Published in Neuron on May 19, 2005
Amyloid precursor protein trafficking, processing, and function. J Biol Chem (2008) 4.79
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron (2007) 2.55
Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease? Nat Rev Neurosci (2010) 2.34
APP processing in Alzheimer's disease. Mol Brain (2011) 2.02
The many substrates of presenilin/γ-secretase. J Alzheimers Dis (2011) 2.02
The amyloid precursor protein: beyond amyloid. Mol Neurodegener (2006) 1.98
The Alzheimer's disease beta-secretase enzyme, BACE1. Mol Neurodegener (2007) 1.81
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep (2006) 1.72
The amyloid-beta precursor protein: integrating structure with biological function. EMBO J (2005) 1.68
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A (2007) 1.61
Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener (2011) 1.58
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem (2008) 1.54
Neurogenesis and Alzheimer's disease: at the crossroads. Exp Neurol (2009) 1.54
Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem (2011) 1.50
A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injury. Brain Pathol (2008) 1.46
Physiological functions of APP family proteins. Cold Spring Harb Perspect Med (2012) 1.44
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A (2010) 1.38
Pathological and physiological functions of presenilins. Mol Neurodegener (2006) 1.38
Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role. Mol Neurodegener (2008) 1.28
A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem (2010) 1.28
Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep (2008) 1.27
Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD). Mol Biol Cell (2006) 1.26
An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener (2007) 1.22
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem (2010) 1.21
Physiological roles for amyloid beta peptides. J Physiol (2006) 1.16
A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem (2005) 1.16
Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration. Mol Cell Biol (2006) 1.14
The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains. Mol Neurodegener (2009) 1.12
Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS One (2010) 1.11
The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus. J Neurosci (2012) 1.11
Prion protein and Alzheimer disease. Prion (2009) 1.05
Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease. Front Physiol (2012) 1.05
Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. PLoS Biol (2008) 1.03
Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease. Neurobiol Aging (2008) 1.02
Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin. Mol Biol Cell (2007) 0.99
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease? Mol Neurodegener (2011) 0.99
Impaired β-amyloid secretion in Alzheimer's disease pathogenesis. J Neurosci (2011) 0.99
BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. J Biol Chem (2009) 0.99
Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis. Transl Neurodegener (2012) 0.98
Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant? Biochem J (2012) 0.97
Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling. Front Physiol (2012) 0.97
Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry (2013) 0.95
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling. EMBO Rep (2011) 0.94
Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease. Front Aging Neurosci (2013) 0.94
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. J Biol Chem (2009) 0.94
A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injury. J Neurotrauma (2009) 0.94
Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease. Front Aging Neurosci (2014) 0.94
Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells. PLoS One (2010) 0.93
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS One (2011) 0.92
Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories. Neurobiol Aging (2008) 0.92
In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin. Neurotoxicology (2011) 0.92
Mutant presenilin 1 increases the expression and activity of BACE1. J Biol Chem (2009) 0.91
TMP21 transmembrane domain regulates gamma-secretase cleavage. J Biol Chem (2009) 0.90
The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease. Curr Genomics (2007) 0.90
What is the role of amyloid precursor protein dimerization? Cell Adh Migr (2010) 0.90
The role of APP proteolytic processing in lipid metabolism. Exp Brain Res (2011) 0.90
beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. FEBS J (2010) 0.89
The E2 domains of APP and APLP1 share a conserved mode of dimerization. Biochemistry (2011) 0.89
Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease. Biomol Ther (Seoul) (2012) 0.89
The keystone of Alzheimer pathogenesis might be sought in Aβ physiology. Neuroscience (2015) 0.89
Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks. Proc Natl Acad Sci U S A (2009) 0.88
Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism. PLoS One (2011) 0.88
The Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it? Int J Alzheimers Dis (2012) 0.88
Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes. PLoS One (2012) 0.87
Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease. Neurobiol Aging (2013) 0.86
Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. PLoS One (2008) 0.85
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett (2011) 0.85
The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury. Aging Dis (2016) 0.84
Turnover of amyloid precursor protein family members determines their nuclear signaling capability. PLoS One (2013) 0.84
Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease. PLoS One (2014) 0.84
Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex. BMC Genomics (2011) 0.83
APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression. Front Aging Neurosci (2015) 0.83
Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease. Int J Alzheimers Dis (2011) 0.82
A TAG on to the neurogenic functions of APP. Cell Adh Migr (2008) 0.82
p53-dependent control of transactivation of the Pen2 promoter by presenilins. J Cell Sci (2009) 0.82
Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain. PLoS One (2012) 0.81
The γ-secretase complex: from structure to function. Front Cell Neurosci (2014) 0.81
The amyloid precursor protein intracellular domain-fe65 multiprotein complexes: a challenge to the amyloid hypothesis for Alzheimer's disease? Int J Alzheimers Dis (2012) 0.81
Presenilins regulate the cellular level of the tumor suppressor PTEN. Neurobiol Aging (2007) 0.80
APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses. Elife (2015) 0.80
β-Amyloid peptides and amyloid plaques in Alzheimer's disease. Neurotherapeutics (2015) 0.80
CD74 interacts with APP and suppresses the production of Abeta. Mol Neurodegener (2009) 0.80
Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo. PLoS One (2010) 0.80
Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles. J Biol Chem (2015) 0.80
Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology. J Cell Mol Med (2011) 0.79
Alphabeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures. J Mol Neurosci (2009) 0.79
Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty. PLoS One (2013) 0.78
Gene expression profiling in cells with enhanced gamma-secretase activity. PLoS One (2009) 0.78
Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer's disease. BMC Complement Altern Med (2015) 0.78
Mediator: the missing link in amyloid precursor protein nuclear signalling. EMBO Rep (2011) 0.77
AICD Overexpression in Neuro 2A Cells Regulates Expression of PTCH1 and TRPC5. Int J Alzheimers Dis (2010) 0.77
The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide. J Neuroinflammation (2016) 0.76
Epigenetic and pharmacological regulation of the amyloid-degrading enzyme neprilysin results in modulation of cognitive functions in mammals. Dokl Biol Sci (2011) 0.76
Molecular and cellular aspects of age-related cognitive decline and Alzheimer's disease. Behav Brain Res (2016) 0.76
The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism. Neurobiol Aging (2015) 0.76
Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism. Front Neurosci (2015) 0.76
The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines. J Biol Chem (2013) 0.76
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol (2002) 6.64
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem (2004) 4.86
Experimental observation of the quantum anomalous Hall effect in a magnetic topological insulator. Science (2013) 4.69
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A (2008) 4.50
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem (2003) 4.36
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron (2004) 4.21
Representativeness of the Patient-Reported Outcomes Measurement Information System Internet panel. J Clin Epidemiol (2010) 4.18
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A (2007) 3.50
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science (2004) 3.38
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron (2005) 3.30
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol (2005) 2.91
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diabetes Care (2012) 2.84
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J (2010) 2.82
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer. PLoS One (2010) 2.64
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. Nat Cell Biol (2004) 2.58
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature (2006) 2.56
Changing the skill-mix of the health care workforce. J Health Serv Res Policy (2004) 2.45
Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A (2010) 2.34
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A (2009) 2.28
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J Biol Chem (2005) 2.26
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J (2004) 2.21
Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. Am J Gastroenterol (2010) 2.20
LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res (2008) 2.09
Nasal intermittent positive pressure ventilation with heliox in premature infants with respiratory distress syndrome: a randomized controlled trial. Indian Pediatr (2014) 2.07
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell (2006) 2.06
admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J Chem Inf Model (2012) 2.04
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development (2004) 2.00
Analysis of the glucocerebrosidase gene in Parkinson's disease. Mov Disord (2005) 1.99
Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J (2005) 1.98
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A (2002) 1.97
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
Activation of telomerase by human cytomegalovirus. J Natl Cancer Inst (2009) 1.92
Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron (2006) 1.91
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. Cancer Res (2008) 1.88
Depletion of CD4+CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune functions in vivo and in vitro. Int J Cancer (2007) 1.85
Molecular biology and genetics of Alzheimer's disease. C R Biol (2005) 1.84
Phenotype associated with APP duplication in five families. Brain (2006) 1.83
Influence of gender of physicians and patients on guideline-recommended treatment of chronic heart failure in a cross-sectional study. Eur J Heart Fail (2009) 1.78
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep (2006) 1.72
Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol (2007) 1.71
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci U S A (2011) 1.70
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum (2012) 1.67
The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. J Biol Chem (2005) 1.67
A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis. Arthritis Res Ther (2009) 1.65
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. Arch Neurol (2004) 1.63
(α-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano (2012) 1.61
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways. Genome Biol Evol (2010) 1.57
Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. J Neurosci (2005) 1.53
Defects in the striatal neuropeptide Y system in X-linked dystonia-parkinsonism. Brain (2013) 1.53
Regulatory T cells stimulate B7-H1 expression in myeloid-derived suppressor cells in ret melanomas. J Invest Dermatol (2011) 1.52
Assessing species distribution using Google Street View: a pilot study with the Pine Processionary Moth. PLoS One (2013) 1.50
The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc Natl Acad Sci U S A (2002) 1.49
SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis. Brain (2010) 1.45
Immunosuppressive therapy in Whipple's disease patients is associated with the appearance of gastrointestinal manifestations. Am J Gastroenterol (2005) 1.45
Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. J Biol Chem (2003) 1.45
Induction of immunosuppressive functions of dendritic cells in vivo by CD4+CD25+ regulatory T cells: role of B7-H3 expression and antigen presentation. Eur J Immunol (2007) 1.45
Neuronal apoptosis is accompanied by amyloid beta-protein accumulation in the endoplasmic reticulum. J Alzheimers Dis (2002) 1.42
BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci (2008) 1.42
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Hum Mol Genet (2012) 1.42
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nat Cell Biol (2009) 1.41
NOTCH signaling in skeletal progenitors is critical for fracture repair. J Clin Invest (2016) 1.41
Racial/Ethnic disparities in ART adherence in the United States: findings from the MACH14 study. J Acquir Immune Defic Syndr (2012) 1.41
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem (2001) 1.40
A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science (2009) 1.40
Metabolic engineering for microbial production of shikimic acid. Metab Eng (2003) 1.40
Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide. J Am Chem Soc (2005) 1.38
A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool. Development (2007) 1.37
Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription. J Biol Chem (2002) 1.37
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm (Vienna) (2011) 1.35
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener (2012) 1.34
Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol (2010) 1.34
Characterization of the glycinergic input to bipolar cells of the mouse retina. Eur J Neurosci (2006) 1.34
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. J Biol Chem (2002) 1.34
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem (2009) 1.34
Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci (2011) 1.34
Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem (2004) 1.33
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J Biol Chem (2002) 1.31
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype. J Clin Invest (2005) 1.30
Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease. J Neurosci (2006) 1.29
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role. Mol Neurodegener (2008) 1.28
A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem (2010) 1.28
IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines. J Neurooncol (2010) 1.27
The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo. J Biol Chem (2009) 1.27