Published in Structure on March 10, 2010
High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. J Mol Biol (2007) 2.88
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14
Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nat Chem Biol (2006) 1.68
X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. J Am Chem Soc (2008) 1.64
Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. J Biol Chem (2006) 1.59
Synthetic antibodies for specific recognition and crystallization of structured RNA. Proc Natl Acad Sci U S A (2007) 1.51
Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat Struct Mol Biol (2011) 1.23
Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Sci (2009) 1.20
Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold. Protein Sci (2008) 1.20
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol (2010) 1.18
Mechanism of activation gating in the full-length KcsA K+ channel. Proc Natl Acad Sci U S A (2011) 1.15
Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J Mol Biol (2007) 1.13
Structure of bistramide A-actin complex at a 1.35 angstroms resolution. J Am Chem Soc (2006) 1.10
The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s). Biochemistry (2005) 1.07
The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity. J Mol Biol (2003) 1.06
Generating conformation-specific synthetic antibodies to trap proteins in selected functional states. Methods (2012) 1.06
An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. Proc Natl Acad Sci U S A (2009) 1.04
The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry. Biochemistry (2006) 1.01
Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin. Angew Chem Int Ed Engl (2005) 0.99
X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. J Am Chem Soc (2009) 0.99
Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization. Protein Sci (2003) 0.98
Exploring and designing protein function with restricted diversity. Curr Opin Chem Biol (2007) 0.97
The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled. Proc Natl Acad Sci U S A (2004) 0.95
Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries. Biochemistry (2004) 0.95
Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proc Natl Acad Sci U S A (2003) 0.95
Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface. J Biol Chem (2005) 0.94
Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis. Protein Sci (2005) 0.94
Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis. J Mol Biol (2005) 0.90
Crystal structure and site 1 binding energetics of human placental lactogen. J Mol Biol (2006) 0.86
Characterization of engineered actin binding proteins that control filament assembly and structure. PLoS One (2010) 0.85
Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions. Proc Natl Acad Sci U S A (2009) 0.82
Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide. Mol Biosyst (2009) 0.79
Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo. Bioconjug Chem (2011) 0.75
The first semi-synthetic serine protease made by native chemical ligation. Protein Expr Purif (2003) 0.75