Published in J Am Chem Soc on June 26, 2002
An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals. Chem Res Toxicol (2009) 1.85
Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res (2006) 1.51
Mitochondrial DNA, base excision repair and neurodegeneration. DNA Repair (Amst) (2008) 1.27
The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage. Prog Mol Biol Transl Sci (2012) 1.22
Chemical and biological consequences of oxidatively damaged guanine in DNA. Free Radic Res (2012) 1.19
Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry. Chem Res Toxicol (2009) 1.11
Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase. Nucleic Acids Res (2005) 1.10
Efficient removal of formamidopyrimidines by 8-oxoguanine glycosylases. Biochemistry (2007) 1.08
The formamidopyrimidines: purine lesions formed in competition with 8-oxopurines from oxidative stress. Acc Chem Res (2011) 1.08
Pre-steady-state kinetics shows differences in processing of various DNA lesions by Escherichia coli formamidopyrimidine-DNA glycosylase. Nucleic Acids Res (2004) 1.02
Site-specific synthesis and characterization of oligonucleotides containing an N6-(2-deoxy-D-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine lesion, the ring-opened product from N7-methylation of deoxyguanosine. Chem Res Toxicol (2008) 1.00
Mitochondrial DNA alterations and reduced mitochondrial function in aging. Mech Ageing Dev (2010) 0.95
WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand. Nucleic Acids Res (2008) 0.91
Synthesis, DNA polymerase incorporation, and enzymatic phosphate hydrolysis of formamidopyrimidine nucleoside triphosphates. J Am Chem Soc (2006) 0.90
Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions. Nat Chem Biol (2013) 0.89
Excision of formamidopyrimidine lesions by endonucleases III and VIII is not a major DNA repair pathway in Escherichia coli. Nucleic Acids Res (2005) 0.86
Solution structure of duplex DNA containing a β-carba-Fapy-dG lesion. Chem Res Toxicol (2012) 0.85
Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase. FEBS J (2009) 0.84
Novel post-synthetic generation, isomeric resolution, and characterization of Fapy-dG within oligodeoxynucleotides: differential anomeric impacts on DNA duplex properties. Nucleic Acids Res (2011) 0.83
Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases. Chem Res Toxicol (2012) 0.81
The effect of the 2-amino group of 7,8-dihydro-8-oxo-2'-deoxyguanosine on translesion synthesis and duplex stability. Nucleic Acids Res (2005) 0.81
Destabilization of DNA duplexes by oxidative damage at guanine: implications for lesion recognition and repair. J R Soc Interface (2008) 0.80
DNA polymerase bypass in vitro and in E. coli of a C-nucleotide analogue of Fapy-dG. Bioorg Med Chem (2008) 0.79
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage. Chem Res Toxicol (2016) 0.78
Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase η and Sulfolobus solfataricus P2 Polymerase IV. J Am Chem Soc (2015) 0.78
The DNA repair function of CUX1 contributes to radioresistance. Oncotarget (2017) 0.75
Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64
Efficient DNA interstrand cross-link formation from a nucleotide radical. J Am Chem Soc (2005) 1.60
Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res (2006) 1.51
Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle. Proc Natl Acad Sci U S A (2010) 1.39
Oxygen independent DNA interstrand cross-link formation by a nucleotide radical. J Am Chem Soc (2006) 1.38
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. J Biol Chem (2007) 1.38
DNA interstrand cross-link formation initiated by reaction between singlet oxygen and a modified nucleotide. J Am Chem Soc (2005) 1.37
Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone. J Biol Chem (2002) 1.30
Self-promoted DNA interstrand cross-link formation by an abasic site. J Am Chem Soc (2008) 1.30
Mutagenic effects of 2-deoxyribonolactone in Escherichia coli. An abasic lesion that disobeys the A-rule. Biochemistry (2004) 1.28
Tandem lesions are the major products resulting from a pyrimidine nucleobase radical. J Am Chem Soc (2003) 1.28
Characterization and mechanism of formation of tandem lesions in DNA by a nucleobase peroxyl radical. J Am Chem Soc (2007) 1.26
Double-strand break formation during nucleotide excision repair of a DNA interstrand cross-link. Biochemistry (2009) 1.23
A comprehensive comparison of DNA replication past 2-deoxyribose and its tetrahydrofuran analog in Escherichia coli. Nucleic Acids Res (2004) 1.22
Synthesis and characterization of oligodeoxynucleotides containing formamidopyrimidine lesions and nonhydrolyzable analogues. J Am Chem Soc (2002) 1.20
Selective detection of 2-deoxyribonolactone in DNA. J Am Chem Soc (2005) 1.18
Effects of the C4'-oxidized abasic site on replication in Escherichia coli. An unusually large deletion is induced by a small lesion. Biochemistry (2004) 1.17
Synthesis and characterization of oligonucleotides containing the c4'-oxidized abasic site produced by bleomycin and other DNA damaging agents. Angew Chem Int Ed Engl (2003) 1.15
Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression. J Am Chem Soc (2013) 1.15
Repair of DNA containing Fapy.dG and its beta-C-nucleoside analogue by formamidopyrimidine DNA glycosylase and MutY. Biochemistry (2003) 1.13
Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase. Proc Natl Acad Sci U S A (2008) 1.13
Cross-linking of 2-deoxyribonolactone and its beta-elimination product by base excision repair enzymes. Biochemistry (2003) 1.13
Scope and mechanism of interstrand cross-link formation by the C4'-oxidized abasic site. J Am Chem Soc (2009) 1.12
Preparation and analysis of oligonucleotides containing lesions resulting from C5'-oxidation. J Org Chem (2005) 1.12
Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines. J Am Chem Soc (2008) 1.10
Efficient removal of formamidopyrimidines by 8-oxoguanine glycosylases. Biochemistry (2007) 1.08
Use of fluorescence sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA. Angew Chem Int Ed Engl (2007) 1.08
Studies on the replication of the ring opened formamidopyrimidine, Fapy.dG in Escherichia coli. Biochemistry (2007) 1.06
Photochemical generation and reactivity of the 5,6-dihydrouridin-6-yl radical. J Org Chem (2009) 1.06
DNA interstrand cross-link formation by the 1,4-dioxobutane abasic lesion. J Am Chem Soc (2009) 1.05
A minor groove binding copper-phenanthroline conjugate produces direct strand breaks via beta-elimination of 2-deoxyribonolactone. J Am Chem Soc (2002) 1.03
DNA tandem lesion repair by strand displacement synthesis and nucleotide excision repair. Biochemistry (2008) 1.03
Multinuclear NMR and kinetic analysis of DNA interstrand cross-link formation. J Am Chem Soc (2008) 1.03
Radiosensitization by a modified nucleotide that produces DNA interstrand cross-links under hypoxic conditions. J Am Chem Soc (2006) 1.01
Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA. DNA Repair (Amst) (2003) 1.00
Selective detection and quantification of oxidized abasic lesions in DNA. J Am Chem Soc (2007) 0.99
Product and mechanistic analysis of the reactivity of a C6-pyrimidine radical in RNA. J Am Chem Soc (2011) 0.99
Mechanistic studies on histone catalyzed cleavage of apyrimidinic/apurinic sites in nucleosome core particles. J Am Chem Soc (2012) 0.99
Histone-catalyzed cleavage of nucleosomal DNA containing 2-deoxyribonolactone. J Am Chem Soc (2012) 0.98
Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free Radic Res (2012) 0.97
Mutagenic effects of abasic and oxidized abasic lesions in Saccharomyces cerevisiae. Nucleic Acids Res (2005) 0.97
Probing the configurations of formamidopyrimidine lesions Fapy.dA and Fapy.dG in DNA using endonuclease IV. Biochemistry (2004) 0.97
Facile quantification of lesions derived from 2'-deoxyguanosine in DNA. J Am Chem Soc (2007) 0.97
Nucleotide excision repair of a DNA interstrand cross-link produces single- and double-strand breaks. Biochemistry (2010) 0.97
Independent generation and characterization of a C2'-oxidized abasic site in chemically synthesized oligonucleotides. J Org Chem (2004) 0.96
Replication of an oxidized abasic site in Escherichia coli by a dNTP-stabilized misalignment mechanism that reads upstream and downstream nucleotides. Biochemistry (2006) 0.96
DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2). J Am Chem Soc (2007) 0.96
Evidence for glycosidic bond rotation in a nucleobase peroxyl radical and its effect on tandem lesion formation. J Org Chem (2004) 0.95
Irreversible inhibition of DNA polymerase beta by an oxidized abasic lesion. J Am Chem Soc (2010) 0.94
Direct strand scission in double stranded RNA via a C5-pyrimidine radical. J Am Chem Soc (2012) 0.94
Direct strand scission from a nucleobase radical in RNA. J Am Chem Soc (2010) 0.94
Synthesis of oligonucleotides containing Fapy.dG (N(6)-(2-deoxy-alpha,beta-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine) using a 5'-dimethoxytrityl dinucleotide phosphoramidite. J Org Chem (2005) 0.94
Mild generation of 5-(2'-deoxyuridinyl)methyl radical from a phenyl selenide precursor. Org Lett (2004) 0.94
Inhibition of short patch and long patch base excision repair by an oxidized abasic site. Biochemistry (2010) 0.93
Photochemical generation and reactivity of the major hydroxyl radical adduct of thymidine. Org Lett (2012) 0.93
Fapy.dA induces nucleotide misincorporation translesionally by a DNA polymerase. Angew Chem Int Ed Engl (2002) 0.92
Facile SNP detection using bifunctional, cross-linking oligonucleotide probes. Nucleic Acids Res (2008) 0.92
Synthesis of oligonucleotides and thermal stability of duplexes containing the beta-C-nucleoside analogue of Fapy*dG. Chem Res Toxicol (2002) 0.92
Nucleosome core particle-catalyzed strand scission at abasic sites. Biochemistry (2013) 0.91
Synthesis, DNA polymerase incorporation, and enzymatic phosphate hydrolysis of formamidopyrimidine nucleoside triphosphates. J Am Chem Soc (2006) 0.90
Long patch base excision repair compensates for DNA polymerase β inactivation by the C4'-oxidized abasic site. Biochemistry (2010) 0.90
Synthesis of a probe for monitoring HSV1-tk reporter gene expression using chemical exchange saturation transfer MRI. Nat Protoc (2013) 0.90
Histone modification via rapid cleavage of C4'-oxidized abasic sites in nucleosome core particles. J Am Chem Soc (2013) 0.89
Interaction of DNA containing Fapy.dA or its C-nucleoside analogues with base excision repair enzymes. Implications for mutagenesis and enzyme inhibition. Biochemistry (2002) 0.89
Synthesis of 5,12-dioxocyclam nickel (II) complexes having quinoxaline substituents at the 6 and 13 positions as potential DNA bis-intercalating and cleaving agents. J Org Chem (2003) 0.88
Protein binding has a large effect on radical mediated DNA damage. J Am Chem Soc (2008) 0.88
DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases. Bioorg Med Chem (2012) 0.87
Independent generation and study of 5,6-Dihydro-2'-deoxyuridin-6-yl, a member of the major family of reactive intermediates formed in DNA from the effects of gamma-radiolysis. J Org Chem (2003) 0.86
Photochemical control of RNA structure by disrupting π-stacking. J Am Chem Soc (2012) 0.86
Probing DNA interstrand cross-link formation by an oxidized abasic site using nonnative nucleotides. Bioorg Med Chem (2011) 0.86
Excision of formamidopyrimidine lesions by endonucleases III and VIII is not a major DNA repair pathway in Escherichia coli. Nucleic Acids Res (2005) 0.86
Hydrogen bonding contributes to the selectivity of nucleotide incorporation opposite an oxidized abasic lesion. J Am Chem Soc (2008) 0.85
Intracellular detection of cytosine incorporation in genomic DNA by using 5-ethynyl-2'-deoxycytidine. Chembiochem (2011) 0.85
The mutagenicity of thymidine glycol in Escherichia coli is increased when it is part of a tandem lesion. Biochemistry (2009) 0.84
Excision of a lyase-resistant oxidized abasic lesion from DNA. Chem Res Toxicol (2010) 0.84
Gamma-radiolysis and hydroxyl radical produce interstrand cross-links in DNA involving thymidine. Chem Res Toxicol (2007) 0.83
Synthesis of cross-linked DNA containing oxidized abasic site analogues. J Org Chem (2014) 0.83
5,6-Dihydropyrimidine peroxyl radical reactivity in DNA. J Am Chem Soc (2014) 0.83
DNA double strand cleavage via interstrand hydrogen atom abstraction. J Am Chem Soc (2013) 0.83
Synthesis and analysis of oligonucleotides containing abasic site analogues. J Org Chem (2008) 0.82
DNA polymerase λ inactivation by oxidized abasic sites. Biochemistry (2013) 0.82
Recommendations for standardized description of and nomenclature concerning oxidatively damaged nucleobases in DNA. Chem Res Toxicol (2010) 0.82
Mechanistic studies on DNA damage by minor groove binding copper-phenanthroline conjugates. Nucleic Acids Res (2005) 0.82
Deconvoluting the reactivity of two intermediates formed from modified pyrimidines. Org Lett (2013) 0.81
The effect of the 2-amino group of 7,8-dihydro-8-oxo-2'-deoxyguanosine on translesion synthesis and duplex stability. Nucleic Acids Res (2005) 0.81
Probing interactions between lysine residues in histone tails and nucleosomal DNA via product and kinetic analysis. ACS Chem Biol (2014) 0.81
Competitive inhibition of uracil DNA glycosylase by a modified nucleotide whose triphosphate is a substrate for DNA polymerase. J Am Chem Soc (2009) 0.81
Repair of oxidized purines and damaged pyrimidines by E. coli Fpg protein: different roles of proline 2 and lysine 57 residues. Environ Mol Mutagen (2002) 0.80
Independent generation and reactivity of uridin-2'-yl radical. J Org Chem (2014) 0.80
Quantification of 8-oxodGuo lesions in double-stranded DNA using a photoelectrochemical DNA sensor. Anal Chem (2012) 0.80
DNA damage and interstrand cross-link formation upon irradiation of aryl iodide C-nucleotide analogues. J Org Chem (2010) 0.80
DNA polymerase bypass in vitro and in E. coli of a C-nucleotide analogue of Fapy-dG. Bioorg Med Chem (2008) 0.79
DNA damage by histone radicals in nucleosome core particles. J Am Chem Soc (2014) 0.79
Preparation and analysis of oligonucleotides containing the c4'-oxidized abasic site and related mechanistic probes. J Org Chem (2005) 0.79
Quantitative detection of 8-Oxo-7,8-dihydro-2'-deoxyguanosine using chemical tagging and qPCR. Chem Res Toxicol (2014) 0.78
Hole migration is the major pathway involved in alkali-labile lesion formation in DNA by the direct effect of ionizing radiation. J Am Chem Soc (2007) 0.78
Nucleotide excision repair of chemically stabilized analogues of DNA interstrand cross-links produced from oxidized abasic sites. Biochemistry (2014) 0.78
Rapid RNA strand scission following C2'-hydrogen atom abstraction. J Am Chem Soc (2015) 0.78
Transcription inhibition using modified pentanucleotides. Bioorg Med Chem (2003) 0.77
A nucleic acid-directed, red light-induced chemical reaction. Chem Commun (Camb) (2010) 0.77