Published in Alcohol Alcohol on May 12, 2008
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature (2010) 2.00
Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Am J Psychiatry (2011) 1.93
Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol (2009) 1.81
Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology (2010) 1.68
Rare nonsynonymous exonic variants in addiction and behavioral disinhibition. Biol Psychiatry (2013) 1.67
Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner. Biol Psychiatry (2012) 1.61
GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. Neuropsychopharmacology (2008) 1.41
Genome-wide association identifies candidate genes that influence the human electroencephalogram. Proc Natl Acad Sci U S A (2010) 1.38
Chronic cigarette smoking: implications for neurocognition and brain neurobiology. Int J Environ Res Public Health (2010) 1.36
Heroin addiction in African Americans: a hypothesis-driven association study. Genes Brain Behav (2009) 1.32
Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. Schizophr Res (2009) 1.32
A genome-wide association study of behavioral disinhibition. Behav Genet (2013) 1.28
Association analysis of 94 candidate genes and schizophrenia-related endophenotypes. PLoS One (2012) 1.27
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. Biol Psychiatry (2010) 1.27
Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants. Exp Clin Psychopharmacol (2009) 1.21
Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder. Biol Psychiatry (2008) 1.20
Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Ann N Y Acad Sci (2010) 1.16
Candidate gene-environment interaction research: reflections and recommendations. Perspect Psychol Sci (2015) 1.16
BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. Neuroimage (2009) 1.14
Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. Alcohol Clin Exp Res (2010) 1.11
Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine. Psychiatr Genet (2010) 1.11
Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world. Dev Psychopathol (2012) 1.10
Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior. J Psychiatr Res (2011) 1.09
Array-based profiling of DNA methylation changes associated with alcohol dependence. Alcohol Clin Exp Res (2012) 1.09
Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. PLoS One (2008) 1.09
Candidate gene studies of a promising intermediate phenotype: failure to replicate. Neuropsychopharmacology (2012) 1.08
Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders. Alcohol Clin Exp Res (2012) 1.07
Interaction between FKBP5 and childhood trauma and risk of aggressive behavior. Arch Gen Psychiatry (2012) 1.04
ERGR: An ethanol-related gene resource. Nucleic Acids Res (2008) 1.04
Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence. Mol Psychiatry (2010) 1.04
The genetics of the opioid system and specific drug addictions. Hum Genet (2012) 1.04
OPRM1 gene variants modulate amphetamine-induced euphoria in humans. Genes Brain Behav (2010) 1.02
The AVPR1A gene and substance use disorders: association, replication, and functional evidence. Biol Psychiatry (2011) 1.02
Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters. J Stud Alcohol Drugs (2011) 0.99
COMT Val158Met and cognition: main effects and interaction with educational attainment. Genes Brain Behav (2008) 0.98
Association of OPRD1 polymorphisms with heroin dependence in a large case-control series. Addict Biol (2012) 0.97
Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression. Arch Gen Psychiatry (2012) 0.97
CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction. Addict Biol (2011) 0.97
Haplotype block structure of the genomic region of the mu opioid receptor gene. J Hum Genet (2010) 0.95
Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm. PLoS One (2009) 0.94
Effect of GABRA2 genotype on development of incentive-motivation circuitry in a sample enriched for alcoholism risk. Neuropsychopharmacology (2014) 0.94
Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures. Neuropsychopharmacology (2014) 0.94
Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation. BMC Res Notes (2010) 0.93
Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems. Genes Brain Behav (2013) 0.93
Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. Behav Genet (2015) 0.92
Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers. Behav Genet (2010) 0.92
Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans. J Neurosci (2012) 0.92
More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine. Neuropsychopharmacology (2009) 0.92
Striatal signal transduction and drug addiction. Front Neuroanat (2011) 0.91
Genetic influences on the development of alcoholism. Curr Psychiatry Rep (2013) 0.91
Gray matter volume in adolescent anxiety: an impact of the brain-derived neurotrophic factor Val(66)Met polymorphism? J Am Acad Child Adolesc Psychiatry (2013) 0.91
Neurotransmitter and neuromodulator genes associated with a history of depressive symptoms in individuals with alcohol dependence. Alcohol Clin Exp Res (2010) 0.91
Genetics of dopamine receptors and drug addiction. Hum Genet (2012) 0.89
Valence-specific effects of BDNF Val66Met polymorphism on dopaminergic stress and reward processing in humans. J Neurosci (2014) 0.89
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence. Drug Alcohol Depend (2008) 0.89
BDNF Val(66)Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study. Addict Biol (2012) 0.89
FAAH selectively influences placebo effects. Mol Psychiatry (2013) 0.89
BDNF polymorphism predicts general intelligence after penetrating traumatic brain injury. PLoS One (2011) 0.88
Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis. Am J Med Genet B Neuropsychiatr Genet (2013) 0.88
The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement. PLoS One (2013) 0.88
Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study. BMC Genomics (2012) 0.88
FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice. Neuropsychopharmacology (2014) 0.88
A candidate gene association study of alcohol consumption in young women. Alcohol Clin Exp Res (2010) 0.87
Drug addiction and stress-response genetic variability: association study in African Americans. Ann Hum Genet (2014) 0.87
Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing. J Neurosci (2012) 0.86
Leptin regulates dopamine responses to sustained stress in humans. J Neurosci (2012) 0.86
Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine-related loci. Brain Behav (2014) 0.85
Multi-view singular value decomposition for disease subtyping and genetic associations. BMC Genet (2014) 0.85
Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder. Psychiatr Genet (2011) 0.85
Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans. J Neural Transm (Vienna) (2009) 0.85
Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice. Behav Pharmacol (2010) 0.85
Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls. J Psychiatr Res (2010) 0.84
Association of COL25A1 with comorbid antisocial personality disorder and substance dependence. Biol Psychiatry (2012) 0.84
Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes. Hum Genet (2014) 0.84
Further evidence of association between amphetamine response and SLC6A2 gene variants. Psychopharmacology (Berl) (2009) 0.84
Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. Psychoneuroendocrinology (2014) 0.84
Genetics and genomics of alcohol sensitivity. Mol Genet Genomics (2014) 0.83
DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder. Int J Neuropsychopharmacol (2013) 0.83
Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). Alcohol Clin Exp Res (2010) 0.83
The influence of three genes on whether adolescents use contraception, USA 1994-2002. Popul Stud (Camb) (2011) 0.83
Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment. Pharmacogenomics J (2011) 0.82
Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. J Neural Transm (Vienna) (2011) 0.82
Gene-environment correlation: difficulties and a natural experiment-based strategy. Am J Public Health (2013) 0.82
Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse. J Child Psychol Psychiatry (2014) 0.82
Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. PLoS One (2011) 0.81
Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations. Hum Genomics (2012) 0.81
Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants. Pharmacogenomics (2014) 0.81
Common and specific liability to addiction: approaches to association studies of opioid addiction. Drug Alcohol Depend (2012) 0.81
Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent. BMC Res Notes (2012) 0.81
Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. Ann Hum Genet (2015) 0.80
Variations in opioid receptor genes in neonatal abstinence syndrome. Drug Alcohol Depend (2015) 0.80
Independent effects of 5' and 3' functional variants in the serotonin transporter gene on suicidal behavior in the context of childhood trauma. J Psychiatr Res (2013) 0.80
Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample. Alcohol Clin Exp Res (2014) 0.80
The relationship between rs3779084 in the dopa decarboxylase (DDC) gene and alcohol consumption is mediated by drinking motives in regular smokers. Alcohol Clin Exp Res (2011) 0.80
Gene-centric analysis of serum cotinine levels in African and European American populations. Neuropsychopharmacology (2011) 0.80
Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction. Pharmacogenomics (2013) 0.80
Genetic variability of smoking persistence in African Americans. Cancer Prev Res (Phila) (2011) 0.80
Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury. Transl Psychiatry (2012) 0.79
A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk. Transl Psychiatry (2013) 0.79
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The structure of haplotype blocks in the human genome. Science (2002) 50.88
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
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Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry (2003) 21.70
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An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res (2005) 3.94
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Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. Am J Med Genet B Neuropsychiatr Genet (2009) 2.98
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Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71
Genetic variation in human NPY expression affects stress response and emotion. Nature (2008) 2.65
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60
Autistic social impairment in the siblings of children with pervasive developmental disorders. Am J Psychiatry (2006) 2.57
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A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry (2002) 2.51
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Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biol Psychiatry (2011) 2.45
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Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41
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DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proc Natl Acad Sci U S A (2005) 2.35
Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry (2006) 2.31
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Autistic traits in a population-based ADHD twin sample. J Child Psychol Psychiatry (2007) 2.24
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med (2009) 2.20
The financial burden from non-communicable diseases in low- and middle-income countries: a literature review. Health Res Policy Syst (2013) 2.20
Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biol Psychiatry (2006) 2.20
Topiramate treatment for heavy drinkers: moderation by a GRIK1 polymorphism. Am J Psychiatry (2014) 2.18
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain (2004) 2.17
Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Neuropsychopharmacology (2010) 2.16
Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry (2004) 2.12
Practical population group assignment with selected informative markers: characteristics and properties of Bayesian clustering via STRUCTURE. Genet Epidemiol (2005) 2.09
A quantitative trait locus analysis of social responsiveness in multiplex autism families. Am J Psychiatry (2007) 2.09
Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry (2006) 2.09
A biosynthetic pathway for anandamide. Proc Natl Acad Sci U S A (2006) 2.08
Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. Am J Med Genet B Neuropsychiatr Genet (2003) 2.07
Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci (2005) 2.04
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Deficits in reciprocal social behavior in male twins: evidence for a genetically independent domain of psychopathology. J Am Acad Child Adolesc Psychiatry (2003) 2.03
Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk: a female twin study. Psychol Med (2005) 2.03
Sex and age differences in attention-deficit/hyperactivity disorder symptoms and diagnoses: implications for DSM-V and ICD-11. J Am Acad Child Adolesc Psychiatry (2010) 2.01
A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature (2010) 2.00
Using ancestry-informative markers to define populations and detect population stratification. J Psychopharmacol (2006) 1.98
Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry (2004) 1.98
Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations. Arch Gen Psychiatry (2009) 1.97
Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. Am J Psychiatry (2004) 1.96
Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci (2008) 1.96
Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biol Psychiatry (2002) 1.94
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