Published in J Am Chem Soc on March 24, 2010
Product and mechanistic analysis of the reactivity of a C6-pyrimidine radical in RNA. J Am Chem Soc (2011) 0.99
Novel modifications in RNA. ACS Chem Biol (2011) 0.99
Direct strand scission in double stranded RNA via a C5-pyrimidine radical. J Am Chem Soc (2012) 0.94
Selective desulfurization significantly expands sequence variety of 3'-peptidyl-tRNA mimics obtained by native chemical ligation. Chembiochem (2012) 0.83
5,6-Dihydropyrimidine peroxyl radical reactivity in DNA. J Am Chem Soc (2014) 0.83
Independent generation and reactivity of uridin-2'-yl radical. J Org Chem (2014) 0.80
Battle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells. Wiley Interdiscip Rev RNA (2013) 0.78
Rapid RNA strand scission following C2'-hydrogen atom abstraction. J Am Chem Soc (2015) 0.78
RNA self-cleavage activated by ultraviolet light-induced oxidation. Nucleic Acids Res (2011) 0.77
Short-lived recombinant adeno-associated virus transgene expression in dystrophic muscle is associated with oxidative damage to transgene mRNA. Mol Ther Methods Clin Dev (2015) 0.76
Pyrimidine Nucleobase Radical Reactivity in DNA and RNA. Radiat Phys Chem Oxf Engl 1993 (2016) 0.75
Mechanistic Studies on RNA Strand Scission from a C2'-Radical. J Org Chem (2016) 0.75
Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly. Nature (2008) 2.19
Mapping nucleic acid structure by hydroxyl radical cleavage. Curr Opin Chem Biol (2005) 2.06
An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals. Chem Res Toxicol (2009) 1.85
Nucleic acid oxidation in Alzheimer disease. Free Radic Biol Med (2008) 1.45
Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates. Org Biomol Chem (2006) 1.37
Tandem lesions are the major products resulting from a pyrimidine nucleobase radical. J Am Chem Soc (2003) 1.28
Semiautomated and rapid quantification of nucleic acid footprinting and structure mapping experiments. Nat Protoc (2008) 1.27
Characterization and mechanism of formation of tandem lesions in DNA by a nucleobase peroxyl radical. J Am Chem Soc (2007) 1.26
Reactive oxygen species induce RNA damage in human atherosclerosis. Eur J Clin Invest (2004) 1.22
Letter: Strand breaks and sugar release by gamma-irradiation of DNA in aqueous solution. J Am Chem Soc (1975) 1.18
Significant effects of phosphorylation on relative stabilities of DNA and RNA sugar radicals: remarkably high susceptibility of h-2' abstraction in RNA. J Phys Chem B (2006) 1.12
Photochemical generation and reactivity of the 5,6-dihydrouridin-6-yl radical. J Org Chem (2009) 1.06
Reactions of OH radicals with poly(U) in deoxygenated solutions: sites of OH radical attack and the kinetics of base release. Int J Radiat Biol Relat Stud Phys Chem Med (1986) 1.03
E.s.r. studies on the mechanism of hydroxyl radical-induced strand breakage of polyuridylic acid. Int J Radiat Biol (1989) 0.98
Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64
Efficient DNA interstrand cross-link formation from a nucleotide radical. J Am Chem Soc (2005) 1.60
Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res (2006) 1.51
Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle. Proc Natl Acad Sci U S A (2010) 1.39
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. J Biol Chem (2007) 1.38
Oxygen independent DNA interstrand cross-link formation by a nucleotide radical. J Am Chem Soc (2006) 1.38
DNA interstrand cross-link formation initiated by reaction between singlet oxygen and a modified nucleotide. J Am Chem Soc (2005) 1.37
Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone. J Biol Chem (2002) 1.30
Self-promoted DNA interstrand cross-link formation by an abasic site. J Am Chem Soc (2008) 1.30
Tandem lesions are the major products resulting from a pyrimidine nucleobase radical. J Am Chem Soc (2003) 1.28
Mutagenic effects of 2-deoxyribonolactone in Escherichia coli. An abasic lesion that disobeys the A-rule. Biochemistry (2004) 1.28
Characterization and mechanism of formation of tandem lesions in DNA by a nucleobase peroxyl radical. J Am Chem Soc (2007) 1.26
Self-assembly of flexible supramolecular metallacyclic ensembles: structures and adsorption properties of their nanoporous crystalline frameworks. J Am Chem Soc (2004) 1.25
Double-strand break formation during nucleotide excision repair of a DNA interstrand cross-link. Biochemistry (2009) 1.23
A comprehensive comparison of DNA replication past 2-deoxyribose and its tetrahydrofuran analog in Escherichia coli. Nucleic Acids Res (2004) 1.22
Synthesis and characterization of oligodeoxynucleotides containing formamidopyrimidine lesions and nonhydrolyzable analogues. J Am Chem Soc (2002) 1.20
Selective detection of 2-deoxyribonolactone in DNA. J Am Chem Soc (2005) 1.18
Effects of the C4'-oxidized abasic site on replication in Escherichia coli. An unusually large deletion is induced by a small lesion. Biochemistry (2004) 1.17
Synthesis and characterization of oligonucleotides containing the c4'-oxidized abasic site produced by bleomycin and other DNA damaging agents. Angew Chem Int Ed Engl (2003) 1.15
Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression. J Am Chem Soc (2013) 1.15
Cross-linking of 2-deoxyribonolactone and its beta-elimination product by base excision repair enzymes. Biochemistry (2003) 1.13
Repair of DNA containing Fapy.dG and its beta-C-nucleoside analogue by formamidopyrimidine DNA glycosylase and MutY. Biochemistry (2003) 1.13
Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase. Proc Natl Acad Sci U S A (2008) 1.13
Scope and mechanism of interstrand cross-link formation by the C4'-oxidized abasic site. J Am Chem Soc (2009) 1.12
Preparation and analysis of oligonucleotides containing lesions resulting from C5'-oxidation. J Org Chem (2005) 1.12
Fapy.dG instructs Klenow exo(-) to misincorporate deoxyadenosine. J Am Chem Soc (2002) 1.11
Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines. J Am Chem Soc (2008) 1.10
Efficient removal of formamidopyrimidines by 8-oxoguanine glycosylases. Biochemistry (2007) 1.08
Use of fluorescence sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA. Angew Chem Int Ed Engl (2007) 1.08
Photochemical generation and reactivity of the 5,6-dihydrouridin-6-yl radical. J Org Chem (2009) 1.06
Studies on the replication of the ring opened formamidopyrimidine, Fapy.dG in Escherichia coli. Biochemistry (2007) 1.06
DNA interstrand cross-link formation by the 1,4-dioxobutane abasic lesion. J Am Chem Soc (2009) 1.05
DNA tandem lesion repair by strand displacement synthesis and nucleotide excision repair. Biochemistry (2008) 1.03
A minor groove binding copper-phenanthroline conjugate produces direct strand breaks via beta-elimination of 2-deoxyribonolactone. J Am Chem Soc (2002) 1.03
Multinuclear NMR and kinetic analysis of DNA interstrand cross-link formation. J Am Chem Soc (2008) 1.03
Radiosensitization by a modified nucleotide that produces DNA interstrand cross-links under hypoxic conditions. J Am Chem Soc (2006) 1.01
Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA. DNA Repair (Amst) (2003) 1.00
Product and mechanistic analysis of the reactivity of a C6-pyrimidine radical in RNA. J Am Chem Soc (2011) 0.99
Selective detection and quantification of oxidized abasic lesions in DNA. J Am Chem Soc (2007) 0.99
Mechanistic studies on histone catalyzed cleavage of apyrimidinic/apurinic sites in nucleosome core particles. J Am Chem Soc (2012) 0.99
Histone-catalyzed cleavage of nucleosomal DNA containing 2-deoxyribonolactone. J Am Chem Soc (2012) 0.98
Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free Radic Res (2012) 0.97
Mutagenic effects of abasic and oxidized abasic lesions in Saccharomyces cerevisiae. Nucleic Acids Res (2005) 0.97
Probing the configurations of formamidopyrimidine lesions Fapy.dA and Fapy.dG in DNA using endonuclease IV. Biochemistry (2004) 0.97
Facile quantification of lesions derived from 2'-deoxyguanosine in DNA. J Am Chem Soc (2007) 0.97
Nucleotide excision repair of a DNA interstrand cross-link produces single- and double-strand breaks. Biochemistry (2010) 0.97
Independent generation and characterization of a C2'-oxidized abasic site in chemically synthesized oligonucleotides. J Org Chem (2004) 0.96
Replication of an oxidized abasic site in Escherichia coli by a dNTP-stabilized misalignment mechanism that reads upstream and downstream nucleotides. Biochemistry (2006) 0.96
DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2). J Am Chem Soc (2007) 0.96
Evidence for glycosidic bond rotation in a nucleobase peroxyl radical and its effect on tandem lesion formation. J Org Chem (2004) 0.95
Irreversible inhibition of DNA polymerase beta by an oxidized abasic lesion. J Am Chem Soc (2010) 0.94
Direct strand scission in double stranded RNA via a C5-pyrimidine radical. J Am Chem Soc (2012) 0.94
Synthesis of oligonucleotides containing Fapy.dG (N(6)-(2-deoxy-alpha,beta-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine) using a 5'-dimethoxytrityl dinucleotide phosphoramidite. J Org Chem (2005) 0.94
Mild generation of 5-(2'-deoxyuridinyl)methyl radical from a phenyl selenide precursor. Org Lett (2004) 0.94
Inhibition of short patch and long patch base excision repair by an oxidized abasic site. Biochemistry (2010) 0.93
Photochemical generation and reactivity of the major hydroxyl radical adduct of thymidine. Org Lett (2012) 0.93
Synthesis of oligonucleotides and thermal stability of duplexes containing the beta-C-nucleoside analogue of Fapy*dG. Chem Res Toxicol (2002) 0.92
Facile SNP detection using bifunctional, cross-linking oligonucleotide probes. Nucleic Acids Res (2008) 0.92
Fapy.dA induces nucleotide misincorporation translesionally by a DNA polymerase. Angew Chem Int Ed Engl (2002) 0.92
Nucleosome core particle-catalyzed strand scission at abasic sites. Biochemistry (2013) 0.91
Synthesis, DNA polymerase incorporation, and enzymatic phosphate hydrolysis of formamidopyrimidine nucleoside triphosphates. J Am Chem Soc (2006) 0.90
Long patch base excision repair compensates for DNA polymerase β inactivation by the C4'-oxidized abasic site. Biochemistry (2010) 0.90
Synthesis of a probe for monitoring HSV1-tk reporter gene expression using chemical exchange saturation transfer MRI. Nat Protoc (2013) 0.90
Histone modification via rapid cleavage of C4'-oxidized abasic sites in nucleosome core particles. J Am Chem Soc (2013) 0.89
Interaction of DNA containing Fapy.dA or its C-nucleoside analogues with base excision repair enzymes. Implications for mutagenesis and enzyme inhibition. Biochemistry (2002) 0.89
Synthesis of 5,12-dioxocyclam nickel (II) complexes having quinoxaline substituents at the 6 and 13 positions as potential DNA bis-intercalating and cleaving agents. J Org Chem (2003) 0.88
Protein binding has a large effect on radical mediated DNA damage. J Am Chem Soc (2008) 0.88
DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases. Bioorg Med Chem (2012) 0.87
Independent generation and study of 5,6-Dihydro-2'-deoxyuridin-6-yl, a member of the major family of reactive intermediates formed in DNA from the effects of gamma-radiolysis. J Org Chem (2003) 0.86
Probing DNA interstrand cross-link formation by an oxidized abasic site using nonnative nucleotides. Bioorg Med Chem (2011) 0.86
Photochemical control of RNA structure by disrupting π-stacking. J Am Chem Soc (2012) 0.86
Excision of formamidopyrimidine lesions by endonucleases III and VIII is not a major DNA repair pathway in Escherichia coli. Nucleic Acids Res (2005) 0.86
Hydrogen bonding contributes to the selectivity of nucleotide incorporation opposite an oxidized abasic lesion. J Am Chem Soc (2008) 0.85
Intracellular detection of cytosine incorporation in genomic DNA by using 5-ethynyl-2'-deoxycytidine. Chembiochem (2011) 0.85
The mutagenicity of thymidine glycol in Escherichia coli is increased when it is part of a tandem lesion. Biochemistry (2009) 0.84
Excision of a lyase-resistant oxidized abasic lesion from DNA. Chem Res Toxicol (2010) 0.84
Synthesis of cross-linked DNA containing oxidized abasic site analogues. J Org Chem (2014) 0.83
DNA double strand cleavage via interstrand hydrogen atom abstraction. J Am Chem Soc (2013) 0.83
5,6-Dihydropyrimidine peroxyl radical reactivity in DNA. J Am Chem Soc (2014) 0.83
Gamma-radiolysis and hydroxyl radical produce interstrand cross-links in DNA involving thymidine. Chem Res Toxicol (2007) 0.83
DNA polymerase λ inactivation by oxidized abasic sites. Biochemistry (2013) 0.82
Synthesis and analysis of oligonucleotides containing abasic site analogues. J Org Chem (2008) 0.82
Recommendations for standardized description of and nomenclature concerning oxidatively damaged nucleobases in DNA. Chem Res Toxicol (2010) 0.82
Mechanistic studies on DNA damage by minor groove binding copper-phenanthroline conjugates. Nucleic Acids Res (2005) 0.82
Competitive inhibition of uracil DNA glycosylase by a modified nucleotide whose triphosphate is a substrate for DNA polymerase. J Am Chem Soc (2009) 0.81
Deconvoluting the reactivity of two intermediates formed from modified pyrimidines. Org Lett (2013) 0.81
The effect of the 2-amino group of 7,8-dihydro-8-oxo-2'-deoxyguanosine on translesion synthesis and duplex stability. Nucleic Acids Res (2005) 0.81
Probing interactions between lysine residues in histone tails and nucleosomal DNA via product and kinetic analysis. ACS Chem Biol (2014) 0.81
DNA damage and interstrand cross-link formation upon irradiation of aryl iodide C-nucleotide analogues. J Org Chem (2010) 0.80
Independent generation and reactivity of uridin-2'-yl radical. J Org Chem (2014) 0.80
Quantification of 8-oxodGuo lesions in double-stranded DNA using a photoelectrochemical DNA sensor. Anal Chem (2012) 0.80
Repair of oxidized purines and damaged pyrimidines by E. coli Fpg protein: different roles of proline 2 and lysine 57 residues. Environ Mol Mutagen (2002) 0.80
Preparation and analysis of oligonucleotides containing the c4'-oxidized abasic site and related mechanistic probes. J Org Chem (2005) 0.79
Large-scale photochemical reactions of nanocrystalline suspensions: a promising green chemistry method. Org Lett (2006) 0.79
DNA polymerase bypass in vitro and in E. coli of a C-nucleotide analogue of Fapy-dG. Bioorg Med Chem (2008) 0.79
DNA damage by histone radicals in nucleosome core particles. J Am Chem Soc (2014) 0.79
Rapid RNA strand scission following C2'-hydrogen atom abstraction. J Am Chem Soc (2015) 0.78