Published in Acta Pharmacol Sin on February 22, 2010
Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma. World J Gastroenterol (2014) 0.91
Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin (2011) 0.86
The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis. J Virol (2013) 0.80
Cooperative effects of hepatitis B virus and TNF may play important roles in the activation of metabolic pathways through the activation of NF-κB. Int J Mol Med (2016) 0.77
Hepatitis B virus X protein in liver tumor microenvironment. Tumour Biol (2016) 0.75
Single nucleotide polymorphism of SREBF-1 gene associated with an increased risk of endometrial cancer in Chinese women. PLoS One (2014) 0.75
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer (2007) 10.20
HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science (1991) 3.78
Global control of hepatitis B virus infection. Lancet Infect Dis (2002) 3.74
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition (2000) 3.58
Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. J Hepatol (2006) 2.04
Hepatitis B virus X protein: a multifunctional viral regulator. J Gastroenterol (2001) 1.98
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol Cancer Res (2003) 1.83
Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Proc Natl Acad Sci U S A (1995) 1.72
Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha. Biochem J (2008) 1.69
Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene (1999) 1.63
Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res (2001) 1.57
Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX. Mol Cell Biol (1994) 1.56
Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochem Biophys Res Commun (2003) 1.52
Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5. J Biol Chem (1997) 1.52
Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res (2002) 1.47
Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. Gastroenterology (2007) 1.45
COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis. Clin Cancer Res (2008) 1.34
Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein. J Virol (2001) 1.32
Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins. Alcohol (2004) 1.29
Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma. Hepatology (2009) 1.29
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues. J Med Virol (2005) 1.24
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. Clin Cancer Res (2005) 1.23
Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. Oncogene (2007) 1.15
Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. Transl Res (2007) 1.14
In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells. J Cell Biochem (2005) 1.14
Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection. J Hepatol (2003) 1.12
A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. Neoplasia (2010) 1.01
COOH-terminal deletion of HBx gene is a frequent event in HBV-associated hepatocellular carcinoma. World J Gastroenterol (2008) 0.98
Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation. Acta Pharmacol Sin (2008) 0.96
Transcriptional regulation of hepatic fatty acid metabolism. Subcell Biochem (2008) 0.96
A positive feedback between activated extracellularly regulated kinase and cyclooxygenase/lipoxygenase maintains proliferation and migration of breast cancer cells. Endocrinology (2008) 0.94
Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses. Carcinogenesis (2008) 0.94
Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis. J Hepatol (2008) 0.92
SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2. FEBS Lett (2007) 0.90
Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression. J Virol (2000) 0.89
Hepatitis B virus X protein mutants exhibit distinct biological activities in hepatoma Huh7 cells. Biochem Biophys Res Commun (2008) 0.89
Effects of different dietary fatty acids on the fatty acid compositions and the expression of lipid metabolic-related genes in mammary tumor tissues of rats. Nutr Cancer (2008) 0.84
Inhibition of tumorigenicity of the hepatitis B virus X gene in Chang liver cell line. Virus Res (2004) 0.82
A proteomics analysis of cellular proteins associated with HBV genotype-specific HBX: potential in identification of early diagnostic markers for HCC. J Clin Virol (2005) 0.78
Synergistic protective effect of picroside II and NGF on PC12 cells against oxidative stress induced by H2O2. Pharmacol Rep (2007) 1.12
Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions. Gut (2011) 1.02
NF-kappaB downregulation may be involved the depression of tumor cell proliferation mediated by human mesenchymal stem cells. Acta Pharmacol Sin (2008) 0.99
Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation. Acta Pharmacol Sin (2008) 0.96
Transformation of human liver L-O2 cells mediated by stable HBx transfection. Acta Pharmacol Sin (2009) 0.95
Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling. Acta Pharmacol Sin (2010) 0.92
[Screening of a sub-clone of human breast cancer cells with high metastasis potential]. Zhonghua Yi Xue Za Zhi (2006) 0.89
Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin (2010) 0.87
Protection of minocycline on early brain injury after subarachnoid hemorrhage in rats. Acta Neurochir Suppl (2011) 0.87
Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. Acta Pharmacol Sin (2008) 0.87
Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin (2011) 0.86
Factors affecting the long-term renal allograft survival. Chin Med J (Engl) (2011) 0.83
Proteomic alteration of Marc-145 cells and PAMs after infection by porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol (2011) 0.83
Matrix metalloproteinase 9 inhibition reduces early brain injury in cortex after subarachnoid hemorrhage. Acta Neurochir Suppl (2011) 0.82
Rapamycin instead of mycophenolate mofetil or azathioprine in treatment of post-renal transplantation urothelial carcinoma. Chin Med J (Engl) (2009) 0.82
A mutant of hepatitis B virus X protein (HBx Delta 127) enhances hepatoma cell migration via osteopontin involving 5-lipoxygenase. Acta Pharmacol Sin (2010) 0.82
ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun (2013) 0.81
Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacol Sin (2009) 0.81
[Applying bladder outlet obstruction number to predict bladder outlet obstruction of benign prostatic hyperplasia]. Zhonghua Wai Ke Za Zhi (2008) 0.81
Multidetector row-CT in evaluation of living renal donors. Chin Med J (Engl) (2010) 0.81
[Synthesis of Gal-BSA-SPIO and magnetic resonance imaging of ASG receptors in rabbits bearing liver VX2 tumor and human liver]. Nan Fang Yi Ke Da Xue Xue Bao (2009) 0.80
Down-regulated energy metabolism genes associated with mitochondria oxidative phosphorylation and fatty acid metabolism in viral cardiomyopathy mouse heart. Mol Biol Rep (2010) 0.79
Rituximab induction therapy in highly sensitized kidney transplant recipients. Chin Med J (Engl) (2011) 0.78
Video-urodynamics study on female patients with bladder neck obstruction. Chin Med J (Engl) (2012) 0.78
[Association of the changes of central serotonin and peripheral blood free amino acids with postoperative fatigue after abdominal surgery]. Zhonghua Wei Chang Wai Ke Za Zhi (2011) 0.78
Association of apolipoprotein E polymorphisms with cerebral vasospasm after spontaneous subarachnoid hemorrhage. Acta Neurochir Suppl (2011) 0.78
A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. Acta Pharmacol Sin (2011) 0.77
[Effect of drainage of the cerebrospinal fluid at the acute period of aneurysmal subarachnoid hemorrhage on the formation of hydrocephalus]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue (2007) 0.77
Protein A immunoadsorption combined with rituximab in highly sensitized kidney transplant recipients. Chin Med J (Engl) (2009) 0.77
Relationship between MDR1 polymorphism and blood concentration of cyclosporine A. Chin Med J (Engl) (2005) 0.77
[Influence of different blood purification treatment on the serum leptin and neuropeptide Y levels in patients with chronic renal failure]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2010) 0.76
[Relationship between MDR1 gene polymorphism and blood concentration of tacrolimus in renal transplant patients]. Zhonghua Yi Xue Za Zhi (2005) 0.76
A retrospective comparison of the efficacy and safety in kidney transplant recipients with basiliximab and anti-thymocyte globulin. Chin Med J (Engl) (2012) 0.76
[Progress and investigation of neuronal plasticity interfered by Borna disease virus infection]. Wei Sheng Wu Xue Bao (2006) 0.75
[Efficacy of E-max porcelain laminate veneer on esthetic restoration for anterior teeth over 2 years]. Shanghai Kou Qiang Yi Xue (2013) 0.75
[Rapid Synthesis of Metal Organic Framework and Its Adsorption Properties on Anonic Dyes]. Huan Jing Ke Xue (2016) 0.75
Electron paramagnetic resonance in monitoring of nitric oxide production after kidney transplantation in rats. Chin Med J (Engl) (2004) 0.75
[Diagnosis and management of transplant renal artery stenosis caused by early stage acute allograft rejection]. Zhonghua Yi Xue Za Zhi (2008) 0.75
[Construction of the plant expression vectors containing the multiepitope gene of Toxoplasma gondii]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2003) 0.75
Nanodissection of single- and double-stranded DNA by atomic force microscopy. J Nanosci Nanotechnol (2005) 0.75
[Identification of lower urinary tract voiding dysfunction in females by using video-urodynamic study]. Zhonghua Wai Ke Za Zhi (2012) 0.75
[Study of spectrum drifting of primary colors and its impact on color rendering properties]. Guang Pu Xue Yu Guang Pu Fen Xi (2012) 0.75
[Study the mutations in polymerase gene of hepatitis B virus by three methods]. Zhonghua Gan Zang Bing Za Zhi (2003) 0.75
Diagnosis of bladder outlet obstruction in men using a near-infrared spectroscopy instrument as the noninvasive monitor for bladder function. Urology (2013) 0.75
[An epidemiological study and analysis of strategy of prevention and treatment of 3134 seriously ill patient in intensive care unit]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue (2012) 0.75
[Sonographic features of lymphoma in the abdominal lymph nodes]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2013) 0.75
Study of PSA, PSMA and hK2 mRNA in peripheral blood of prostate cancer patients and its clinical implications. Beijing Da Xue Xue Bao (2004) 0.75
Should simultaneous ureteral reimplantation be performed during sigmoid bladder augmentation to reduce vesicoureteral reflux in neurogenic bladder cases? Int Urol Nephrol (2015) 0.75
[Clinical character of renal transplant recipients with bilateral native upper urinary transitional cell carcinoma]. Zhonghua Yi Xue Za Zhi (2009) 0.75
[Experimental study of tissue engineered bone loaded with osteointergrated dental implants]. Zhonghua Kou Qiang Yi Xue Za Zhi (2005) 0.75
[Effect of TIEG-siRNA on Smad2, p-smad2 and collagen IV in diabetic nephropathy]. Zhonghua Yi Xue Za Zhi (2010) 0.75
[Effects of drynaria total flavonoid on osteogenic differentiation of bone marrow mesenchymal stem cells at different glucose concentrations: experiment with rats]. Zhonghua Yi Xue Za Zhi (2010) 0.75
[Measurement of Nitrogen Content in Lettuce Canopy Using Spectroscopy Combined with BiPLS-GA-SPA and ELM]. Guang Pu Xue Yu Guang Pu Fen Xi (2016) 0.75
[Application of minimally invasive, decompression bone graft implantation combined with metal trabecular bone reconstruction system for early stage osteonecrosis of femoral head]. Zhongguo Gu Shang (2015) 0.75
Changes in biochemical parameters on the first day after kidney transplantation: risk factors for nosocomial infection? Chin Med J (Engl) (2010) 0.75
[Epirubicin combined with DDP and 5-Fu for treatment of advanced gastric cancer]. Zhonghua Zhong Liu Za Zhi (2009) 0.75
Comparison of catheter ablation and surgical ablation in patients with long-standing persistent atrial fibrillation and rheumatic heart disease: a four-year follow-up study. Int J Cardiol (2013) 0.75
[Retrospective study on regimens of capecitabine-based chemotherapy in the treatment for advanced gastric cancer]. Zhonghua Zhong Liu Za Zhi (2009) 0.75
[Clinical research of the implantation of phakic anterior chamber intraocular lens for high myopia]. Zhonghua Yan Ke Za Zhi (2003) 0.75
[Effects of reduced glutathione on contents of hydroxyproline and oxidation stress reaction in kidney of unilateral ureteral obstruction in rat]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue (2007) 0.75
[Cloning and sequence analysis of tomato fruit-specific E8 promoter from Lycopersicon esculentum (Zhongshu No.5)]. Di Yi Jun Yi Da Xue Xue Bao (2003) 0.75
[A Study of the Relationship Among Genetic Distances, NIR Spectra Distances, and NIR-Based Identification Model Performance of the Seeds of Maize Iinbred Lines]. Guang Pu Xue Yu Guang Pu Fen Xi (2015) 0.75
Effect of Wenhua Juanbi recipe on proliferation and apoptosis of synoviocytes in rats with collagen-inducing arthritis. Chin J Integr Med (2011) 0.75
Controversy of the prostate-specific antigen test era: should prostate cancer be detected and treated in all patients? Chin Med J (Engl) (2013) 0.75
[Early diagnosis and treatment of invasive pulmonary aspergillosis following kidney transplantation]. Zhonghua Yi Xue Za Zhi (2010) 0.75
[Length and volume of intravesical prostatic protrusion closely correlated with bladder outflow obstruction in BPH patients]. Zhonghua Nan Ke Xue (2007) 0.75
Cognitive inhibition and shifting in Asperger's syndrome. Psychopathology (2012) 0.75
[Diagnostic value and clinical application of inner ear imaging after an intratympanic injection of gadolinium for Meniere's disease]. Zhonghua Yi Xue Za Zhi (2011) 0.75
[Fuzzing pattern recognition study on Raman spectrum of tumor peripheral tissue]. Guang Pu Xue Yu Guang Pu Fen Xi (2006) 0.75
[Expression and role of vascular endothelial growth inhibitor in sporadic clear cell renal cell carcinoma]. Zhonghua Yi Xue Za Zhi (2013) 0.75