PubRank

Lars C Pedersen

Author PubWeight™ 81.46‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure 2006 3.37
2 A closed conformation for the Pol lambda catalytic cycle. Nat Struct Mol Biol 2004 2.07
3 The X family portrait: structural insights into biological functions of X family polymerases. DNA Repair (Amst) 2007 1.98
4 Enzymatic redesigning of biologically active heparan sulfate. J Biol Chem 2005 1.89
5 Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Mol Cell 2008 1.88
6 A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction. Protein Sci 2010 1.66
7 Structural insight into the substrate specificity of DNA Polymerase mu. Nat Struct Mol Biol 2006 1.64
8 A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Mol Cell 2004 1.64
9 Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Biochemistry 2007 1.61
10 Energy analysis of chemistry for correct insertion by DNA polymerase beta. Proc Natl Acad Sci U S A 2006 1.56
11 (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. J Am Chem Soc 2007 1.48
12 Anticoagulant heparan sulfate: structural specificity and biosynthesis. Appl Microbiol Biotechnol 2006 1.42
13 Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. J Biol Chem 2004 1.41
14 Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase. Cell 2006 1.41
15 Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1. J Biol Chem 2004 1.38
16 Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Org Lett 2009 1.34
17 Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta. Proc Natl Acad Sci U S A 2008 1.33
18 Engineering sulfotransferases to modify heparan sulfate. Nat Chem Biol 2008 1.32
19 Replication infidelity via a mismatch with Watson-Crick geometry. Proc Natl Acad Sci U S A 2011 1.30
20 Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis. Environ Health Perspect 2013 1.25
21 DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". J Biol Chem 2009 1.25
22 Role of the catalytic metal during polymerization by DNA polymerase lambda. DNA Repair (Amst) 2007 1.23
23 Structure-function studies of DNA polymerase lambda. DNA Repair (Amst) 2005 1.22
24 Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues. J Am Chem Soc 2010 1.21
25 The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. J Allergy Clin Immunol 2010 1.20
26 Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. DNA Repair (Amst) 2005 1.19
27 Template strand scrunching during DNA gap repair synthesis by human polymerase lambda. Nat Struct Mol Biol 2009 1.19
28 Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure 2005 1.17
29 Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. Environ Health Perspect 2003 1.15
30 Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum. Microbiology 2003 1.14
31 Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin. Proc Natl Acad Sci U S A 2012 1.11
32 Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. J Biol Chem 2003 1.10
33 Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nat Struct Mol Biol 2010 1.08
34 Structural insights into the mechanism of nuclease A, a betabeta alpha metal nuclease from Anabaena. J Biol Chem 2005 1.07
35 Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol 2013 1.07
36 Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2. Biochem Biophys Res Commun 2003 1.05
37 Promiscuous mismatch extension by human DNA polymerase lambda. Nucleic Acids Res 2006 1.03
38 Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda. EMBO Rep 2008 1.03
39 Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex. J Biol Chem 2006 1.02
40 Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis. Proc Natl Acad Sci U S A 2008 1.01
41 Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction. J Am Chem Soc 2013 1.00
42 2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. J Biol Chem 2008 0.99
43 Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc Natl Acad Sci U S A 2013 0.98
44 Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. J Biol Chem 2007 0.98
45 Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity. Nucleic Acids Res 2008 0.97
46 Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proc Natl Acad Sci U S A 2006 0.96
47 The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ. Nucleic Acids Res 2012 0.96
48 Reaction mechanism of the epsilon subunit of E. coli DNA polymerase III: insights into active site metal coordination and catalytically significant residues. J Am Chem Soc 2009 0.95
49 The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α. Environ Health Perspect 2013 0.95
50 Der p 5 crystal structure provides insight into the group 5 dust mite allergens. J Biol Chem 2010 0.94
51 Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase. J Biol Chem 2014 0.94
52 Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity. Environ Health Perspect 2014 0.94
53 Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR. Biochem J 2005 0.92
54 The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment. J Allergy Clin Immunol 2013 0.91
55 A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda. DNA Repair (Amst) 2008 0.91
56 Understanding the substrate specificity of the heparan sulfate sulfotransferases by an integrated biosynthetic and crystallographic approach. Curr Opin Struct Biol 2012 0.91
57 The nuclease a-inhibitor complex is characterized by a novel metal ion bridge. J Biol Chem 2006 0.90
58 Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae. Nucleic Acids Res 2010 0.89
59 Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proc Natl Acad Sci U S A 2010 0.89
60 A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate. Biochemistry 2004 0.88
61 Novel DNA motif binding activity observed in vivo with an estrogen receptor α mutant mouse. Mol Endocrinol 2014 0.86
62 Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation. Nucleic Acids Res 2014 0.85
63 Molecular determinants of the stereoselectivity of agonist activity of estrogen receptors (ER) alpha and beta. J Biol Chem 2003 0.83
64 The molecular basis of peanut allergy. Curr Allergy Asthma Rep 2014 0.83
65 Inhibitors of Streptococcus pneumoniae surface endonuclease EndA discovered by high-throughput screening using a PicoGreen fluorescence assay. J Biomol Screen 2012 0.82
66 Structure-function studies of DNA polymerase λ. Biochemistry 2014 0.82
67 Functional residues on the surface of the N-terminal domain of yeast Pms1. DNA Repair (Amst) 2010 0.81
68 Explicit water near the catalytic I helix Thr in the predicted solution structure of CYP2A4. Biophys J 2003 0.78
69 Modeling of the DNA-binding site of yeast Pms1 by mass spectrometry. DNA Repair (Amst) 2011 0.76
70 Crystallographic analysis and mimicking of estradiol binding: Pedersen et al. Respond. Environ Health Perspect 2014 0.75