A role for mitochondria in NLRP3 inflammasome activation.

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature (2012) 10.74

Inflammasomes in health and disease. Nature (2012) 6.75

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol (2011) 6.53

Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature (2011) 6.38

Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71

Sensing and reacting to microbes through the inflammasomes. Nat Immunol (2012) 5.24

Signal transduction by reactive oxygen species. J Cell Biol (2011) 5.21

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08

Physiological roles of mitochondrial reactive oxygen species. Mol Cell (2012) 5.05

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med (2011) 4.81

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol (2012) 4.72

TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell (2012) 4.44

Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16

Regulation of inflammasome signaling. Nat Immunol (2012) 4.10

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity (2013) 4.08

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity (2013) 3.96

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (2011) 3.74

Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol (2013) 3.73

Integrating mechanisms of pulmonary fibrosis. J Exp Med (2011) 3.57

Mitochondria in innate immune responses. Nat Rev Immunol (2011) 3.31

Metabolic pathways in immune cell activation and quiescence. Immunity (2013) 3.09

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol (2013) 3.08

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol (2011) 3.05

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β. EMBO J (2011) 3.04

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature (2011) 2.93

Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med (2012) 2.92

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal (2013) 2.78

Mechanisms of age-related macular degeneration. Neuron (2012) 2.62

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? Nat Immunol (2012) 2.59

Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal (2013) 2.59

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med (2012) 2.49

Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity (2013) 2.45

Age-dependent dysregulation of innate immunity. Nat Rev Immunol (2013) 2.44

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell (2016) 2.40

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol (2013) 2.38

Fanconi Anemia Proteins Function in Mitophagy and Immunity. Cell (2016) 2.36

Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med (2011) 2.35

Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol (2013) 2.31

Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) (2011) 2.26

PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev (2012) 2.24

Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A (2012) 2.19

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. Proc Natl Acad Sci U S A (2011) 2.18

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A (2012) 2.10

Autophagy links inflammasomes to atherosclerotic progression. Cell Metab (2012) 2.08

The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nat Immunol (2015) 2.06

The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis. PLoS Pathog (2015) 2.04

Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem (2012) 2.04

Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity (2013) 2.02

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood (2014) 2.01

Cell biology. Metabolic control of cell death. Science (2014) 1.98

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage. Ann Neurol (2014) 1.95

Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol Chem (2012) 1.95

The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. J Cell Biol (2012) 1.93

The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell (2013) 1.93

The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature (2013) 1.86

Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. Sci Signal (2012) 1.82

Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage. Endocrinology (2011) 1.82

HMGB1 in cancer: good, bad, or both? Clin Cancer Res (2013) 1.79

The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome. Immunity (2013) 1.78

Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection. Cell Host Microbe (2015) 1.77

TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. Immunity (2012) 1.75

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity (2015) 1.74

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation. Blood (2013) 1.74

Sensing damage by the NLRP3 inflammasome. Immunol Rev (2011) 1.69

NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol (2011) 1.69

Autophagy: for better or for worse. Cell Res (2011) 1.65

Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization. Cell Metab (2014) 1.65

Signal transduction by mitochondrial oxidants. J Biol Chem (2011) 1.65

Oxidative stress induced inflammation initiates functional decline of tear production. PLoS One (2012) 1.64

Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes (2012) 1.62

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis (2012) 1.60

Recent insights into the cellular biology of atherosclerosis. J Cell Biol (2015) 1.60

Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY) (2012) 1.58

Mitohormesis. Cell Metab (2014) 1.57

Oncogene-induced senescence results in marked metabolic and bioenergetic alterations. Cell Cycle (2012) 1.57

Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell (2012) 1.57

Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. PLoS One (2013) 1.56

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol (2011) 1.56

Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors. Curr Opin Immunol (2011) 1.55

Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci (2014) 1.54

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res (2013) 1.54

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med (2017) 1.53

Mitochondria and cell signalling. J Cell Sci (2012) 1.52

Reactive oxygen species in health and disease. J Biomed Biotechnol (2012) 1.52

Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury. Crit Care Med (2014) 1.52

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons. Immunity (2016) 1.50

TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One (2012) 1.48

The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2012) 1.47

Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking. PLoS One (2015) 1.47

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol (2013) 1.47

A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans. PLoS Pathog (2011) 1.47

Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress. Toxicol Appl Pharmacol (2012) 1.45

Inflammasomes in the CNS. Nat Rev Neurosci (2014) 1.44

NADPH oxidase-induced NALP3 inflammasome activation is driven by thioredoxin-interacting protein which contributes to podocyte injury in hyperglycemia. J Diabetes Res (2015) 1.43

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J Hematol Oncol (2013) 1.42

Innate and adaptive immune responses to cell death. Immunol Rev (2011) 1.40

Pyroptotic cell death defends against intracellular pathogens. Immunol Rev (2015) 1.40

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 24.43

The inflammasomes. Cell (2010) 19.37

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science (2008) 16.54

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24

Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol (2004) 7.23

Hydrogen peroxide sensing and signaling. Mol Cell (2007) 6.24

NLRX1 is a regulator of mitochondrial antiviral immunity. Nature (2008) 4.55

Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem (2002) 4.48

MAM: more than just a housekeeper. Trends Cell Biol (2009) 4.27

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat Protoc (2009) 3.65

The inflammasomes: mechanisms of activation and function. Curr Opin Immunol (2010) 3.41

VDAC: the channel at the interface between mitochondria and the cytosol. Mol Cell Biochem (2004) 3.26

Autoinflammatory disease reloaded: a clinical perspective. Cell (2010) 3.04

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Rep (2008) 2.83

The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. J Exp Med (2000) 2.67

The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ (2007) 2.49

Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol Cell Biol (2006) 2.33

Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem (2009) 2.04

Autophagy and the degradation of mitochondria. Mitochondrion (2010) 1.75

Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum. J Neurochem (2010) 1.73

Inflammasomes as microbial sensors. Eur J Immunol (2010) 1.70

Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells. J Immunol (2004) 1.61

Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax. Oncogene (2009) 1.32

NOX-free inflammasome activation. Blood (2010) 1.29

Mitochondrial dysfunction in a patient with crohn disease: possible role in pathogenesis. J Pediatr Gastroenterol Nutr (2004) 1.17

Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 24.43

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science (2008) 16.54

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55

The inflammasomes: guardians of the body. Annu Rev Immunol (2009) 12.89

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (2003) 11.07

Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24

Intracellular pattern recognition receptors in the host response. Nature (2006) 8.04

The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol (2007) 6.81

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell (2004) 6.06

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol (2004) 5.74

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature (2009) 5.00

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol (2004) 4.89

A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther (2007) 4.65

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science (2004) 4.17

NLRs join TLRs as innate sensors of pathogens. Trends Immunol (2005) 4.12

Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97

Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol (2008) 3.66

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity (2012) 3.51

PIDD mediates NF-kappaB activation in response to DNA damage. Cell (2005) 3.48

The molecular architecture of the TNF superfamily. Trends Biochem Sci (2002) 3.39

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med (2003) 3.24

Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell (2006) 3.23

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem (2006) 3.20

CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.16

Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One (2009) 2.93

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem (2002) 2.75

Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem (2006) 2.75

Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol (2007) 2.73

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol (2007) 2.68

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature (2009) 2.59

Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum (2002) 2.58

Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity (2012) 2.57

The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci (2005) 2.56

cFLIP regulation of lymphocyte activation and development. Nat Rev Immunol (2006) 2.53

Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol Cell Biol (2003) 2.50

Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med (2009) 2.45

Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity (2003) 2.41

TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity (2008) 2.37

Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity (2004) 2.36

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. Curr Biol (2009) 2.34

Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol Cell Biol (2006) 2.33

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol (2008) 2.32

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog (2009) 2.24

NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure (2003) 2.15

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol Cell Biol (2004) 2.11

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proc Natl Acad Sci U S A (2010) 2.09

Identification of proteoglycans as the APRIL-specific binding partners. J Exp Med (2005) 2.03

Caspase-independent cell death in T lymphocytes. Nat Immunol (2003) 1.99

NALP inflammasomes: a central role in innate immunity. Semin Immunopathol (2007) 1.91

Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. J Exp Med (2010) 1.86

TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood (2007) 1.85

Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol (2009) 1.74

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J (2006) 1.74

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep (2009) 1.72

NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells. Nat Immunol (2012) 1.62

Differential expression of NLRP3 among hematopoietic cells. J Immunol (2011) 1.60

The inflammasome. Curr Biol (2005) 1.58

New insights into the mechanism of IL-1beta maturation. Curr Opin Immunol (2003) 1.54

The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J Immunol (2011) 1.54

Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections. Circulation (2005) 1.52

The value of molecular analysis by PCR in the diagnosis of cutaneous lymphocytic infiltrates. J Cutan Pathol (2002) 1.51

Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. Curr Biol (2002) 1.50

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci U S A (2010) 1.50

Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. J Immunol (2010) 1.43

The role of interleukin-1 and the inflammasome in gout: implications for therapy. Arthritis Rheum (2007) 1.39

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes. Mol Cell Biol (2002) 1.36

Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. FEBS Lett (2005) 1.36

TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1. Trends Immunol (2003) 1.32

BAFF is a survival and maturation factor for mouse B cells. Eur J Immunol (2002) 1.31

Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens. PLoS One (2010) 1.29

BAFF production by antigen-presenting cells provides T cell co-stimulation. Int Immunol (2004) 1.29

Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. Gastroenterology (2007) 1.29

The role of potassium in inflammasome activation by bacteria. J Biol Chem (2010) 1.29

RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. EMBO Rep (2002) 1.23

From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases. Trends Mol Med (2007) 1.20

The role of the inflammasome in nonmyeloid cells. J Clin Immunol (2010) 1.18

Intracellular trafficking of interleukin-1 receptor I requires Tollip. Curr Biol (2006) 1.18

BAFF and the regulation of B cell survival. Immunol Lett (2003) 1.18

Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. Eur J Immunol (2011) 1.18

Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes. Mol Cell (2012) 1.17

Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system. Hepatology (2010) 1.15

NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol (2012) 1.14

The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF. Eur J Immunol (2004) 1.08

Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization. J Immunol (2008) 1.08

Protein-based therapeutic approaches targeting death receptors. Cell Death Differ (2003) 1.08

The T1796A mutation of the BRAF gene is absent in Spitz nevi. J Cutan Pathol (2004) 1.07

Analysis of 14-3-3sigma expression in hyperproliferative skin diseases reveals selective loss associated with CpG-methylation in basal cell carcinoma. Oncogene (2003) 1.04

Defective death receptor signaling as a cause of tumor immune escape. Semin Cancer Biol (2002) 1.04

Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages. Eur J Immunol (2010) 1.02

Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8. J Immunol (2005) 1.01

The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome. Immunobiology (2012) 0.96

Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci U S A (2012) 0.95

SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis. Arthritis Rheum (2010) 0.94

Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions. J Biol Chem (2002) 0.94

NALP3 is not necessary for early protection against experimental tuberculosis. Immunobiology (2010) 0.94