Published in Structure on March 10, 2010
Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement. Proc Natl Acad Sci U S A (2012) 0.99
Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med (2013) 0.94
A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations. PLoS One (2012) 0.88
Alternative tasks of Drosophila tan in neurotransmitter recycling versus cuticle sclerotization disclosed by kinetic properties. J Biol Chem (2010) 0.83
Autoproteolytic activation of ThnT results in structural reorganization necessary for substrate binding and catalysis. J Mol Biol (2012) 0.81
Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ. ACS Chem Biol (2017) 0.75
Homology modeling of the structure of acyl coA:isopenicillin N-acyltransferase (IAT) from Penicillium chrysogenum. IAT interaction studies with isopenicillin-N, combining molecular dynamics simulations and docking. J Mol Model (2011) 0.75
A G protein-coupled receptor responsive to bile acids. J Biol Chem (2003) 4.76
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature (2009) 4.49
Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins. J Biol Chem (2002) 1.71
Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus: nucleotide-free and nucleotide-bound conformations. J Mol Biol (2003) 1.59
Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39. J Biol Chem (2003) 1.56
Crystal structure of Agaricus bisporus mushroom tyrosinase: identity of the tetramer subunits and interaction with tropolone. Biochemistry (2011) 1.49
Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. Life Sci (2005) 1.32
Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr. Phytochemistry (2006) 1.30
Formation of the productive ATP-Mg2+-bound dimer of GlcV, an ABC-ATPase from Sulfolobus solfataricus. J Mol Biol (2003) 1.28
Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation. Nat Chem (2013) 1.28
Prebiotic synthesis of simple sugars by photoredox systems chemistry. Nat Chem (2012) 1.28
Crystal structure of the copper-containing quercetin 2,3-dioxygenase from Aspergillus japonicus. Structure (2002) 1.22
Direct assembly of nucleoside precursors from two- and three-carbon units. Angew Chem Int Ed Engl (2006) 1.19
Anaerobic enzyme.substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase. Proc Natl Acad Sci U S A (2002) 1.18
Development of vaccine strains of H5 and H7 influenza viruses. Jpn J Vet Res (2008) 1.18
Chemoselective multicomponent one-pot assembly of purine precursors in water. J Am Chem Soc (2010) 1.17
The X-ray structure of trans-3-chloroacrylic acid dehalogenase reveals a novel hydration mechanism in the tautomerase superfamily. J Biol Chem (2003) 1.15
Crystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymes. Proc Natl Acad Sci U S A (2010) 1.12
Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase. Structural basis for substrate specificity and inactivation by (R)-oxirane-2-carboxylate. J Biol Chem (2006) 1.12
Three-way stabilization of the covalent intermediate in amylomaltase, an alpha-amylase-like transglycosylase. J Biol Chem (2007) 1.12
A new peptidic ligand and its receptor regulating adrenal function in rats. J Biol Chem (2003) 1.11
Glucansucrases: three-dimensional structures, reactions, mechanism, α-glucan analysis and their implications in biotechnology and food applications. J Biotechnol (2012) 1.10
Structure and mechanism of bacterial dehalogenases: different ways to cleave a carbon-halogen bond. Curr Opin Struct Biol (2003) 1.08
Towards an evolutionary theory of the origin of life based on kinetics and thermodynamics. Open Biol (2013) 1.07
EPR characterization of the mononuclear Cu-containing Aspergillus japonicus quercetin 2,3-dioxygenase reveals dramatic changes upon anaerobic binding of substrates. Eur J Biochem (2002) 1.07
Expression and characterization of active site mutants of hevamine, a chitinase from the rubber tree Hevea brasiliensis. Eur J Biochem (2002) 1.07
Functional analysis of the copper-dependent quercetin 2,3-dioxygenase. 1. Ligand-induced coordination changes probed by X-ray crystallography: inhibition, ordering effect, and mechanistic insights. Biochemistry (2002) 1.07
A crystallographic study of Cys69Ala flavodoxin II from Azotobacter vinelandii: structural determinants of redox potential. Protein Sci (2005) 1.06
A stereoelectronic effect in prebiotic nucleotide synthesis. ACS Chem Biol (2010) 1.06
Structure of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose: implications for peptidoglycan binding and cleavage. J Biol Chem (2007) 1.05
Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. J Biol Chem (2002) 1.04
The sequence and crystal structure of the alpha-amino acid ester hydrolase from Xanthomonas citri define a new family of beta-lactam antibiotic acylases. J Biol Chem (2003) 1.04
Structure of Spa15, a type III secretion chaperone from Shigella flexneri with broad specificity. EMBO Rep (2004) 1.03
RNA: prebiotic product, or biotic invention? Chem Biodivers (2007) 1.03
The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket. Proc Natl Acad Sci U S A (2009) 1.02
Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold. J Mol Biol (2005) 1.02
Two major archaeal pseudomurein endoisopeptidases: PeiW and PeiP. Archaea (2010) 0.98
On the prebiotic synthesis of ribonucleotides: photoanomerisation of cytosine nucleosides and nucleotides revisited. Chembiochem (2007) 0.97
Structural insights into the processivity of endopolygalacturonase I from Aspergillus niger. FEBS Lett (2003) 0.97
Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. Glycobiology (2008) 0.97
Phosphate-mediated interconversion of ribo- and arabino-configured prebiotic nucleotide intermediates. Angew Chem Int Ed Engl (2010) 0.97
Mutations converting cyclodextrin glycosyltransferase from a transglycosylase into a starch hydrolase. FEBS Lett (2002) 0.97
Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution. Biochem J (2008) 0.96
Synthesis of aldehydic ribonucleotide and amino acid precursors by photoredox chemistry. Angew Chem Int Ed Engl (2013) 0.95
DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells. Cancer Sci (2008) 0.94
Acetobacter turbidans alpha-amino acid ester hydrolase: how a single mutation improves an antibiotic-producing enzyme. J Biol Chem (2005) 0.93
A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda. J Biol Chem (2001) 0.93
Carbohydrate recognition mechanism of HA70 from Clostridium botulinum deduced from X-ray structures in complexes with sialylated oligosaccharides. FEBS Lett (2012) 0.93
Functional and structural characterization of α-(1->2) branching sucrase derived from DSR-E glucansucrase. J Biol Chem (2012) 0.93
Structure of the α-1,6/α-1,4-specific glucansucrase GTFA from Lactobacillus reuteri 121. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.92
Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities. J Agric Food Chem (2012) 0.92
Structural and mutational characterization of the catalytic A-module of the mannuronan C-5-epimerase AlgE4 from Azotobacter vinelandii. J Biol Chem (2008) 0.92
Simultaneous nucleotide activation and synthesis of amino acid amides by a potentially prebiotic multi-component reaction. Angew Chem Int Ed Engl (2007) 0.91
Murein and pseudomurein cell wall binding domains of bacteria and archaea--a comparative view. Appl Microbiol Biotechnol (2011) 0.91
Exploratory studies to investigate a linked prebiotic origin of RNA and coded peptides. Chem Biodivers (2004) 0.91
Crystal structure of quinohemoprotein alcohol dehydrogenase from Comamonas testosteroni: structural basis for substrate oxidation and electron transfer. J Biol Chem (2001) 0.90
A low pathogenic H5N2 influenza virus isolated in Taiwan acquired high pathogenicity by consecutive passages in chickens. J Vet Med Sci (2011) 0.90
Escherichia coli MltA: MAD phasing and refinement of a tetartohedrally twinned protein crystal structure. Acta Crystallogr D Biol Crystallogr (2005) 0.89
Acetobacter turbidans alpha-amino acid ester hydrolase: merohedral twinning in P21 obscured by pseudo-translational NCS. Acta Crystallogr D Biol Crystallogr (2003) 0.89
Identification of acceptor substrate binding subsites +2 and +3 in the amylomaltase from Thermus thermophilus HB8. Biochemistry (2007) 0.89
Suppressive effects of Amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expression. J Agric Food Chem (2011) 0.89
The search for a potentially prebiotic synthesis of nucleotides via arabinose-3-phosphate and its cyanamide derivative. Chemistry (2008) 0.88
Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda. Genes Cells (2006) 0.88
AcmD, a homolog of the major autolysin AcmA of Lactococcus lactis, binds to the cell wall and contributes to cell separation and autolysis. PLoS One (2013) 0.88
Improved catalytic properties of halohydrin dehalogenase by modification of the halide-binding site. Biochemistry (2005) 0.88
A sulphoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor. Biochem J (2003) 0.88
Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-kappaB activation. Int J Mol Med (2010) 0.87
Characterization of avian influenza viruses isolated from domestic ducks in Vietnam in 2009 and 2010. Arch Virol (2011) 0.87
The remote substrate binding subsite -6 in cyclodextrin-glycosyltransferase controls the transferase activity of the enzyme via an induced-fit mechanism. J Biol Chem (2001) 0.87
Inhibitory action of conjugated C18-fatty acids on DNA polymerases and DNA topoisomerases. Lipids (2004) 0.87
Conversion of cyclodextrin glycosyltransferase into a starch hydrolase by directed evolution: the role of alanine 230 in acceptor subsite +1. Biochemistry (2003) 0.87
Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases. Bioorg Med Chem (2009) 0.86
Crystal structure and biochemical properties of a novel thermostable esterase containing an immunoglobulin-like domain. J Mol Biol (2008) 0.86
Inhibitory effect of conjugated eicosapentaenoic acid on human DNA topoisomerases I and II. Arch Biochem Biophys (2005) 0.86
Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri. EMBO Rep (2006) 0.86
Functional analysis of the copper-dependent quercetin 2,3-dioxygenase. 2. X-ray absorption studies of native enzyme and anaerobic complexes with the substrates quercetin and myricetin. Biochemistry (2002) 0.86
The X-ray structure of the haloalcohol dehalogenase HheA from Arthrobacter sp. strain AD2: insight into enantioselectivity and halide binding in the haloalcohol dehalogenase family. J Bacteriol (2006) 0.86
Structural basis of phospholipase activity of Staphylococcus hyicus lipase. J Mol Biol (2007) 0.86
Inhibitory effects of cholesterol derivatives on DNA polymerase and topoisomerase activities, and human cancer cell growth. Lipids (2008) 0.86
Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities. Evid Based Complement Alternat Med (2011) 0.86
Fortuitous structure determination of 'as-isolated' Escherichia coli bacterioferritin in a novel crystal form. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.86
Structure-function relationship of synthetic sulfoquinovosyl-acylglycerols as mammalian DNA polymerase inhibitors. Arch Biochem Biophys (2002) 0.85
Engineering cyclodextrin glycosyltransferase into a starch hydrolase with a high exo-specificity. J Biotechnol (2003) 0.85
3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain. Mar Drugs (2009) 0.85
Petasiphenol: a DNA polymerase lambda inhibitor. Biochemistry (2002) 0.85
Improved thermostability of bacillus circulans cyclodextrin glycosyltransferase by the introduction of a salt bridge. Proteins (2004) 0.85
Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells. Biosci Biotechnol Biochem (2002) 0.85
Prebiotic chemistry: a new modus operandi. Philos Trans R Soc Lond B Biol Sci (2011) 0.85
Decreased nm23 expression, but not Ki-67 labeling index, is significantly correlated with lymph node metastasis of breast invasive ductal carcinoma. Int J Mol Med (2002) 0.84
The fully conserved Asp residue in conserved sequence region I of the alpha-amylase family is crucial for the catalytic site architecture and activity. FEBS Lett (2003) 0.84
Expeditious, potentially primordial, aminoacylation of nucleotides. Angew Chem Int Ed Engl (2005) 0.84
Inhibitory effects of α-mangostin on mammalian DNA polymerase, topoisomerase, and human cancer cell proliferation. Food Chem Toxicol (2013) 0.84
Inhibitory effect on replicative DNA polymerases, human cancer cell proliferation, and in vivo anti-tumor activity by glycolipids from spinach. Curr Med Chem (2007) 0.84
Structural basis for the enantioselectivity of an epoxide ring opening reaction catalyzed by halo alcohol dehalogenase HheC. J Am Chem Soc (2005) 0.84
Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. Biochimie (2007) 0.84
Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ. Proc Natl Acad Sci U S A (2014) 0.84
Inhibition of telomerase by linear-chain fatty acids: a structural analysis. Biochem J (2002) 0.84
1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis. Cancer Lett (2009) 0.84