Published in PLoS One on March 02, 2010
Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment. Invest Ophthalmol Vis Sci (2011) 2.14
CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function. Invest Ophthalmol Vis Sci (2014) 1.51
Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. Proc Natl Acad Sci U S A (2011) 1.47
CNTF and retina. Prog Retin Eye Res (2011) 1.34
Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa. Am J Ophthalmol (2013) 1.34
Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. Mol Ther (2013) 1.10
Current concepts in the treatment of retinitis pigmentosa. J Ophthalmol (2010) 1.03
Gene therapy in animal models of autosomal dominant retinitis pigmentosa. Mol Vis (2012) 0.99
CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS One (2011) 0.97
Functional architecture of the retina: development and disease. Prog Retin Eye Res (2014) 0.96
Retinal degeneration in two lines of transgenic S334ter rats. Exp Eye Res (2010) 0.96
Ciliary neurotrophic factor for macular telangiectasia type 2: results from a phase 1 safety trial. Am J Ophthalmol (2014) 0.96
Oncostatin M protects rod and cone photoreceptors and promotes regeneration of cone outer segment in a rat model of retinal degeneration. PLoS One (2011) 0.90
Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration in rat models of retinal degenerative disease. Invest Ophthalmol Vis Sci (2012) 0.90
Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival. Exp Eye Res (2015) 0.86
Spectral-domain optical coherence tomography staging and autofluorescence imaging in achromatopsia. JAMA Ophthalmol (2014) 0.86
A novel protective role for the innate immunity Toll-Like Receptor 3 (TLR3) in the retina via Stat3. Mol Cell Neurosci (2014) 0.85
CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa. Mol Ther (2015) 0.85
Rearrangement of the cone mosaic in the retina of the rat model of retinitis pigmentosa. J Comp Neurol (2012) 0.83
Regeneration of cone outer segments induced by CNTF. Adv Exp Med Biol (2012) 0.83
Prospectives for gene therapy of retinal degenerations. Curr Genomics (2012) 0.83
Activation of Wnt/β-catenin signaling in Muller glia protects photoreceptors in a mouse model of inherited retinal degeneration. Neuropharmacology (2014) 0.82
Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration. Eur J Neurosci (2012) 0.82
Spontaneous Regeneration of Human Photoreceptor Outer Segments. Sci Rep (2015) 0.81
Hypoxia-regulated retinal glial cell-specific promoter for potential gene therapy in disease. Invest Ophthalmol Vis Sci (2011) 0.81
Phenotypic characteristics including in vivo cone photoreceptor mosaic in KCNV2-related "cone dystrophy with supernormal rod electroretinogram". Invest Ophthalmol Vis Sci (2013) 0.81
Mesenchymal stem cells for retinal diseases. Int J Ophthalmol (2011) 0.80
A novel in vivo model of focal light emitting diode-induced cone-photoreceptor phototoxicity: neuroprotection afforded by brimonidine, BDNF, PEDF or bFGF. PLoS One (2014) 0.80
Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88. Exp Neurol (2015) 0.78
Clinical and Rehabilitative Management of Retinitis Pigmentosa: Up-to-Date. Curr Genomics (2011) 0.78
Reshaping the Cone-Mosaic in a Rat Model of Retinitis Pigmentosa: Modulatory Role of ZO-1 Expression in DL-Alpha-Aminoadipic Acid Reshaping. PLoS One (2016) 0.77
Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia. Invest Ophthalmol Vis Sci (2015) 0.77
Defining the Relationships Among Retinal Function, Layer Thickness and Visual Behavior During Oxidative Stress-Induced Retinal Degeneration. Curr Eye Res (2015) 0.76
Quantifying the metabolic contribution to photoreceptor death in retinitis pigmentosa via a mathematical model. J Theor Biol (2016) 0.75
Chapter 6 - Restoring Vision to the Blind: Neuroprotection. Transl Vis Sci Technol (2014) 0.75
Sustained Neural Stem Cell-Based Intraocular Delivery of CNTF Attenuates Photoreceptor Loss in the nclf Mouse Model of Neuronal Ceroid Lipofuscinosis. PLoS One (2015) 0.75
Retinitis pigmentosa. Lancet (2006) 13.62
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron (1995) 3.51
Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci U S A (2006) 3.49
Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res (2004) 3.43
Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci (2008) 2.94
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci U S A (1992) 2.78
Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Exp Eye Res (2003) 2.73
Identification and characterization of rod-derived cone viability factor. Nat Genet (2004) 2.63
Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci U S A (2006) 2.57
Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci (1998) 2.32
Microglia activation in retinal degeneration. J Leukoc Biol (2007) 2.31
Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci (2002) 1.97
Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor. Nature (1990) 1.80
Mouse cone arrestin expression pattern: light induced translocation in cone photoreceptors. Mol Vis (2002) 1.78
Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. J Cell Physiol (2005) 1.73
Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neurons. Science (1979) 1.66
Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res (2002) 1.56
Mechanisms of photoreceptor death and survival in mammalian retina. Prog Retin Eye Res (1999) 1.53
Selective lectin binding of the developing mouse retina. J Comp Neurol (1983) 1.52
Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J Neurosci (1998) 1.51
Purification, cloning, and expression of ciliary neurotrophic factor (CNTF). Science (1989) 1.50
Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther (1997) 1.45
Inherited retinal degenerations: therapeutic prospects. Biol Cell (2004) 1.44
Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Mol Ther (2001) 1.43
Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration. J Neurosci (1999) 1.40
Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. Development (1997) 1.37
Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci (2006) 1.23
Application of encapsulated cell technology for retinal degenerative diseases. Expert Opin Biol Ther (2006) 1.14
Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration. Invest Ophthalmol Vis Sci (1999) 1.14
Cholinergic neuronotrophic factors: I. Survival, neurite outgrowth and choline acetyltransferase activity in monolayer cultures from chick embryo ciliary ganglia. Brain Res (1979) 1.10
Ciliary neurotrophic factor promotes chick photoreceptor development in vitro. Development (1995) 1.08
Müller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of development. Development (1997) 1.08
Ciliary neurotrophic factor promotes muller glia differentiation from the postnatal retinal progenitor pool. Dev Neurosci (2004) 1.07
Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo. Neurobiol Dis (2000) 1.05
CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters. Invest Ophthalmol Vis Sci (1999) 1.03
A combination of CNTF and BDNF rescues rd photoreceptors but changes rod differentiation in the presence of RPE in retinal explants. Invest Ophthalmol Vis Sci (2001) 0.97
Ciliary neurotrophic factor as a transient negative regulator of rod development in rat retina. Invest Ophthalmol Vis Sci (2002) 0.95
Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells. Neuroscience (1999) 0.93
Biochemical characterization of the major peanut-agglutinin-binding glycoproteins in vertebrate retinae. J Comp Neurol (1986) 0.91
Green cone opsin and rhodopsin regulation by CNTF and staurosporine in cultured chick photoreceptors. Invest Ophthalmol Vis Sci (2000) 0.89
CNTF exerts opposite effects on in vitro development of rat and chick photoreceptors. Neuroreport (1996) 0.87
CNTF negatively regulates the phototransduction machinery in rod photoreceptors: implication for light-induced photostasis plasticity. Adv Exp Med Biol (2008) 0.86
Cone-rod dependence in the rat retina: variation with the rate of rod damage. Invest Ophthalmol Vis Sci (2009) 0.82
Involvement of Ath3 in CNTF-mediated differentiation of the late retinal progenitors. Mol Cell Neurosci (2004) 0.81
IRE1 signaling affects cell fate during the unfolded protein response. Science (2007) 9.01
Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci U S A (2006) 3.49
Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol (2003) 3.04
Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI. Nat Protoc (2008) 2.29
Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment. Invest Ophthalmol Vis Sci (2011) 2.14
Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci (2002) 1.97
AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun (2004) 1.95
Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa. Am J Hum Genet (2011) 1.85
Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1. J Biol Chem (2002) 1.48
Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Invest Ophthalmol Vis Sci (2008) 1.47
Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. Proc Natl Acad Sci U S A (2011) 1.47
Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells. Invest Ophthalmol Vis Sci (2005) 1.40
CNTF and retina. Prog Retin Eye Res (2011) 1.34
Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa. Am J Ophthalmol (2013) 1.34
A 4-year update on the safety of sildenafil citrate (Viagra). Urology (2002) 1.28
Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology. Invest Ophthalmol Vis Sci (2004) 1.27
Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery. Invest Ophthalmol Vis Sci (2008) 1.24
Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci (2006) 1.23
Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci (2007) 1.22
Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. J Physiol (2012) 1.17
Increased expression of ceruloplasmin in the retina following photic injury. Mol Vis (2003) 1.13
Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo. Exp Eye Res (2010) 1.12
Acute increase of intraocular pressure releases ATP into the anterior chamber. Exp Eye Res (2007) 1.12
Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. Mol Ther (2013) 1.10
Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. PLoS One (2012) 1.10
Misfolded proteins and retinal dystrophies. Adv Exp Med Biol (2010) 1.09
Notch and Schwann cell transformation. Oncogene (2004) 1.08
A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap. Invest Ophthalmol Vis Sci (2010) 1.06
Two-year intraocular delivery of ciliary neurotrophic factor by encapsulated cell technology implants in patients with chronic retinal degenerative diseases. Invest Ophthalmol Vis Sci (2012) 1.05
AMPK exerts dual regulatory effects on the PI3K pathway. J Mol Signal (2010) 1.05
Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells. PLoS One (2012) 1.05
CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina. Exp Eye Res (2005) 1.04
Regulation of neonatal development of retinal ganglion cell dendrites by neurotrophin-3 overexpression. J Comp Neurol (2009) 1.04
Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration. Int J Inflam (2013) 1.04
Identification of the A3 adenosine receptor in rat retinal ganglion cells. Mol Vis (2006) 1.04
Balance of purines may determine life or death of retinal ganglion cells as A3 adenosine receptors prevent loss following P2X7 receptor stimulation. J Neurochem (2006) 1.03
Choroidal thickness in fellow eyes of patients with acute primary angle-closure measured by enhanced depth imaging spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci (2013) 1.01
Degradation of extracellular ATP by the retinal pigment epithelium. Am J Physiol Cell Physiol (2005) 0.98
Collagen: a potential factor involved in the pathogenesis of glaucoma. Med Sci Monit Basic Res (2013) 0.97
CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS One (2011) 0.97
Exacerbation of retinal degeneration and choroidal neovascularization induced by subretinal injection of Matrigel in CCL2/MCP-1-deficient mice. Ophthalmic Res (2005) 0.96
Induction of focal angiogenesis through adenoviral vector mediated vascular endothelial cell growth factor gene transfer in the mature mouse brain. Angiogenesis (2003) 0.96
Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device. Tissue Eng (2005) 0.96
Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem (2012) 0.96
Translocation of the retinal pigment epithelium and formation of sub-retinal pigment epithelium deposit induced by subretinal deposit. Mol Vis (2007) 0.96
14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1. Mol Endocrinol (2002) 0.95
Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci (2008) 0.94
Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina. Exp Eye Res (2007) 0.94
Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells. Am J Physiol Cell Physiol (2012) 0.94
Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor. FASEB J (2013) 0.93
CCR3 and choroidal neovascularization. PLoS One (2011) 0.92
The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells. Neurochem Int (2009) 0.91
Oncostatin M protects rod and cone photoreceptors and promotes regeneration of cone outer segment in a rat model of retinal degeneration. PLoS One (2011) 0.90
Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma. Exp Eye Res (2011) 0.89
Photoreceptor protection by cardiotrophin-1 in transgenic rats with the rhodopsin mutation s334ter. Invest Ophthalmol Vis Sci (2003) 0.89
Retinal TrkB receptors regulate neural development in the inner, but not outer, retina. Mol Cell Neurosci (2008) 0.88
BDNF reduces the retinal toxicity of verteporfin photodynamic therapy. Invest Ophthalmol Vis Sci (2004) 0.88
Identification of a novel inducible cytosolic Hsp70 gene in Chinese shrimp Fenneropenaeus chinensis and comparison of its expression with the cognate Hsc70 under different stresses. Cell Stress Chaperones (2009) 0.88
Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog. Biochem Pharmacol (2004) 0.87
TRPC6 channel protects retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death. Invest Ophthalmol Vis Sci (2010) 0.87
Sustained-release tablets of indomethacin-loaded microcapsules: preparation, in vitro and in vivo characterization. Int J Pharm (2006) 0.86
Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease. PLoS One (2013) 0.86
CNTF negatively regulates the phototransduction machinery in rod photoreceptors: implication for light-induced photostasis plasticity. Adv Exp Med Biol (2008) 0.86
A strong genetic determinant of hyperoxia-related retinal degeneration on mouse chromosome 6. Invest Ophthalmol Vis Sci (2007) 0.85
Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells. Adv Exp Med Biol (2014) 0.85
Acute nonarteritic anterior ischemic optic neuropathy and exposure to phosphodiesterase type 5 inhibitors. J Sex Med (2014) 0.85
Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells. Purinergic Signal (2006) 0.84
Regeneration of cone outer segments induced by CNTF. Adv Exp Med Biol (2012) 0.83
SMAD7: a timer of tumor progression targeting TGF-β signaling. Tumour Biol (2014) 0.83
Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapy. Invest Ophthalmol Vis Sci (2007) 0.83
Matrix metalloproteinase 1: role in sarcoma biology. PLoS One (2010) 0.83
Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium. Hum Gene Ther (2007) 0.82
Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells. Graefes Arch Clin Exp Ophthalmol (2005) 0.81
CREB1/ATF1 activation in photoreceptor degeneration and protection. Invest Ophthalmol Vis Sci (2009) 0.81
A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration. Am J Ophthalmol (2002) 0.81
Nerve fiber layer splaying at vascular crossings. Invest Ophthalmol Vis Sci (2002) 0.80
Caspase inhibitors protect against NMDA-mediated retinal ganglion cell death. Clin Experiment Ophthalmol (2011) 0.80