Published in Nutrition on March 01, 2000
Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia (2011) 5.53
Comparing functional annotation analyses with Catmap. BMC Bioinformatics (2004) 2.92
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology (2010) 2.48
Adiponectin and cancer: a systematic review. Br J Cancer (2006) 2.33
SREBPs: metabolic integrators in physiology and metabolism. Trends Endocrinol Metab (2011) 2.29
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br J Cancer (2009) 2.05
Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol (2010) 2.00
Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner. J Cell Mol Med (2011) 1.93
Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta (2010) 1.88
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med (2016) 1.81
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci U S A (2004) 1.77
Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems. Microbiol Mol Biol Rev (2004) 1.76
Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene (2010) 1.68
Is cancer a disease of abnormal cellular metabolism? New angles on an old idea. Genet Med (2008) 1.50
Sugar and fat - that's where it's at: metabolic changes in tumors. Breast Cancer Res (2008) 1.49
The fat side of prostate cancer. Biochim Biophys Acta (2013) 1.46
Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther (2010) 1.42
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev (2013) 1.40
Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker. Int J Biochem Mol Biol (2010) 1.38
Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model. J Biol Chem (2010) 1.36
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. Oncogene (2009) 1.34
Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proc Natl Acad Sci U S A (2012) 1.32
Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN). J Biol Chem (2008) 1.32
Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res (2012) 1.31
Metabolic alterations and targeted therapies in prostate cancer. J Pathol (2010) 1.28
Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell (2013) 1.25
Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE. BMC Syst Biol (2012) 1.24
Caspase-independent mitochondrial cell death results from loss of respiration, not cytotoxic protein release. Mol Biol Cell (2009) 1.23
Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4. J Biol Chem (2008) 1.23
The public road to high-quality curated biological pathways. Drug Discov Today (2008) 1.22
Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls. J Biol Chem (2009) 1.19
Central carbon metabolism in the progression of mammary carcinoma. Breast Cancer Res Treat (2007) 1.16
HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. Mol Cancer Res (2010) 1.16
The prince and the pauper. A tale of anticancer targeted agents. Mol Cancer (2008) 1.12
Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. Breast Cancer Res Treat (2010) 1.11
Targeting SREBP-1-driven lipid metabolism to treat cancer. Curr Pharm Des (2014) 1.11
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest (2015) 1.09
Serum fatty acid synthase as a marker of pancreatic neoplasia. Cancer Epidemiol Biomarkers Prev (2009) 1.08
Fatty acid synthase expression is induced by the Epstein-Barr virus immediate-early protein BRLF1 and is required for lytic viral gene expression. J Virol (2004) 1.08
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas. Br J Cancer (2012) 1.07
Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer. BMC Genomics (2007) 1.05
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells. Cell Cycle (2012) 1.04
Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues. J Proteome Res (2011) 1.02
Lipids and prostate cancer. Prostaglandins Other Lipid Mediat (2012) 1.01
Metastatic progression and gene expression between breast cancer cell lines from African American and Caucasian women. J Carcinog (2007) 1.00
Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol (2014) 0.99
G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts. J Biol Chem (2012) 0.99
Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A. J Biol Chem (2011) 0.97
The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Cancer Invest (2008) 0.96
Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans. Prog Lipid Res (2013) 0.96
Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem (2014) 0.95
Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells. BMC Cancer (2011) 0.95
Role of sp transcription factors in the regulation of cancer cell metabolism. Genes Cancer (2011) 0.94
Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity. Cancer Res (2009) 0.94
Different fatty acid metabolism effects of (-)-epigallocatechin-3-gallate and C75 in adenocarcinoma lung cancer. BMC Cancer (2012) 0.93
Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development. Mol Cell Biol (2007) 0.93
De novo fatty acid biosynthesis contributes significantly to establishment of a bioenergetically favorable environment for vaccinia virus infection. PLoS Pathog (2014) 0.93
Re-thinking cell cycle regulators: the cross-talk with metabolism. Front Oncol (2013) 0.92
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses. Mol Cancer (2013) 0.91
PET imaging with 11C-acetate in prostate cancer: a biochemical, radiochemical and clinical perspective. Eur J Nucl Med Mol Imaging (2008) 0.91
Fatty acid synthesis is a therapeutic target in human liposarcoma. Int J Oncol (2010) 0.91
Downregulation of plasma insulin levels and hepatic PPARgamma expression during the first week of caloric restriction in mice. Exp Gerontol (2007) 0.91
1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH). Antimicrob Agents Chemother (2004) 0.91
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention. Int J Cancer (2009) 0.91
Associations between obesity and cancer: the role of fatty acid synthase. J Natl Cancer Inst (2012) 0.90
Cancer cell metabolism and the modulating effects of nitric oxide. Free Radic Biol Med (2014) 0.90
Deregulation of lipid metabolism pathway genes in nasopharyngeal carcinoma cells. Mol Med Rep (2012) 0.90
Changes in gene expression due to chronic exposure to environmental pollutants. Aquat Toxicol (2008) 0.90
Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75. Metabolomics (2011) 0.90
Expedient synthesis of norbenzomorphan library via multicomponent assembly process coupled with ring-closing reactions. ACS Comb Sci (2012) 0.89
Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. Genes Nutr (2010) 0.89
Proteome analysis of multidrug-resistant, breast cancer-derived microparticles. J Extracell Vesicles (2014) 0.87
The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: adipophilin. PLoS One (2012) 0.87
Targeting FASN in Breast Cancer and the Discovery of Promising Inhibitors from Natural Products Derived from Traditional Chinese Medicine. Evid Based Complement Alternat Med (2014) 0.86
Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells. J Biol Chem (2012) 0.86
Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation. ACS Med Chem Lett (2012) 0.86
Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun (2016) 0.86
Quercetin induces HepG2 cell apoptosis by inhibiting fatty acid biosynthesis. Oncol Lett (2014) 0.85
Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells. Mol Cancer (2014) 0.85
Retracted Fatty acid synthase is a novel therapeutic target in multiple myeloma. Br J Haematol (2008) 0.85
ras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells. J Biol Chem (2012) 0.85
Defining the molecular nexus of cancer, type 2 diabetes and cardiovascular disease. Curr Mol Med (2010) 0.84
Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor. Biochemistry (2010) 0.84
Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis. Mol Med (2011) 0.84
Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer. Oncol Rep (2012) 0.84
Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts. Cell Chem Biol (2016) 0.84
Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium. J Lipid Res (2014) 0.84
Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death. Mol Cancer Ther (2008) 0.84
Fatty acid synthase mediates the epithelial-mesenchymal transition of breast cancer cells. Int J Biol Sci (2014) 0.84
A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin (2010) 0.83
Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. Virchows Arch (2008) 0.83
PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials. PPAR Res (2012) 0.83
Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model. PLoS One (2012) 0.83
Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. J Biol Chem (2012) 0.83
Adiponectin and leptin molecular actions and clinical significance in breast cancer. Int J Hematol Oncol Stem Cell Res (2014) 0.83
Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth. Oncogene (2012) 0.82
Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells. J Ocul Biol Dis Infor (2011) 0.82
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer. Oncotarget (2016) 0.82
Recent evidence regarding triclosan and cancer risk. Int J Environ Res Public Health (2014) 0.82