Published in J Virol on May 01, 1991
Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins. J Virol (1992) 1.77
Distinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors. J Virol (1995) 1.45
Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat. J Virol (1996) 1.28
Human T-cell lymphotropic virus type 3: complete nucleotide sequence and characterization of the human tax3 protein. J Virol (2006) 1.11
HTLV-I Tax self-association in optimal trans-activation function. Nucleic Acids Res (1997) 1.07
Mutations in the bovine leukemia virus Tax protein can abrogate the long terminal repeat-directed transactivating activity without concomitant loss of transforming potential. Proc Natl Acad Sci U S A (1992) 1.04
Dominant-negative mutants are clustered in a domain of the human T-cell leukemia virus type I Rex protein: implications for trans dominance. J Virol (1992) 1.01
Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2. Leuk Res Treatment (2011) 0.94
Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences. Viruses (2011) 0.94
Expression and characterization of the trans-activating protein Tax of human T-cell leukemia virus type I in Saccharomyces cerevisiae. J Virol (1992) 0.89
The central region of human T-cell leukemia virus type 1 Tax protein contains distinct domains involved in subunit dimerization. J Virol (2003) 0.89
Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of Rev. J Virol (1992) 0.88
Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1. J Leukoc Biol (2007) 0.88
Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation. Front Microbiol (2013) 0.88
Transcriptional activation of the human T-lymphotropic virus type I long terminal repeat by functional interaction of Tax1 and Ets1. J Virol (1993) 0.88
Dimerization and a novel Tax speckled structure localization signal are required for Tax nuclear localization. J Virol (2009) 0.87
Molecular Mechanisms of Neurodegenerative Diseases Induced by Human Retroviruses: A Review. Am J Infect Dis (2009) 0.86
Role of resident CNS cell populations in HTLV-1-associated neuroinflammatory disease. Front Biosci (Landmark Ed) (2009) 0.84
The oncoprotein Tax of the human T-cell leukemia virus type 1 activates transcription via interaction with cellular ATF-1/CREB factors in Saccharomyces cerevisiae. J Virol (1996) 0.84
Anti-apoptotic effect of Tax: an NF-κB path or a CREB way? Viruses (2011) 0.79
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75
A short amino acid sequence able to specify nuclear location. Cell (1984) 21.17
Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A (1982) 12.84
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem (1989) 11.06
Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature (1984) 10.52
Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science (1984) 9.14
Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev (1988) 8.82
Identification and characterization of a nuclear pore complex protein. Cell (1986) 7.93
Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function. Cell (1989) 7.46
HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor. Nature (1988) 7.35
Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores. Cell (1988) 7.23
Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation. Cell (1988) 6.60
The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science (1985) 6.60
The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science (1989) 6.46
Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen. Cell (1984) 5.81
Nuclear location signals in polyoma virus large-T. Cell (1986) 5.74
Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Proc Natl Acad Sci U S A (1984) 4.90
Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I. Cell (1987) 4.76
Tat protein from human immunodeficiency virus forms a metal-linked dimer. Science (1988) 4.63
Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J (1986) 4.58
HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus. Cell (1989) 4.40
Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes. Proc Natl Acad Sci U S A (1987) 4.10
Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. Science (1988) 4.01
The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science (1987) 4.01
Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing. Cell (1988) 3.92
Structural and functional characterization of human immunodeficiency virus tat protein. J Virol (1989) 3.57
Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins. EMBO J (1988) 3.45
Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. Proc Natl Acad Sci U S A (1987) 3.43
Amino acid sequences that determine the nuclear localization of yeast histone 2B. Mol Cell Biol (1987) 3.31
Identification of the human c-myc protein nuclear translocation signal. Mol Cell Biol (1988) 3.30
c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A (1988) 3.24
Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements. Genes Dev (1989) 3.09
Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat. J Virol (1987) 3.03
The effects of variations in the number and sequence of targeting signals on nuclear uptake. J Cell Biol (1988) 2.89
Protein import through the nuclear pore complex is a multistep process. J Cell Biol (1989) 2.89
Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. Proc Natl Acad Sci U S A (1990) 2.76
Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc Natl Acad Sci U S A (1989) 2.64
Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T cell leukemia. Science (1982) 2.62
Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol Cell Biol (1990) 2.46
Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol Cell Biol (1990) 2.42
Mutational analysis of HIV-1 Tat minimal domain peptides: identification of trans-dominant mutants that suppress HIV-LTR-driven gene expression. Cell (1989) 2.33
Pentapeptide nuclear localization signal in adenovirus E1a. Mol Cell Biol (1987) 2.30
Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis. Nature (1988) 2.27
Location of cis-acting regulatory sequences in the human T-cell leukemia virus type I long terminal repeat. Proc Natl Acad Sci U S A (1985) 2.25
Detection of human T-cell lymphoma/leukemia virus type I DNA and antigen in spinal fluid and blood of patients with chronic progressive myelopathy. N Engl J Med (1988) 2.25
Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I. Science (1985) 2.25
T-cell activation signals and human T-cell leukemia virus type I-encoded p40x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element. Mol Cell Biol (1988) 2.08
Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice. Nature (1989) 1.98
The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol Cell Biol (1990) 1.91
Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science (1990) 1.81
Trans-dominant inactivation of HTLV-I and HIV-1 gene expression by mutation of the HTLV-I Rex transactivator. Nature (1989) 1.77
Stimulation of the adenovirus E2 promoter by simian virus 40 T antigen or E1A occurs by different mechanisms. Mol Cell Biol (1986) 1.76
Studies of the putative transforming protein of the type I human T-cell leukemia virus. Science (1985) 1.65
Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA. Proc Natl Acad Sci U S A (1989) 1.59
A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat. Proc Natl Acad Sci U S A (1990) 1.55
Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype. Virology (1990) 1.48
The carboxyl 35 amino acids of SV40 Vp3 are essential for its nuclear accumulation. Virology (1987) 1.26
Subnuclear localization of the trans-activating protein of human T-cell leukemia virus type I. J Virol (1988) 1.15
Enzymatic amplification of exogenous and endogenous retroviral sequences from DNA of patients with tropical spastic paraparesis. EMBO J (1988) 1.12
An adenovirus type 5 E1A protein with a single amino acid substitution blocks wild-type E1A transactivation. Mol Cell Biol (1987) 1.10
HTLV x gene mutants exhibit novel transcriptional regulatory phenotypes. Science (1987) 0.85
Use of N-ethylmaleimide to prevent interference by sulfhydryl reagents with the glucose oxidase assay for glucose. Anal Biochem (1981) 0.84
Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature (1996) 3.27
Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma. Nature (1994) 3.05
Phosphorylation of p53 serine 15 increases interaction with CBP. J Biol Chem (1998) 2.97
Direct interaction of human TFIID with the HIV-1 transactivator tat. Nature (1994) 2.87
Dissociation of polyoma virus by the chelation of calcium ions found associated with purified virions. J Virol (1977) 2.62
Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Mol Cell Biol (2000) 2.58
Characterization of a DNA-protein complex and capsomere subunits derived from polyoma virus by treatment with ethyleneglycol-bis-N,N'-tetraacetic acid and dithiothreitol. J Virol (1978) 2.19
Binding of the Sp1 transcription factor by the human Harvey ras1 proto-oncogene promoter. Science (1986) 2.08
Identification of kaposin (open reading frame K12) as a human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) transforming gene. J Virol (1998) 2.02
PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner. Mol Cell Biol (1999) 1.59
Indirect binding of human T-cell leukemia virus type I tax1 to a responsive element in the viral long terminal repeat. Mol Cell Biol (1989) 1.55
Simian virus 40 guanine-cytosine-rich sequences function as independent transcriptional control elements in vitro. Mol Cell Biol (1984) 1.52
Determination of residual antiplatelet activity of clopidogrel before neuraxial injections. Br J Anaesth (2011) 1.44
A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeat. Mol Cell Biol (1990) 1.42
Methods of cytologic smear preparation and fixation. Effect on the immunoreactivity of commonly used anticytokeratin antibody AE1/AE3. Acta Cytol (2000) 1.41
In vitro transcription initiation by purified RNA polymerase II within the adenovirus 2 major late promoter region. J Biol Chem (1984) 1.38
Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein. J Virol (1998) 1.38
Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein. New Biol (1990) 1.36
Analysis of Tat transactivation of human immunodeficiency virus transcription in vitro. Gene Expr (1992) 1.34
Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site. Mol Cell Biol (1995) 1.31
Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells. J Virol (1998) 1.28
Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation. Mol Cell Biol (2000) 1.26
Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I. Oncogene (1993) 1.23
A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. Chem Res Toxicol (2001) 1.23
Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I. J Virol (1991) 1.23
Soluble HTLV-I Tax1 protein stimulates proliferation of human peripheral blood lymphocytes. New Biol (1991) 1.22
Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes. J Virol (1996) 1.22
Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice. J Biol Chem (2001) 1.21
Efficient transcription of a compact nucleoprotein complex isolated from purified simian virus 40 virions. J Virol (1980) 1.21
The coactivator CBP stimulates human T-cell lymphotrophic virus type I Tax transactivation in vitro. J Biol Chem (1998) 1.21
Electroporation of viral transactivator proteins into lymphocyte suspension cells. Nucleic Acids Res (1992) 1.20
Early events in polyomavirus infection: fusion of monopinocytotic vesicles containing virions with mouse kidney cell nuclei. Virus Res (1988) 1.19
Chromatographic separation of the polyoma virus proteins and renaturation of the isolated VP1 major capsid protein. J Virol (1978) 1.18
Anti-idiotypic antibodies to a polyomavirus monoclonal antibody recognize cell surface components of mouse kidney cells and prevent polyomavirus infection. J Virol (1987) 1.16
Extracellular Tax1 protein stimulates tumor necrosis factor-beta and immunoglobulin kappa light chain expression in lymphoid cells. J Virol (1992) 1.15
Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter. J Virol (1997) 1.14
Prostate-specific antigen expression and lipochrome pigment granules in the differential diagnosis of prostatic adenocarcinoma versus seminal vesicle-ejaculatory duct epithelium. Arch Pathol Lab Med (1999) 1.13
Expression profiling of acetaminophen liver toxicity in mice using microarray technology. Biochem Biophys Res Commun (2001) 1.12
Accelerated G(1) phase progression induced by the human T cell leukemia virus type I (HTLV-I) Tax oncoprotein. J Biol Chem (2001) 1.12
The use of additive and subtractive approaches to examine the nuclear localization sequence of the polyomavirus major capsid protein VP1. Virology (1992) 1.11
Disruption of nucleotide excision repair by the human T-cell leukemia virus type 1 Tax protein. J Virol (1999) 1.11
Inhibition of human immunodeficiency virus type 1 transcription and replication by DNA sequence-selective plant lignans. Proc Natl Acad Sci U S A (1995) 1.10
TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription. J Biol Chem (2001) 1.10
Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax. J Virol (1997) 1.09
Cell cycle-regulated transcription by the human immunodeficiency virus type 1 Tat transactivator. J Virol (2000) 1.08
Octyl-beta-D-glucopyranoside extracts polyomavirus receptor moieties from the surfaces of mouse kidney cells. J Virol (1987) 1.08
Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression. J Virol (1994) 1.07
Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis. Cancer Res (1996) 1.07
Identification of a nuclear localization sequence in the polyomavirus capsid protein VP2. Virology (1992) 1.07
Function of the human T-cell leukemia virus type 1 21-base-pair repeats in basal transcription. J Virol (1997) 1.04
Differences in the ability of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53 function. J Virol (2000) 1.04
Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription. J Virol (1996) 1.03
Interaction of the human T-cell lymphotropic virus type 1 tax transactivator with transcription factor IIA. Mol Cell Biol (1996) 1.03
In vitro reassembly of infectious polyoma virions. J Virol (1979) 1.01
Human T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2. Oncogene (2006) 1.01
Production and characterization of monoclonal antibodies to polyomavirus major capsid protein VP1. J Virol (1985) 1.00
Transcription of the HIV-1 LTR is regulated by the density of DNA CpG methylation. J Acquir Immune Defic Syndr (1993) 1.00
Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits. J Biol Chem (2001) 0.99
Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53. Oncogene (1997) 0.99
Cutting edge: a short polypeptide domain of HIV-1-Tat protein mediates pathogenesis. J Immunol (1999) 0.99
The tax protein from the primate T-cell lymphotropic virus type 3 is expressed in vivo and is functionally related to HTLV-1 Tax rather than HTLV-2 Tax. Oncogene (2006) 0.99
Transactivation of the human T-cell lymphotropic virus type 1 Tax1-responsive 21-base-pair repeats requires Holo-TFIID and TFIIA. J Virol (1995) 0.97
HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300. Oncogene (2000) 0.97
Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage. Blood (2001) 0.96
Transcriptional activation of minimal HIV-1 promoter by ORF-1 protein expressed from the SalI-L fragment of human herpesvirus 6. Virology (1994) 0.96
An Ets site in the whey acidic protein gene promoter mediates transcriptional activation in the mammary gland of pregnant mice but is dispensable during lactation. Mol Endocrinol (1995) 0.96
Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter. J Biol Chem (1997) 0.96
Suppression of DNA repair by human T cell leukemia virus type 1 Tax is rescued by a functional p53 signaling pathway. J Biol Chem (2000) 0.95
Activation of interleukin-2 receptor alpha expression by extracellular HTLV-I Tax1 protein: a potential role in HTLV-I pathogenesis. Oncogene (1992) 0.95
Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex. J Virol (1996) 0.95
HIV Tat represses transcription through Sp1-like elements in the basal promoter. Immunity (1995) 0.94
Enhancer function in viral and cellular gene regulation. Biochim Biophys Acta (1989) 0.94
Human T-lymphotropic virus type I Tax protein utilizes distinct pathways for p53 inhibition that are cell type-dependent. J Biol Chem (2001) 0.94
Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1. J Virol (1993) 0.92
Regulation of parathyroid hormone-related protein (PTHrP) gene expression. Sp1 binds through an inverted CACCC motif and regulates promoter activity in cooperation with Ets1. J Biol Chem (1994) 0.92
Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax. AIDS Res Hum Retroviruses (2000) 0.92
The cellular stress response enhances human T-cell lymphotropic virus type 1 basal gene expression through the core promoter region of the long terminal repeat. J Virol (1997) 0.92
Pax-6 interactions with TATA-box-binding protein and retinoblastoma protein. Invest Ophthalmol Vis Sci (1999) 0.92
Human T-cell lymphotropic virus type 1 Tax1 activation of NF-kappa B: involvement of the protein kinase C pathway. J Virol (1996) 0.92
Stable association of viral protein VP1 with simian virus 40 DNA. J Virol (1981) 0.91
Twenty-one base pair repeat elements influence the ability of a Gal4-Tax fusion protein to transactivate the HTLV-I long terminal repeat. Virology (1993) 0.91
Antioxidant treatment inhibits activation of myocardial nuclear factor kappa B and inhibits nitrosylation of myocardial heme protein in cardiac transplant rejection. Antioxid Redox Signal (2001) 0.90
Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression. AIDS Res Hum Retroviruses (2000) 0.89
Transcription of the human T-cell lymphotropic virus type I promoter by an alpha-amanitin-resistant polymerase. J Virol (1994) 0.88
Extracellular human T cell leukemia virus type I tax protein stimulates the proliferation of human synovial cells. Arthritis Rheum (1998) 0.88
Transcriptional activation of the human T-lymphotropic virus type I long terminal repeat by functional interaction of Tax1 and Ets1. J Virol (1993) 0.88
Inactivation of p53 by HTLV type 1 and HTLV type 2 Tax trans-activators. AIDS Res Hum Retroviruses (2000) 0.87
Sequences downstream of the RNA initiation site regulate human T-cell lymphotropic virus type I basal gene expression. J Virol (1993) 0.87
Accurate transcription of simian virus 40 chromatin in a HeLa cell extract. J Virol (1982) 0.86