Published in Development on August 01, 2007
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature (2009) 9.29
The transcriptional and epigenomic foundations of ground state pluripotency. Cell (2012) 5.87
Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development (2009) 5.49
Capturing pluripotency. Cell (2008) 5.08
Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis. Cell Stem Cell (2010) 4.97
Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol (2009) 4.60
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development (2009) 4.25
Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell (2013) 3.15
Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell (2012) 3.03
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev (2010) 2.68
The transcriptional and signalling networks of pluripotency. Nat Cell Biol (2011) 2.54
Extrinsic regulation of pluripotent stem cells. Nature (2010) 2.39
Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol (2010) 2.38
The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev (2009) 2.19
Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways. PLoS One (2009) 2.18
Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93
Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol (2013) 1.91
Making the blastocyst: lessons from the mouse. J Clin Invest (2010) 1.85
Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs. Cell (2014) 1.85
Reorganization of enhancer patterns in transition from naive to primed pluripotency. Cell Stem Cell (2014) 1.81
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol (2014) 1.76
Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis. Dev Cell (2015) 1.75
MEK Is a Key Regulator of Gliogenesis in the Developing Brain. Neuron (2012) 1.68
Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation. Cell Stem Cell (2015) 1.65
FGF signalling inhibits neural induction in human embryonic stem cells. EMBO J (2011) 1.61
Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo. PLoS One (2009) 1.61
FGF signalling: diverse roles during early vertebrate embryogenesis. Development (2010) 1.60
Genetic exploration of the exit from self-renewal using haploid embryonic stem cells. Cell Stem Cell (2014) 1.54
Regulation of neural specification from human embryonic stem cells by BMP and FGF. Stem Cells (2009) 1.53
Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development. J Biol Chem (2008) 1.49
FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse. Development (2012) 1.47
Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Cell Stem Cell (2013) 1.42
Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor. Biochem J (2011) 1.41
Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation. EMBO Rep (2013) 1.39
JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency. Nat Commun (2012) 1.37
A PiggyBac-based recessive screening method to identify pluripotency regulators. PLoS One (2011) 1.30
Current perspectives of the signaling pathways directing neural crest induction. Cell Mol Life Sci (2012) 1.30
Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis. PLoS One (2010) 1.29
A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells. Development (2013) 1.26
BMP4 induction of trophoblast from mouse embryonic stem cells in defined culture conditions on laminin. In Vitro Cell Dev Biol Anim (2009) 1.25
LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease. Nat Cell Biol (2010) 1.25
Pluripotent stem cells: private obsession and public expectation. EMBO Mol Med (2010) 1.24
Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming. Cell Stem Cell (2015) 1.21
An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Cell Rep (2013) 1.21
The liberation of embryonic stem cells. PLoS Genet (2011) 1.20
Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction. FASEB J (2010) 1.17
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol (2009) 1.16
Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation. Development (2010) 1.15
The transcriptional regulation of pluripotency. Cell Res (2012) 1.15
Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells (2013) 1.14
Microfluidic perfusion for regulating diffusible signaling in stem cells. PLoS One (2011) 1.14
Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells. J Am Chem Soc (2014) 1.14
Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Stem Cells (2012) 1.13
MAPK/ERK signalling mediates VEGF-induced bone marrow stem cell differentiation into endothelial cell. J Cell Mol Med (2008) 1.13
Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Proc Natl Acad Sci U S A (2010) 1.12
Heparan sulfate is required for embryonic stem cells to exit from self-renewal. J Biol Chem (2009) 1.09
Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency. J Cell Biol (2012) 1.08
Attenuation of extrinsic signaling reveals the importance of matrix remodeling on maintenance of embryonic stem cell self-renewal. Proc Natl Acad Sci U S A (2012) 1.08
Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells. Development (2011) 1.08
Role of oxidative stress in stem, cancer, and cancer stem cells. Cancers (Basel) (2010) 1.06
Roles for MYC in the establishment and maintenance of pluripotency. Cold Spring Harb Perspect Med (2013) 1.06
A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. PLoS Genet (2012) 1.05
MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Genes Dev (2013) 1.04
Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development (2012) 1.04
Pausing of RNA polymerase II regulates mammalian developmental potential through control of signaling networks. Mol Cell (2015) 1.03
Roles of FGF signaling in stem cell self-renewal, senescence and aging. Aging (Albany NY) (2011) 1.02
Mapping the route from naive pluripotency to lineage specification. Philos Trans R Soc Lond B Biol Sci (2014) 1.01
FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast. Stem Cells Dev (2012) 1.01
A comparative study of protocols for mouse embryonic stem cell culturing. PLoS One (2013) 1.01
Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling. Genes Cells (2010) 1.00
Mesodermal fate decisions of a stem cell: the Wnt switch. Cell Mol Life Sci (2008) 0.99
Wnt pathway regulation of embryonic stem cell self-renewal. Cold Spring Harb Perspect Biol (2012) 0.99
SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency. Proc Natl Acad Sci U S A (2012) 0.99
Probing embryonic stem cell autocrine and paracrine signaling using microfluidics. Annu Rev Anal Chem (Palo Alto Calif) (2012) 0.98
SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism. Stem Cells (2013) 0.98
X-chromosome inactivation in rett syndrome human induced pluripotent stem cells. Front Psychiatry (2012) 0.97
Switching on pluripotency: a perspective on the biological requirement of Nanog. Philos Trans R Soc Lond B Biol Sci (2011) 0.97
Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A (2015) 0.97
Inhibition of ERK promotes collagen gel compaction and fibrillogenesis to amplify the osteogenesis of human mesenchymal stem cells in three-dimensional collagen I culture. Stem Cells Dev (2009) 0.96
Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming. Nat Commun (2016) 0.96
Tcf15 primes pluripotent cells for differentiation. Cell Rep (2013) 0.95
Pluripotency and Epigenetic Factors in Mouse Embryonic Stem Cell Fate Regulation. Mol Cell Biol (2015) 0.95
Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells. Proc Natl Acad Sci U S A (2015) 0.95
Differentiation-dependent association of phosphorylated extracellular signal-regulated kinase with the chromatin of osteoblast-related genes. J Bone Miner Res (2010) 0.95
Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development. BMC Dev Biol (2009) 0.95
Generation and characterization of a novel mouse embryonic stem cell line with a dynamic reporter of Nanog expression. PLoS One (2013) 0.94
Stemness as a cell default state. EMBO Rep (2012) 0.94
Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible cross-talk with microRNAs. Antioxid Redox Signal (2014) 0.94
STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ESC fates. Stem Cells (2014) 0.94
Stable generation of serum- and feeder-free embryonic stem cell-derived mice with full germline-competency by using a GSK3 specific inhibitor. Genesis (2009) 0.93
Generation of human induced pluripotent stem (Ips) cells in serum- and feeder-free defined culture and TGF-Β1 regulation of pluripotency. PLoS One (2014) 0.92
Transcription factor heterogeneity and epiblast pluripotency. Philos Trans R Soc Lond B Biol Sci (2011) 0.92
Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations. J R Soc Interface (2012) 0.91
Spinal cord injury induces astroglial conversion towards neuronal lineage. Mol Neurodegener (2016) 0.90
Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network. Cell Mol Life Sci (2015) 0.90
Troika of the mouse blastocyst: lineage segregation and stem cells. Curr Stem Cell Res Ther (2012) 0.90
microRNAs as novel regulators of stem cell pluripotency and somatic cell reprogramming. Bioessays (2012) 0.89
Neuronatin promotes neural lineage in ESCs via Ca(2+) signaling. Stem Cells (2010) 0.89
Chondroitin sulfate is indispensable for pluripotency and differentiation of mouse embryonic stem cells. Sci Rep (2014) 0.89
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47
Nanog safeguards pluripotency and mediates germline development. Nature (2007) 13.01
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol (2003) 9.41
Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol (2005) 9.12
Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Naive and primed pluripotent states. Cell Stem Cell (2009) 7.15
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell (2009) 6.77
Capture of authentic embryonic stem cells from rat blastocysts. Cell (2008) 6.60
The transcriptional and epigenomic foundations of ground state pluripotency. Cell (2012) 5.87
Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development (2009) 5.49
Capturing pluripotency. Cell (2008) 5.08
Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol (2002) 5.00
Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene (2004) 4.40
Nanog promotes transfer of pluripotency after cell fusion. Nature (2006) 4.38
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development (2009) 4.25
Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell (2010) 3.42
Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Cell Stem Cell (2009) 3.27
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol (2011) 3.25
Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell (2013) 3.15
Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells (2006) 3.07
Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell (2012) 3.03
Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proc Natl Acad Sci U S A (2003) 2.86
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol (2002) 2.64
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep (2003) 2.52
Naive pluripotency is associated with global DNA hypomethylation. Nat Struct Mol Biol (2013) 2.49
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell (2011) 2.35
Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat Med (2009) 2.26
Genesis of embryonic stem cells. Philos Trans R Soc Lond B Biol Sci (2003) 1.97
Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci U S A (2007) 1.93
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J Hematol Oncol (2010) 1.92
Adherent neural stem (NS) cells from fetal and adult forebrain. Cereb Cortex (2006) 1.88
Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev (2013) 1.88
Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol (2010) 1.86
The IKK-related kinases: from innate immunity to oncogenesis. Cell Res (2008) 1.71
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation (2004) 1.69
Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol Cell Neurosci (2008) 1.62
The origin and identity of embryonic stem cells. Development (2011) 1.60
Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells. J Cell Sci (2002) 1.58
Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state. Development (2010) 1.58
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circ Res (2010) 1.56
Atypical mitogen-activated protein kinases: structure, regulation and functions. Biochim Biophys Acta (2006) 1.56
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. EMBO J (2008) 1.53
Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases. Physiol Rev (2009) 1.53
A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development (2010) 1.51
CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent. PLoS One (2009) 1.50
Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor. EMBO J (2013) 1.46
Human hypoblast formation is not dependent on FGF signalling. Dev Biol (2011) 1.46
Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One (2012) 1.46
Parameters influencing derivation of embryonic stem cells from murine embryos. Genesis (2008) 1.43
Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. EMBO J (2004) 1.43
N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Mol Cell Biol (2004) 1.40
The nature of embryonic stem cells. Annu Rev Cell Dev Biol (2014) 1.40
'No' to ban on stem-cell patents. Nature (2011) 1.39
ERKs in cancer: friends or foes? Cancer Res (2014) 1.37
JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency. Nat Commun (2012) 1.37
The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity. Neurobiol Dis (2012) 1.35
Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. Mol Cell Biol (2003) 1.35
A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. Mol Cell Proteomics (2010) 1.34
Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells. Stem Cells (2012) 1.33
Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition. Stem Cell Reports (2013) 1.31
A PiggyBac-based recessive screening method to identify pluripotency regulators. PLoS One (2011) 1.30
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. EMBO J (2013) 1.28
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals. J Biol Chem (2004) 1.24
Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells. Stem Cells (2007) 1.23
The eIF4E RNA regulon promotes the Akt signaling pathway. J Cell Biol (2008) 1.22
Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Mol Cell Biol (2003) 1.22
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. J Cell Physiol (2008) 1.20
The liberation of embryonic stem cells. PLoS Genet (2011) 1.20
Fibroblast growth factor induces a neural stem cell phenotype in foetal forebrain progenitors and during embryonic stem cell differentiation. Mol Cell Neurosci (2008) 1.20
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol (2008) 1.19
Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression. J Biol Chem (2003) 1.19
Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J Immunol (2006) 1.19
Germline potential of parthenogenetic haploid mouse embryonic stem cells. Development (2012) 1.19
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev (2013) 1.18
Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4. J Biol Chem (2006) 1.16
Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood (2013) 1.15
Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2. Cell Cycle (2010) 1.13
Tripotential differentiation of adherently expandable neural stem (NS) cells. PLoS One (2007) 1.13
Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proc Natl Acad Sci U S A (2009) 1.12
Rebuilding pluripotency from primordial germ cells. Stem Cell Reports (2013) 1.09
Cyclic AMP induces morphological changes of vascular smooth muscle cells by inhibiting a Rac-dependent signaling pathway. J Cell Physiol (2005) 1.09
Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells. J Cell Sci (2011) 1.07
Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Mol Cell Biol (2010) 1.07
Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development (2010) 1.07
A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. PLoS Genet (2012) 1.05
Stem cells: Fusion brings down barriers. Nature (2003) 1.05