Published in Semin Cell Dev Biol on September 08, 2007
One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol (2008) 8.68
The ubiquitin-26S proteasome system at the nexus of plant biology. Nat Rev Mol Cell Biol (2009) 3.81
The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum. Traffic (2008) 3.07
A stress-responsive system for mitochondrial protein degradation. Mol Cell (2010) 2.05
New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the International Myeloma Working Group (IMWG). Leukemia (2013) 2.04
The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev (2012) 1.95
Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Mol Cell (2011) 1.91
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell (2009) 1.82
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev (2008) 1.81
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry (2009) 1.78
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Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol (2013) 1.65
Inhibitors of the AAA+ chaperone p97. Molecules (2015) 1.61
WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol Cell (2010) 1.50
Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans. J Biol Chem (2009) 1.47
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol (2009) 1.45
Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery. J Biol Chem (2008) 1.39
Protein folding and quality control in the ER. Cold Spring Harb Perspect Biol (2011) 1.33
Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. Crit Rev Biochem Mol Biol (2010) 1.29
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. J Biol Chem (2010) 1.28
Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. Biol Direct (2010) 1.26
An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors. J Biol Chem (2009) 1.26
Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Proc Natl Acad Sci U S A (2010) 1.22
The complexities of p97 function in health and disease. Mol Biosyst (2010) 1.17
Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin. PLoS One (2009) 1.10
A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. J Biol Chem (2011) 1.04
The RAD23 family provides an essential connection between the 26S proteasome and ubiquitylated proteins in Arabidopsis. Plant Cell (2010) 1.03
The deubiquitinating enzyme USP-46 negatively regulates the degradation of glutamate receptors to control their abundance in the ventral nerve cord of Caenorhabditis elegans. J Neurosci (2011) 1.01
Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97. Proc Natl Acad Sci U S A (2012) 0.99
Endoplasmic reticulum (ER) stress response and its physiological roles in plants. Int J Mol Sci (2013) 0.97
How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD. Biochim Biophys Acta (2013) 0.96
Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner. J Biol Chem (2010) 0.96
Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation. PLoS One (2012) 0.96
p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association? Genes Cancer (2010) 0.96
Regulation of Endoplasmic Reticulum-Associated Protein Degradation (ERAD) by Ubiquitin. Cells (2014) 0.95
The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain. J Biol Chem (2010) 0.95
The role of deubiquitinating enzymes in synaptic function and nervous system diseases. Neural Plast (2012) 0.93
Destroying the ring: Freeing DNA from Ku with ubiquitin. FEBS Lett (2011) 0.93
Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem (2009) 0.93
Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission. Proc Natl Acad Sci U S A (2012) 0.93
Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance. J Biol Chem (2010) 0.92
The proteasome and the degradation of oxidized proteins: Part I-structure of proteasomes. Redox Biol (2013) 0.92
Future agents and treatment directions in multiple myeloma. Expert Rev Hematol (2013) 0.92
Endoplasmic reticulum-mediated protein quality control in Arabidopsis. Front Plant Sci (2014) 0.91
Feline calicivirus p32, p39 and p30 proteins localize to the endoplasmic reticulum to initiate replication complex formation. J Gen Virol (2009) 0.91
A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J Biol Chem (2010) 0.90
Structural basis for ubiquitin recognition by a novel domain from human phospholipase A2-activating protein. J Biol Chem (2009) 0.89
The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel. J Biol Chem (2013) 0.89
Culling sick mitochondria from the herd. J Cell Biol (2010) 0.88
The defective proteasome but not substrate recognition function is responsible for the null phenotypes of the Arabidopsis proteasome subunit RPN10. Plant Cell (2011) 0.88
Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol. J Biol Chem (2010) 0.86
Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. J Biol Chem (2010) 0.86
The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis. Mol Cell Biol (2013) 0.84
Genome-wide analyses of a plant-specific LIM-domain gene family implicate its evolutionary role in plant diversification. Genome Biol Evol (2014) 0.84
TRAM1 is involved in disposal of ER membrane degradation substrates. Exp Cell Res (2010) 0.83
Stabilization of an archaeal DNA-sliding clamp protein, PCNA, by proteasome-activating nucleotidase gene knockout in Haloferax volcanii. FEMS Microbiol Lett (2009) 0.81
Toxin instability and its role in toxin translocation from the endoplasmic reticulum to the cytosol. Biomolecules (2013) 0.81
The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Elife (2016) 0.80
NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex. J Biol Chem (2013) 0.78
The C-terminal amino acid of the MHC-I heavy chain is critical for binding to Derlin-1 in human cytomegalovirus US11-induced MHC-I degradation. PLoS One (2013) 0.78
Comprehensive analysis of the endoplasmic reticulum stress response in the soybean genome: conserved and plant-specific features. BMC Genomics (2015) 0.77
In silico analysis of ubiquitin/ubiquitin-like modifiers and their conjugating enzymes in Entamoeba species. Parasitol Res (2012) 0.77
Vacuolar protein sorting receptor in Giardia lamblia. PLoS One (2012) 0.76
Just one position-independent lysine residue can direct MelanA into proteasomal degradation following N-terminal fusion of ubiquitin. PLoS One (2013) 0.76
The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans. Genetics (2015) 0.75
Proteomes and Ubiquitylomes Analysis Reveals the Involvement of Ubiquitination in Protein Degradation. Plant Physiol (2016) 0.75
Interactions Between Intersubunit Transmembrane Domains Regulate the Chaperone Dependent Degradation of an Oligomeric Membrane Protein. Biochem J (2016) 0.75
A Christianson syndrome-linked deletion mutation (∆(287)ES(288)) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death. Mol Neurodegener (2016) 0.75
In vivo relevance of substrate recognition function of major Arabidopsis ubiquitin receptors. Plant Signal Behav (2012) 0.75
Novel Proteasome Inhibitors and Histone Deacetylase Inhibitors: Progress in Myeloma Therapeutics. Pharmaceuticals (Basel) (2017) 0.75
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol (2002) 4.06
For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J (2003) 2.82
Cdc48: a power machine in protein degradation. Trends Biochem Sci (2011) 2.08
A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation. EMBO Rep (2004) 2.02
Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. J Biol Chem (2003) 1.99
The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell (2006) 1.61
Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1. FEBS Lett (2008) 1.61
ER-golgi traffic is a prerequisite for efficient ER degradation. Mol Biol Cell (2002) 1.42
A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins. FEBS Lett (2004) 1.40
Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways. Mol Biol Cell (2003) 1.37
Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system. Biochim Biophys Acta (2013) 1.28
Importance of carbohydrate positioning in the recognition of mutated CPY for ER-associated degradation. J Cell Sci (2005) 1.27
Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast. Mol Biol Cell (2004) 1.25
The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Mol Biol Cell (2008) 1.15
Endoplasmic reticulum-associated protein degradation--one model fits all? Biochim Biophys Acta (2004) 1.10
Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J (2009) 1.07
Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins. FEMS Yeast Res (2004) 1.05
Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation. J Biol Chem (2008) 1.01
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell. Biochim Biophys Acta (2010) 0.99
Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. J Biol Chem (2012) 0.99
DER7, encoding alpha-glucosidase I is essential for degradation of malfolded glycoproteins of the endoplasmic reticulum. FEMS Yeast Res (2004) 0.96
Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem (2009) 0.93
Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation. FEBS Lett (2011) 0.87
Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation. Proc Natl Acad Sci U S A (2013) 0.83
Waste disposal in plants: where and how? Trends Plant Sci (2003) 0.83
Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. FEBS Lett (2011) 0.82
Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD. Traffic (2010) 0.81
The ubiquitin-proteasome-system. Biochim Biophys Acta (2013) 0.81
The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase. Biochem Biophys Res Commun (2010) 0.81
Mutants of the deubiquitinating enzyme Ubp14 decipher pathway diversity of ubiquitin-proteasome linked protein degradation. Biochem Biophys Res Commun (2006) 0.80
Yeast genomics in the elucidation of endoplasmic reticulum (ER) quality control and associated protein degradation (ERQD). Methods Enzymol (2005) 0.79
Endoplasmic reticulum-associated protein quality control and degradation: genome-wide screen for ERAD components. Methods Mol Biol (2005) 0.78
The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase. Biochem Biophys Res Commun (2010) 0.78
Use of CPY and its derivatives to study protein quality control in various cell compartments. Methods Mol Biol (2012) 0.77
Ubiquitylation in the ERAD Pathway. Subcell Biochem (2010) 0.77
Endoplasmic reticulum-associated protein quality control and degradation: screen for ERAD mutants after ethylmethane sulfonate mutagenesis. Methods Mol Biol (2005) 0.76
Death gives birth to life: the essential role of the ubiquitin-proteasome system in biology. Biochim Biophys Acta (2004) 0.76
Mnl2, a novel component of the ER associated protein degradation pathway. Biochem Biophys Res Commun (2011) 0.75