Published in Cell on December 26, 2003
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25
MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell (2007) 38.42
Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2008) 37.16
Human MicroRNA targets. PLoS Biol (2004) 34.51
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
The impact of microRNAs on protein output. Nature (2008) 32.39
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60
Principles of microRNA-target recognition. PLoS Biol (2005) 23.70
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
MicroRNA genes are transcribed by RNA polymerase II. EMBO J (2004) 20.65
Fast and effective prediction of microRNA/target duplexes. RNA (2004) 18.10
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet (2005) 17.07
The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci U S A (2004) 14.59
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA (2005) 14.14
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods (2007) 13.94
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature (2010) 13.82
Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature (2013) 13.60
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep (2008) 10.71
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42
MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci U S A (2006) 10.11
A combined computational-experimental approach predicts human microRNA targets. Genes Dev (2004) 9.82
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A (2007) 9.82
Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res (2005) 9.80
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
Initial impact of the sequencing of the human genome. Nature (2011) 9.18
Novel and stress-regulated microRNAs and other small RNAs from Arabidopsis. Plant Cell (2004) 9.18
miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res (2008) 8.97
The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci U S A (2005) 8.60
TarBase: A comprehensive database of experimentally supported animal microRNA targets. RNA (2005) 8.40
A MicroRNA feedback circuit in midbrain dopamine neurons. Science (2007) 8.33
microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci U S A (2006) 8.24
miRiad roles for the miR-17-92 cluster in development and disease. Cell (2008) 8.02
Sequence-specific inhibition of small RNA function. PLoS Biol (2004) 7.98
Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR. Proc Natl Acad Sci U S A (2007) 7.93
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell (2007) 7.70
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science (2008) 7.59
RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res (2006) 7.39
Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer (2010) 7.39
High-throughput sequencing of Arabidopsis microRNAs: evidence for frequent birth and death of MIRNA genes. PLoS One (2007) 7.34
A microRNA signature of hypoxia. Mol Cell Biol (2006) 7.24
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA (2006) 7.06
Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A (2008) 6.89
microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77
Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells (2005) 6.72
Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA (2007) 6.44
Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression. Mol Cell Biol (2007) 6.43
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol (2007) 6.41
A three-dimensional view of the molecular machinery of RNA interference. Nature (2009) 6.31
miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res (2008) 6.30
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. EMBO J (2004) 6.27
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature (2005) 6.23
Inference of miRNA targets using evolutionary conservation and pathway analysis. BMC Bioinformatics (2007) 6.21
Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A (2006) 6.19
Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov (2010) 6.07
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med (2008) 5.97
The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes Dev (2005) 5.78
A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain. Genome Res (2004) 5.77
Incorporating structure to predict microRNA targets. Proc Natl Acad Sci U S A (2005) 5.68
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol (2011) 5.57
Isolation of microRNA targets by miRNP immunopurification. RNA (2007) 5.50
miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One (2007) 5.43
Synonymous but not the same: the causes and consequences of codon bias. Nat Rev Genet (2010) 5.37
Structure of the guide-strand-containing argonaute silencing complex. Nature (2008) 5.36
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci (2009) 5.27
Identification and analysis of alternative splicing events conserved in human and mouse. Proc Natl Acad Sci U S A (2005) 5.26
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet (2008) 5.26
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood (2008) 5.23
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
Genomic analysis of human microRNA transcripts. Proc Natl Acad Sci U S A (2007) 5.20
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev (2007) 5.16
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03
Spatial preferences of microRNA targets in 3' untranslated regions. BMC Genomics (2007) 4.99
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Distance constraints between microRNA target sites dictate efficacy and cooperativity. Nucleic Acids Res (2007) 4.91
RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA (2005) 4.91
miRGen: a database for the study of animal microRNA genomic organization and function. Nucleic Acids Res (2006) 4.91
Probing microRNAs with microarrays: tissue specificity and functional inference. RNA (2004) 4.91
Reliable prediction of regulator targets using 12 Drosophila genomes. Genome Res (2007) 4.89
The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nat Struct Mol Biol (2008) 4.88
Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci U S A (2007) 4.87
Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev (2007) 4.79
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol (2008) 4.76
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics (2013) 4.73
Sorting of Drosophila small silencing RNAs. Cell (2007) 4.67
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell (2008) 4.57
Concern Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic Acids Res (2004) 4.50
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
Alternative isoform regulation in human tissue transcriptomes. Nature (2008) 52.76
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95
MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell (2007) 38.42
Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2008) 37.16
The impact of microRNAs on protein output. Nature (2008) 32.39
MicroRNAs modulate hematopoietic lineage differentiation. Science (2003) 30.05
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature (2010) 22.04
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51
A uniform system for microRNA annotation. RNA (2003) 20.28
MicroRNAs in plants. Genes Dev (2002) 20.12
Prediction of plant microRNA targets. Cell (2002) 19.20
MicroRNA-directed cleavage of HOXB8 mRNA. Science (2004) 18.33
The microRNAs of Caenorhabditis elegans. Genes Dev (2003) 17.70
Vertebrate microRNA genes. Science (2003) 17.42
Predictive identification of exonic splicing enhancers in human genes. Science (2002) 16.86
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell (2006) 15.12
MicroRNAS and their regulatory roles in plants. Annu Rev Plant Biol (2006) 14.44
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA (2005) 14.14
Computational identification of plant microRNAs and their targets, including a stress-induced miRNA. Mol Cell (2004) 12.97
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science (2007) 12.42
A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana. Genes Dev (2006) 11.71
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (2008) 11.33
MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell (2009) 10.50
Analysis and design of RNA sequencing experiments for identifying isoform regulation. Nat Methods (2010) 10.13
A biochemical framework for RNA silencing in plants. Genes Dev (2003) 9.95
Intronic microRNA precursors that bypass Drosha processing. Nature (2007) 9.65
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell (2005) 9.35
Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals. J Comput Biol (2004) 9.00
Systematic identification and analysis of exonic splicing silencers. Cell (2004) 8.50
Transcriptional amplification in tumor cells with elevated c-Myc. Cell (2012) 8.24
Characterization of the piRNA complex from rat testes. Science (2006) 7.86
Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs. Mol Cell (2004) 7.68
Criteria for annotation of plant MicroRNAs. Plant Cell (2008) 7.49
An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data. PLoS Comput Biol (2009) 7.47
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev (2010) 7.14
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev (2008) 7.07
Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals. Nature (2008) 6.81
The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. Genes Dev (2004) 6.69
lincRNAs: genomics, evolution, and mechanisms. Cell (2013) 6.50
Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA (2007) 6.44
Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA (2008) 6.29
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. EMBO J (2004) 6.27
Small RNAs correspond to centromere heterochromatic repeats. Science (2002) 5.96
The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90
Variation in alternative splicing across human tissues. Genome Biol (2004) 5.70
Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. Cell (2011) 5.65
A two-hit trigger for siRNA biogenesis in plants. Cell (2006) 5.60
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol (2011) 5.57
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
Identification and analysis of alternative splicing events conserved in human and mouse. Proc Natl Acad Sci U S A (2005) 5.26
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature (2008) 5.05
Endogenous siRNA and miRNA targets identified by sequencing of the Arabidopsis degradome. Curr Biol (2008) 5.00
Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs. Curr Biol (2005) 4.98
Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev (2007) 4.79
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues. Science (2012) 4.52
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Mol Cell (2008) 4.48
Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell (2010) 4.20
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A (2007) 4.15
MicroRNAs: at the root of plant development? Plant Physiol (2003) 4.12
Antiquity of microRNAs and their targets in land plants. Plant Cell (2005) 3.88
Formation, regulation and evolution of Caenorhabditis elegans 3'UTRs. Nature (2010) 3.87
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78
General and specific functions of exonic splicing silencers in splicing control. Mol Cell (2006) 3.76
Biased chromatin signatures around polyadenylation sites and exons. Mol Cell (2009) 3.74
RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Res (2004) 3.70
MicroRNA regulation of NAC-domain targets is required for proper formation and separation of adjacent embryonic, vegetative, and floral organs. Curr Biol (2004) 3.63
Revisiting global gene expression analysis. Cell (2012) 3.63
MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genes. Plant Cell (2005) 3.62
Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell (2013) 3.35
Variation in sequence and organization of splicing regulatory elements in vertebrate genes. Proc Natl Acad Sci U S A (2004) 3.34
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A (2008) 3.33
Common functions for diverse small RNAs of land plants. Plant Cell (2007) 3.30
Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell (2012) 3.20
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet (2011) 2.99
TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway. Nat Struct Mol Biol (2008) 2.98
AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1. Mol Cell (2006) 2.94
Widespread selection for local RNA secondary structure in coding regions of bacterial genes. Genome Res (2003) 2.81
Single nucleotide polymorphism-based validation of exonic splicing enhancers. PLoS Biol (2004) 2.77
Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature (2013) 2.63
Direct measurement of DNA affinity landscapes on a high-throughput sequencing instrument. Nat Biotechnol (2011) 2.60
Identification of let-7-regulated oncofetal genes. Cancer Res (2008) 2.56
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
A combinatorial code for splicing silencing: UAGG and GGGG motifs. PLoS Biol (2005) 2.48
A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. Genes Dev (2008) 2.45
Expanded identification and characterization of mammalian circular RNAs. Genome Biol (2014) 2.39