Published in PLoS Genet on February 26, 2010
A high-resolution map of human evolutionary constraint using 29 mammals. Nature (2011) 8.67
DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. Int J Epidemiol (2012) 1.30
Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies. Genet Epidemiol (2011) 1.29
eXclusion: toward integrating the X chromosome in genome-wide association analyses. Am J Hum Genet (2013) 1.24
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. Hum Mol Genet (2013) 1.17
Children of the 90s: Coming of age. Nature (2012) 1.10
Large-effect pleiotropic or closely linked QTL segregate within and across ten US cattle breeds. BMC Genomics (2014) 1.06
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun (2016) 0.99
Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels. Am J Hum Genet (2014) 0.96
Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses. PLoS Genet (2015) 0.94
Genetic, environmental and epigenetic influences on variation in human tooth number, size and shape. Odontology (2011) 0.88
Genome-wide association study identifies four loci associated with eruption of permanent teeth. PLoS Genet (2011) 0.84
Candidate Gene Analyses of Skeletal Variation in Malocclusion. J Dent Res (2015) 0.82
Towards unraveling the human tooth transcriptome: the dentome. PLoS One (2015) 0.82
Distinctive genetic activity pattern of the human dental pulp between deciduous and permanent teeth. PLoS One (2014) 0.82
Gene-based association analysis identified novel genes associated with bone mineral density. PLoS One (2015) 0.79
Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds. BMC Genomics (2015) 0.79
A non-parametric approach for detecting gene-gene interactions associated with age-at-onset outcomes. BMC Genet (2014) 0.77
Genetics of the dentofacial variation in human malocclusion. Orthod Craniofac Res (2015) 0.76
Maternal and early life factors of tooth emergence patterns and number of teeth at 1 and 2 years of age. J Dev Orig Health Dis (2015) 0.76
The role of polymorphisms associated with early tooth eruption in dental and occlusal traits in East Asian populations. Korean J Orthod (2014) 0.75
Genome-wide association studies: prospects and challenges for oral health. J Dent Res (2012) 0.75
The association between primary tooth emergence and anthropometric measures in young adults: findings from a large prospective cohort study. PLoS One (2014) 0.75
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Genomic control for association studies. Biometrics (1999) 64.39
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet (2007) 10.81
Interpreting principal component analyses of spatial population genetic variation. Nat Genet (2008) 8.49
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell (2006) 6.49
Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet (2004) 3.21
Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence. Nat Genet (2009) 3.03
The cutting-edge of mammalian development; how the embryo makes teeth. Nat Rev Genet (2004) 2.89
Cohort studies and the genetics of complex disease. Nat Genet (2009) 2.77
The pathophysiology of HOX genes and their role in cancer. J Pathol (2005) 2.18
Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol (2004) 2.08
Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs. Int J Dev Biol (1995) 2.01
Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet (2009) 1.99
An ancient gene network is co-opted for teeth on old and new jaws. PLoS Biol (2009) 1.60
Genetic basis of tooth development and dental defects. Acta Odontol Scand (2000) 1.58
Ectodysplasin signaling in development. Cytokine Growth Factor Rev (2003) 1.48
Homeobox genes: a molecular link between development and cancer. Pesqui Odontol Bras (2003) 1.23
A curriculum vitae of teeth: evolution, generation, regeneration. Int J Biol Sci (2009) 1.19
Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer. Int J Oncol (2004) 1.14
Strong genetic control of emergence of human primary incisors. J Dent Res (2007) 1.05
Patient presentation at medical practices with dental problems: an analysis of the 1996 General Practice Morbidity Database for Wales. Br Dent J (1999) 1.01
From ectodermal dysplasia to selective tooth agenesis. Am J Med Genet A (2009) 0.93
Andersen-Tawil syndrome: prospective cohort analysis and expansion of the phenotype. Am J Med Genet A (2006) 0.86
Tooth development is independent of a Hox patterning programme. Dev Dyn (2002) 0.85
Identification of novel genes expressed during mouse tooth development by microarray gene expression analysis. Dev Dyn (2007) 0.85
Identification of differentially expressed genes in clinically distinct groups of serous ovarian carcinomas using cDNA microarray. Int J Mol Med (2004) 0.83
Injections of osteoprotegerin and PMA delay tooth eruption. Clin Anat (2006) 0.80
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Finding the missing heritability of complex diseases. Nature (2009) 67.95
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Population genomics of human gene expression. Nat Genet (2007) 24.49
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23