Published in Hum Mol Genet on January 30, 2009
Prioritizing GWAS results: A review of statistical methods and recommendations for their application. Am J Hum Genet (2010) 5.39
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet (2011) 2.34
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A (2010) 2.20
Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet (2012) 2.07
Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta. Am J Hum Genet (2010) 1.89
Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density. Nat Genet (2009) 1.73
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genet (2012) 1.49
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genet (2010) 1.40
A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure. Am J Hum Genet (2010) 1.32
Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. J Clin Endocrinol Metab (2010) 1.30
European bone mineral density loci are also associated with BMD in East-Asian populations. PLoS One (2010) 1.29
Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx. J Orthop Surg Res (2010) 1.27
The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations. Osteoporos Int (2016) 1.25
Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review. Am J Epidemiol (2010) 1.21
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. PLoS Genet (2014) 1.21
Genetic and molecular control of osterix in skeletal formation. J Cell Biochem (2013) 1.19
Female reproductive system and bone. Arch Biochem Biophys (2010) 1.19
p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix. J Biol Chem (2010) 1.18
Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women. J Bone Miner Res (2013) 1.16
Genetics of osteoporosis: accelerating pace in gene identification and validation. Hum Genet (2009) 1.14
Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone. PLoS Genet (2010) 1.10
Children of the 90s: Coming of age. Nature (2012) 1.10
ACTN3 genotype, athletic status, and life course physical capability: meta-analysis of the published literature and findings from nine studies. Hum Mutat (2011) 1.10
Osteoblast-specific transcription factor Osterix (Osx) is an upstream regulator of Satb2 during bone formation. J Biol Chem (2011) 1.09
Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed. J Clin Endocrinol Metab (2012) 1.04
The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation. J Cell Physiol (2012) 1.00
Molecular genetic studies of gene identification for osteoporosis: the 2009 update. Endocr Rev (2010) 1.00
Molecular and population analysis of natural selection on the human haptoglobin duplication. Ann Hum Genet (2012) 0.98
A trans-ethnic genome-wide association study identifies gender-specific loci influencing pediatric aBMD and BMC at the distal radius. Hum Mol Genet (2015) 0.96
Genome-wide Association Studies for Osteoporosis: A 2013 Update. J Bone Metab (2014) 0.90
VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey. PLoS One (2010) 0.88
The genetics of bone loss: challenges and prospects. J Clin Endocrinol Metab (2011) 0.88
OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts. J Clin Endocrinol Metab (2010) 0.88
Assessing bone health in children and adolescents. Indian J Endocrinol Metab (2012) 0.87
Regulation of the osterix (Osx, Sp7) promoter by osterix and its inhibition by parathyroid hormone. J Mol Endocrinol (2013) 0.87
Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. J Bone Miner Res (2010) 0.87
Mitogen-activated protein kinase (MAPK)-regulated interactions between Osterix and Runx2 are critical for the transcriptional osteogenic program. J Biol Chem (2014) 0.87
Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women. PLoS One (2012) 0.87
Future of osteoporosis genetics: enhancing genome-wide association studies. J Bone Miner Res (2009) 0.86
The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. Am J Med Genet B Neuropsychiatr Genet (2010) 0.84
Genetic regulation of bone metabolism in the chicken: similarities and differences to Mammalian systems. PLoS Genet (2015) 0.83
The genetics of bone mass and susceptibility to bone diseases. Nat Rev Rheumatol (2016) 0.82
Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures. Dev Biol (2016) 0.80
Polymorphisms of the WNT16 gene are associated with the heel ultrasound parameter in young adults. Osteoporos Int (2015) 0.79
Genetics of pediatric bone strength. Bonekey Rep (2016) 0.78
Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects. J Bone Miner Res (2015) 0.78
Developmental origins of genotype-phenotype correlations in chronic diseases of old age. Aging Dis (2012) 0.78
Osterix acetylation at K307 and K312 enhances its transcriptional activity and is required for osteoblast differentiation. Oncotarget (2016) 0.76
The case for genome-wide association studies of bone acquisition in paediatric and adolescent populations. Bonekey Rep (2016) 0.76
β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Int J Mol Med (2015) 0.75
Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka, Oryzias latipes. Toxicol Sci (2016) 0.75
Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis. Hum Genet (2017) 0.75
Genetic Dissection of Trabecular Bone Structure with Mouse Inter-subspecific Consomic Strains. G3 (Bethesda) (2017) 0.75
Tet-mediated DNA demethylation is required for SWI/SNF-dependent chromatin remodeling and histone modifying activities that trigger expression of the Sp7 osteoblast master gene during mesenchymal lineage commitment. Mol Cell Biol (2017) 0.75
p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation. Cell Death Differ (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
A haplotype map of the human genome. Nature (2005) 105.70
Genomic control for association studies. Biometrics (1999) 64.39
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell (2002) 15.20
ALSPAC--the Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatr Perinat Epidemiol (2001) 14.31
Evaluating coverage of genome-wide association studies. Nat Genet (2006) 11.40
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet (2008) 7.05
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Multiple genetic loci for bone mineral density and fractures. N Engl J Med (2008) 6.35
Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med (2006) 4.09
New sequence variants associated with bone mineral density. Nat Genet (2008) 3.43
Prediction of osteoporotic fractures by postural instability and bone density. BMJ (1993) 2.93
The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med (2006) 2.74
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA (2008) 2.52
Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA (2004) 2.20
Suggestive linkage of the parathyroid receptor type 1 to osteoporosis. J Bone Miner Res (1999) 1.69
The exclusion of high trauma fractures may underestimate the prevalence of bone fragility fractures in the community: the Geelong Osteoporosis Study. J Bone Miner Res (1998) 1.65
Segregation analysis and variance components analysis of bone mineral density in healthy families. J Bone Miner Res (1995) 1.55
Familial resemblance for bone mineral mass is expressed before puberty. J Clin Endocrinol Metab (1998) 1.39
Genetic and environmental determinants of peak bone mass in young men and women. J Bone Miner Res (2002) 1.27
Correlates of knee pain in older adults: Tasmanian Older Adult Cohort Study. Arthritis Rheum (2006) 1.26
A comparison of bone mineral density between Caucasian, Asian and Afro-Caribbean women. Clin Sci (Lond) (1994) 1.19
Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene. Gene (2004) 1.09
Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study. Bone (2007) 1.07
The effect of LRP5 polymorphisms on bone mineral density is apparent in childhood. Calcif Tissue Int (2007) 1.00
Associations between maternal peak bone mass and bone mass in prepubertal male and female children. J Bone Miner Res (2000) 0.99
Influence of age at menarche on forearm bone microstructure in healthy young women. J Clin Endocrinol Metab (2008) 0.98
Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study. J Bone Miner Res (2006) 0.97
Pathogenesis of osteoporosis. Baillieres Best Pract Res Clin Endocrinol Metab (2000) 0.96
Estrogen receptor alpha regulates area-adjusted bone mineral content in late pubertal girls. J Clin Endocrinol Metab (2006) 0.90
PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton. Calcif Tissue Int (2007) 0.87
A novel AAAS gene mutation (p.R194X) in a patient with triple A syndrome. Horm Res (2006) 0.83
Phenotypic heterogeneity in AAAS gene mutation. Acta Paediatr (2004) 0.79
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Population genomics of human gene expression. Nat Genet (2007) 24.49
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Common variants conferring risk of schizophrenia. Nature (2009) 10.37
Signatures of mutation and selection in the cancer genome. Nature (2010) 9.75
Convergent adaptation of human lactase persistence in Africa and Europe. Nat Genet (2006) 9.44
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet (2007) 8.50