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1
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The essential toxin: impact of zinc on human health.
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Int J Environ Res Public Health
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2010
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2.09
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2
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Zinc-altered immune function.
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J Nutr
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2003
|
2.06
|
|
3
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Functional significance of zinc-related signaling pathways in immune cells.
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Annu Rev Nutr
|
2009
|
1.46
|
|
4
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Zinc and diabetes--clinical links and molecular mechanisms.
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J Nutr Biochem
|
2009
|
1.45
|
|
5
|
Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes.
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J Immunol
|
2008
|
1.31
|
|
6
|
Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells.
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Anal Biochem
|
2006
|
1.21
|
|
7
|
Zinc supplementation for the treatment or prevention of disease: current status and future perspectives.
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Exp Gerontol
|
2007
|
1.14
|
|
8
|
A new closed-tube multiplex real-time PCR to detect eleven superantigens of Streptococcus pyogenes identifies a strain without superantigen activity.
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Int J Med Microbiol
|
2007
|
1.13
|
|
9
|
Superantigen genes are more important than the emm type for the invasiveness of group A Streptococcus infection.
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J Infect Dis
|
2010
|
1.11
|
|
10
|
Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression.
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J Leukoc Biol
|
2011
|
1.08
|
|
11
|
Zinc-dependent suppression of TNF-alpha production is mediated by protein kinase A-induced inhibition of Raf-1, I kappa B kinase beta, and NF-kappa B.
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J Immunol
|
2007
|
1.06
|
|
12
|
Signal transduction in monocytes: the role of zinc ions.
|
Biometals
|
2007
|
1.06
|
|
13
|
Zinc-mediated inhibition of cyclic nucleotide phosphodiesterase activity and expression suppresses TNF-alpha and IL-1 beta production in monocytes by elevation of guanosine 3',5'-cyclic monophosphate.
|
J Immunol
|
2005
|
1.05
|
|
14
|
Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases.
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Arch Immunol Ther Exp (Warsz)
|
2008
|
1.04
|
|
15
|
Multiple impacts of zinc on immune function.
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Metallomics
|
2014
|
1.04
|
|
16
|
The immune system and the impact of zinc during aging.
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Immun Ageing
|
2009
|
1.03
|
|
17
|
Regulatory T cells increased while IL-1β decreased during antidepressant therapy.
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J Psychiatr Res
|
2010
|
1.02
|
|
18
|
Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles.
|
Exp Gerontol
|
2007
|
1.02
|
|
19
|
Zinc signals promote IL-2-dependent proliferation of T cells.
|
Eur J Immunol
|
2010
|
0.97
|
|
20
|
The Th17/Treg balance is disturbed during aging.
|
Exp Gerontol
|
2013
|
0.97
|
|
21
|
Zinc signals and immune function.
|
Biofactors
|
2013
|
0.94
|
|
22
|
Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc.
|
J Nutr Biochem
|
2012
|
0.94
|
|
23
|
Zinc homeostasis in aging: two elusive faces of the same "metal".
|
Rejuvenation Res
|
2006
|
0.93
|
|
24
|
Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.
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J Leukoc Biol
|
2007
|
0.92
|
|
25
|
Immunosenescence of polymorphonuclear neutrophils.
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ScientificWorldJournal
|
2010
|
0.92
|
|
26
|
Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators.
|
Immunology
|
2006
|
0.91
|
|
27
|
Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study.
|
Biogerontology
|
2006
|
0.91
|
|
28
|
Correlation between zinc status and immune function in the elderly.
|
Biogerontology
|
2006
|
0.90
|
|
29
|
Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study.
|
Clin Chem Lab Med
|
2008
|
0.90
|
|
30
|
Crosslinking of CD66B on peripheral blood neutrophils mediates the release of interleukin-8 from intracellular storage.
|
Hum Immunol
|
2006
|
0.90
|
|
31
|
Differential gene expression after zinc supplementation and deprivation in human leukocyte subsets.
|
Mol Med
|
2007
|
0.90
|
|
32
|
Neutrophil immunity of the elderly.
|
Mech Ageing Dev
|
2003
|
0.90
|
|
33
|
Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study.
|
Exp Gerontol
|
2008
|
0.88
|
|
34
|
Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.
|
Rejuvenation Res
|
2008
|
0.87
|
|
35
|
TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation.
|
Exp Gerontol
|
2007
|
0.87
|
|
36
|
Overproduction of monokines by leukocytes after stimulation with lipopolysaccharide in the elderly.
|
Exp Gerontol
|
2002
|
0.87
|
|
37
|
Contrasting contributions of complementarity-determining region 2 and hypervariable region 4 of rat BV8S2+ (Vbeta8.2) TCR to the recognition of myelin basic protein and different types of bacterial superantigens.
|
Int Immunol
|
2004
|
0.87
|
|
38
|
Zinc deficiency induces production of the proinflammatory cytokines IL-1β and TNFα in promyeloid cells via epigenetic and redox-dependent mechanisms.
|
J Nutr Biochem
|
2012
|
0.85
|
|
39
|
T-lymphocytes: a target for stimulatory and inhibitory effects of zinc ions.
|
Endocr Metab Immune Disord Drug Targets
|
2009
|
0.85
|
|
40
|
Assessment of gene-nutrient interactions on inflammatory status of the elderly with the use of a zinc diet score--ZINCAGE study.
|
J Nutr Biochem
|
2009
|
0.85
|
|
41
|
Differential regulation of TLR-dependent MyD88 and TRIF signaling pathways by free zinc ions.
|
J Immunol
|
2013
|
0.84
|
|
42
|
Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts.
|
Biochem Biophys Res Commun
|
2010
|
0.83
|
|
43
|
MHC class II molecules activate NFAT and the ERK group of MAPK through distinct signaling pathways in B cells.
|
Eur J Immunol
|
2009
|
0.83
|
|
44
|
Mycoplasma arthritidis-derived superantigen (MAM) displays DNase activity.
|
FEMS Immunol Med Microbiol
|
2007
|
0.82
|
|
45
|
PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation.
|
Metallomics
|
2014
|
0.82
|
|
46
|
Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals.
|
Biogerontology
|
2006
|
0.82
|
|
47
|
Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio.
|
BMC Immunol
|
2006
|
0.81
|
|
48
|
Cadmium ions induce monocytic production of tumor necrosis factor-alpha by inhibiting mitogen activated protein kinase dephosphorylation.
|
Toxicol Lett
|
2010
|
0.81
|
|
49
|
Changes in chromatin structure and methylation of the human interleukin-1beta gene during monopoiesis.
|
Immunology
|
2010
|
0.81
|
|
50
|
Differential impact of zinc deficiency on phagocytosis, oxidative burst, and production of pro-inflammatory cytokines by human monocytes.
|
Metallomics
|
2014
|
0.80
|
|
51
|
Dendritic cell subsets in lymph nodes are characterized by the specific draining area and influence the phenotype and fate of primed T cells.
|
Immunology
|
2007
|
0.80
|
|
52
|
Zinc differentially regulates mitogen-activated protein kinases in human T cells.
|
J Nutr Biochem
|
2011
|
0.80
|
|
53
|
The consumption of cigarettes, coffee and sweets in detoxified alcoholics and its association with relapse and a family history of alcoholism.
|
Eur Psychiatry
|
2005
|
0.80
|
|
54
|
T-helper type 1 cytokine release is enhanced by in vitro zinc supplementation due to increased natural killer cells.
|
Nutrition
|
2006
|
0.79
|
|
55
|
Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3.
|
J Leukoc Biol
|
2010
|
0.79
|
|
56
|
Zinc ions cause the thimerosal-induced signal of fluorescent calcium probes in lymphocytes.
|
Cell Calcium
|
2008
|
0.79
|
|
57
|
Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species.
|
Toxicol Appl Pharmacol
|
2010
|
0.79
|
|
58
|
Cadmium ions promote monocytic differentiation of human leukemia HL-60 cells treated with 1α,25-dihydroxyvitamin D3.
|
Biol Chem
|
2010
|
0.78
|
|
59
|
UK food standards agency workshop report: diet and immune function.
|
Br J Nutr
|
2010
|
0.78
|
|
60
|
Repletion of zinc in zinc-deficient cells strongly up-regulates IL-1β-induced IL-2 production in T-cells.
|
Metallomics
|
2012
|
0.78
|
|
61
|
Zinc as a micronutrient and its preventive role of oxidative damage in cells.
|
Food Funct
|
2015
|
0.78
|
|
62
|
IFN-gamma reduction by tricyclic antidepressants.
|
Int J Psychiatry Med
|
2010
|
0.78
|
|
63
|
Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation.
|
Genes Nutr
|
2014
|
0.78
|
|
64
|
In vitro and in vivo effects of zinc on cytokine signalling in human T cells.
|
Exp Gerontol
|
2007
|
0.78
|
|
65
|
Metallothionein downregulation in very old age: a phenomenon associated with cellular senescence?
|
Rejuvenation Res
|
2008
|
0.78
|
|
66
|
Surveillance program for former PCB-exposed workers of a transformer and capacitor recycling company, family members, employees of surrounding companies, and area residents--executive summary.
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J Toxicol Environ Health A
|
2012
|
0.78
|
|
67
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Differential synthesis of two interleukin-1 receptor antagonist variants and interleukin-8 by peripheral blood neutrophils.
|
Cytokine
|
2005
|
0.78
|
|
68
|
Effects of long-term zinc supplementation and deprivation on gene expression in human THP-1 mononuclear cells.
|
J Trace Elem Med Biol
|
2008
|
0.77
|
|
69
|
The superantigen staphylococcal enterotoxin A (SEA) and monoclonal antibody L243 share a common epitope but differ in their ability to induce apoptosis via MHC-II.
|
Immunobiology
|
2006
|
0.77
|
|
70
|
Application of Zinpyr-1 for the investigation of zinc signals in Escherichia coli.
|
Biometals
|
2013
|
0.77
|
|
71
|
Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study.
|
Ann N Y Acad Sci
|
2007
|
0.77
|
|
72
|
Zinc and ageing (ZINCAGE Project).
|
Biogerontology
|
2006
|
0.77
|
|
73
|
The superantigen-induced polarization of T cells in rat peripheral lymph nodes is influenced by genetic polymorphisms in the IL-4 and IL-6 gene clusters.
|
Int Immunol
|
2006
|
0.77
|
|
74
|
Effects of human Toll-like receptor 1 polymorphisms on ageing.
|
Immun Ageing
|
2013
|
0.77
|
|
75
|
Zinc signals in neutrophil granulocytes are required for the formation of neutrophil extracellular traps.
|
Innate Immun
|
2012
|
0.77
|
|
76
|
Activation of IL-1β and TNFα genes is mediated by the establishment of permissive chromatin structures during monopoiesis.
|
Immunobiology
|
2012
|
0.76
|
|
77
|
Impact of lead and mercuric ions on the interleukin-2-dependent proliferation and survival of T cells.
|
Arch Toxicol
|
2012
|
0.76
|
|
78
|
Superantigen-presentation by rat major histocompatibility complex class II molecules RT1.Bl and RT1.Dl.
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Immunology
|
2008
|
0.75
|