| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.
|
J Biol Chem
|
2002
|
1.71
|
|
2
|
Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus: nucleotide-free and nucleotide-bound conformations.
|
J Mol Biol
|
2003
|
1.59
|
|
3
|
Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
|
J Biol Chem
|
2003
|
1.56
|
|
4
|
Crystal structure of Agaricus bisporus mushroom tyrosinase: identity of the tetramer subunits and interaction with tropolone.
|
Biochemistry
|
2011
|
1.49
|
|
5
|
Formation of the productive ATP-Mg2+-bound dimer of GlcV, an ABC-ATPase from Sulfolobus solfataricus.
|
J Mol Biol
|
2003
|
1.28
|
|
6
|
Crystal structure of the copper-containing quercetin 2,3-dioxygenase from Aspergillus japonicus.
|
Structure
|
2002
|
1.22
|
|
7
|
Anaerobic enzyme.substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase.
|
Proc Natl Acad Sci U S A
|
2002
|
1.18
|
|
8
|
The X-ray structure of trans-3-chloroacrylic acid dehalogenase reveals a novel hydration mechanism in the tautomerase superfamily.
|
J Biol Chem
|
2003
|
1.15
|
|
9
|
Crystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymes.
|
Proc Natl Acad Sci U S A
|
2010
|
1.12
|
|
10
|
Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase. Structural basis for substrate specificity and inactivation by (R)-oxirane-2-carboxylate.
|
J Biol Chem
|
2006
|
1.12
|
|
11
|
Three-way stabilization of the covalent intermediate in amylomaltase, an alpha-amylase-like transglycosylase.
|
J Biol Chem
|
2007
|
1.12
|
|
12
|
Glucansucrases: three-dimensional structures, reactions, mechanism, α-glucan analysis and their implications in biotechnology and food applications.
|
J Biotechnol
|
2012
|
1.10
|
|
13
|
Structure and mechanism of bacterial dehalogenases: different ways to cleave a carbon-halogen bond.
|
Curr Opin Struct Biol
|
2003
|
1.08
|
|
14
|
EPR characterization of the mononuclear Cu-containing Aspergillus japonicus quercetin 2,3-dioxygenase reveals dramatic changes upon anaerobic binding of substrates.
|
Eur J Biochem
|
2002
|
1.07
|
|
15
|
Functional analysis of the copper-dependent quercetin 2,3-dioxygenase. 1. Ligand-induced coordination changes probed by X-ray crystallography: inhibition, ordering effect, and mechanistic insights.
|
Biochemistry
|
2002
|
1.07
|
|
16
|
Expression and characterization of active site mutants of hevamine, a chitinase from the rubber tree Hevea brasiliensis.
|
Eur J Biochem
|
2002
|
1.07
|
|
17
|
A crystallographic study of Cys69Ala flavodoxin II from Azotobacter vinelandii: structural determinants of redox potential.
|
Protein Sci
|
2005
|
1.06
|
|
18
|
Structure of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose: implications for peptidoglycan binding and cleavage.
|
J Biol Chem
|
2007
|
1.05
|
|
19
|
The sequence and crystal structure of the alpha-amino acid ester hydrolase from Xanthomonas citri define a new family of beta-lactam antibiotic acylases.
|
J Biol Chem
|
2003
|
1.04
|
|
20
|
Structure of Spa15, a type III secretion chaperone from Shigella flexneri with broad specificity.
|
EMBO Rep
|
2004
|
1.03
|
|
21
|
Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold.
|
J Mol Biol
|
2005
|
1.02
|
|
22
|
The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket.
|
Proc Natl Acad Sci U S A
|
2009
|
1.02
|
|
23
|
Two major archaeal pseudomurein endoisopeptidases: PeiW and PeiP.
|
Archaea
|
2010
|
0.98
|
|
24
|
Structural insights into the processivity of endopolygalacturonase I from Aspergillus niger.
|
FEBS Lett
|
2003
|
0.97
|
|
25
|
Mutations converting cyclodextrin glycosyltransferase from a transglycosylase into a starch hydrolase.
|
FEBS Lett
|
2002
|
0.97
|
|
26
|
Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution.
|
Biochem J
|
2008
|
0.96
|
|
27
|
Acetobacter turbidans alpha-amino acid ester hydrolase: how a single mutation improves an antibiotic-producing enzyme.
|
J Biol Chem
|
2005
|
0.93
|
|
28
|
Functional and structural characterization of α-(1->2) branching sucrase derived from DSR-E glucansucrase.
|
J Biol Chem
|
2012
|
0.93
|
|
29
|
Structural and mutational characterization of the catalytic A-module of the mannuronan C-5-epimerase AlgE4 from Azotobacter vinelandii.
|
J Biol Chem
|
2008
|
0.92
|
|
30
|
Structure of the α-1,6/α-1,4-specific glucansucrase GTFA from Lactobacillus reuteri 121.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2012
|
0.92
|
|
31
|
Murein and pseudomurein cell wall binding domains of bacteria and archaea--a comparative view.
|
Appl Microbiol Biotechnol
|
2011
|
0.91
|
|
32
|
Crystal structure of quinohemoprotein alcohol dehydrogenase from Comamonas testosteroni: structural basis for substrate oxidation and electron transfer.
|
J Biol Chem
|
2001
|
0.90
|
|
33
|
Escherichia coli MltA: MAD phasing and refinement of a tetartohedrally twinned protein crystal structure.
|
Acta Crystallogr D Biol Crystallogr
|
2005
|
0.89
|
|
34
|
Identification of acceptor substrate binding subsites +2 and +3 in the amylomaltase from Thermus thermophilus HB8.
|
Biochemistry
|
2007
|
0.89
|
|
35
|
Acetobacter turbidans alpha-amino acid ester hydrolase: merohedral twinning in P21 obscured by pseudo-translational NCS.
|
Acta Crystallogr D Biol Crystallogr
|
2003
|
0.89
|
|
36
|
Structures of an isopenicillin N converting Ntn-hydrolase reveal different catalytic roles for the active site residues of precursor and mature enzyme.
|
Structure
|
2010
|
0.88
|
|
37
|
AcmD, a homolog of the major autolysin AcmA of Lactococcus lactis, binds to the cell wall and contributes to cell separation and autolysis.
|
PLoS One
|
2013
|
0.88
|
|
38
|
Improved catalytic properties of halohydrin dehalogenase by modification of the halide-binding site.
|
Biochemistry
|
2005
|
0.88
|
|
39
|
The remote substrate binding subsite -6 in cyclodextrin-glycosyltransferase controls the transferase activity of the enzyme via an induced-fit mechanism.
|
J Biol Chem
|
2001
|
0.87
|
|
40
|
Conversion of cyclodextrin glycosyltransferase into a starch hydrolase by directed evolution: the role of alanine 230 in acceptor subsite +1.
|
Biochemistry
|
2003
|
0.87
|
|
41
|
Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri.
|
EMBO Rep
|
2006
|
0.86
|
|
42
|
Functional analysis of the copper-dependent quercetin 2,3-dioxygenase. 2. X-ray absorption studies of native enzyme and anaerobic complexes with the substrates quercetin and myricetin.
|
Biochemistry
|
2002
|
0.86
|
|
43
|
Crystal structure and biochemical properties of a novel thermostable esterase containing an immunoglobulin-like domain.
|
J Mol Biol
|
2008
|
0.86
|
|
44
|
The X-ray structure of the haloalcohol dehalogenase HheA from Arthrobacter sp. strain AD2: insight into enantioselectivity and halide binding in the haloalcohol dehalogenase family.
|
J Bacteriol
|
2006
|
0.86
|
|
45
|
Structural basis of phospholipase activity of Staphylococcus hyicus lipase.
|
J Mol Biol
|
2007
|
0.86
|
|
46
|
Fortuitous structure determination of 'as-isolated' Escherichia coli bacterioferritin in a novel crystal form.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2006
|
0.86
|
|
47
|
Engineering cyclodextrin glycosyltransferase into a starch hydrolase with a high exo-specificity.
|
J Biotechnol
|
2003
|
0.85
|
|
48
|
Improved thermostability of bacillus circulans cyclodextrin glycosyltransferase by the introduction of a salt bridge.
|
Proteins
|
2004
|
0.85
|
|
49
|
The fully conserved Asp residue in conserved sequence region I of the alpha-amylase family is crucial for the catalytic site architecture and activity.
|
FEBS Lett
|
2003
|
0.84
|
|
50
|
Structural basis for the enantioselectivity of an epoxide ring opening reaction catalyzed by halo alcohol dehalogenase HheC.
|
J Am Chem Soc
|
2005
|
0.84
|
|
51
|
Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ.
|
Proc Natl Acad Sci U S A
|
2014
|
0.84
|
|
52
|
Crystallization and preliminary X-ray crystallographic analysis of tyrosinase from the mushroom Agaricus bisporus.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2011
|
0.83
|
|
53
|
A genetically engineered protein domain binding to bacterial murein, archaeal pseudomurein, and fungal chitin cell wall material.
|
Appl Microbiol Biotechnol
|
2012
|
0.83
|
|
54
|
Mechanism-inspired engineering of phenylalanine aminomutase for enhanced β-regioselective asymmetric amination of cinnamates.
|
Angew Chem Int Ed Engl
|
2011
|
0.83
|
|
55
|
A minimum of three motifs is essential for optimal binding of pseudomurein cell wall-binding domain of Methanothermobacter thermautotrophicus.
|
PLoS One
|
2011
|
0.83
|
|
56
|
Thermus thermophilus glycoside hydrolase family 57 branching enzyme: crystal structure, mechanism of action, and products formed.
|
J Biol Chem
|
2010
|
0.82
|
|
57
|
Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases.
|
Biochem J
|
2007
|
0.82
|
|
58
|
Characterization of aptamer-protein complexes by X-ray crystallography and alternative approaches.
|
Int J Mol Sci
|
2012
|
0.82
|
|
59
|
Directed evolution of Bacillus subtilis lipase A by use of enantiomeric phosphonate inhibitors: crystal structures and phage display selection.
|
Chembiochem
|
2006
|
0.82
|
|
60
|
Thermoanaerobacterium thermosulfurigenes cyclodextrin glycosyltransferase.
|
Eur J Biochem
|
2003
|
0.82
|
|
61
|
Crystal structure of the leucine aminopeptidase from Pseudomonas putida reveals the molecular basis for its enantioselectivity and broad substrate specificity.
|
J Mol Biol
|
2010
|
0.81
|
|
62
|
Crystal structure of inulosucrase from Lactobacillus: insights into the substrate specificity and product specificity of GH68 fructansucrases.
|
J Mol Biol
|
2011
|
0.81
|
|
63
|
Purification, crystallization and preliminary X-ray diffraction analysis of an archaeal ABC-ATPase.
|
Acta Crystallogr D Biol Crystallogr
|
2002
|
0.80
|
|
64
|
Loop grafting of Bacillus subtilis lipase A: inversion of enantioselectivity.
|
Chem Biol
|
2008
|
0.80
|
|
65
|
Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase.
|
Chembiochem
|
2013
|
0.80
|
|
66
|
Single-crystal EPR study at 95 GHz of the type 2 copper site of the inhibitor-bound quercetin 2,3-dioxygenase.
|
Biophys J
|
2003
|
0.80
|
|
67
|
A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.
|
Chembiochem
|
2008
|
0.80
|
|
68
|
Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase.
|
Protein Eng Des Sel
|
2004
|
0.80
|
|
69
|
Purification, crystallization and preliminary X-ray crystallographic analysis of 3-ketosteroid Δ1-dehydrogenase from Rhodococcus erythropolis SQ1.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2012
|
0.79
|
|
70
|
Biophysical characterization of mutants of Bacillus subtilis lipase evolved for thermostability: factors contributing to increased activity retention.
|
Protein Sci
|
2012
|
0.79
|
|
71
|
Purification, crystallization and preliminary X-ray analysis of a thermostable glycoside hydrolase family 43 beta-xylosidase from Geobacillus thermoleovorans IT-08.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2007
|
0.79
|
|
72
|
Structure and catalytic mechanism of 3-ketosteroid-Delta4-(5α)-dehydrogenase from Rhodococcus jostii RHA1 genome.
|
J Biol Chem
|
2012
|
0.79
|
|
73
|
Crystal structure and site-directed mutagenesis of 3-ketosteroid Δ1-dehydrogenase from Rhodococcus erythropolis SQ1 explain its catalytic mechanism.
|
J Biol Chem
|
2013
|
0.78
|
|
74
|
The crystal structure of a hyperthermoactive exopolygalacturonase from Thermotoga maritima reveals a unique tetramer.
|
FEBS Lett
|
2009
|
0.78
|
|
75
|
The role of conserved inulosucrase residues in the reaction and product specificity of Lactobacillus reuteri inulosucrase.
|
FEBS J
|
2012
|
0.78
|
|
76
|
Crystal structure of α-1,4-glucan lyase, a unique glycoside hydrolase family member with a novel catalytic mechanism.
|
J Biol Chem
|
2013
|
0.77
|
|
77
|
Flexibility of truncated and full-length glucansucrase GTF180 enzymes from Lactobacillus reuteri 180.
|
FEBS J
|
2014
|
0.77
|
|
78
|
Biochemical properties and crystal structure of a β-phenylalanine aminotransferase from Variovorax paradoxus.
|
Appl Environ Microbiol
|
2012
|
0.77
|
|
79
|
Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from Taxus chinensis.
|
Biochemistry
|
2014
|
0.76
|
|
80
|
Crystallization and preliminary X-ray analysis of an enantioselective halohydrin dehalogenase from Agrobacterium radiobacter AD1.
|
Acta Crystallogr D Biol Crystallogr
|
2001
|
0.76
|
|
81
|
Structural investigation of the transmembrane C domain of the mannitol permease from Escherichia coli using 5-FTrp fluorescence spectroscopy.
|
Biochim Biophys Acta
|
2011
|
0.76
|
|
82
|
Structural determinants of the β-selectivity of a bacterial aminotransferase.
|
J Biol Chem
|
2012
|
0.76
|
|
83
|
Catalysis and regulation - from structure to function.
|
Curr Opin Struct Biol
|
2003
|
0.76
|
|
84
|
Crystallization and preliminary crystallographic analysis of an esterase with a novel domain from the hyperthermophile Thermotoga maritima.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2007
|
0.76
|
|
85
|
Cloning, overexpression, purification, crystallization and preliminary X-ray analysis of 3-ketosteroid Δ(4)-(5α)-dehydrogenase from Rhodococcus jostii RHA1.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2011
|
0.76
|
|
86
|
Purification, crystallization and preliminary X-ray diffraction of Cys103Ala acyl coenzyme A: isopenicillin N acyltransferase from Penicillium chrysogenum.
|
Acta Crystallogr D Biol Crystallogr
|
2002
|
0.76
|
|
87
|
An approach to prevent aggregation during the purification and crystallization of wild type acyl coenzyme A: isopenicillin N acyltransferase from Penicillium chrysogenum.
|
Protein Expr Purif
|
2005
|
0.76
|
|
88
|
Functional importance of calcium binding sites in outer membrane phospholipase A.
|
Biochim Biophys Acta
|
2002
|
0.75
|
|
89
|
Crystallization and preliminary X-ray analysis of carnein, a serine protease from Ipomoea carnea.
|
Acta Crystallogr Sect F Struct Biol Cryst Commun
|
2009
|
0.75
|
|
90
|
Three-dimensional structures of enzymes useful for beta-lactam antibiotic production.
|
Curr Opin Biotechnol
|
2004
|
0.75
|
|
91
|
Crystal structure of endo-xylogalacturonan hydrolase from Aspergillus tubingensis.
|
FEBS J
|
2013
|
0.75
|
|
92
|
Enhancement of the enantioselectivity of carboxylesterase A by structure-based mutagenesis.
|
J Biotechnol
|
2012
|
0.75
|
|
93
|
X-ray analysis of two antibiotic-synthesizing bacterial ester hydrolases: preliminary results.
|
Acta Crystallogr D Biol Crystallogr
|
2002
|
0.75
|
|
94
|
X-ray crystallographic validation of structure predictions used in computational design for protein stabilization.
|
Proteins
|
2015
|
0.75
|
|
95
|
Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase.
|
ACS Chem Biol
|
2015
|
0.75
|
|
96
|
Oils used in microbatch crystallization do not remove a detergent from the drops they cover.
|
Acta Crystallogr D Biol Crystallogr
|
2003
|
0.75
|
|
97
|
Purification, crystallization and preliminary X-ray analysis of the lytic transglycosylase MltA from Escherichia coli.
|
Acta Crystallogr D Biol Crystallogr
|
2004
|
0.75
|