Published in Cell on April 06, 2007
Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell (2009) 14.51
Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77
The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36
Targeting the unfolded protein response in disease. Nat Rev Drug Discov (2013) 3.37
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron (2008) 2.99
BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem (2007) 2.96
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci (2013) 2.35
RNA granules: the good, the bad and the ugly. Cell Signal (2010) 2.31
The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci (2009) 2.12
mTORC2 controls actin polymerization required for consolidation of long-term memory. Nat Neurosci (2013) 2.04
Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition. Cell (2011) 1.89
Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife (2013) 1.85
JNK3 perpetuates metabolic stress induced by Aβ peptides. Neuron (2012) 1.80
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science (2015) 1.80
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Mol Biol Cell (2011) 1.73
Remote control of gene function by local translation. Cell (2014) 1.72
Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. J Biol Chem (2009) 1.64
Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants. PLoS Genet (2009) 1.62
Novel translational control in Arc-dependent long term potentiation consolidation in vivo. J Biol Chem (2009) 1.52
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J Biol Chem (2008) 1.51
Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression. J Biol Chem (2008) 1.47
Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders. Trends Mol Med (2010) 1.46
Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. Proc Natl Acad Sci U S A (2011) 1.41
The role of protein synthesis in memory consolidation: progress amid decades of debate. Neurobiol Learn Mem (2007) 1.39
From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis. J Intellect Disabil Res (2009) 1.37
Transfer RNA and human disease. Front Genet (2014) 1.35
eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation. J Neurosci (2010) 1.34
The role of protein synthesis during the labile phases of memory: revisiting the skepticism. Neurobiol Learn Mem (2007) 1.32
Mechanisms and cellular roles of local protein synthesis in mammalian cells. Curr Opin Cell Biol (2008) 1.31
Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons. Proc Natl Acad Sci U S A (2008) 1.29
Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Mol Cell (2012) 1.29
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep (2012) 1.24
Translational control in synaptic plasticity and cognitive dysfunction. Annu Rev Neurosci (2014) 1.21
eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. Nature (2010) 1.21
Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation. Learn Mem (2008) 1.20
Altered protein synthesis is a trigger for long-term memory formation. Neurobiol Learn Mem (2007) 1.19
The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. Elife (2015) 1.19
A versatile method for cell-specific profiling of translated mRNAs in Drosophila. PLoS One (2012) 1.19
Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology. Eur J Neurosci (2009) 1.14
The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. J Cell Biol (2009) 1.11
Control of cellular GADD34 levels by the 26S proteasome. Mol Cell Biol (2008) 1.09
Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2. Trends Neurosci (2012) 1.08
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nat Neurosci (2014) 1.08
Proteolysis of proBDNF is a key regulator in the formation of memory. PLoS One (2008) 1.07
Translational control mechanisms in long-lasting synaptic plasticity and memory. J Biol Chem (2010) 1.02
Molecular mechanisms underlying memory consolidation of taste information in the cortex. Front Behav Neurosci (2012) 1.02
The Drosophila cell adhesion molecule klingon is required for long-term memory formation and is regulated by Notch. Proc Natl Acad Sci U S A (2008) 1.02
Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in progression of HIV-associated neurocognitive disorder. Mol Brain (2014) 1.02
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease. Neurobiol Aging (2014) 1.00
Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2alpha in Caenorhabditis elegans. Genes Dev (2008) 1.00
DISC1 genetics, biology and psychiatric illness. Front Biol (Beijing) (2013) 1.00
Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1. Cell Death Dis (2010) 0.99
Pro-autophagic signal induction by bacterial pore-forming toxins. Med Microbiol Immunol (2010) 0.98
Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein. J Neurosci (2010) 0.98
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia. Acta Neuropathol (2015) 0.97
Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice. Learn Mem (2012) 0.95
Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. J Biol Chem (2011) 0.95
Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem (2010) 0.92
Facilitation of taste memory acquisition by experiencing previous novel taste is protein-synthesis dependent. Learn Mem (2008) 0.92
eIF5 is a dual function GAP and GDI for eukaryotic translational control. Small GTPases (2010) 0.92
eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation. Mol Cell (2012) 0.92
The unfolded protein response in Alzheimer's disease. Semin Immunopathol (2013) 0.90
Post-training dephosphorylation of eEF-2 promotes protein synthesis for memory consolidation. PLoS One (2009) 0.89
Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease. PLoS One (2013) 0.89
Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons. J Biol Chem (2009) 0.89
Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease. Front Cell Neurosci (2015) 0.89
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription. Hum Mol Genet (2012) 0.88
Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS. EMBO J (2015) 0.88
Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia. Learn Mem (2011) 0.88
Alternative splicing within the elk-1 5' untranslated region serves to modulate initiation events downstream of the highly conserved upstream open reading frame 2. Mol Cell Biol (2012) 0.88
Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory. Neuropathol Appl Neurobiol (2015) 0.88
Effects of minocycline on spatial learning, hippocampal neurogenesis and microglia in aged and adult mice. Behav Brain Res (2012) 0.88
The roles of protein expression in synaptic plasticity and memory consolidation. Front Mol Neurosci (2014) 0.87
The Regulation of Synaptic Protein Turnover. J Biol Chem (2015) 0.87
Mechanisms of translational regulation in synaptic plasticity. Curr Opin Neurobiol (2010) 0.87
The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem (2014) 0.86
Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory. Neurobiol Learn Mem (2013) 0.86
Prions: generation and spread versus neurotoxicity. J Biol Chem (2014) 0.86
ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin. PLoS One (2014) 0.85
Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease. J Neurosci (2015) 0.85
Molecular determinants of the spacing effect. Neural Plast (2012) 0.85
A cytoskeletal platform for local translation in axons. Sci Signal (2008) 0.84
ATF4 activity: a common feature shared by many kinds of slow-aging mice. Aging Cell (2014) 0.84
Genes and signaling pathways involved in memory enhancement in mutant mice. Mol Brain (2014) 0.84
Localized Rho GTPase activation regulates RNA dynamics and compartmentalization in tumor cell protrusions. J Biol Chem (2008) 0.83
Specific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memory. Cell Rep (2015) 0.82
Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease. Front Aging Neurosci (2015) 0.82
Protein phosphatase-dependent circadian regulation of intermediate-term associative memory. J Neurosci (2013) 0.82
Increasing our understanding of human cognition through the study of Fragile X Syndrome. Dev Neurobiol (2013) 0.82
The unfolded protein response: mechanisms and therapy of neurodegeneration. Brain (2016) 0.82
Less translational control, more memory. Elife (2013) 0.81
β-Adrenergic receptor signaling and modulation of long-term potentiation in the mammalian hippocampus. Learn Mem (2015) 0.81
Activating transcription factor 4 (ATF4) modulates post-synaptic development and dendritic spine morphology. Front Cell Neurosci (2014) 0.81
Roles of eIF2α kinases in the pathogenesis of Alzheimer's disease. Front Mol Neurosci (2014) 0.81
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. Elife (2015) 0.80
Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation. Sci Rep (2012) 0.80
The rates of protein synthesis and degradation account for the differential response of neurons to spaced and massed training protocols. PLoS Comput Biol (2011) 0.80
IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth. J Biol Chem (2013) 0.79
Dendritic protein synthesis in the normal and diseased brain. Neuroscience (2012) 0.79
Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation. Mol Cell Proteomics (2015) 0.78
A synaptic model of memory: long-term potentiation in the hippocampus. Nature (1993) 29.13
Emotion circuits in the brain. Annu Rev Neurosci (2000) 24.39
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
Place navigation impaired in rats with hippocampal lesions. Nature (1982) 15.79
The molecular biology of memory storage: a dialogue between genes and synapses. Science (2001) 11.85
Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol (2005) 11.48
Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell (2001) 11.21
Long-term potentiation--a decade of progress? Science (1999) 10.24
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc Natl Acad Sci U S A (1981) 6.73
The neurobiology of consolidations, or, how stable is the engram? Annu Rev Psychol (2004) 6.33
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol (2004) 5.44
Dendritic protein synthesis, synaptic plasticity, and memory. Cell (2006) 5.18
CREB and memory. Annu Rev Neurosci (1998) 4.76
Cellular and systems reconsolidation in the hippocampus. Neuron (2002) 3.71
Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron (2004) 3.64
Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala. Neuron (1999) 3.62
Protein phosphatase 1 is a molecular constraint on learning and memory. Nature (2002) 2.91
Biochemical mechanisms for translational regulation in synaptic plasticity. Nat Rev Neurosci (2004) 2.88
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med (2005) 2.83
Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell (1995) 2.75
Memory reconsolidation: sensitivity of spatial memory to inhibition of protein synthesis in dorsal hippocampus during encoding and retrieval. Neuron (2006) 2.75
Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learn Mem (1999) 2.72
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature (2005) 2.67
Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin. Cell (2001) 2.62
Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase. Learn Mem (1999) 2.06
Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP. Nat Neurosci (2004) 1.95
Taste memory: the role of protein synthesis in gustatory cortex. Behav Neural Biol (1993) 1.89
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood (2002) 1.88
Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins. Neuron (2003) 1.80
Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin. J Biol Chem (2001) 1.69
Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain. Annu Rev Neurosci (1997) 1.53
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell (2006) 1.51
Reward value of a non-nutritive sweet-taste. J Comp Physiol Psychol (1950) 1.37
In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus. Philos Trans R Soc Lond B Biol Sci (2003) 1.27
Imaging physiologic dysfunction of individual hippocampal subregions in humans and genetically modified mice. Neuron (2000) 1.06
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet (2008) 32.08
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem (2010) 12.06
Translational control in stress and apoptosis. Nat Rev Mol Cell Biol (2005) 8.91
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature (2004) 8.76
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res (2006) 6.99
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72
Short RNAs repress translation after initiation in mammalian cells. Mol Cell (2006) 6.70
Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature (2005) 6.69
Statistical practice in high-throughput screening data analysis. Nat Biotechnol (2006) 5.85
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res (2007) 5.45
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (2010) 4.81
Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem (2007) 4.45
MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science (2007) 4.33
Antimicrobial drug discovery through bacteriophage genomics. Nat Biotechnol (2004) 4.17
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A (2001) 4.16
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol (2002) 4.11
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell (2010) 4.01
Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes Dev (2005) 3.92
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol (2003) 3.90
Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat Chem Biol (2006) 3.89
The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages. Proc Natl Acad Sci U S A (2005) 3.84
eIF4E--from translation to transformation. Oncogene (2004) 3.78
Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature (2010) 3.77
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem (2005) 3.74
Cellular and systems reconsolidation in the hippocampus. Neuron (2002) 3.71
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J (2006) 3.57
Dissecting eIF4E action in tumorigenesis. Genes Dev (2007) 3.53
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol (2012) 3.42
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J (2004) 3.29
Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J Psychiatr Res (2007) 3.19
Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature (2012) 3.13
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A (2010) 3.13
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell (2008) 3.10
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00
14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98
Astrocytes are endogenous regulators of basal transmission at central synapses. Cell (2011) 2.97
Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci (2002) 2.94
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell (2004) 2.91
Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta (2009) 2.89
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest (2007) 2.86
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. Mol Biol Cell (2006) 2.84
A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell (2005) 2.80
Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol (2005) 2.80
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature (2005) 2.67
Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem (2006) 2.67
miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol (2011) 2.61
Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell (2009) 2.60
Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J Mol Biol (2002) 2.53
A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. J Cell Biol (2005) 2.51
Characterization of fear memory reconsolidation. J Neurosci (2004) 2.50
mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A (2008) 2.50
A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation. J Biol Chem (2002) 2.43
mRNA helicases: the tacticians of translational control. Nat Rev Mol Cell Biol (2011) 2.41
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J (2006) 2.41
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest (2008) 2.40
Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A (2009) 2.40
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol (2004) 2.38
eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol (2004) 2.38
Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS One (2007) 2.35
The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci (2005) 2.33
Translational control of the innate immune response through IRF-7. Nature (2008) 2.30
PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nat Neurosci (2010) 2.28
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (2002) 2.28
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J (2007) 2.27
The dynamics of mammalian P body transport, assembly, and disassembly in vivo. Mol Biol Cell (2008) 2.25
The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prev Res (Phila) (2008) 2.23
Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol Cell (2012) 2.19
Comparative genomic analysis of 18 Pseudomonas aeruginosa bacteriophages. J Bacteriol (2006) 2.18
The Akt of translational control. Oncogene (2005) 2.15
NMDA receptors are critical for unleashing consolidated auditory fear memories. Nat Neurosci (2006) 2.13
Cap and cap-binding proteins in the control of gene expression. Wiley Interdiscip Rev RNA (2010) 2.11
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One (2009) 2.11
Characterization of an RNA granule from developing brain. Mol Cell Proteomics (2005) 2.07
Reconstitution reveals the functional core of mammalian eIF3. EMBO J (2007) 2.06
Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression. J Neurosci (2006) 2.04
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host Microbe (2011) 2.01
Translation initiator EIF4G1 mutations in familial Parkinson disease. Am J Hum Genet (2011) 2.00
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc Natl Acad Sci U S A (2005) 2.00
Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. Structure (2006) 1.99
Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Mol Cell Biol (2005) 1.99
A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A (2004) 1.97
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol Cell Proteomics (2005) 1.95
Structural conservation of druggable hot spots in protein-protein interfaces. Proc Natl Acad Sci U S A (2011) 1.95
GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression. J Neurosci (2006) 1.93
Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species. Mol Cell Biol (2006) 1.93