DNA methylation: conducting the orchestra from exposure to phenotype?

PubWeight™: 0.81‹?›

🔗 View Article (PMID 27602172)

Published in Clin Epigenetics on September 06, 2016

Authors

Fleur A D Leenen1, Claude P Muller1, Jonathan D Turner2

Author Affiliations

1: Department of Infection and Immunity, Luxembourg Institute of Health, 29 rue Henri Koch, 4354 Esch-sur-Alzette, Luxembourg ; Department of Immunology, Research Institute of Psychobiology, University of Trier, 54290 Trier, Germany.
2: Department of Infection and Immunity, Luxembourg Institute of Health, 29 rue Henri Koch, 4354 Esch-sur-Alzette, Luxembourg.

Articles cited by this

(truncated to the top 100)

Epigenetic programming by maternal behavior. Nat Neurosci (2004) 20.92

Landscape of transcription in human cells. Nature (2012) 20.18

DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08

Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19

Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet (2012) 15.21

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci (2009) 10.17

DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics (2012) 9.31

Transcription regulation and animal diversity. Nature (2003) 9.22

Epigenetic inheritance at the agouti locus in the mouse. Nat Genet (1999) 9.14

Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A (2008) 8.39

Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96

A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol (2008) 7.95

Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics (2010) 7.78

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol (2011) 6.48

Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet (2008) 5.66

Guidelines for human gene nomenclature. Genomics (2002) 5.58

What is a gene, post-ENCODE? History and updated definition. Genome Res (2007) 4.96

Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci (2009) 4.53

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet (2009) 4.25

Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry (2009) 4.12

Obesity at the age of 50 y in men and women exposed to famine prenatally. Am J Clin Nutr (1999) 4.07

DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol (1999) 3.76

The HPA axis in major depression: classical theories and new developments. Trends Neurosci (2008) 3.47

MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucleic Acids Res (2009) 3.29

Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet (2010) 3.17

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet (2007) 3.06

Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study. Ann Hum Genet (2004) 2.95

Reference-free cell mixture adjustments in analysis of DNA methylation data. Bioinformatics (2014) 2.61

Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS One (2010) 2.54

DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression. Genome Res (2008) 2.48

Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res (2007) 2.47

Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation. PLoS Genet (2011) 2.41

Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males. Hum Genet (2007) 2.36

Pervasive transcription constitutes a new level of eukaryotic genome regulation. EMBO Rep (2009) 2.22

Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping. Nucleic Acids Res (2008) 2.19

Recommendations for the design and analysis of epigenome-wide association studies. Nat Methods (2013) 2.19

Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry (2012) 2.13

The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts. Genome Biol (2014) 2.01

Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements. Cell Mol Life Sci (2012) 1.96

Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One (2012) 1.89

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice. Nat Neurosci (2010) 1.87

Broad epigenetic signature of maternal care in the brain of adult rats. PLoS One (2011) 1.86

Maternal high-fat diet effects on third-generation female body size via the paternal lineage. Endocrinology (2011) 1.85

Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol (2009) 1.74

Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome. Cancer Res (2009) 1.73

Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology (2009) 1.71

Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am J Med Genet B Neuropsychiatr Genet (2010) 1.71

Interindividual variability and parent of origin DNA methylation differences at specific human Alu elements. Hum Mol Genet (2005) 1.65

Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1. J Mol Endocrinol (2005) 1.62

Hungry in the womb: what are the consequences? Lessons from the Dutch famine. Maturitas (2011) 1.60

Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder. Biol Psychiatry (2014) 1.57

Environmental epigenetics of asthma: an update. J Allergy Clin Immunol (2010) 1.53

Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development. Genome Res (2011) 1.52

Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry (2010) 1.49

Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus. Proc Natl Acad Sci U S A (2012) 1.45

A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes. Genome Res (2011) 1.45

Glucose tolerance at age 58 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine. Diabetologia (2006) 1.43

Redox proteomics of protein-bound methionine oxidation. Mol Cell Proteomics (2011) 1.37

Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS One (2010) 1.36

Sex differential in methylation patterns of selected genes in Singapore Chinese. Hum Genet (2005) 1.35

Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33

Impaired insulin secretion after prenatal exposure to the Dutch famine. Diabetes Care (2006) 1.32

Rapid glucocorticoid effects on immune cells. Steroids (2002) 1.32

Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing. BMC Evol Biol (2007) 1.30

A conceptual framework for the developmental origins of health and disease. J Dev Orig Health Dis (2010) 1.25

Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics (2012) 1.25

Exposure to famine during gestation, size at birth, and blood pressure at age 59 y: evidence from the Dutch Famine. Eur J Epidemiol (2006) 1.24

Genome-wide quantitative assessment of variation in DNA methylation patterns. Nucleic Acids Res (2011) 1.23

Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more. Biochem Pharmacol (2010) 1.18

Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed. Psychoneuroendocrinology (2009) 1.18

DNA methylation as a universal biomarker. Expert Rev Mol Diagn (2010) 1.18

Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia. J Psychiatr Res (2006) 1.18

Antenatal prediction of postpartum depression with blood DNA methylation biomarkers. Mol Psychiatry (2013) 1.16

Highly individual methylation patterns of alternative glucocorticoid receptor promoters suggest individualized epigenetic regulatory mechanisms. Nucleic Acids Res (2008) 1.16

GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease. Am J Hum Genet (2014) 1.15

Developmental origins of health and disease: reducing the burden of chronic disease in the next generation. Genome Med (2010) 1.13

DNA methylation biomarkers: cancer and beyond. Genes (Basel) (2014) 1.11

Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter. Front Psychiatry (2012) 1.08

DNA methylation of BDNF as a biomarker of early-life adversity. Proc Natl Acad Sci U S A (2014) 1.05

The glucocorticoid receptor gene exon 1-F promoter is not methylated at the NGFI-A binding site in human hippocampus. World J Biol Psychiatry (2007) 1.05

Epigenome-wide Association Studies and the Interpretation of Disease -Omics. PLoS Genet (2016) 1.05

The role of genetics in the development of asthma and atopy. Curr Opin Allergy Clin Immunol (2005) 1.03

Effect of maternal diet on the epigenome: implications for human metabolic disease. Proc Nutr Soc (2011) 1.03

Interplay between Epigenetics and Genetics in Cancer. Genomics Inform (2013) 1.03

Basic concepts of epigenetics: impact of environmental signals on gene expression. Epigenetics (2012) 1.02

Dissociation between the prevalence of atopy and allergic disease in rural China among children and adults. J Allergy Clin Immunol (2008) 1.02

Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells. Cancer Metastasis Rev (2013) 1.02

Participation of leaky ribosome scanning in protein dual targeting by alternative translation initiation in higher plants. Plant Cell (2009) 1.00

DNA methylation as clinically useful biomarkers-light at the end of the tunnel. Pharmaceuticals (Basel) (2012) 0.99

Tissue specific glucocorticoid receptor expression, a role for alternative first exon usage? Biochem Pharmacol (2006) 0.98

Epigenetic regulation of the glucocorticoid receptor promoter 1(7) in adult rats. Epigenetics (2012) 0.96

Traumatic stress and human DNA methylation: a critical review. Epigenomics (2015) 0.94

Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation. Int J Epidemiol (2015) 0.94

Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder. Transl Psychiatry (2014) 0.91

Insufficient DNA methylation affects healthy aging and promotes age-related health problems. Clin Epigenetics (2011) 0.90

Connections between alternative transcription and alternative splicing in mammals. Genome Biol Evol (2010) 0.90

Transcriptional control of the human glucocorticoid receptor: identification and analysis of alternative promoter regions. Hum Genet (2011) 0.89

BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues. Neurosci Res (2014) 0.88