Published in Cell Cycle on March 09, 2010
Roles of COP9 signalosome in cancer. Cell Cycle (2011) 1.37
Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle (2010) 1.10
Rapamycin resistance is linked to defective regulation of Skp2. Cancer Res (2012) 1.04
AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2. Oncotarget (2015) 0.91
ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication. Cell Cycle (2013) 0.91
Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer. Endocrinology (2013) 0.90
A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins. J Biol Chem (2011) 0.90
Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. Oncotarget (2015) 0.90
Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer. PLoS One (2012) 0.89
The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway. Cancer Cell Int (2014) 0.88
Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem (2010) 0.87
PI3K regulation of the SKP-2/p27 axis through mTORC2. Oncogene (2012) 0.86
Connexin Controls Cell-Cycle Exit and Cell Differentiation by Directly Promoting Cytosolic Localization and Degradation of E3 Ligase Skp2. Dev Cell (2015) 0.86
Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. EMBO J (2012) 0.84
APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1. PLoS One (2011) 0.82
Androgen suppresses the proliferation of androgen receptor-positive castration-resistant prostate cancer cells via inhibition of Cdk2, CyclinA, and Skp2. PLoS One (2014) 0.81
Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2). J Biol Chem (2014) 0.76
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development (2007) 5.62
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep (2003) 2.52
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell (2011) 2.35
Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features. Genome Res (2011) 1.94
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci U S A (2007) 1.93
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J Hematol Oncol (2010) 1.92
The IKK-related kinases: from innate immunity to oncogenesis. Cell Res (2008) 1.71
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation (2004) 1.69
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circ Res (2010) 1.56
Atypical mitogen-activated protein kinases: structure, regulation and functions. Biochim Biophys Acta (2006) 1.56
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. EMBO J (2008) 1.53
Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases. Physiol Rev (2009) 1.53
Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. EMBO J (2004) 1.43
Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther (2010) 1.42
N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Mol Cell Biol (2004) 1.40
ERKs in cancer: friends or foes? Cancer Res (2014) 1.37
Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. Mol Cell Biol (2003) 1.35
A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. Mol Cell Proteomics (2010) 1.34
The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. EMBO Rep (2008) 1.33
New insights into replication origin characteristics in metazoans. Cell Cycle (2012) 1.29
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals. J Biol Chem (2004) 1.24
The eIF4E RNA regulon promotes the Akt signaling pathway. J Cell Biol (2008) 1.22
Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Mol Cell Biol (2003) 1.22
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. J Cell Physiol (2008) 1.20
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol (2008) 1.19
Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression. J Biol Chem (2003) 1.19
Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J Immunol (2006) 1.19
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev (2013) 1.18
Genetic and epigenetic determinants of DNA replication origins, position and activation. Curr Opin Genet Dev (2013) 1.17
Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4. J Biol Chem (2006) 1.16
Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood (2013) 1.15
Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proc Natl Acad Sci U S A (2009) 1.12
Cyclic AMP induces morphological changes of vascular smooth muscle cells by inhibiting a Rac-dependent signaling pathway. J Cell Physiol (2005) 1.09
Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Mol Cell Biol (2010) 1.07
Programming DNA replication origins and chromosome organization. Chromosome Res (2010) 1.05
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells. Genes Dev (2006) 1.04
p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. J Cell Biol (2005) 1.03
ER stress affects processing of MHC class I-associated peptides. BMC Immunol (2009) 1.02
Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. J Biol Chem (2010) 1.01
Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. BMC Cancer (2008) 1.01
Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol (2013) 0.99
The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Mol Cell Biol (2012) 0.96
Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1. J Biol Chem (2002) 0.96
C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis. Biochem J (2010) 0.96
Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells. Exp Hematol (2007) 0.95
EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors. Am J Physiol Cell Physiol (2002) 0.95
Genome-scale identification of active DNA replication origins. Methods (2012) 0.95
Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity. PLoS Pathog (2012) 0.95
EN2 is a candidate oncogene in human breast cancer. Oncogene (2005) 0.93
Role of p44/p42 MAP kinase in the age-dependent increase in vascular smooth muscle cell proliferation and neointimal formation. Arterioscler Thromb Vasc Biol (2003) 0.93
Liver fibrosis protects mice from acute hepatocellular injury. Gastroenterology (2011) 0.92
Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis. Proc Natl Acad Sci U S A (2010) 0.92
Artifactual sulfation of silver-stained proteins: implications for the assignment of phosphorylation and sulfation sites. Mol Cell Proteomics (2008) 0.89
ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses. Proteomics (2011) 0.89
Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation. Cancer Res (2012) 0.89
The protein kinase ERK3 is encoded by a single functional gene: genomic analysis of the ERK3 gene family. Genomics (2002) 0.88
Dual-tag prokaryotic vectors for enhanced expression of full-length recombinant proteins. Anal Biochem (2002) 0.87
Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases. Mol Cell Biol (2010) 0.87
PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage. Nucleic Acids Res (2014) 0.87
The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism. Oncogene (2002) 0.85
Cell viability and secretion of active proteins in Schizosaccharomyces pombe do not require the chaperone function of calnexin. Biochem J (2004) 0.83
Phosphorylation of the MAPKKK regulator Ste50p in Saccharomyces cerevisiae: a casein kinase I phosphorylation site is required for proper mating function. Eukaryot Cell (2003) 0.82
Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood (2012) 0.80
The atypical MAPK ERK3 controls positive selection of thymocytes. Immunology (2015) 0.80
E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells. Autophagy (2011) 0.77
[Cdc14B/Skp2/p27 : a novel cancer axis of evil?]. Med Sci (Paris) (2009) 0.77
Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression. Oncogene (2003) 0.76
Angiotensin II AT(2) receptor inhibits smooth muscle cell migration via fibronectin cell production and binding. Am J Physiol Cell Physiol (2002) 0.76
Effects of angiotensin-converting enzyme inhibitor versus valsartan on cellular signaling events in heart transplant. Ann Pharmacother (2009) 0.75