MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-kappaB signaling.

PubWeight™: 1.62‹?› | Rank: Top 4%

🔗 View Article (PMC 2853303)

Published in Am J Physiol Gastrointest Liver Physiol on February 18, 2010

Authors

Rebecca T Marquez1, Erik Wendlandt, Courtney Searcey Galle, Kathy Keck, Anton P McCaffrey

Author Affiliations

1: University of Iowa School of Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

Articles citing this

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00

MicroRNAs in NF-kappaB signaling. J Mol Cell Biol (2011) 2.50

Apoptosis and the target genes of microRNA-21. Chin J Cancer (2011) 1.74

Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancer. Am J Transl Res (2010) 1.74

mirConnX: condition-specific mRNA-microRNA network integrator. Nucleic Acids Res (2011) 1.62

New concepts in liver regeneration. J Gastroenterol Hepatol (2011) 1.55

A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration. J Clin Invest (2012) 1.43

Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid. Am J Physiol Gastrointest Liver Physiol (2010) 1.38

The role of microRNAs in human liver cancers. Semin Oncol (2011) 1.34

Regulation of zebrafish heart regeneration by miR-133. Dev Biol (2012) 1.24

Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design. Gene Ther (2011) 1.22

MicroRNA-149 inhibits proliferation and cell cycle progression through the targeting of ZBTB2 in human gastric cancer. PLoS One (2012) 1.20

Mir-34a is upregulated during liver regeneration in rats and is associated with the suppression of hepatocyte proliferation. PLoS One (2011) 1.17

microRNAs: fad or future of liver disease. World J Gastroenterol (2011) 1.15

Regulation of breast cancer and bone metastasis by microRNAs. Dis Markers (2013) 1.12

The Mammalian response to virus infection is independent of small RNA silencing. Cell Rep (2014) 1.12

The role of microRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation. Innate Immun (2012) 1.07

Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver. BMC Genomics (2013) 1.06

Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration. Hepatology (2011) 1.05

Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol (2012) 1.04

miRNAs in newt lens regeneration: specific control of proliferation and evidence for miRNA networking. PLoS One (2010) 1.03

MicroRNA-21 knockout improve the survival rate in DSS induced fatal colitis through protecting against inflammation and tissue injury. PLoS One (2013) 1.02

Down-regulation of microRNA-26a promotes mouse hepatocyte proliferation during liver regeneration. PLoS One (2012) 1.00

Toll like receptor signaling in "inflammaging": microRNA as new players. Immun Ageing (2013) 0.99

Down-regulation of MiR-127 facilitates hepatocyte proliferation during rat liver regeneration. PLoS One (2012) 0.94

Chronic ethanol feeding alters miRNA expression dynamics during liver regeneration. Alcohol Clin Exp Res (2012) 0.93

Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells. Acta Pharmacol Sin (2012) 0.93

Hepatic miRNA expression reprogrammed by Plasmodium chabaudi malaria. Parasitol Res (2010) 0.85

Time-course changes in the expression levels of miR-122, -155, and -21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats. J Vet Sci (2016) 0.85

Non-Coding RNAs in Primary Liver Cancer. Front Med (Lausanne) (2015) 0.85

Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats. Am J Physiol Gastrointest Liver Physiol (2012) 0.85

MicroRNAs and hepatitis C virus: toward the end of miR-122 supremacy. Virol J (2012) 0.84

Long noncoding RNA are aberrantly expressed in human papillary thyroid carcinoma. Oncol Lett (2016) 0.82

MicroRNA-183 inhibits gastric cancer proliferation and invasion via directly targeting Bmi-1. Oncol Lett (2014) 0.81

Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis. Sci Rep (2015) 0.80

Functional and structural features of cholangiocytes in health and disease. Cell Mol Gastroenterol Hepatol (2015) 0.79

MicroRNA-26b Modulates the NF-κB Pathway in Alveolar Macrophages by Regulating PTEN. J Immunol (2015) 0.78

Neuronal calcium signaling pathways are associated with the development of epilepsy. Mol Med Rep (2014) 0.78

MicroRNA-34a regulates liver regeneration and the development of liver cancer in rats by targeting Notch signaling pathway. Oncotarget (2017) 0.77

Measures of association for identifying microRNA-mRNA pairs of biological interest. PLoS One (2012) 0.77

Isolation and characterization of vesicular and non-vesicular microRNAs circulating in sera of partially hepatectomized rats. Sci Rep (2016) 0.76

Systematic analysis of the p53-related microRNAs in breast cancer revealing their essential roles in the cell cycle. Oncol Lett (2015) 0.76

PELI1 expression is correlated with MYC and BCL6 expression and associated with poor prognosis in diffuse large B-cell lymphoma. Mod Pathol (2016) 0.76

Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats. Am J Physiol Gastrointest Liver Physiol (2016) 0.76

A step-by-step microRNA guide to cancer development and metastasis. Cell Oncol (Dordr) (2017) 0.75

Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections. J Biomed Sci (2016) 0.75

MicroRNA-21 Contributes to Liver Regeneration by Targeting PTEN. Med Sci Monit (2016) 0.75

Comprehensive CircRNA expression profile and selection of key CircRNAs during priming phase of rat liver regeneration. BMC Genomics (2017) 0.75

Independent effects of sham laparotomy and anesthesia on hepatic microRNA expression in rats. BMC Res Notes (2014) 0.75

The microRNA Expression Profile in Donation after Cardiac Death (DCD) Livers and Its Ability to Identify Primary Non Function. PLoS One (2015) 0.75

Articles cited by this

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87

Prediction of mammalian microRNA targets. Cell (2003) 53.70

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95

A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21

Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2008) 37.16

The impact of microRNAs on protein output. Nature (2008) 32.39

MicroRNA gene expression deregulation in human breast cancer. Cancer Res (2005) 27.56

NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res (2005) 18.58

MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology (2007) 13.20

Liver regeneration. Science (1997) 12.80

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene (2007) 10.79

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36

Ribo-gnome: the big world of small RNAs. Science (2005) 10.10

miR-21-mediated tumor growth. Oncogene (2006) 9.90

SMAD proteins control DROSHA-mediated microRNA maturation. Nature (2008) 9.67

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res (2008) 7.53

Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem (2007) 7.46

Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology (2006) 7.06

MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem (2007) 6.88

Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene (2006) 6.61

Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer (2007) 6.57

Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol (2004) 6.36

miR-21: a small multi-faceted RNA. J Cell Mol Med (2009) 5.59

MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology (2008) 5.28

MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol (2008) 5.21

Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood (2007) 5.14

Improved northern blot method for enhanced detection of small RNA. Nat Protoc (2008) 4.47

MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci U S A (2009) 3.97

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. Blood (2007) 3.64

miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol (2008) 3.26

MicroRNAs modulate the chemosensitivity of tumor cells. Mol Cancer Ther (2008) 3.06

Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations. Proc Natl Acad Sci U S A (2004) 2.43

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology (2009) 2.23

Control of protein synthesis and mRNA degradation by microRNAs. Curr Opin Cell Biol (2008) 2.00

Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration. Cell Growth Differ (1995) 1.75

Rapid activation of post-hepatectomy factor/nuclear factor kappa B in hepatocytes, a primary response in the regenerating liver. J Biol Chem (1994) 1.64

Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest (2002) 1.58

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes. Hepatology (2009) 1.45

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. J Biol Chem (2002) 1.45

Hepatic function is preserved in the absence of mature microRNAs. Hepatology (2009) 1.44

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. Nat Immunol (2006) 1.42

Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration. Semin Liver Dis (1999) 1.41

Microarray analysis of microRNA expression in hepatocellular carcinoma and non-tumorous tissues without viral hepatitis. J Gastroenterol Hepatol (2008) 1.38

Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-beta. Cell Regul (1991) 1.27

Interleukin-1 beta is a potent growth inhibitor of adult rat hepatocytes in primary culture. Exp Cell Res (1988) 1.15

Nonparenchymal cells from regenerating rat liver generate interleukin-1alpha and -1beta: a mechanism of negative regulation of hepatocyte proliferation. Hepatology (1997) 1.06

Regulation of liver regeneration. Nephrol Dial Transplant (2004) 1.05

Normal liver regeneration in p50/nuclear factor kappaB1 knockout mice. Hepatology (2001) 1.04

Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol (2009) 0.97

Articles by these authors

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol (2009) 3.78

In vivo activity of nuclease-resistant siRNAs. RNA (2004) 2.33

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Res (2012) 2.26

Biliverdin inhibits hepatitis C virus nonstructural 3/4A protease activity: mechanism for the antiviral effects of heme oxygenase? Hepatology (2010) 1.75

Identifying functional microRNAs in macrophages with polarized phenotypes. J Biol Chem (2012) 1.67

Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans. Lab Invest (2010) 1.61

Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs. Mol Ther (2010) 1.61

Transepithelial migration of neutrophils into the lung requires TREM-1. J Clin Invest (2012) 1.31

Hepatitis C virus infection and hepatic stellate cell activation downregulate miR-29: miR-29 overexpression reduces hepatitis C viral abundance in culture. J Infect Dis (2011) 1.20

ZFN-site searches genomes for zinc finger nuclease target sites and off-target sites. BMC Bioinformatics (2011) 1.16

Rational design leads to more potent RNA interference against hepatitis B virus: factors effecting silencing efficiency. Mol Ther (2008) 1.10

Advances in microRNAs: implications for gene therapists. Hum Gene Ther (2008) 1.08

The role of microRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation. Innate Immun (2012) 1.07

Low serum miR-19a expression as a novel poor prognostic indicator in multiple myeloma. Int J Cancer (2014) 0.84

5' Unlocked Nucleic Acid Modification Improves siRNA Targeting. Mol Ther Nucleic Acids (2013) 0.78

Characterization of a novel mouse model with genetic deletion of CD177. Protein Cell (2014) 0.77

Neoplastic plasma cell aberrant antigen expression patterns and their association with genetic abnormalities. Leuk Lymphoma (2014) 0.75

A subset of CD20(+) MM patients without the t(11;14) are associated with poor prognosis and a link to aberrant expression of Wnt signaling. Hematol Oncol (2014) 0.75