrosome duplication. Nat Cell Biol (2009) 1.18
BRCA1 regulates gamma-tubulin binding to centrosomes. Cancer Biol Ther (2007) 1.15
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol (2011) 1.12
KIAA0101 interacts with BRCA1 and regulates centrosome number. Mol Cancer Res (2011) 1.04
Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulin. J Virol (2007) 1.04
Heterochromatin instability in cancer: from the Barr body to satellites and the nuclear periphery. Semin Cancer Biol (2012) 1.01
Centrosomes as signalling centres. Philos Trans R Soc Lond B Biol Sci (2014) 0.97
Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase. J Biol Chem (2012) 0.97
Ubiquitin editing enzyme UCH L1 and microtubule dynamics: implication in mitosis. Cell Cycle (2010) 0.96
Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther (2008) 0.93
Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. J Biol Chem (2010) 0.91
Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation. Cell Cycle (2012) 0.90
DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability. Oncogenesis (2014) 0.90
BRCA1 regulates microtubule dynamics and taxane-induced apoptotic cell signaling. Oncogene (2013) 0.85
The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations. Scientifica (Cairo) (2012) 0.85
BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression. J Biol Chem (2009) 0.85
Can the status of the breast and ovarian cancer susceptibility gene 1 product (BRCA1) predict response to taxane-based cancer therapy? Anticancer Agents Med Chem (2009) 0.84
Proteomic survey of ubiquitin-linked nuclear proteins in interferon-stimulated macrophages. J Interferon Cytokine Res (2011) 0.82
NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels. Cancer Biol Ther (2014) 0.80
Mitotic functions for SNAP45, a subunit of the small nuclear RNA-activating protein complex SNAPc. J Biol Chem (2008) 0.79
Delocalization of gamma-tubulin due to increased solubility in human breast cancer cell lines. Cancer Biol Ther (2010) 0.79
Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2. Cell Cycle (2014) 0.77
Centrosomes in the DNA damage response-the hub outside the centre. Chromosome Res (2016) 0.77
Cell cycle-dependent localization of CHK2 at centrosomes during mitosis. Cell Div (2013) 0.76
The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia. Oncotarget (2015) 0.76
ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. J Cell Biol (2016) 0.75
Plk1-mediated stabilization of 53BP1 through USP7 regulates centrosome positioning to maintain bipolarity. Oncogene (2016) 0.75
Targeting mitotic pathways for endocrine-related cancer therapeutics. Endocr Relat Cancer (2017) 0.75
Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat Genet (1996) 12.96
Cell cycle extracts. Methods Cell Biol (1991) 9.47
Proteomic characterization of the human centrosome by protein correlation profiling. Nature (2003) 8.74
BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer (2004) 6.24
Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex. Nature (1995) 6.12
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell (1999) 5.28
Centrosome aberrations: cause or consequence of cancer progression? Nat Rev Cancer (2002) 4.88
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem (2001) 4.51
The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. Methods Cell Biol (1999) 4.31
In vitro reconstitution of centrosome assembly and function: the central role of gamma-tubulin. Cell (1994) 4.27
Pericentrin and gamma-tubulin form a protein complex and are organized into a novel lattice at the centrosome. J Cell Biol (1998) 4.23
Assembly of centrosomal proteins and microtubule organization depends on PCM-1. J Cell Biol (2002) 3.86
Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci U S A (2002) 3.81
Centrosome-dependent exit of cytokinesis in animal cells. Science (2001) 3.68
Structural and chemical characterization of isolated centrosomes. Cell Motil Cytoskeleton (1987) 3.57
The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules. J Cell Biol (1999) 3.42
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex. Proc Natl Acad Sci U S A (2003) 3.37
Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proc Natl Acad Sci U S A (1998) 3.23
Re-evaluating centrosome function. Nat Rev Mol Cell Biol (2001) 2.96
Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet (1999) 2.83
gamma-Tubulin in mammalian cells: the centrosomal and the cytosolic forms. J Cell Sci (1996) 2.59
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet (1998) 2.55
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol (2004) 2.46
Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle. J Cell Biol (1981) 2.43
Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds. J Cell Biol (1998) 2.42
BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell (2002) 2.24
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem (2002) 2.08
Isolation of mammalian centrosomes. Methods Enzymol (1986) 1.94
Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase. J Cell Biol (1992) 1.82
BRCA1 is associated with the centrosome during mitosis. Proc Natl Acad Sci U S A (1998) 1.81
Tracing the network connecting BRCA and Fanconi anaemia proteins. Nat Rev Cancer (2004) 1.76
Insights into microtubule nucleation from the crystal structure of human gamma-tubulin. Nature (2005) 1.66
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair. Curr Opin Cell Biol (2003) 1.65
Parthenogenesis in Xenopus eggs requires centrosomal integrity. J Cell Biol (1990) 1.62
Amplified centrosomes in breast cancer: a potential indicator of tumor aggressiveness. Breast Cancer Res Treat (2002) 1.58
BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. J Biol Chem (2005) 1.46
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Oncogene (2003) 1.43
Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase. J Biol Chem (2004) 1.39
Identification of a gamma-tubulin-binding domain in BRCA1. Cancer Res (2001) 1.26
Subcellular localization of the BRCA1 gene product in mitotic cells. Genes Chromosomes Cancer (2002) 1.22
An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers. Int J Cancer (1998) 1.17
Conditional mutations in gamma-tubulin reveal its involvement in chromosome segregation and cytokinesis. Mol Biol Cell (2001) 1.13
Regulating centrosomes by protein phosphorylation. Curr Top Dev Biol (2000) 1.13
Epidemiology, prevention, and early detection of breast cancer. Curr Opin Oncol (1997) 0.99
Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells. J Cell Sci (1999) 0.94
The nucleolar phosphoprotein B23 redistributes in part to the spindle poles during mitosis. J Cell Sci (1999) 0.93
Genetic epidemiology of BRCA1. Cancer Biol Ther (2004) 0.86
Microtubule nucleating capacity of centrosomes in tissue sections. J Histochem Cytochem (1999) 0.83
Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet (2007) 4.69
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell (2006) 3.46
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell (2013) 3.26
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol (2004) 2.46
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol (2004) 2.06
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet (2006) 2.03
Evidence for an upper limit to mitotic spindle length. Curr Biol (2008) 1.94
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair. Curr Opin Cell Biol (2003) 1.65
How does a millimeter-sized cell find its center? Cell Cycle (2009) 1.48
Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase. J Biol Chem (2005) 1.47
BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. J Biol Chem (2005) 1.46
A new method reveals microtubule minus ends throughout the meiotic spindle. J Cell Biol (2006) 1.46
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Oncogene (2003) 1.43
Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells. Genes Dev (2005) 1.42
The tumor suppressor protein p53 functions similarly to p63 and p73 in activating transcription in vitro. Cancer Biol Ther (2005) 1.42
Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination. Cancer Res (2010) 1.41
NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell (2006) 1.37
Direct DNA binding activity of the Fanconi anemia D2 protein. J Biol Chem (2005) 1.33
Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. Cancer Res (2006) 1.32
Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage. Mol Cell (2009) 1.27
Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Curr Biol (2009) 1.27
Weighted frequent gene co-expression network mining to identify genes involved in genome stability. PLoS Comput Biol (2012) 1.19
Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity. Curr Biol (2009) 1.19
Substrates of the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther (2006) 1.18
BRCA1 regulates gamma-tubulin binding to centrosomes. Cancer Biol Ther (2007) 1.15
The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. Cancer Res (2002) 1.14
Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function. Cancer Res (2006) 1.13
BRCA1 DNA-binding activity is stimulated by BARD1. Cancer Res (2006) 1.12
Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation. Cancer Res (2007) 1.07
Elongation by RNA polymerase II on chromatin templates requires topoisomerase activity. Nucleic Acids Res (2003) 1.06
KIAA0101 interacts with BRCA1 and regulates centrosome number. Mol Cancer Res (2011) 1.04
MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples. Bioinformatics (2013) 1.04
Histone deacetylases 9 and 10 are required for homologous recombination. J Biol Chem (2011) 1.03
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2007) 1.01
Centrosome function in normal and tumor cells. J Cell Biochem (2006) 1.01
Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. J Biol Chem (2007) 1.00
Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes. Nucleic Acids Res (2012) 0.98
BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein. Cancer Sci (2011) 0.96
Phosphorylation of histone H2A inhibits transcription on chromatin templates. J Biol Chem (2004) 0.96
TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells. J Biol Chem (2010) 0.95
Binding of SeqA protein to hemi-methylated GATC sequences enhances their interaction and aggregation properties. J Biol Chem (2004) 0.94
Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther (2008) 0.93
The RANTES -403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease. Clin Sci (Lond) (2007) 0.92
Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol. Mol Biol Cell (2013) 0.92
DFI: gene feature discovery in RNA-seq experiments from multiple sources. BMC Genomics (2012) 0.90
Multiple mechanisms contribute to inhibit transcription in response to DNA damage. J Biol Chem (2008) 0.89
BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A (2013) 0.88
Analysis of BRCA1 variants in double-strand break repair by homologous recombination and single-strand annealing. Hum Mutat (2012) 0.88
BRCA1 represses amphiregulin gene expression. Cancer Res (2010) 0.88
Unique classes of mutations in the Saccharomyces cerevisiae G-protein translation elongation factor 1A suppress the requirement for guanine nucleotide exchange. Genetics (2006) 0.87
Human TopBP1 localization to the mitotic centrosome mediates mitotic progression. Exp Cell Res (2011) 0.85
Direct stimulation of transcription initiation by BRCA1 requires both its amino and carboxyl termini. J Biol Chem (2006) 0.85
BRCA1 control of steroid receptor ubiquitination. Sci STKE (2007) 0.85
PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells. PLoS One (2010) 0.84
Gene Co-expression analysis predicts genetic aberration loci associated with colon cancer metastasis. Int J Comput Biol Drug Des (2013) 0.83
Expression of an amino-terminal BRCA1 deletion mutant causes a dominant growth inhibition in MCF10A cells. Oncogene (2004) 0.82
Comparing multiple ChIP-sequencing experiments. J Bioinform Comput Biol (2011) 0.81
Transcription from the perspective of the DNA: twists and bumps in the road. Crit Rev Eukaryot Gene Expr (2003) 0.80
BRCA1/BARD1 E3 ubiquitin ligase can modify histones H2A and H2B in the nucleosome particle. J Biomol Struct Dyn (2010) 0.80
Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver. Pharmacogenet Genomics (2013) 0.79
Promoters active in interphase are bookmarked during mitosis by ubiquitination. Nucleic Acids Res (2012) 0.78
Acquisition of selective antitumoral effects of recombinant adeno-associated virus by genetically inserting tumor-targeting peptides into capsid proteins. Oncol Lett (2011) 0.76
Electron microscopy of microtubule cytoskeleton assembly in vitro. Methods Mol Biol (2014) 0.75