Published in Immunol Rev on January 01, 2010
NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A (2013) 1.61
Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis. Arthritis Res Ther (2011) 1.51
Notch regulation of bone development and remodeling and related skeletal disorders. Calcif Tissue Int (2011) 1.05
Transient muscle paralysis degrades bone via rapid osteoclastogenesis. FASEB J (2011) 0.97
NFATC1 promotes epicardium-derived cell invasion into myocardium. Development (2011) 0.96
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One (2012) 0.92
Primers on molecular pathways--the NFAT transcription pathway in pancreatic cancer. Pancreatology (2010) 0.90
Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. J Clin Invest (2013) 0.88
Osteopontin signals through calcium and nuclear factor of activated T cells (NFAT) in osteoclasts: a novel RGD-dependent pathway promoting cell survival. J Biol Chem (2011) 0.87
The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone (2012) 0.87
Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts. J Biol Chem (2012) 0.86
Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells. J Bone Miner Res (2011) 0.84
Physicochemical and biomechanical stimuli in cell-based articular cartilage repair. Curr Rheumatol Rep (2015) 0.84
The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures. J Biol Chem (2013) 0.84
Treatment with Rhizoma Dioscoreae extract has protective effect on osteopenia in ovariectomized rats. ScientificWorldJournal (2014) 0.81
Excavatolide B Attenuates Rheumatoid Arthritis through the Inhibition of Osteoclastogenesis. Mar Drugs (2017) 0.77
Tacrolimus treatment increases bone formation in patients with rheumatoid arthritis. Rheumatol Int (2012) 0.77
RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol (2016) 0.75
Association of the Smad3 and NFATc2 gene polymorphisms and their serum levels with susceptibility to rheumatoid arthritis in Polish cohorts. Clin Exp Immunol (2015) 0.75
TNFα Increases RANKL Expression via PGE₂-Induced Activation of NFATc1. Int J Mol Sci (2017) 0.75
Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis. Sci Rep (2017) 0.75
Amyloid β Peptide Enhances RANKL-Induced Osteoclast Activation through NF-κB, ERK, and Calcium Oscillation Signaling. Int J Mol Sci (2016) 0.75
Osteoclast differentiation and activation. Nature (2003) 18.59
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell (1997) 15.96
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell (2002) 15.20
Evolving concepts of rheumatoid arthritis. Nature (2003) 14.31
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell (1997) 13.53
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature (1999) 12.32
Burden of major musculoskeletal conditions. Bull World Health Organ (2003) 10.89
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell (2002) 9.10
Genetic regulation of osteoclast development and function. Nat Rev Genet (2003) 7.94
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Reaching a genetic and molecular understanding of skeletal development. Dev Cell (2002) 7.55
Dickkopf-1 is a master regulator of joint remodeling. Nat Med (2007) 7.29
Identification of a putative regulator of early T cell activation genes. Science (1988) 6.62
NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol (2005) 6.25
Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science (2002) 5.82
Osteoarthritis. J Cell Physiol (2007) 5.55
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med (2002) 5.50
Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31
Clinical practice. Osteoarthritis of the knee. N Engl J Med (2006) 4.69
The molecular understanding of osteoclast differentiation. Bone (2006) 4.39
The transcription factor NF-ATc is essential for cardiac valve formation. Nature (1998) 4.14
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis Rheum (2008) 4.02
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med (2008) 3.98
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med (2005) 3.70
RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med (2005) 3.68
TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol (2001) 3.53
Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum (2000) 3.51
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
NFAT and Osterix cooperatively regulate bone formation. Nat Med (2005) 2.99
Osteopetrosis. N Engl J Med (2004) 2.95
Bradykinin and inflammatory pain. Trends Neurosci (1993) 2.83
Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease. Nat Med (2001) 2.81
Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Crit Rev Eukaryot Gene Expr (2004) 2.81
Vascular endothelial growth factor signaling pathways: therapeutic perspective. Clin Cancer Res (2006) 2.75
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J Exp Med (1998) 2.68
Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol (1994) 2.66
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun (1998) 2.66
Fos/AP-1 proteins in bone and the immune system. Immunol Rev (2005) 2.58
Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator. J Biol Chem (2002) 2.49
Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Nat Genet (2001) 2.43
NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity (2001) 2.38
Review: angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum (1998) 2.38
Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther (2007) 2.30
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest (2008) 2.29
NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). Mol Endocrinol (2007) 2.25
Association of concomitant fibromyalgia with worse disease activity score in 28 joints, health assessment questionnaire, and short form 36 scores in patients with rheumatoid arthritis. Arthritis Rheum (2009) 2.22
Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. J Exp Med (2001) 2.22
Neutrophil-derived leukotriene B4 is required for inflammatory arthritis. J Exp Med (2006) 2.21
Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell (2007) 2.18
A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis. J Exp Med (2006) 2.15
Bone destruction in arthritis. Ann Rheum Dis (2002) 2.15
NFAT signaling in vertebrate development. Curr Opin Genet Dev (2001) 2.15
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell (2008) 2.13
Rheumatic diseases: the effects of inflammation on bone. Immunol Rev (2005) 2.07
NFAT signaling and the invention of vertebrates. Trends Cell Biol (2007) 1.98
Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science (1987) 1.97
The role of NFAT in osteoclast formation. Ann N Y Acad Sci (2007) 1.96
Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell (2006) 1.95
The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis. Immunol Rev (2008) 1.91
Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun (2005) 1.89
Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev (2006) 1.86
Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol Rev (2005) 1.81
Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling. Mol Cells (2004) 1.75
Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Pract Res Clin Rheumatol (2006) 1.68
Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption. Semin Cell Dev Biol (2008) 1.63
The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. J Exp Med (2000) 1.63
Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J Biol Chem (2005) 1.62
Preferences for improved health examined in 1,024 patients with rheumatoid arthritis: pain has highest priority. Arthritis Rheum (2002) 1.60
Osteoclast precursors, RANKL/RANK, and immunology. Immunol Rev (2005) 1.57
MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation. J Biol Chem (2007) 1.53
The role of T lymphocytes in bone metabolism. Immunol Rev (2005) 1.53
Rheumatoid arthritis: regulation of synovial inflammation. Int J Biochem Cell Biol (2004) 1.51
Molecular physiology of SLC4 anion exchangers. Exp Physiol (2005) 1.50
Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric. J Biol Chem (2004) 1.50
Vascular endothelial growth factor levels in the serum and synovial fluid of patients with rheumatoid arthritis. Clin Exp Rheumatol (2001) 1.49
Evolutionary relationships among Rel domains indicate functional diversification by recombination. Proc Natl Acad Sci U S A (2001) 1.45
RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation. Exp Cell Res (2006) 1.39
Angiogenesis in rheumatoid arthritis. Histol Histopathol (2006) 1.39
Interplay between interferon and other cytokine systems in bone metabolism. Immunol Rev (2005) 1.36
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis. Proc Natl Acad Sci U S A (2008) 1.35
Perspectives on glucocorticoid-induced osteoporosis. Bone (2004) 1.34
Nuclear factor of activated T cells balances angiogenesis activation and inhibition. J Exp Med (2004) 1.30
Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis. Arthritis Res Ther (2009) 1.29
NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation. Gene (2006) 1.28
Role of nuclear factor-kappaB in the immune system and bone. Immunol Rev (2005) 1.21
Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis. Curr Opin Rheumatol (2007) 1.19
Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation. Arthritis Res (2002) 1.19
Expression of vascular endothelial growth factor isoforms and their receptors Flt-1, KDR, and neuropilin-1 in synovial tissues of rheumatoid arthritis. J Pathol (2000) 1.19
Osteoclastic acidification pathways during bone resorption. Bone (2002) 1.18
Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation. Arthritis Rheum (2009) 1.18
Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation. Bone (2007) 1.17
Calcineurin regulates bone formation by the osteoblast. Proc Natl Acad Sci U S A (2005) 1.16
The roles of annexins and alkaline phosphatase in mineralization process. Acta Biochim Pol (2003) 1.14
Proinflammatory role of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis: prospects for therapeutic intervention. Mediators Inflamm (2009) 1.14
Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. Cancer Res (2009) 1.12
Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines. Biochem Biophys Res Commun (2006) 1.11
NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation. Bone (2009) 1.11
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest (2012) 1.72
NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A (2013) 1.61
Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol (2012) 1.32
Graft versus host disease in the bone marrow, liver and thymus humanized mouse model. PLoS One (2012) 1.16
Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection. J Clin Invest (2011) 1.05
HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A (2008) 1.02
Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheum (2013) 1.00
Control of bone resorption in mice by Schnurri-3. Proc Natl Acad Sci U S A (2012) 0.90
SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts. Proc Natl Acad Sci U S A (2013) 0.90
The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone (2012) 0.87
The immune pathogenesis of scleroderma: context is everything. Curr Rheumatol Rep (2013) 0.83
Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression. J Rheumatol (2011) 0.76
Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis. Arthritis Res Ther (2014) 0.75