Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.

Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. RNA Biol (2012) 1.13

Chaperoning proteins for destruction: diverse roles of Hsp70 chaperones and their co-chaperones in targeting misfolded proteins to the proteasome. Biomolecules (2014) 0.95

Cellular responses to misfolded proteins and protein aggregates. Methods Mol Biol (2012) 0.86

Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration. Molecules (2010) 0.86

Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation. Proc Natl Acad Sci U S A (2013) 0.83

Self-organization and regulation of intrinsically disordered proteins with folded N-termini. PLoS Biol (2011) 0.82

Targeting ricin to the ribosome. Toxicon (2013) 0.80

Cloning and expression of synthetic genes encoding the broad antimicrobial spectrum bacteriocins SRCAM 602, OR-7, E-760, and L-1077, by recombinant Pichia pastoris. Biomed Res Int (2015) 0.79

Molecular regulation of lysophosphatidic acid receptor 1 trafficking to the cell surface. Cell Signal (2014) 0.79

The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia. J Biol Chem (2014) 0.79

Ubiquitin ligase gp78 targets unglycosylated prion protein PrP for ubiquitylation and degradation. PLoS One (2014) 0.78

Sirtuins and proteolytic systems: implications for pathogenesis of synucleinopathies. Biomolecules (2015) 0.78

Storage-induced changes in erythrocyte membrane proteins promote recognition by autoantibodies. PLoS One (2012) 0.77

Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. PLoS One (2016) 0.76

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient. Front Pharmacol (2016) 0.76

Quantitative analysis of the interplay between hsc70 and its co-chaperone HspBP1. PeerJ (2015) 0.75

Gene expression profiling of NB4 cells following knockdown of nucleostemin using DNA microarrays. Mol Med Rep (2016) 0.75

Investigation of protein secretion and secretion stress in Ashbya gossypii. BMC Genomics (2014) 0.75

OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway. J Biol Chem (2015) 0.75

HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum. Gene (2017) 0.75

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol (2002) 4.06

For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J (2003) 2.82

Cdc48: a power machine in protein degradation. Trends Biochem Sci (2011) 2.08

A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation. EMBO Rep (2004) 2.02

Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. J Biol Chem (2003) 1.99

Ubiquitin receptors and ERAD: a network of pathways to the proteasome. Semin Cell Dev Biol (2007) 1.88

The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell (2006) 1.61

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1. FEBS Lett (2008) 1.61

ER-golgi traffic is a prerequisite for efficient ER degradation. Mol Biol Cell (2002) 1.42

A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins. FEBS Lett (2004) 1.40

Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways. Mol Biol Cell (2003) 1.37

Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system. Biochim Biophys Acta (2013) 1.28

Importance of carbohydrate positioning in the recognition of mutated CPY for ER-associated degradation. J Cell Sci (2005) 1.27

Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast. Mol Biol Cell (2004) 1.25

The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Mol Biol Cell (2008) 1.15

Endoplasmic reticulum-associated protein degradation--one model fits all? Biochim Biophys Acta (2004) 1.10

Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J (2009) 1.07

Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins. FEMS Yeast Res (2004) 1.05

Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation. J Biol Chem (2008) 1.01

Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. J Biol Chem (2012) 0.99

Two distinct proteolytic systems responsible for glucose-induced degradation of fructose-1,6-bisphosphatase and the Gal2p transporter in the yeast Saccharomyces cerevisiae share the same protein components of the glucose signaling pathway. J Biol Chem (2001) 0.98

DER7, encoding alpha-glucosidase I is essential for degradation of malfolded glycoproteins of the endoplasmic reticulum. FEMS Yeast Res (2004) 0.96

Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem (2009) 0.93

Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation. FEBS Lett (2011) 0.87

Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation. Proc Natl Acad Sci U S A (2013) 0.83

Waste disposal in plants: where and how? Trends Plant Sci (2003) 0.83

Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. FEBS Lett (2011) 0.82

Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD. Traffic (2010) 0.81

The ubiquitin-proteasome-system. Biochim Biophys Acta (2013) 0.81

The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase. Biochem Biophys Res Commun (2010) 0.81

Mutants of the deubiquitinating enzyme Ubp14 decipher pathway diversity of ubiquitin-proteasome linked protein degradation. Biochem Biophys Res Commun (2006) 0.80

Yeast genomics in the elucidation of endoplasmic reticulum (ER) quality control and associated protein degradation (ERQD). Methods Enzymol (2005) 0.79

Endoplasmic reticulum-associated protein quality control and degradation: genome-wide screen for ERAD components. Methods Mol Biol (2005) 0.78

The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase. Biochem Biophys Res Commun (2010) 0.78

Use of CPY and its derivatives to study protein quality control in various cell compartments. Methods Mol Biol (2012) 0.77

Ubiquitylation in the ERAD Pathway. Subcell Biochem (2010) 0.77

Endoplasmic reticulum-associated protein quality control and degradation: screen for ERAD mutants after ethylmethane sulfonate mutagenesis. Methods Mol Biol (2005) 0.76

Death gives birth to life: the essential role of the ubiquitin-proteasome system in biology. Biochim Biophys Acta (2004) 0.76

Mnl2, a novel component of the ER associated protein degradation pathway. Biochem Biophys Res Commun (2011) 0.75