Published in J Alzheimers Dis on January 01, 2010
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci (2011) 5.64
Nontraditional risk factors combine to predict Alzheimer disease and dementia. Neurology (2011) 1.81
Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clin Proc (2011) 1.79
Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease. J Neuroinflammation (2011) 1.68
Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathol (2012) 1.45
Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease. Front Neurol (2011) 1.41
Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.32
Neuropathologic basis of white matter hyperintensity accumulation with advanced age. Neurology (2013) 1.29
Early adult to midlife cardiovascular risk factors and cognitive function. Circulation (2014) 1.28
Developmental aspects of the intracerebral microvasculature and perivascular spaces: insights into brain response to late-life diseases. J Neuropathol Exp Neurol (2011) 1.17
Association of diabetes with amnestic and nonamnestic mild cognitive impairment. Alzheimers Dement (2013) 1.13
The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol (2014) 0.96
Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer's disease. J Alzheimers Dis (2012) 0.95
Stress, exercise, and Alzheimer's disease: a neurovascular pathway. Med Hypotheses (2011) 0.91
Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats. Psychopharmacology (Berl) (2011) 0.90
[Stress and optimal ageing]. Z Gerontol Geriatr (2015) 0.90
Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study. BMC Neurol (2013) 0.89
Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia. Front Aging Neurosci (2013) 0.88
Contributions and complexities from the use of in vivo animal models to improve understanding of human neuroimaging signals. Front Neurosci (2014) 0.85
The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline. Cell Mol Neurobiol (2016) 0.85
The impact of obesity and exercise on cognitive aging. Front Aging Neurosci (2013) 0.84
Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults. JAMA Neurol (2015) 0.83
Imaging the Alzheimer brain. J Alzheimers Dis (2011) 0.83
Alzheimer's disease promotion by obesity: induced mechanisms-molecular links and perspectives. Curr Gerontol Geriatr Res (2012) 0.79
Longitudinal effects of metabolic syndrome on Alzheimer and vascular related brain pathology. Dement Geriatr Cogn Dis Extra (2014) 0.78
Adjusting the compass: new insights into the role of angiogenesis in Alzheimer's disease. Alzheimers Res Ther (2013) 0.78
S-nitrosoglutathione reduces tau hyper-phosphorylation and provides neuroprotection in rat model of chronic cerebral hypoperfusion. Brain Res (2015) 0.78
Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice. Oncotarget (2016) 0.78
Independent and combined effects of cognitive and physical activity on incident MCI. Alzheimers Dement (2015) 0.77
Preventing vascular effects on brain injury and cognition late in life: knowns and unknowns. Neuropsychol Rev (2014) 0.77
The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer's Disease. Cell Mol Neurobiol (2016) 0.77
Depression, strokes and dementia: new biological insights into an unfortunate pathway. Cardiovasc Psychiatry Neurol (2011) 0.77
Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD. Ann Clin Transl Neurol (2016) 0.76
Higher Brain Perfusion May Not Support Memory Functions in Cognitively Normal Carriers of the ApoE ε4 Allele Compared to Non-Carriers. Front Aging Neurosci (2016) 0.75
Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition. J Neuropathol Exp Neurol (2016) 0.75
Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease. Neurobiol Aging (2016) 0.75
Preeclampsia and cognitive impairment later in life. Am J Obstet Gynecol (2017) 0.75
Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (1991) 49.03
Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology (1993) 16.92
Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA (1997) 10.75
Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med (2003) 10.61
Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology (2007) 9.27
Influence of education and occupation on the incidence of Alzheimer's disease. JAMA (1994) 8.43
Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke (1996) 7.81
Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology (1999) 7.55
15-year longitudinal study of blood pressure and dementia. Lancet (1996) 6.44
Age, neuropathology, and dementia. N Engl J Med (2009) 6.36
Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet (1998) 6.20
Central obesity and increased risk of dementia more than three decades later. Neurology (2008) 6.03
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ (2001) 5.40
Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ (2005) 5.34
Midlife cardiovascular risk factors and risk of dementia in late life. Neurology (2005) 5.12
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol (2004) 5.11
Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes (2002) 4.97
Use of ramipril in preventing stroke: double blind randomised trial. BMJ (2002) 4.91
Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology (2001) 4.78
Hypertension in adults across the age spectrum: current outcomes and control in the community. JAMA (2005) 4.64
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol (2005) 4.49
Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol (2007) 4.47
An 18-year follow-up of overweight and risk of Alzheimer disease. Arch Intern Med (2003) 4.20
Socioeconomic status and trends in disparities in 4 major risk factors for cardiovascular disease among US adults, 1971-2002. Arch Intern Med (2006) 4.17
Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology (2005) 4.04
The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults. Neurology (1995) 3.95
Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA (2004) 3.69
Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol (2004) 3.67
Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology (2004) 3.61
Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study. Neurology (2001) 3.56
A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol (2005) 3.49
Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology (2004) 3.47
Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. Am J Epidemiol (2001) 3.43
The association between midlife blood pressure levels and late-life cognitive function. The Honolulu-Asia Aging Study. JAMA (1995) 3.39
Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke (2004) 3.26
Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann N Y Acad Sci (2002) 3.11
Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke (2002) 3.05
Brain structure and obesity. Hum Brain Mapp (2010) 3.04
Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med (2003) 3.02
Brain abnormalities in human obesity: a voxel-based morphometric study. Neuroimage (2006) 2.94
Hyperinsulinemia and risk of Alzheimer disease. Neurology (2004) 2.87
Relation of diabetes to mild cognitive impairment. Arch Neurol (2007) 2.86
Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study. Stroke (1998) 2.83
Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study. Arch Neurol (1998) 2.77
Antihypertensive medication use and incident Alzheimer disease: the Cache County Study. Arch Neurol (2006) 2.71
Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study. Am J Epidemiol (1993) 2.67
Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia (2003) 2.66
Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons. Ann Neurol (2007) 2.66
Cognitive impact of subcortical vascular and Alzheimer's disease pathology. Ann Neurol (2006) 2.62
Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology (1998) 2.61
Risk of dementia among persons with diabetes mellitus: a population-based cohort study. Am J Epidemiol (1997) 2.60
Regional obesity and risk of cardiovascular disease; the Framingham Study. J Clin Epidemiol (1991) 2.56
Change in body mass index and risk of incident Alzheimer disease. Neurology (2005) 2.48
Diabetes is related to cerebral infarction but not to AD pathology in older persons. Neurology (2006) 2.48
The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons. JAMA (1999) 2.42
Cognitive impairment after stroke: frequency, patterns, and relationship to functional abilities. J Neurol Neurosurg Psychiatry (1994) 2.40
Brain imaging in patients with diabetes: a systematic review. Diabetes Care (2006) 2.39
The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study. Neuroepidemiology (1997) 2.31
Low blood pressure and the risk of dementia in very old individuals. Neurology (2003) 2.30
Relationship between body mass index and gray matter volume in 1,428 healthy individuals. Obesity (Silver Spring) (2008) 2.30
Insulin increases CSF Abeta42 levels in normal older adults. Neurology (2003) 2.27
Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study. Neurobiol Aging (2000) 2.26
Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology (2005) 2.24
Longitudinal study of blood pressure and white matter hyperintensities: the EVA MRI Cohort. Neurology (2001) 2.18
Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study. Diabetes (2004) 2.17
Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984) Neurology (1996) 2.16
Treatment of hypertension and prevention of dementia. Alzheimers Dement (2005) 2.13
Effect of infarcts on dementia in the Baltimore longitudinal study of aging. Ann Neurol (2008) 2.10
Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Neurology (2004) 2.10
Association of midlife blood pressure to late-life cognitive decline and brain morphology. Neurology (1998) 2.09
High total cholesterol levels in late life associated with a reduced risk of dementia. Neurology (2005) 2.07
Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons. Arch Neurol (1997) 2.07
Association of duration and severity of diabetes mellitus with mild cognitive impairment. Arch Neurol (2008) 2.04
Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation. Neurobiol Aging (2005) 1.99
Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging. Dement Geriatr Cogn Disord (2002) 1.95
Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review. Eur J Pharmacol (2008) 1.91
Incident dementia in women is preceded by weight loss by at least a decade. Neurology (2007) 1.91
NIDDM and blood pressure as risk factors for poor cognitive performance. The Framingham Study. Diabetes Care (1997) 1.89
Association of diabetes mellitus and dementia: the Rotterdam Study. Diabetologia (1996) 1.82
Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study. Neurology (2007) 1.81
Cholesterol and neuropathologic markers of AD: a population-based autopsy study. Neurology (2001) 1.80
Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons. Neurology (2009) 1.78
Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study. Arch Neurol (2006) 1.78
The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function. Neurology (2002) 1.77
Impaired insulin secretion increases the risk of Alzheimer disease. Neurology (2008) 1.76
Different patterns of cerebral injury in dementia with or without diabetes. Arch Neurol (2009) 1.76
Serum cholesterol and risk of Alzheimer disease: a community-based cohort study. Neurology (2005) 1.75
Lipid profile components and risk of ischemic stroke: the Northern Manhattan Study (NOMAS). Arch Neurol (2009) 1.74
Determinants of vascular dementia in the Cardiovascular Health Cognition Study. Neurology (2005) 1.70
Blood pressure and white-matter disease progression in a biethnic cohort: Atherosclerosis Risk in Communities (ARIC) study. Stroke (2009) 1.70
Diabetes mellitus in midlife and the risk of dementia three decades later. Neurology (2004) 1.70
Associations of microalbuminuria with brain atrophy and white matter hyperintensities in hypertensive sibships. J Neurol Sci (2008) 1.69
A follow-up study of blood pressure and cerebral white matter lesions. Ann Neurol (1999) 1.67
Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study. Am J Epidemiol (2008) 1.66
Stroke and memory performance in elderly persons without dementia. Arch Neurol (2006) 1.65
Body mass index and incidence of dementia: the PAQUID study. Neurology (2003) 1.63
The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study. Hypertension (2004) 1.59
Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study. Arch Intern Med (2003) 1.58
Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology. J Gerontol A Biol Sci Med Sci (2005) 1.55
Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study. Diabetes Care (2006) 1.54
Risk factors for dementia with Lewy bodies: a case-control study. Neurology (2013) 2.38
Mild cognitive impairment due to Alzheimer disease in the community. Ann Neurol (2013) 1.68
Clinical trial design issues in mild to moderate Alzheimer disease. Cogn Behav Neurol (2008) 0.97
Longitudinal tracking of FTLD: toward developing clinical trial methodology. Alzheimer Dis Assoc Disord (2007) 0.88