Published in Genes Dev on March 01, 2010
PGC-1 coactivators in cardiac development and disease. Circ Res (2010) 1.86
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A (2011) 1.86
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab (2013) 1.76
The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth. Cell Metab (2011) 1.48
Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev (2012) 1.34
Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond. Nat Rev Cancer (2012) 1.33
Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs. PLoS Genet (2011) 1.12
Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proc Natl Acad Sci U S A (2013) 1.07
The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism. Mol Cell Biol (2012) 1.02
Regulation of glycolysis and the Warburg effect by estrogen-related receptors. Oncogene (2012) 1.01
Estrogen-related receptor alpha modulates lactate dehydrogenase activity in thyroid tumors. PLoS One (2013) 1.00
Eating disorder predisposition is associated with ESRRA and HDAC4 mutations. J Clin Invest (2013) 0.97
A highly integrated and complex PPARGC1A transcription factor binding network in HepG2 cells. Genome Res (2012) 0.96
Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer. Clin Cancer Res (2012) 0.92
The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases. Acta Pharmacol Sin (2014) 0.91
Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development (2014) 0.91
Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology (2011) 0.87
Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study. Br J Pharmacol (2013) 0.87
Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances. Proc Natl Acad Sci U S A (2013) 0.86
Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation. Nucleic Acids Res (2013) 0.86
Dedifferentiation of neurons precedes tumor formation in Lola mutants. Dev Cell (2014) 0.85
The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells. Mol Endocrinol (2016) 0.82
Characterization of Prox1 and VEGFR-3 expression and lymphatic phenotype in normal organs of mice lacking p50 subunit of NF-κB. Microcirculation (2011) 0.82
ELF3 is a repressor of androgen receptor action in prostate cancer cells. Oncogene (2013) 0.81
Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells. Cancer Res (2015) 0.80
Rapamycin up-regulates triglycerides in hepatocytes by down-regulating Prox1. Lipids Health Dis (2016) 0.77
ES1 is a mitochondrial enlarging factor contributing to form mega-mitochondria in zebrafish cones. Sci Rep (2016) 0.77
ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nat Commun (2016) 0.76
Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice. J Physiol (2015) 0.76
ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Rep (2016) 0.76
ERRα induces H3K9 demethylation by LSD1 to promote cell invasion. Proc Natl Acad Sci U S A (2017) 0.75
The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis. Cell Mol Gastroenterol Hepatol (2016) 0.75
Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells. Diabetes (2015) 0.75
An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides. Nat Commun (2017) 0.75
Sodium butyrate protects against oxidative stress in HepG2 cells through modulating Nrf2 pathway and mitochondrial function. J Physiol Biochem (2017) 0.75
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab (2005) 11.66
Prox1 function is required for the development of the murine lymphatic system. Cell (1999) 7.57
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet (2005) 3.93
Transcriptional regulation of metabolism. Physiol Rev (2006) 3.68
The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc Natl Acad Sci U S A (2004) 3.65
Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev (2008) 3.05
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab (2007) 3.00
Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev (2008) 2.91
Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol (2007) 2.40
DNA motifs in human and mouse proximal promoters predict tissue-specific expression. Proc Natl Acad Sci U S A (2006) 2.38
ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab (2007) 2.14
Hepatocyte migration during liver development requires Prox1. Nat Genet (2000) 2.09
Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics (2004) 1.73
Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev (2007) 1.67
Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity. Cancer Res (2009) 1.58
Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm. Mech Dev (2002) 1.55
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. J Biol Chem (2006) 1.48
Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate. Blood (2008) 1.36
Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene. Mol Endocrinol (2004) 1.29
COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. Genes Cells (2009) 1.22
Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells". Histochem Cell Biol (2006) 0.98
Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts. Hepatology (2008) 0.95
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
A mitochondrial protein compendium elucidates complex I disease biology. Cell (2008) 13.51
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature (2007) 7.12
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (2012) 6.79
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature (2011) 6.48
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet (2010) 5.79
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35
MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature (2010) 4.88
Systematic identification of human mitochondrial disease genes through integrative genomics. Nat Genet (2006) 4.67
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Proc Natl Acad Sci U S A (2009) 4.58
A mammalian organelle map by protein correlation profiling. Cell (2006) 4.54
Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression. Genome Res (2006) 4.32
From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc Natl Acad Sci U S A (2005) 4.16
The dynamic process of β(2)-adrenergic receptor activation. Cell (2013) 4.09
Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. Sci Transl Med (2012) 4.02
Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol (2008) 3.82
High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nat Genet (2010) 3.31
TXNIP regulates peripheral glucose metabolism in humans. PLoS Med (2007) 3.27
MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion. Nat Genet (2006) 3.17
Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol (2004) 3.12
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat Biotechnol (2010) 3.08
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest (2007) 3.02
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab (2007) 3.00
Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy. Nat Biotechnol (2012) 2.98
PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol (2005) 2.93
Large-scale chemical dissection of mitochondrial function. Nat Biotechnol (2008) 2.91
Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. J Biol Rhythms (2005) 2.87
Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations. Proc Natl Acad Sci U S A (2009) 2.77
Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol Cell Biol (2003) 2.65
Activation mechanism of the β2-adrenergic receptor. Proc Natl Acad Sci U S A (2011) 2.53
Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care (2005) 2.52
Mitochondrial disorders as windows into an ancient organelle. Nature (2012) 2.51
Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest (2008) 2.46
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab (2009) 2.45
Pathway and mechanism of drug binding to G-protein-coupled receptors. Proc Natl Acad Sci U S A (2011) 2.44
High-resolution crystal structure of human protease-activated receptor 1. Nature (2012) 2.44
EMRE is an essential component of the mitochondrial calcium uniporter complex. Science (2013) 2.39
The mitochondrial proteome and human disease. Annu Rev Genomics Hum Genet (2010) 2.38
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter. Cell Metab (2013) 2.15
ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab (2007) 2.14
The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. EMBO J (2005) 2.12
The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab (2007) 2.11
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proc Natl Acad Sci U S A (2007) 2.03
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One (2013) 1.99
Correlation of mRNA and protein levels: cell type-specific gene expression of cluster designation antigens in the prostate. BMC Genomics (2008) 1.95
miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway. Cell Metab (2010) 1.89
Application of Affymetrix array and Massively Parallel Signature Sequencing for identification of genes involved in prostate cancer progression. BMC Cancer (2005) 1.73
Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev (2007) 1.67
VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res (2011) 1.62
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs. Nature (2013) 1.59
Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. J Biol Chem (2005) 1.58
Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease. Am J Hum Genet (2008) 1.58
Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity. Cancer Res (2009) 1.58
A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis. PLoS Genet (2009) 1.56
Disease gene discovery through integrative genomics. Annu Rev Genomics Hum Genet (2005) 1.51
Evolutionary diversity of the mitochondrial calcium uniporter. Science (2012) 1.45
A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells. Proc Natl Acad Sci U S A (2010) 1.43
MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter. EMBO Rep (2014) 1.40
Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway. Mol Cancer (2008) 1.39
MCU encodes the pore conducting mitochondrial calcium currents. Elife (2013) 1.39
Targeted exome sequencing of suspected mitochondrial disorders. Neurology (2013) 1.39
An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha. Mol Endocrinol (2010) 1.36
Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond. Nat Rev Cancer (2012) 1.33
Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem (2005) 1.31
Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease. Nat Genet (2013) 1.30
Lymphocyte development and function in the absence of retinoic acid-related orphan receptor alpha. J Immunol (2004) 1.28
Mitochondrial and nuclear genomic responses to loss of LRPPRC expression. J Biol Chem (2010) 1.27
New treatments for mitochondrial disease-no time to drop our standards. Nat Rev Neurol (2013) 1.26
Development of the Minimum Information Specification for In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE). OMICS (2006) 1.26
Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells. Mol Endocrinol (2005) 1.23
Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks. Mitochondrion (2011) 1.18
Novel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants. Mol Cell Biol (2002) 1.17
The NR3B subgroup: an ovERRview. Nucl Recept Signal (2007) 1.16
Next-generation sequencing reveals DGUOK mutations in adult patients with mitochondrial DNA multiple deletions. Brain (2012) 1.16
Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos. Mech Dev (2004) 1.15
Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation. Cell Metab (2011) 1.14
Antitumor activity of GSK1904529A, a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase. Clin Cancer Res (2009) 1.14
Nuclear receptor location analyses in mammalian genomes: from gene regulation to regulatory networks. Mol Endocrinol (2008) 1.13
Isolation of tumorigenic circulating melanoma cells. Biochem Biophys Res Commun (2010) 1.13
Mutation in the novel nuclear-encoded mitochondrial protein CHCHD10 in a family with autosomal dominant mitochondrial myopathy. Neurogenetics (2014) 1.13
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations. Mol Genet Metab (2011) 1.13
Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs. PLoS Genet (2011) 1.12
Epidermal growth factor-induced signaling in breast cancer cells results in selective target gene activation by orphan nuclear receptor estrogen-related receptor alpha. Cancer Res (2005) 1.11
PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Res (2012) 1.10