Published in Arch Gen Psychiatry on March 01, 2010
Timing is everything: the when and how of environmentally induced changes in the epigenome of animals. Epigenetics (2011) 1.67
Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Res (2011) 1.61
Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. J Psychiatr Res (2011) 1.57
DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS One (2011) 1.48
Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. Mol Psychiatry (2011) 1.48
Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol (2012) 1.45
Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder. Am J Psychiatry (2012) 1.28
Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene. Transl Psychiatry (2013) 1.17
DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways. Transl Psychiatry (2014) 1.12
DNA methylation of BDNF as a biomarker of early-life adversity. Proc Natl Acad Sci U S A (2014) 1.05
Suicide and suicidal behaviour. Lancet (2015) 1.03
Toward a biosignature for suicide. Am J Psychiatry (2014) 1.03
The molecular bases of the suicidal brain. Nat Rev Neurosci (2014) 1.02
Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation. Neurobiol Learn Mem (2011) 0.93
Toward the identification of peripheral epigenetic biomarkers of schizophrenia. J Neurogenet (2014) 0.91
CpG methylation in neurons: message, memory, or mask? Neuropsychopharmacology (2010) 0.89
Exploring epigenetic regulation of fear memory and biomarkers associated with post-traumatic stress disorder. Front Psychiatry (2013) 0.89
Brain-derived neurotrophic factor epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice. Biol Psychiatry (2014) 0.88
Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes. Epigenomics (2012) 0.87
Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression. Mol Psychiatry (2013) 0.86
Bdnf DNA methylation modifications in the hippocampus and amygdala of male and female rats exposed to different caregiving environments outside the homecage. Dev Psychobiol (2014) 0.86
Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy. Epigenetics (2014) 0.86
Effects on specific promoter DNA methylation in zebrafish embryos and larvae following benzo[a]pyrene exposure. Comp Biochem Physiol C Toxicol Pharmacol (2014) 0.86
Epigenetic alterations in depression and antidepressant treatment. Dialogues Clin Neurosci (2014) 0.85
Neurobiology of suicide: do biomarkers exist? Int J Legal Med (2013) 0.84
Epigenetic mechanisms in the development of behavior: advances, challenges, and future promises of a new field. Dev Psychopathol (2013) 0.84
Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age. Neuropsychopharmacology (2015) 0.83
Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants. J Exp Biol (2015) 0.83
Epigenetic modifications associated with suicide and common mood and anxiety disorders: a systematic review of the literature. Biol Mood Anxiety Disord (2012) 0.83
Clinical and genetic factors associated with suicide in mood disorder patients. Eur Arch Psychiatry Clin Neurosci (2015) 0.83
BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis. Behav Brain Funct (2016) 0.82
Gene-environment interaction in major depression: focus on experience-dependent biological systems. Front Psychiatry (2015) 0.82
DNA methylation of stress-related genes and LINE-1 repetitive elements across the healthy human placenta. Placenta (2012) 0.81
DNA methylation: conducting the orchestra from exposure to phenotype? Clin Epigenetics (2016) 0.81
BDNF promoter methylation and genetic variation in late-life depression. Transl Psychiatry (2015) 0.80
The role of cytokines in the pathophysiology of suicidal behavior. Psychoneuroendocrinology (2015) 0.80
Depressed Adolescents Treated with Exercise (DATE): A pilot randomized controlled trial to test feasibility and establish preliminary effect sizes. Ment Health Phys Act (2013) 0.80
Stress and the Emerging Roles of Chromatin Remodeling in Signal Integration and Stable Transmission of Reversible Phenotypes. Front Behav Neurosci (2017) 0.79
Effects of negative stressors on DNA methylation in the brain: implications for mood and anxiety disorders. Am J Med Genet B Neuropsychiatr Genet (2014) 0.79
Altered DNA methylation status of human brain derived neurotrophis factor gene could be useful as biomarker of depression. Am J Med Genet B Neuropsychiatr Genet (2014) 0.79
Gene-environment interactions in geriatric depression. Psychiatr Clin North Am (2011) 0.79
Strain differences in the effects of chronic corticosterone exposure in the hippocampus. Neuroscience (2012) 0.79
Epigenetic pathways through which experiences become linked with biology. Dev Psychopathol (2015) 0.78
NEUROBIOLOGICAL ASPECTS OF SUICIDE AND SUICIDE ATTEMPTS IN BIPOLAR DISORDER. Transl Neurosci (2013) 0.78
Genetic and epigenetic regulation of the brain-derived neurotrophic factor in the central nervous system. Yale J Biol Med (2014) 0.78
Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis. Front Cell Neurosci (2015) 0.78
DNA methylation state of the galectin-3 gene represents a potential new marker of thyroid malignancy. Oncol Lett (2013) 0.77
Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions. Front Psychiatry (2016) 0.77
Quantitative leukocyte BDNF promoter methylation analysis in bipolar disorder. Int J Bipolar Disord (2013) 0.77
Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus. Epigenetics (2016) 0.77
Epigenetics and suicidal behavior research pathways. Am J Prev Med (2014) 0.77
BDNF Methylation and Maternal Brain Activity in a Violence-Related Sample. PLoS One (2015) 0.77
The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental Disorders. Genes (Basel) (2017) 0.76
Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring. Int J Dev Neurosci (2017) 0.75
The Life Span Model of Suicide and Its Neurobiological Foundation. Front Neurosci (2017) 0.75
DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation. J Psychiatr Res (2017) 0.75
Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene. Epigenetics (2016) 0.75
Serum Brain-Derived Neurotrophic Factors in Taiwanese Patients with Drug-Naïve First-Episode Major Depressive Disorder: Effects of Antidepressants. Int J Neuropsychopharmacol (2016) 0.75
Antidepressive and BDNF effects of enriched environment treatment across ages in mice lacking BDNF expression through promoter IV. Transl Psychiatry (2016) 0.75
Understanding epigenetic architecture of suicide neurobiology: A critical perspective. Neurosci Biobehav Rev (2016) 0.75
The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders. Transl Psychiatry (2016) 0.75
Loss of promoter IV-driven BDNF expression impacts oscillatory activity during sleep, sensory information processing and fear regulation. Transl Psychiatry (2016) 0.75
The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review. PLoS One (2016) 0.75
Selection of Suitable Reference Genes for Analysis of Salivary Transcriptome in Non-Syndromic Autistic Male Children. Int J Mol Sci (2016) 0.75
Neuropathology of suicide: recent findings and future directions. Mol Psychiatry (2017) 0.75
Suicide prevention strategies: a systematic review. JAMA (2005) 14.79
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab (2003) 4.93
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med (2002) 4.69
Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies. Br J Psychiatry (2012) 3.87
MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle. Endocr Relat Cancer (2007) 3.53
Familial cancer associated with a polymorphism in ARLTS1. N Engl J Med (2005) 3.35
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res (2002) 3.33
Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol (2008) 3.13
DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science (2008) 3.09
DNA damage, homology-directed repair, and DNA methylation. PLoS Genet (2007) 2.29
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer. FEBS Lett (2004) 2.17
Mutation of the PIK3CA gene in anaplastic thyroid cancer. Cancer Res (2005) 2.10
Retracted The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. J Clin Invest (2005) 2.09
The Finno-Ugrian suicide hypothesis: variation in European suicide rates by latitude and longitude. Percept Mot Skills (2003) 2.04
Prevalence of pathological internet use among adolescents in Europe: demographic and social factors. Addiction (2012) 2.01
Functional variants of the HMGA1 gene and type 2 diabetes mellitus. JAMA (2011) 2.00
Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Oncogene (2002) 1.99
RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of papillary carcinoma. J Clin Endocrinol Metab (2006) 1.98
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell (2006) 1.96
Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women. Stroke (2002) 1.93
Genetic modifiers of liver disease in cystic fibrosis. JAMA (2009) 1.88
Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia. Hum Mol Genet (2009) 1.85
Life-time prevalence and psychosocial correlates of adolescent direct self-injurious behavior: a comparative study of findings in 11 European countries. J Child Psychol Psychiatry (2013) 1.85
Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. Am J Psychiatry (2009) 1.70
Psychotic symptoms and population risk for suicide attempt: a prospective cohort study. JAMA Psychiatry (2013) 1.69
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat Med (2005) 1.64
Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors. Oncogene (2004) 1.63
Best practice elements of multilevel suicide prevention strategies: a review of systematic reviews. Crisis (2011) 1.55
Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene (2005) 1.53
A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. Cancer Res (2007) 1.47
HMGA and cancer. Biochim Biophys Acta (2010) 1.45
The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma. Am J Pathol (2004) 1.43
Genetic changes in Slovenian patients with gastric adenocarcinoma evaluated in terms of microsatellite DNA. Eur J Gastroenterol Hepatol (2007) 1.40
Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J Clin Endocrinol Metab (2004) 1.36
Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res (2006) 1.34
Retracted High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. J Clin Invest (2007) 1.34
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture. Eur J Endocrinol (2006) 1.29
Progressive GAA expansions in dorsal root ganglia of Friedreich's ataxia patients. Ann Neurol (2007) 1.29
Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. Cancer Res (2008) 1.28
Genotype-phenotype correlation in cystic fibrosis: the role of modifier genes. Am J Med Genet (2002) 1.28
Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry (2005) 1.28
MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha. J Clin Endocrinol Metab (2011) 1.28
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. Biol Psychiatry (2010) 1.27
Mental Health First Aid is an effective public health intervention for improving knowledge, attitudes, and behaviour: a meta-analysis. Int Rev Psychiatry (2014) 1.26
Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization. Cell Cycle (2003) 1.25
Childhood trauma and psychosis in a prospective cohort study: cause, effect, and directionality. Am J Psychiatry (2013) 1.25
Moderation of antidepressant response by the serotonin transporter gene. Br J Psychiatry (2009) 1.25
Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Cancer Res (2009) 1.25
Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk. J Child Psychol Psychiatry (2013) 1.24
CBX7 is a tumor suppressor in mice and humans. J Clin Invest (2012) 1.24
HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression. Clin Cancer Res (2004) 1.23
Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. Eur J Cancer (2010) 1.21
Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma. Mol Cell Biol (2003) 1.20
Depression is a risk factor for poor glycemic control and retinopathy in African-Americans with type 1 diabetes. Psychosom Med (2007) 1.19
Suicide attempts in the United States: the role of physical illness. Soc Sci Med (2003) 1.19
Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas. Carcinogenesis (2005) 1.18
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. Am J Pathol (2005) 1.18
LPS-induced IL-8 activation in human intestinal epithelial cells is accompanied by specific histone H3 acetylation and methylation changes. BMC Microbiol (2010) 1.18
Molecular mechanisms of RET activation in human cancer. Ann N Y Acad Sci (2002) 1.17
Congenital diarrheal disorders: improved understanding of gene defects is leading to advances in intestinal physiology and clinical management. J Pediatr Gastroenterol Nutr (2010) 1.16
Deregulation of microRNA expression in follicular-cell-derived human thyroid carcinomas. Endocr Relat Cancer (2010) 1.16
HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. Cancer Res (2009) 1.16
A region of the N-terminal domain of meningococcal factor H-binding protein that elicits bactericidal antibody across antigenic variant groups. Mol Immunol (2009) 1.16
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1. J Clin Endocrinol Metab (2012) 1.15
The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients. Eur J Cancer (2010) 1.15
HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias. Eur J Cancer (2008) 1.14
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene (2004) 1.14
Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity. Antimicrob Agents Chemother (2010) 1.14
Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases. PLoS One (2009) 1.14
Somatic instability of the expanded GAA triplet-repeat sequence in Friedreich ataxia progresses throughout life. Genomics (2007) 1.13
Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein. Genes Cancer (2010) 1.13
Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression. Br J Psychiatry (2009) 1.13
TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters. Nucleic Acids Res (2006) 1.12