Published in Mol Cancer Ther on June 08, 2010
Cellular fatty acid metabolism and cancer. Cell Metab (2013) 2.82
Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis. Cancer Cell (2015) 2.21
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Dis Model Mech (2013) 1.55
The fat side of prostate cancer. Biochim Biophys Acta (2013) 1.46
Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells. PLoS One (2010) 1.24
Stearoyl CoA desaturase 1: role in cellular inflammation and stress. Adv Nutr (2011) 1.16
Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells. Cell Death Dis (2013) 1.07
Lipids and prostate cancer. Prostaglandins Other Lipid Mediat (2012) 1.01
Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis. Cell Cycle (2012) 0.97
Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer. PLoS One (2011) 0.97
Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene (2015) 0.97
PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation. Cell Death Dis (2012) 0.97
High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients. Breast Cancer Res Treat (2012) 0.97
Lipid metabolism in prostate cancer. Am J Clin Exp Urol (2014) 0.96
Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol (2012) 0.95
The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer (2016) 0.95
Roles of StearoylCoA Desaturase-1 in the Regulation of Cancer Cell Growth, Survival and Tumorigenesis. Cancers (Basel) (2011) 0.94
Prostate cancer gene expression signature of patients with high body mass index. Prostate Cancer Prostatic Dis (2010) 0.92
Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1. Oncotarget (2014) 0.92
Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. World J Gastroenterol (2014) 0.91
Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy (2013) 0.88
Stearoyl CoA desaturase (SCD) facilitates proliferation of prostate cancer cells through enhancement of androgen receptor transactivation. Mol Cells (2011) 0.87
StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. PLoS One (2012) 0.86
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab (2016) 0.85
A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy. Oncotarget (2015) 0.84
Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth. Oncogene (2012) 0.82
p53 attenuates AKT signaling by modulating membrane phospholipid composition. Oncotarget (2015) 0.79
SCD1 Expression is dispensable for hepatocarcinogenesis induced by AKT and Ras oncogenes in mice. PLoS One (2013) 0.78
17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells. BMC Cancer (2015) 0.78
Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification. Oncogene (2015) 0.78
Subcutaneous adipose tissue fatty acid desaturation in adults with and without rare adipose disorders. Lipids Health Dis (2012) 0.78
Stearoyl-CoA desaturase enzyme 1 inhibition reduces glucose utilization for de novo fatty acid synthesis and cell proliferation in 3T3-L1 adipocytes. Metabolomics (2013) 0.78
Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells. J Cell Physiol (2014) 0.77
Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells. J Biol Chem (2016) 0.76
Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. Cell Rep (2015) 0.76
A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis. Oncotarget (2016) 0.76
Aberrant Lipid Metabolism Promotes Prostate Cancer: Role in Cell Survival under Hypoxia and Extracellular Vesicles Biogenesis. Int J Mol Sci (2016) 0.76
Prediction of therapeutic microRNA based on the human metabolic network. Bioinformatics (2014) 0.76
Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes. Cancer Biol Ther (2015) 0.76
Design, radiosynthesis, and evaluation of radiotracers for positron emission tomography imaging of stearoyl-CoA desaturase-1. Bioorg Med Chem Lett (2015) 0.75
Targeting Lipid Metabolic Reprogramming as Anticancer Therapeutics. J Cancer Prev (2016) 0.75
PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase. FEBS Open Bio (2017) 0.75
Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer (2017) 0.75
Metabolic Effect of Estrogen Receptor Agonists on Breast Cancer Cells in the Presence or Absence of Carbonic Anhydrase Inhibitors. Metabolites (2016) 0.75
EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer. Mol Cancer (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
On the origin of cancer cells. Science (1956) 49.55
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (1997) 29.34
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1996) 26.30
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
On respiratory impairment in cancer cells. Science (1956) 14.07
The development of androgen-independent prostate cancer. Nat Rev Cancer (2001) 11.88
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer (2007) 10.20
Akt stimulates aerobic glycolysis in cancer cells. Cancer Res (2004) 9.35
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell (2006) 7.49
The program of androgen-responsive genes in neoplastic prostate epithelium. Proc Natl Acad Sci U S A (2002) 5.98
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell (2006) 4.89
Lipid signalling in disease. Nat Rev Mol Cell Biol (2008) 4.85
Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Invest (2008) 4.13
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell (2009) 3.85
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition (2000) 3.58
Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci U S A (1994) 3.50
ATP citrate lyase is an important component of cell growth and transformation. Oncogene (2005) 3.48
AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest (2006) 3.39
Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care (2006) 3.09
The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell (2002) 2.61
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem (2005) 2.57
Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab (2007) 2.25
Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer. Cancer Res (2004) 2.15
Protein lipidation. FEBS J (2007) 2.10
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br J Cancer (2009) 2.05
Dissecting lipid raft facilitated cell signaling pathways in cancer. Biochim Biophys Acta (2007) 2.04
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res (1999) 1.95
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol Cancer Res (2003) 1.83
Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res (1953) 1.64
Signal transduction in prostate cancer progression. Clin Sci (Lond) (2005) 1.64
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol (2005) 1.63
Pten inactivation and the emergence of androgen-independent prostate cancer. Cancer Res (2007) 1.59
Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2. J Cell Sci (2002) 1.48
Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int J Oncol (2008) 1.36
Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression. Prostate (2001) 1.32
Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab (2005) 1.31
Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Cancer Res (2002) 1.31
FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene (2005) 1.29
Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma. J Hepatol (2008) 1.25
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. Cancer Res (2009) 1.24
Endocrine-induced regression of cancers. Science (1967) 1.22
PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner. Oncogene (2003) 1.05
v-rasH expression confers hormone-independent in vitro growth to LNCaP prostate carcinoma cells. Mol Endocrinol (1991) 0.93
Role of the Akt pathway in prostate cancer. Curr Cancer Drug Targets (2009) 0.89
Chain separation of monounsaturated fatty acid methyl esters by argentation thin-layer chromatography. J Chromatogr A (2001) 0.79
A map of the interactome network of the metazoan C. elegans. Science (2004) 15.60
Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA (2006) 11.78
Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract. J Clin Oncol (2009) 5.11
Prostate cancer detection rate in patients with repeated extended 21-sample needle biopsy. Eur Urol (2008) 3.83
Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. J Biol Chem (2002) 3.48
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer Discov (2011) 3.43
Extended 21-sample needle biopsy protocol for diagnosis of prostate cancer in 1000 consecutive patients. Eur Urol (2007) 2.92
Update on the medical treatment of metastatic renal cell carcinoma. Eur Urol (2008) 2.80
Extensive biopsies and transurethral prostate resection in men with previous negative biopsies and high or increasing prostate specific antigen. J Urol (2009) 2.77
E2Fs regulate adipocyte differentiation. Dev Cell (2002) 2.71
Impact of graft nephrectomy on outcomes of second kidney transplantation. Int J Urol (2014) 2.67
Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect (2009) 2.57
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell (2006) 2.50
Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy. Eur Urol (2008) 2.48
Tumor size does not predict risk of metastatic disease or prognosis of small renal cell carcinomas. J Urol (2008) 2.45
Prostate cancer gene 3 (PCA3): development and internal validation of a novel biopsy nomogram. Eur Urol (2009) 2.45
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J Cell Biol (2007) 2.39
Negative regulation of transcription by the type II arginine methyltransferase PRMT5. EMBO Rep (2002) 2.38
Prognostic value of renal vein and inferior vena cava involvement in renal cell carcinoma. Eur Urol (2008) 2.37
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells. Nat Cell Biol (2010) 2.35
Regional copy number-independent deregulation of transcription in cancer. Nat Genet (2006) 2.33
Collecting duct renal cell carcinoma: a matched analysis of 41 cases. Eur Urol (2007) 2.30
Serum isoform [-2]proPSA derivatives significantly improve prediction of prostate cancer at initial biopsy in a total PSA range of 2-10 ng/ml: a multicentric European study. Eur Urol (2013) 2.26
European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. Eur Urol (2007) 2.21
Evaluation of combined oncological and functional outcomes after radical prostatectomy: trifecta rate of achieving continence, potency and cancer control--a literature review. Urology (2010) 2.19
Prognostic factors in patients with advanced transitional cell carcinoma of the urothelial tract experiencing treatment failure with platinum-containing regimens. J Clin Oncol (2010) 2.18
Renal cell carcinoma with nodal metastases in the absence of distant metastatic disease: prognostic indicators of disease-specific survival. Eur Urol (2006) 2.15
Impact of body mass index on perioperative morbidity, oncological, and functional outcomes after extraperitoneal laparoscopic radical prostatectomy. Urology (2012) 2.13
SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer. Cancer Res (2009) 2.03
Expression of follicle-stimulating hormone receptor in tumor blood vessels. N Engl J Med (2010) 1.92
Radiation recall: a well recognized but neglected phenomenon. Cancer Treat Rev (2005) 1.85
miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. PLoS One (2009) 1.84
Prostate cancer antigen 3 score accurately predicts tumour volume and might help in selecting prostate cancer patients for active surveillance. Eur Urol (2010) 1.82
Initial prostate biopsy: development and internal validation of a biopsy-specific nomogram based on the prostate cancer antigen 3 assay. Eur Urol (2012) 1.81
A preoperative prognostic model for patients treated with nephrectomy for renal cell carcinoma. Eur Urol (2008) 1.77
Inflammation in benign prostatic hyperplasia: a 282 patients' immunohistochemical analysis. Prostate (2009) 1.73
Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A (2006) 1.69
Pelvic lymph node dissection during robot-assisted radical prostatectomy: efficacy, limitations, and complications-a systematic review of the literature. Eur Urol (2013) 1.69
N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer. Neoplasia (2009) 1.68
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab (2009) 1.68
Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: a multicenter validation study. Clin Cancer Res (2007) 1.68
Early predicted time to normalization of tumor markers predicts outcome in poor-prognosis nonseminomatous germ cell tumors. J Clin Oncol (2004) 1.67
In vitro and in vivo anti-melanoma effects of ciglitazone. J Invest Dermatol (2009) 1.67
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol (2005) 1.63
Oncologic outcome after extraperitoneal laparoscopic radical prostatectomy: midterm follow-up of 1115 procedures. Eur Urol (2009) 1.63
Overexpression of the human glucocorticoid receptor alpha and beta isoforms inhibits AP-1 and NF-kappaB activities hormone independently. J Mol Med (Berl) (2001) 1.60
Modified supine percutaneous nephrolithotomy for large kidney and ureteral stones: technique and results. Eur Urol (2011) 1.58
Targeted therapy in renal cell carcinoma. World J Urol (2008) 1.56
The role of biopsy core number in selecting prostate cancer patients for active surveillance. Eur Urol (2009) 1.54
Gemcitabine and docetaxel as front-line chemotherapy in patients with carcinoma of an unknown primary site. Cancer (2004) 1.54
Acute bacterial prostatitis after transrectal ultrasound-guided prostate biopsy: epidemiological, bacteria and treatment patterns from a 4-year prospective study. Int J Urol (2013) 1.51
The risk of upstaged disease increases with body mass index in low-risk prostate cancer patients eligible for active surveillance. Eur Urol (2011) 1.50
Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. Eur J Pharmacol (2005) 1.50
Biomarkers for the diagnosis of prostatic inflammation in benign prostatic hyperplasia. Prostate (2011) 1.49
Competing-risks analysis in patients with T1 squamous cell carcinoma of the penis. BJU Int (2012) 1.48
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J Biol Chem (2004) 1.46
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc Natl Acad Sci U S A (2007) 1.46
Complete clinical and biological response to zoledronic acid in castrate-resistant prostate cancer metastatic to bone. Anticancer Drugs (2012) 1.45
Clinical judgment versus biomarker prostate cancer gene 3: which is best when determining the need for repeat prostate biopsy? Urology (2013) 1.45
The CDK4-pRB-E2F1 pathway controls insulin secretion. Nat Cell Biol (2009) 1.45
A contemporary population-based assessment of the rate of lymph node dissection for penile carcinoma. Ann Surg Oncol (2010) 1.43
Oncologic outcomes and survival in pT0 tumors after radical cystectomy in patients without neoadjuvant chemotherapy: results from a large multicentre collaborative study. Ann Surg Oncol (2011) 1.42
International Prostate Symptom Score is a predictive factor of lower urinary tract symptoms after radical prostatectomy. Int J Urol (2015) 1.41
N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Mol Cell Biol (2004) 1.40
Sexual dysfunction is common and overlooked in female patients with hypertension. J Sex Marital Ther (2002) 1.40
Anti-inflammatory properties of desipramine and fluoxetine. Respir Res (2007) 1.38
Surgical management of BPH in patients on oral anticoagulation: transurethral bipolar plasma vaporization in saline versus transurethral monopolar resection of the prostate. Can J Urol (2011) 1.38
Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer. Mol Cell Biol (2006) 1.37
European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part II. Eur Urol (2007) 1.37
Contemporary role of prostate cancer antigen 3 in the management of prostate cancer. Eur Urol (2011) 1.36
Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. Mol Cell Biol (2003) 1.35
The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. EMBO Rep (2008) 1.33
Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer. Surgery (2006) 1.33
Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab (2005) 1.31
[Standards, Options and Recommendations for the management of patient with carcinoma of unknown primary site]. Bull Cancer (2002) 1.24
Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome. Mol Cell Biol (2002) 1.24
Molecular detection of localized prostate cancer using quantitative methylation-specific PCR on urinary cells obtained following prostate massage. Clin Cancer Res (2007) 1.23
The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene. Oncogene (2005) 1.21