Published in Expert Rev Anti Infect Ther on February 01, 2011
Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly. Immunity (2012) 2.08
Role of innate immunity in neonatal infection. Am J Perinatol (2013) 1.16
Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways. J Allergy Clin Immunol (2012) 1.09
Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy. J Clin Invest (2012) 1.06
The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. PLoS One (2013) 1.03
Autoimmune dysregulation and purine metabolism in adenosine deaminase deficiency. Front Immunol (2012) 0.97
Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine. J Biol Chem (2013) 0.95
Targeting regulatory T cells to improve vaccine immunogenicity in early life. Front Microbiol (2014) 0.88
Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol (2013) 0.82
High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates. Proc Natl Acad Sci U S A (2016) 0.81
The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes. PLoS One (2015) 0.79
Toll-like receptor signaling in primary immune deficiencies. Ann N Y Acad Sci (2015) 0.79
Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage. Front Immunol (2016) 0.77
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
The inflammasomes. Cell (2010) 19.37
Receptors for purines and pyrimidines. Pharmacol Rev (1998) 13.92
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev (2001) 9.90
Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev (1999) 6.26
Caffeine therapy for apnea of prematurity. N Engl J Med (2006) 5.97
The P2X7 receptor: a key player in IL-1 processing and release. J Immunol (2006) 5.35
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov (2008) 4.76
Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol (2004) 4.28
Adenosine: an endogenous regulator of innate immunity. Trends Immunol (2004) 4.07
Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther (2006) 3.93
Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun (1988) 3.63
CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat Med (2002) 3.18
Directing transition from innate to acquired immunity: defining a role for IL-6. J Immunol (2005) 3.17
Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J Immunol (1996) 2.55
Inflammasomes: too big to miss. J Clin Invest (2009) 2.51
Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. J Immunol (2005) 2.49
Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. J Pharmacol Exp Ther (2005) 2.03
Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J Immunol (2005) 1.98
The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. J Immunol (2006) 1.94
Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells. J Immunol (2001) 1.89
Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Sci Signal (2009) 1.85
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol (2009) 1.81
An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol (2003) 1.80
Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells. Immunology (1991) 1.76
From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci U S A (2009) 1.75
How I treat ADA deficiency. Blood (2009) 1.70
Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol (2010) 1.70
Inflammasomes as microbial sensors. Eur J Immunol (2010) 1.70
Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol (2009) 1.68
Differential regulatory effects of adenosine on cytokine release by activated human monocytes. J Immunol (1994) 1.57
Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes. J Immunol (2000) 1.54
A2B adenosine receptor gene deletion attenuates murine colitis. Gastroenterology (2008) 1.49
The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol (2006) 1.48
Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein. Immunity (2009) 1.43
Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation. Adv Immunol (2005) 1.43
Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes. J Immunol (1991) 1.38
High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock. Crit Care Med (2000) 1.38
A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria. J Immunol (2003) 1.36
Adenosine: an endogenous modulator of innate immune system with therapeutic potential. Eur J Pharmacol (2009) 1.35
Blockade of adenosine A2B receptors ameliorates murine colitis. Br J Pharmacol (2008) 1.35
Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors. Am J Pathol (2007) 1.32
ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis. Cell Microbiol (2009) 1.29
Spatiotemporal control of cAMP signalling processes by anchored signalling complexes. Biochem Soc Trans (2007) 1.27
The antiviral activity of Toll-like receptor 7 and 7/8 agonists. Drug News Perspect (2008) 1.23
Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. J Infect Dis (2002) 1.23
Regulation of immune response by P2X7 receptor. Crit Rev Immunol (2006) 1.22
Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes (2008) 1.18
Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link. Immunol Rev (2010) 1.17
Caffeine for Apnea of Prematurity trial: benefits may vary in subgroups. J Pediatr (2009) 1.14
Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis. Gastroenterology (2010) 1.14
P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican mestizo patients with pulmonary tuberculosis. Clin Exp Immunol (2007) 1.11
cAMP/CREB-mediated transcriptional regulation of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) expression. J Biol Chem (2010) 1.11
Plasma deoxyadenosine, adenosine, and erythrocyte deoxyATP are elevated at birth in an adenosine deaminase-deficient child. J Clin Invest (1980) 1.10
Adjuvant activities of immune response modifier R-848: comparison with CpG ODN. Cell Immunol (2000) 1.10
NTPDase1 governs P2X7-dependent functions in murine macrophages. Eur J Immunol (2010) 1.09
Inflammasomes bridge signaling between pathogen identification and the immune response. Drugs Today (Barc) (2009) 1.08
Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases. FEBS Lett (1999) 1.07
Extracellular nucleotides as negative modulators of immunity. Curr Opin Pharmacol (2009) 1.07
Update on gene therapy for immunodeficiencies. Clin Immunol (2010) 1.03
The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans' cells. Clin Immunol (2000) 1.02
An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis models. BMC Infect Dis (2008) 1.02
Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors. Pediatr Res (2009) 1.01
Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages. J Infect Dis (2005) 1.00
Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells. J Leukoc Biol (2008) 1.00
cAMP elevators inhibit LPS-induced IL-12 p40 expression by interfering with phosphorylation of p38 MAPK in murine peritoneal macrophages. Cell Res (2002) 0.98
Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway. Int Immunopharmacol (2004) 0.97
Inhibiting adenosine deaminase modulates the systemic inflammatory response syndrome in endotoxemia and sepsis. Am J Physiol Regul Integr Comp Physiol (2002) 0.95
New insights into the pathogenesis of adenosine deaminase-severe combined immunodeficiency and progress in gene therapy. Curr Opin Allergy Clin Immunol (2009) 0.93
Adenosine receptors: what we know and what we are learning. Curr Top Med Chem (2010) 0.93
Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respir Res (2009) 0.92
Polymorphism in the p2x7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children. Pediatr Infect Dis J (2010) 0.91
Suppression of tumor necrosis factor alpha production by cAMP in human monocytes: dissociation with mRNA level and independent of interleukin-10. J Surg Res (2001) 0.91
The adenosinergic immunomodulatory drugs. Curr Opin Pharmacol (2009) 0.88
Disordered lymphoid purine metabolism contributes to the pathogenesis of persistent Borrelia garinii infection in mice. J Immunol (2010) 0.87
Adjunctive immunologic interventions in neonatal sepsis. Clin Perinatol (2010) 0.86
The effect of adenosine receptor agonists on cytokine release by human mononuclear cells depends on the specific Toll-like receptor subtype used for stimulation. Cytokine (2006) 0.85
The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol (2010) 0.85
Pentoxifylline for neonatal sepsis. Cochrane Database Syst Rev (2003) 0.85
Mycobacterium tuberculosis co-existence with humans: making an imprint on the macrophage P2X(7) receptor gene? J Med Microbiol (2008) 0.84
Inhibition of LPS-induced TNF alpha production in human monocytes by adenosine (A2) receptor selective agonists. Int J Immunopharmacol (1995) 0.83
Effects of adenosine on adhesion molecule expression and cytokine production in human PBMC depend on the receptor subtype activated. Br J Pharmacol (2007) 0.81
Reduced ligand affinity leads to an impaired function of the adenosine A2A receptor of human granulocytes in sepsis. J Cell Mol Med (2009) 0.78
Immunomodulation, part I: pentoxifylline. Neonatal Netw (2005) 0.77
Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N Engl J Med (2013) 5.06
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore) (2010) 2.26
Challenges in infant immunity: implications for responses to infection and vaccines. Nat Immunol (2011) 2.17
Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly. Immunity (2012) 2.08
TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs. J Immunol (2006) 2.05
Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia. Proc Natl Acad Sci U S A (2002) 2.01
Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood (2008) 1.94
Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010. Virology (2011) 1.80
Neonatal babesiosis: case report and review of the literature. Pediatr Infect Dis J (2006) 1.78
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci U S A (2009) 1.77
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis (2007) 1.71
Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics (2011) 1.70
Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo. Pediatr Res (2006) 1.59
Neck injury and fibromyalgia-- are they really associated? J Rheumatol (2006) 1.56
Opioid receptors control viral replication in the airways. Crit Care Med (2013) 1.43
Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. J Allergy Clin Immunol (2004) 1.43
Role of innate host defenses in susceptibility to early-onset neonatal sepsis. Clin Perinatol (2010) 1.39
Management of first-time dislocations of the shoulder in patients older than 40 years: the prevalence of iatrogenic fracture. J Orthop Trauma (2013) 1.39
Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. J Infect Dis (2002) 1.38
Developmental biology of the innate immune response: implications for neonatal and infant vaccine development. Pediatr Res (2009) 1.33
Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunol Rev (2005) 1.28
Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. J Immunol (2003) 1.23
Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants. PLoS One (2011) 1.22
Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. J Infect Dis (2004) 1.18
Safety and efficacy of neonatal vaccination. Eur J Immunol (2009) 1.17
Role of innate immunity in neonatal infection. Am J Perinatol (2013) 1.16
Arthroscopic management of the painful snapping scapula. Arthroscopy (2006) 1.11
Development of newborn and infant vaccines. Sci Transl Med (2011) 1.09
Plasma-mediated immune suppression: a neonatal perspective. Pediatr Allergy Immunol (2012) 1.09
Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways. J Allergy Clin Immunol (2012) 1.09
Neonatal and infantile immune responses to encapsulated bacteria and conjugate vaccines. Clin Dev Immunol (2008) 1.07
Operative management of the frozen shoulder in patients with diabetes. J Shoulder Elbow Surg (2002) 1.05
Prospective validation of a prognostic model for respiratory syncytial virus bronchiolitis in late preterm infants: a multicenter birth cohort study. PLoS One (2013) 1.05
TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS One (2010) 1.04
Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors. PLoS One (2012) 1.04
The role of arthroscopy for the problem shoulder arthroplasty. J Shoulder Elbow Surg (2002) 1.03
The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. PLoS One (2013) 1.03
Geometrical analysis of Copeland surface replacement shoulder arthroplasty in relation to normal anatomy. J Shoulder Elbow Surg (2005) 1.02
Systemic stimulation of TLR2 impairs neonatal mouse brain development. PLoS One (2011) 1.02
Evidence of a bactericidal permeability increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI. Proc Natl Acad Sci U S A (2007) 1.02
High incidence of recurrent wheeze in children with down syndrome with and without previous respiratory syncytial virus lower respiratory tract infection. Pediatr Infect Dis J (2010) 1.02
The association between intrauterine inflammation and spontaneous vaginal delivery at term: a cross-sectional study. PLoS One (2009) 1.02
Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites. Trends Immunol (2008) 1.02
Wear in the prosthetic shoulder: association with design parameters. J Biomech Eng (2007) 1.00
The "anchor shape" technique for long head of the biceps tenotomy to avoid the popeye deformity. Arthrosc Tech (2013) 0.99
Neonatal innate immunity in allergy development. Curr Opin Pediatr (2009) 0.99
Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. Sci Transl Med (2011) 0.98
Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease. Infect Immun (2006) 0.98
Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept. Proc Natl Acad Sci U S A (2009) 0.98
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Pediatr Infect Dis J (2009) 0.97
Distinct abnormalities in the innate immune system of children with Down syndrome. J Pediatr (2010) 0.97
Responsiveness of human monocytes to the commensal bacterium Staphylococcus epidermidis develops late in gestation. Pediatr Res (2012) 0.95
Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine. J Biol Chem (2013) 0.95
Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol (2008) 0.95
Clinical prediction rule for RSV bronchiolitis in healthy newborns: prognostic birth cohort study. Pediatrics (2010) 0.95
Arthroscopic treatment of a massive acromioclavicular joint cyst. Arthroscopy (2006) 0.94
17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. J Leukoc Biol (2011) 0.94
IL-13 genetic polymorphism identifies children with late wheezing after respiratory syncytial virus infection. J Allergy Clin Immunol (2007) 0.93
Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes. Eur J Immunol (2013) 0.92
Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system. Microbes Infect (2010) 0.92
Neonatal immune responses to coagulase-negative staphylococci. Curr Opin Infect Dis (2007) 0.92
Subacromial plica as a cause of impingement in the shoulder. J Shoulder Elbow Surg (2006) 0.91
Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection. PLoS One (2013) 0.91
Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis. Innate Immun (2010) 0.91
Respiratory syncytial virus and recurrent wheeze. N Engl J Med (2013) 0.89
Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein. Am J Physiol Gastrointest Liver Physiol (2005) 0.89
Genetic predisposition of RSV infection-related respiratory morbidity in preterm infants. Eur J Pediatr (2014) 0.88
Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheeze. Respir Res (2011) 0.88
Can fibromyalgia be associated with whiplash injury? A 3-year follow-up study. Rheumatol Int (2010) 0.88
Human neonatal peripheral blood leukocytes demonstrate pathogen-specific coordinate expression of TLR2, TLR4/MD2, and MyD88 during bacterial infection in vivo. Pediatr Res (2010) 0.88
Immune thrombocytopenic purpura following influenza vaccination. Isr Med Assoc J (2006) 0.87
Reverse shoulder arthroplasty with a short metaphyseal humeral stem. Int Orthop (2014) 0.87
Medium to long-term outcome of thoracoscapular arthrodesis with screw fixation for facioscapulohumeral muscular dystrophy. J Bone Joint Surg Am (2013) 0.87
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Pediatr Pulmonol (2010) 0.86
Hip arthroscopy: an emerging technique and indications. Isr Med Assoc J (2012) 0.85
Gene expression differences in lungs of mice during secondary immune responses to respiratory syncytial virus infection. J Virol (2010) 0.85
A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses. PLoS One (2012) 0.84
Proteins involved in extracellular matrix dynamics are associated with respiratory syncytial virus disease severity. Eur Respir J (2012) 0.83
Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapy. Biochem Soc Trans (2011) 0.83
Neonatal host defense against Staphylococcal infections. Clin Dev Immunol (2013) 0.83
Aortoesophageal fistula due to double aortic arch and prolonged nasogastric intubation: case report and review of the literature. Eur J Pediatr (2006) 0.83
Systemic signature of the lung response to respiratory syncytial virus infection. PLoS One (2011) 0.83
Histologic evaluation of the glenohumeral joint capsule after radiofrequency capsular shrinkage for atraumatic instability. J Shoulder Elbow Surg (2006) 0.83
Defective control of vitamin D receptor-mediated epithelial STAT1 signalling predisposes to severe respiratory syncytial virus bronchiolitis. J Pathol (2014) 0.82
Endotoxin-directed innate immunity in tracheal aspirates of mechanically ventilated human neonates. Pediatr Res (2009) 0.81
Decreased thymic output accounts for decreased naive T cell numbers in children with Down syndrome. J Immunol (2011) 0.81
The effect of balneotherapy on osteoarthritis. Is an intermittent regimen effective? Eur J Intern Med (2004) 0.81
Long-term result after traumatic anterior shoulder dislocation: what works best? Musculoskelet Surg (2011) 0.80
The vertical-apical suture Bankart lesion repair for anteroinferior glenohumeral instability. J Shoulder Elbow Surg (2002) 0.80
Mechanical properties of regenerated coracoacromial ligament after subacromial decompression. J Shoulder Elbow Surg (2004) 0.79
Stress fracture of the clavicle in a patient with no obvious risk factors. Ann R Coll Surg Engl (2005) 0.79