T-cell activation signals and human T-cell leukemia virus type I-encoded p40x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element.

PubWeight™: 2.08‹?› | Rank: Top 2%

🔗 View Article (PMC 365666)

Published in Mol Cell Biol on December 01, 1988

Authors

S Miyatake1, M Seiki, M Yoshida, K Arai

Author Affiliations

1: Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304-1104.

Articles citing this

Mechanism of action of regulatory proteins encoded by complex retroviruses. Microbiol Rev (1992) 3.60

NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells. Proc Natl Acad Sci U S A (1990) 2.75

Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. J Clin Invest (1991) 2.08

Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia. J Exp Med (1990) 1.83

Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. J Virol (1991) 1.80

NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene. Mol Cell Biol (1990) 1.69

Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol Cell Biol (1998) 1.66

Effect of human T-cell leukemia virus type I tax protein on activation of the human vimentin gene. J Virol (1990) 1.64

Purification and characterization of multiple nuclear factors that bind to the TAX-inducible enhancer within the human T-cell leukemia virus type 1 long terminal repeat. Mol Cell Biol (1989) 1.63

The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT. Mol Cell Biol (1993) 1.52

Distinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors. J Virol (1995) 1.45

A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeat. Mol Cell Biol (1990) 1.42

Lymphotoxin activation by human T-cell leukemia virus type I-infected cell lines: role for NF-kappa B. J Virol (1990) 1.30

Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages. Mol Cell Biol (1990) 1.29

Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28. Mol Cell Biol (1992) 1.28

Structures of human genes coding for cytokine LD78 and their expression. Mol Cell Biol (1990) 1.27

Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures. Proc Natl Acad Sci U S A (1992) 1.24

Proliferative response of Tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway. J Virol (1993) 1.24

Quantitative studies of the effect of HTLV-I Tax protein on CREB protein--DNA binding. Nucleic Acids Res (1994) 1.23

Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activator tax. J Virol (1989) 1.22

Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5. Mol Cell Biol (1991) 1.20

Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cells. J Clin Invest (1992) 1.14

Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter. J Virol (1997) 1.14

SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily. J Virol (1996) 1.13

trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene. Mol Cell Biol (1989) 1.12

In vitro activation of transcription by the human T-cell leukemia virus type I Tax protein. Mol Cell Biol (1992) 1.10

CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein. J Virol (2001) 1.08

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals. Proc Natl Acad Sci U S A (1992) 1.08

HTLV-I Tax self-association in optimal trans-activation function. Nucleic Acids Res (1997) 1.07

A novel tumor necrosis factor-responsive transcription factor which recognizes a regulatory element in hemopoietic growth factor genes. Mol Cell Biol (1990) 1.06

Regulation of expression of the c-sis proto-oncogene. Nucleic Acids Res (1989) 1.05

Transdominant human T-cell lymphotropic virus type I TAX1 mutant that fails to localize to the nucleus. J Virol (1991) 1.04

The repeated sequence CATT(A/T) is required for granulocyte-macrophage colony-stimulating factor promoter activity. Mol Cell Biol (1990) 1.03

Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40tax. J Virol (1997) 1.00

Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements. Mol Cell Biol (1990) 0.97

Transactivation of the human T-cell lymphotropic virus type 1 Tax1-responsive 21-base-pair repeats requires Holo-TFIID and TFIIA. J Virol (1995) 0.97

Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene. J Clin Invest (1993) 0.96

Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter. Mol Cell Biol (1994) 0.95

Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells: involvement of the conserved lymphokine element 0. Mol Biol Cell (1994) 0.94

Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein. J Virol (1993) 0.93

Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1. J Virol (1993) 0.92

Identification of a negative element in the human vimentin promoter: modulation by the human T-cell leukemia virus type I Tax protein. Mol Cell Biol (1993) 0.91

Transcription of the human T-cell lymphotropic virus type I promoter by an alpha-amanitin-resistant polymerase. J Virol (1994) 0.88

Transcriptional activation of the human T-lymphotropic virus type I long terminal repeat by functional interaction of Tax1 and Ets1. J Virol (1993) 0.88

Sequences downstream of the RNA initiation site regulate human T-cell lymphotropic virus type I basal gene expression. J Virol (1993) 0.87

Infection of human synovial cells by human T cell lymphotropic virus type I. Proliferation and granulocyte/macrophage colony-stimulating factor production by synovial cells. J Clin Invest (1993) 0.87

Characterization of the promoter region of the src family gene lyn and its trans activation by human T-cell leukemia virus type I-encoded p40tax. Mol Cell Biol (1992) 0.86

Increased number of circulating HTLV-1 infected cells in peripheral blood mononuclear cells of HTLV-1 uveitis patients: a quantitative polymerase chain reaction study. Br J Ophthalmol (1995) 0.86

trans activation of nerve growth factor in transgenic mice containing the human T-cell lymphotropic virus type I tax gene. Mol Cell Biol (1991) 0.85

Human T-cell leukemia retrovirus-Tax protein is a repressor of nuclear receptor signaling. Proc Natl Acad Sci U S A (1999) 0.85

Overexpression of transforming growth factor-beta in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene. Mol Cell Biol (1991) 0.84

trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein. J Virol (1992) 0.84

cis-Acting inhibitory elements within the pol-env region of human T-cell leukemia virus type 1 possibly involved in viral persistence. J Virol (1997) 0.84

MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene. Mol Cell Biol (1995) 0.83

Requirements for interleukin 2 promoter transactivation by the Tax protein of human T-cell leukemia virus type 1. Mol Cell Biol (1996) 0.83

A cis element required for induction of the interleukin 2 enhancer by human T-cell leukemia virus type I binds a novel Tax-inducible nuclear protein. Mol Cell Biol (1993) 0.81

T-cell nuclei contain a protein that binds upstream of the murine granulocyte-macrophage colony-stimulating factor gene. Proc Natl Acad Sci U S A (1989) 0.81

The maedi-visna virus Tat protein induces multiorgan lymphoid hyperplasia in transgenic mice. J Virol (1994) 0.81

Characterization of a cell-type-restricted negative regulatory activity of the human granulocyte-macrophage colony-stimulating factor gene. Mol Cell Biol (1994) 0.80

Cytokine production by endothelial cells infected with human T cell lymphotropic virus type I. Ann Rheum Dis (1996) 0.79

A sequence-specific single-strand DNA binding protein that contacts repressor sequences in the human GM-CSF promoter. Nucleic Acids Res (1994) 0.79

A regulatory element in the promoter of the human granulocyte-macrophage colony-stimulating factor gene that has related sequences in other T-cell-expressed cytokine genes. Proc Natl Acad Sci U S A (1995) 0.77

Strong trans activation of the human cytomegalovirus major immediate-early enhancer by p40tax of human T-cell leukemia virus type I via two repetitive tax-responsive sequence elements. J Virol (1992) 0.77

Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV-1 Perspective. Leuk Res Treatment (2012) 0.76

Constitutive production of multiple colony-stimulating factors in patients with lung cancer associated with neutrophilia. Br J Cancer (1994) 0.75

Retargeting Oncolytic Vesicular Stomatitis Virus to Human T-Cell Lymphotropic Virus Type 1-Associated Adult T-Cell Leukemia. J Virol (2015) 0.75

Contrasting effects of hyperoxia on GM-CSF gene transcription in alveolar epithelial cells and T cells. Physiol Rep (2015) 0.75

Articles cited by this

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75

The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58

Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature (1984) 25.71

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell (1987) 20.61

Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell (1986) 20.08

An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (1987) 19.23

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell (1987) 14.62

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins. Nature (1985) 14.41

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol Cell Biol (1988) 12.84

Efficient infection of monkey cells with DNA of simian virus 40. Proc Natl Acad Sci U S A (1981) 8.66

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature (1986) 8.64

Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell (1985) 8.16

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell (1987) 7.75

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence. Proc Natl Acad Sci U S A (1984) 7.74

Correct transcription of an immunoglobulin kappa gene requires an upstream fragment containing conserved sequence elements. Nature (1984) 7.66

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses. Genes Dev (1988) 7.52

Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell (1987) 7.51

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor. Nature (1988) 7.35

The role of the T3/antigen receptor complex in T-cell activation. Annu Rev Immunol (1986) 5.67

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV. Cell (1988) 5.33

Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I. Science (1987) 5.22

Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I. Cell (1987) 4.76

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J (1986) 4.58

Discrete elements within the SV40 enhancer region display different cell-specific enhancer activities. EMBO J (1987) 4.28

The SV40 enhancer can be dissected into multiple segments, each with a different cell type specificity. Genes Dev (1987) 4.20

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity. Nature (1987) 4.11

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes. Proc Natl Acad Sci U S A (1987) 4.10

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell (1987) 4.10

Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. Science (1988) 4.01

Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature (1987) 3.94

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator. EMBO J (1986) 3.86

Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) genes. Proc Natl Acad Sci U S A (1986) 3.81

Human immunodeficiency virus long terminal repeat responds to T-cell activation signals. Proc Natl Acad Sci U S A (1987) 3.47

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. Proc Natl Acad Sci U S A (1987) 3.43

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. EMBO J (1985) 3.04

Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene. Proc Natl Acad Sci U S A (1988) 2.74

Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B gene. Mol Cell Biol (1986) 2.69

Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature (1988) 2.54

Structure of the chromosomal gene for murine interleukin 3. Proc Natl Acad Sci U S A (1985) 2.33

Characterization of the human granulocyte-macrophage colony-stimulating factor promoter region by genetic analysis: correlation with DNase I footprinting. Mol Cell Biol (1988) 1.97

Activation of T cell-derived lymphokine genes in T cells and fibroblasts: effects of human T cell leukemia virus type I p40x protein and bovine papilloma virus encoded E2 protein. Nucleic Acids Res (1988) 1.86

Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol Rev (1988) 1.84

Regulation of interleukin 2 receptor alpha subunit (Tac or CD25 antigen) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation. Proc Natl Acad Sci U S A (1988) 1.74

Coordinate regulation of immune and inflammatory responses by T cell-derived lymphokines. FASEB J (1988) 1.37

Recent advances in the molecular biology of HTLV-1: trans-activation of viral and cellular genes. Annu Rev Immunol (1987) 1.29

Articles by these authors

A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A (2001) 33.71

CRM1 is an export receptor for leucine-rich nuclear export signals. Cell (1997) 18.60

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci U S A (1983) 14.09

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A (1982) 12.84

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol Cell Biol (1988) 12.84

CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature (1997) 10.49

Direct observation of the rotation of F1-ATPase. Nature (1997) 9.57

A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature (1994) 9.31

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A (1999) 6.81

Laparoscopic cholecystectomy using fine-caliber instruments. Surg Endosc (1998) 6.62

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp Cell Res (1998) 6.11

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A (1984) 5.81

Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase. Nature (2001) 5.63

High-efficiency cloning of full-length cDNA; construction and screening of cDNA expression libraries for mammalian cells. Methods Enzymol (1987) 5.08

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci U S A (1988) 5.03

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A (1984) 4.97

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc Natl Acad Sci U S A (1986) 4.59

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J (1986) 4.58

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell (1987) 4.50

F1-ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps. Cell (1998) 4.47

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science (1993) 4.39

Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae. EMBO J (1985) 4.37

Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus. Nature (1982) 4.33

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J Biol Chem (1994) 4.28

Exploring the protein interactome using comprehensive two-hybrid projects. Trends Biotechnol (2001) 4.27

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases. EMBO J (1988) 4.27

Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor. Proc Natl Acad Sci U S A (1985) 4.24

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature (1999) 4.19

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes. Proc Natl Acad Sci U S A (1987) 4.10

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell (1987) 4.10

Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. Proc Natl Acad Sci U S A (1985) 3.95

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator. EMBO J (1986) 3.86

A novel ES cell line, TT2, with high germline-differentiating potency. Anal Biochem (1993) 3.79

Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J Biol Chem (1997) 3.74

Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy. Science (1995) 3.66

Plasma (1-->3)-beta-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes. Lancet (1995) 3.64

Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity. Proc Natl Acad Sci U S A (1980) 3.58

Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J (1989) 3.56

A transcriptional enhancer sequence of HTLV-I is responsible for trans-activation mediated by p40 chi HTLV-I. EMBO J (1986) 3.53

Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins. EMBO J (1988) 3.45

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A (1990) 3.36

Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science (1990) 3.35

Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J Biol Chem (1999) 3.34

p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A (1985) 3.34

Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol (2001) 3.32

The poliovirus receptor protein is produced both as membrane-bound and secreted forms. EMBO J (1990) 3.31

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells. Proc Natl Acad Sci U S A (1985) 3.31

Cytokine receptors and signal transduction. Annu Rev Immunol (1992) 3.27

Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes. J Exp Med (1987) 3.22

Human adult T-cell leukemia virus: molecular cloning of the provirus DNA and the unique terminal structure. Proc Natl Acad Sci U S A (1982) 3.19

Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family. Science (1985) 3.18

GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity (2001) 3.13

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. EMBO J (1985) 3.04

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell (2001) 2.97

Wortmannin, a microbial product inhibitor of myosin light chain kinase. J Biol Chem (1992) 2.85

Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell (1991) 2.84

Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells. Nature (1984) 2.78

The virus of Japanese adult T-cell leukaemia is a member of the human T-cell leukaemia virus group. Nature (1982) 2.75

HIV/HTLV gene nomenclature. Nature (1988) 2.72

Primary structure of elongation factor Tu from Escherichia coli. Proc Natl Acad Sci U S A (1980) 2.72

Structure, expression and divergence of T-cell receptor beta-chain variable regions. Nature (1984) 2.71

Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction. Biochemistry (1993) 2.70

A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. Proc Natl Acad Sci U S A (2000) 2.64

ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J (1989) 2.62

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene (1993) 2.55

Heat-inactivated proteins are rescued by the DnaK.J-GrpE set and ClpB chaperones. Proc Natl Acad Sci U S A (1999) 2.54

Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc Natl Acad Sci U S A (1988) 2.54

Beta-sarcoglycan (A3b) mutations cause autosomal recessive muscular dystrophy with loss of the sarcoglycan complex. Nat Genet (1995) 2.53

The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1. Proc Natl Acad Sci U S A (1993) 2.52

Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma. Cancer (2001) 2.51

Unifected avian cells contain structurally unrelated progenitors of viral sarcoma genes. Nature (1980) 2.50

Complications and diagnosis of Meckel's diverticulum in 776 patients. Am J Surg (1992) 2.48

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. EMBO J (1990) 2.44

Unique primed start of phage phi X174 DNA replication and mobility of the primosome in a direction opposite chain synthesis. Proc Natl Acad Sci U S A (1981) 2.44

Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. J Biol Chem (1993) 2.40

Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med (1989) 2.37

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proc Natl Acad Sci U S A (1997) 2.35

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line. Mol Cell Biol (1986) 2.33

Structure of the chromosomal gene for murine interleukin 3. Proc Natl Acad Sci U S A (1985) 2.33

Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc Natl Acad Sci U S A (2000) 2.32

B cell growth-promoting activity of recombinant human interleukin 4. J Immunol (1987) 2.31

Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci (1999) 2.30

Small hepatocellular carcinoma: treatment with subsegmental transcatheter arterial embolization. Radiology (1993) 2.30

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. EMBO J (1999) 2.29

Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A (1988) 2.25