Published in Mol Cancer on February 21, 2010
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer (2011) 1.75
Polycomb preferentially targets stalled promoters of coding and noncoding transcripts. Genome Res (2010) 1.63
Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer. PLoS One (2012) 1.08
DNA and histone methylation in gastric carcinogenesis. World J Gastroenterol (2013) 1.03
Oncogenic role of the chromobox protein CBX7 in gastric cancer. J Exp Clin Cancer Res (2010) 0.99
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Aberrant upregulation of 14-3-3ơ expression serves as an inferior prognostic biomarker for gastric cancer. BMC Cancer (2011) 0.97
Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer. PLoS One (2013) 0.92
Context-dependent actions of Polycomb repressors in cancer. Oncogene (2015) 0.89
MEL-18 loss mediates estrogen receptor-α downregulation and hormone independence. J Clin Invest (2015) 0.86
The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells. Oncotarget (2014) 0.84
The nuclear receptor NR2E1/TLX controls senescence. Oncogene (2014) 0.83
Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma. J Exp Clin Cancer Res (2010) 0.81
Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients. Mol Clin Oncol (2014) 0.81
Bmi-1 regulates stem cell-like properties of gastric cancer cells via modulating miRNAs. J Hematol Oncol (2016) 0.80
In aggressive variants of non-Hodgkin lymphomas, Ezh2 is strongly expressed and polycomb repressive complex PRC1.4 dominates over PRC1.2. Virchows Arch (2013) 0.80
Histone modifications: Targeting head and neck cancer stem cells. World J Stem Cells (2014) 0.78
Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer. Oncotarget (2016) 0.77
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The evolutionary landscape of PRC1 core components in green lineage. Planta (2016) 0.76
Mel-18 negatively regulates stem cell-like properties through downregulation of miR-21 in gastric cancer. Oncotarget (2016) 0.75
B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma. Oncol Lett (2017) 0.75
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature (2003) 12.06
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res (2006) 7.91
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol (2005) 5.00
Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res (2008) 4.64
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol (2003) 4.05
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol (2000) 3.37
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res (2002) 3.16
Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res (2006) 3.12
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Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci U S A (2008) 2.04
Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer. Breast (2004) 2.01
The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Cancer Lett (2004) 2.00
Role of polycomb group proteins in stem cell self-renewal and cancer. DNA Cell Biol (2005) 1.89
Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways. Cancer Res (2007) 1.70
Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol Biol Cell (2006) 1.67
MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer. Cancer Res (2009) 1.64
Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma. Int J Cancer (2007) 1.62
BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression. Cancer Res (2008) 1.56
Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res (2007) 1.56
Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. Mol Cell Biol (2007) 1.50
Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol (2008) 1.31
Expression of Bmi-1 is a prognostic marker in bladder cancer. BMC Cancer (2009) 1.26
The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev (2009) 1.24
Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas. Clin Cancer Res (2006) 1.23
Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas. Lab Invest (2006) 1.15
Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer. Cancer Res (2008) 1.00
mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Immunity (1998) 0.98
Lysophosphatidic acid induces cell migration through the selective activation of Akt1. Exp Mol Med (2008) 0.94
Inhibition of the proliferation of human gastric cancer cells SGC-7901 in vitro and in vivo using Bcl-2 siRNA. Chin Med J (Engl) (2007) 0.85
Oncoprotein BMI-1 induces the malignant transformation of HaCaT cells. J Cell Biochem (2009) 0.85
Inducible re-expression of p16 in an orthotopic mouse model of pancreatic cancer inhibits lymphangiogenesis and lymphatic metastasis. Br J Cancer (2008) 0.84
Analysis of Mel-18 expression in prostate cancer tissues and correlation with clinicopathologic features. Urol Oncol (2009) 0.83
Overexpression of CyclinD1 and underexpression of p16 correlate with lymph node metastases in laryngeal squamous cell carcinoma in Chinese patients. Clin Exp Metastasis (2008) 0.82
Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion. World J Gastroenterol (2009) 0.81
Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells. Exp Hematol (2009) 0.80
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol (2003) 4.05
Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors. J Clin Oncol (2010) 4.01
Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell (2012) 3.50
miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med (2010) 3.50
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34
Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res (2006) 3.12
Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States. Am J Kidney Dis (2005) 2.82
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The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala. Neurosci Bull (2013) 2.78
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KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 2.55
Complicated acute type B dissection: is surgery still the best option?: a report from the International Registry of Acute Aortic Dissection. JACC Cardiovasc Interv (2008) 2.47
Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell (2010) 2.46
Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol (2007) 2.42
Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron (2011) 2.42
KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: a meta-analysis of 22 studies. Lung Cancer (2009) 2.27
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell (2012) 2.22
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Living donor liver transplantation: the Asian perspective. Transplantation (2014) 2.13
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab (2010) 2.09
Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res (2003) 2.05
Glucocorticoids promote hepatic cholestasis in mice by inhibiting the transcriptional activity of the farnesoid X receptor. Gastroenterology (2012) 2.05
Molecular characterization of meiotic recombination across the 140-kb multigenic a1-sh2 interval of maize. Proc Natl Acad Sci U S A (2002) 1.98
On evaluating molecular-docking methods for pose prediction and enrichment factors. J Chem Inf Model (2006) 1.90
Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis. J Am Soc Nephrol (2010) 1.89
Dinitrosyliron complexes and the mechanism(s) of cellular protein nitrosothiol formation from nitric oxide. Proc Natl Acad Sci U S A (2009) 1.84
Impact of duty hours restrictions on quality of care and clinical outcomes. Am J Med (2007) 1.81
Mechanisms of cellular senescence in human and mouse cells. Biogerontology (2004) 1.76
Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents. J Cereb Blood Flow Metab (2010) 1.75
Cediranib plus FOLFOX/CAPOX versus placebo plus FOLFOX/CAPOX in patients with previously untreated metastatic colorectal cancer: a randomized, double-blind, phase III study (HORIZON II). J Clin Oncol (2012) 1.73
Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways. Cancer Res (2007) 1.70
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A (2011) 1.69
Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. J Hepatol (2010) 1.67
Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol Biol Cell (2006) 1.67
PCR-based methods for the enrichment of minority alleles and mutations. Clin Chem (2009) 1.65
Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. Hum Genet (2012) 1.64
Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. J Biol Chem (2006) 1.64
Is the Cancer of the Liver Italian Program system an adequate weighting for survival of hepatocellular carcinoma? Evaluation of intrascore prognostic value among 36 subgroups. Liver Int (2008) 1.63
HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Mol Cell (2011) 1.59
Prophylactic intraoperative uterine artery embolization to control hemorrhage in abnormal placentation during late gestation. Fertil Steril (2008) 1.59
Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell (2007) 1.59
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A (2011) 1.58
βTrCP regulates BMI1 protein turnover via ubiquitination and degradation. Cell Cycle (2011) 1.58
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Microstructure abnormalities in adolescents with internet addiction disorder. PLoS One (2011) 1.56
Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res (2007) 1.56
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Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity (2005) 1.54
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YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci (2011) 1.53
The MTA family proteins as novel histone H3 binding proteins. Cell Biosci (2013) 1.52
Coral energy reserves and calcification in a high-CO2 world at two temperatures. PLoS One (2013) 1.52
Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior. Cancer Res (2007) 1.51
Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Mol Endocrinol (2010) 1.47
Short-term ex vivo expansion sustains the homing-related properties of umbilical cord blood hematopoietic stem and progenitor cells. Haematologica (2004) 1.46
Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor. Eur J Pharmacol (2004) 1.45
A new simple model for prediction of hospital mortality in patients with intracerebral hemorrhage. CNS Neurosci Ther (2012) 1.45
Microarrays with varying carbohydrate density reveal distinct subpopulations of serum antibodies. J Proteome Res (2009) 1.45
Novel mutations of the FRMD7 gene in X-linked congenital motor nystagmus. Mol Vis (2007) 1.45
Optical coherence tomography of human kidney. J Urol (2010) 1.44
Determinants of childhood immunization uptake among socio-economically disadvantaged migrants in East China. Int J Environ Res Public Health (2013) 1.42
Observation of microsphere movement driven by optical pulse. Opt Lett (2011) 1.42
Failure of uterine arterial embolization: placenta accreta with profuse postpartum hemorrhage. Acta Obstet Gynecol Scand (2004) 1.41
Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. J Surg Res (2011) 1.41
Apoptosis repressor with caspase recruitment domain contributes to chemotherapy resistance by abolishing mitochondrial fission mediated by dynamin-related protein-1. Cancer Res (2009) 1.41
Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study). Gastric Cancer (2014) 1.41
Role of age in acute type A aortic dissection outcome: report from the International Registry of Acute Aortic Dissection (IRAD). J Thorac Cardiovasc Surg (2010) 1.41
National survey of knowledge, attitude and practice of fibromyalgia among rheumatologists in China. Int J Rheum Dis (2013) 1.39
Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks. Brain Res (2009) 1.39
Ice-COLD-PCR enables rapid amplification and robust enrichment for low-abundance unknown DNA mutations. Nucleic Acids Res (2010) 1.38
A two-stage linkage analysis of Chinese schizophrenia pedigrees in 10 target chromosomes. Biochem Biophys Res Commun (2006) 1.37
Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. Int J Pharm (2006) 1.37
Gold nanorods and their plasmonic properties. Chem Soc Rev (2013) 1.36
Do we really need closed-suction drainage in total hip arthroplasty? A meta-analysis. Int Orthop (2013) 1.35
Hepatocellular carcinoma surveillance and appropriate treatment options improve survival for patients with liver cirrhosis. Eur J Cancer (2010) 1.34
Refractures in cemented vertebrae after percutaneous vertebroplasty: a retrospective analysis. Eur Spine J (2008) 1.33
SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. EMBO J (2011) 1.33
Retrospective survey of 452 patients with inflammatory bowel disease in Wuhan city, central China. Inflamm Bowel Dis (2006) 1.32
Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population. Mol Carcinog (2013) 1.32
Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease. Am J Hum Genet (2013) 1.31
The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model. Cancer Prev Res (Phila) (2010) 1.28
Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis. J Invest Dermatol (2007) 1.28
Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study. Mol Pain (2010) 1.28
Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze. Neuropsychopharmacology (2003) 1.27
Splenic abscess: diagnosis and management. Hepatogastroenterology (2002) 1.27
A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem (2002) 1.27
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First prospective, population-based inflammatory bowel disease incidence study in mainland of China: the emergence of "western" disease. Inflamm Bowel Dis (2013) 1.25
Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model. J Neurosci (2002) 1.24
Time-varied characteristics of acupuncture effects in fMRI studies. Hum Brain Mapp (2009) 1.23
Simultaneously typing nine serotypes of enteroviruses associated with hand, foot, and mouth disease by a GeXP analyzer-based multiplex reverse transcription-PCR assay. J Clin Microbiol (2011) 1.23
A gene locus responsible for dyschromatosis symmetrica hereditaria (DSH) maps to chromosome 6q24.2-q25.2. Am J Hum Genet (2003) 1.23
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Immunization with Epstein-Barr Virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T-cell immunity and may lead to tumor regression in patients with EBV-positive nasopharyngeal carcinoma. Cancer Res (2002) 1.22
Multicenter phase II study of apatinib, a novel VEGFR inhibitor in heavily pretreated patients with metastatic triple-negative breast cancer. Int J Cancer (2014) 1.22
Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci (2013) 1.22
Do we really need tranexamic acid in total hip arthroplasty? A meta-analysis of nineteen randomized controlled trials. Arch Orthop Trauma Surg (2013) 1.20
Membrane "lens" effect: focusing the formation of reactive nitrogen oxides from the *NO/O2 reaction. Chem Res Toxicol (2007) 1.20