PubRank

Anthony A Kossiakoff

Author PubWeight™ 39.08‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. J Mol Biol 2007 2.88
2 Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature 2013 2.14
3 Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nat Chem Biol 2006 1.68
4 X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. J Am Chem Soc 2008 1.64
5 Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. J Biol Chem 2006 1.59
6 Synthetic antibodies for specific recognition and crystallization of structured RNA. Proc Natl Acad Sci U S A 2007 1.51
7 Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat Struct Mol Biol 2011 1.23
8 Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Sci 2009 1.20
9 Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold. Protein Sci 2008 1.20
10 A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol 2010 1.18
11 Mechanism of activation gating in the full-length KcsA K+ channel. Proc Natl Acad Sci U S A 2011 1.15
12 Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J Mol Biol 2007 1.13
13 Structure of bistramide A-actin complex at a 1.35 angstroms resolution. J Am Chem Soc 2006 1.10
14 The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s). Biochemistry 2005 1.07
15 Generating conformation-specific synthetic antibodies to trap proteins in selected functional states. Methods 2012 1.06
16 The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity. J Mol Biol 2003 1.06
17 An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. Proc Natl Acad Sci U S A 2009 1.04
18 The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry. Biochemistry 2006 1.01
19 X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. J Am Chem Soc 2009 0.99
20 Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin. Angew Chem Int Ed Engl 2005 0.99
21 Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization. Protein Sci 2003 0.98
22 Exploring and designing protein function with restricted diversity. Curr Opin Chem Biol 2007 0.97
23 Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proc Natl Acad Sci U S A 2003 0.95
24 Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries. Biochemistry 2004 0.95
25 The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled. Proc Natl Acad Sci U S A 2004 0.95
26 Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface. J Biol Chem 2005 0.94
27 Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis. Protein Sci 2005 0.94
28 Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis. J Mol Biol 2005 0.90
29 Crystal structure and site 1 binding energetics of human placental lactogen. J Mol Biol 2006 0.86
30 Characterization of engineered actin binding proteins that control filament assembly and structure. PLoS One 2010 0.85
31 Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions. Proc Natl Acad Sci U S A 2009 0.82
32 Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide. Mol Biosyst 2009 0.79
33 Keeping signaling in check. Structure 2010 0.75
34 Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo. Bioconjug Chem 2011 0.75
35 The first semi-synthetic serine protease made by native chemical ligation. Protein Expr Purif 2003 0.75