Published in Mol Cell on March 12, 2010
The microcosmos of cancer. Nature (2012) 4.50
Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One (2010) 3.50
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab (2012) 3.35
Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol (2011) 1.98
A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs. Cancer Res (2011) 1.89
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev (2010) 1.80
Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev (2010) 1.75
Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol (2010) 1.66
A systematic review of microRNA in glioblastoma multiforme: micro-modulators in the mesenchymal mode of migration and invasion. Mol Neurobiol (2012) 1.44
Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells. J Biol Chem (2012) 1.43
MicroRNAs are exported from malignant cells in customized particles. Nucleic Acids Res (2012) 1.43
Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549). J Exp Clin Cancer Res (2011) 1.33
AMP-activated protein kinase regulation and biological actions in the heart. Circ Res (2012) 1.33
Recent advances in the molecular understanding of glioblastoma. J Neurooncol (2012) 1.29
MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. J Cancer Res Clin Oncol (2011) 1.27
Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. RNA Biol (2013) 1.26
Current Progress on Understanding MicroRNAs in Glioblastoma Multiforme. Genes Cancer (2012) 1.25
Targeting adaptive glioblastoma: an overview of proliferation and invasion. Neuro Oncol (2014) 1.24
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. EMBO J (2011) 1.23
General principals of miRNA biogenesis and regulation in the brain. Neuropsychopharmacology (2012) 1.23
Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL. J Exp Med (2011) 1.21
Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res (2013) 1.19
Life history trade-offs in cancer evolution. Nat Rev Cancer (2013) 1.16
MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes. PLoS One (2011) 1.15
Differential effects of AMPK agonists on cell growth and metabolism. Oncogene (2014) 1.09
The role of microRNAs in glioma initiation and progression. Front Biosci (Landmark Ed) (2012) 1.07
microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. Cancer Res (2014) 1.07
Farnesoid X receptor protects hepatocytes from injury by repressing miR-199a-3p, which increases levels of LKB1. Gastroenterology (2012) 1.03
MicroRNA Control of Invasion and Metastasis Pathways. Front Genet (2011) 1.02
MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use. Genome Biol (2014) 0.99
miR451 and AMPK mutual antagonism in glioma cell migration and proliferation: a mathematical model. PLoS One (2011) 0.99
Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25. PLoS One (2012) 0.98
Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers. Ann Transl Med (2014) 0.97
miR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancer. Mol Cancer (2013) 0.97
Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate. BMC Genomics (2012) 0.96
Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma. Cell Death Differ (2014) 0.95
Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Rep (2015) 0.95
The P2X7 receptor is a key modulator of aerobic glycolysis. Cell Death Dis (2012) 0.95
Intratumoral heterogeneity in glioblastoma: don't forget the peritumoral brain zone. Neuro Oncol (2015) 0.95
TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PLoS One (2012) 0.94
The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells. PLoS One (2012) 0.94
MicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinoma. Oncotarget (2015) 0.93
MicroRNAs in cancer: glioblastoma and glioblastoma cancer stem cells. Neurochem Int (2014) 0.93
The dark face of AMPK as an essential tumor promoter. Cell Logist (2012) 0.92
Potential biofluid markers and treatment targets for renal cell carcinoma. Nat Rev Urol (2013) 0.91
Understanding the effects of tobacco smoke on the pathogenesis of aortic aneurysm. Arterioscler Thromb Vasc Biol (2013) 0.91
Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells. J Biol Chem (2011) 0.90
Regulation of cell proliferation and migration in glioblastoma: new therapeutic approach. Front Oncol (2013) 0.89
The altered expression profile of microRNAs in cardiopulmonary bypass canine models and the effects of mir-499 on myocardial ischemic reperfusion injury. J Transl Med (2013) 0.89
A novel miR-451a isomiR, associated with amelanotypic phenotype, acts as a tumor suppressor in melanoma by retarding cell migration and invasion. PLoS One (2014) 0.89
Regulation of Aerobic Glycolysis by microRNAs in Cancer. Mol Cell Pharmacol (2011) 0.89
miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway. Cell Oncol (Dordr) (2015) 0.89
The elephant in the room: do microRNA-based therapies have a realistic chance of succeeding for brain tumors such as glioblastoma? J Neurooncol (2010) 0.88
The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cells. PLoS One (2010) 0.88
Hypoxia induced tumor metabolic switch contributes to pancreatic cancer aggressiveness. Cancers (Basel) (2010) 0.88
Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro Oncol (2014) 0.88
Drug-target network in myocardial infarction reveals multiple side effects of unrelated drugs. Sci Rep (2011) 0.88
Molecular Pathways: Is AMPK a Friend or a Foe in Cancer? Clin Cancer Res (2015) 0.87
MicroRNA in Human Glioma. Cancers (Basel) (2013) 0.87
microRNA Expression in Prospectively Collected Blood as a Potential Biomarker of Breast Cancer Risk in the BCFR. Anticancer Res (2015) 0.86
Stretch-sensitive down-regulation of the miR-144/451 cluster in vascular smooth muscle and its role in AMP-activated protein kinase signaling. PLoS One (2013) 0.86
Long non-coding RNA in glioma: signaling pathways. Oncotarget (2017) 0.86
Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer? Int Neurourol J (2015) 0.85
NDRG2 overexpression enhances glucose deprivation-mediated apoptosis in breast cancer cells via inhibition of the LKB1-AMPK pathway. Genes Cancer (2014) 0.85
Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets. Stem Cells Int (2016) 0.85
MiR-451, a potential prognostic biomarker and tumor suppressor for gastric cancer. Int J Clin Exp Pathol (2015) 0.84
MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. J Cell Mol Med (2014) 0.84
Chemical Inhibitors and microRNAs (miRNA) Targeting the Mammalian Target of Rapamycin (mTOR) Pathway: Potential for Novel Anticancer Therapeutics. Int J Mol Sci (2013) 0.84
Interplay Between Metabolism and Oncogenic Process: Role of microRNAs. Transl Oncogenomics (2015) 0.84
MicroRNAs in Liver Health and Disease. Curr Pathobiol Rep (2013) 0.83
A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies. Oncotarget (2015) 0.83
Decoding the cancer stem cell hypothesis in glioblastoma. CNS Oncol (2013) 0.82
MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma. Cancer Sci (2016) 0.82
microRNA Regulation and Its Consequences in Cancer. Curr Pathobiol Rep (2012) 0.82
Strategies of eradicating glioma cells: a multi-scale mathematical model with MiR-451-AMPK-mTOR control. PLoS One (2015) 0.82
Circulating microRNA signature as liquid-biopsy to monitor lung cancer in low-dose computed tomography screening. Oncotarget (2015) 0.81
MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. PLoS One (2012) 0.81
Hydrogen sulfide mitigates hyperglycemic remodeling via liver kinase B1-adenosine monophosphate-activated protein kinase signaling. Biochim Biophys Acta (2014) 0.81
MicroRNAs: Allies or foes in erythropoiesis? J Cell Physiol (2012) 0.81
Micro-masters of glioblastoma biology and therapy: increasingly recognized roles for microRNAs. Neuro Oncol (2014) 0.81
Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20. Sci Rep (2015) 0.80
A genome-wide systematic analysis reveals different and predictive proliferation expression signatures of cancerous vs. non-cancerous cells. PLoS Genet (2013) 0.80
Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells. Front Neurosci (2015) 0.80
Probucol suppresses human glioma cell proliferation in vitro via ROS production and LKB1-AMPK activation. Acta Pharmacol Sin (2014) 0.80
A microRNA Link to Glioblastoma Heterogeneity. Cancers (Basel) (2012) 0.80
Tumor Protein p63/microRNA Network in Epithelial Cancer Cells. Curr Genomics (2013) 0.80
Edge effects in game-theoretic dynamics of spatially structured tumours. J R Soc Interface (2015) 0.79
Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma. Oncotarget (2015) 0.78
Role of a DNA damage checkpoint pathway in ionizing radiation-induced glioblastoma cell migration and invasion. Cell Mol Neurobiol (2012) 0.78
Altered expression of microRNA-451 in eutopic endometrium of baboons (Papio anubis) with endometriosis. Hum Reprod (2015) 0.78
Phenotypic Transition as a Survival Strategy of Glioma. Neurol Med Chir (Tokyo) (2016) 0.78
Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects. World J Gastroenterol (2016) 0.77
MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis. Int J Mol Sci (2016) 0.77
CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis. PLoS One (2016) 0.77
miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas. Neuro Oncol (2016) 0.77
Identification of crucial parameters in a mathematical multiscale model of glioblastoma growth. Comput Math Methods Med (2014) 0.77
Metabolic Reprogramming in Glioma. Front Cell Dev Biol (2017) 0.77
The role of octamer binding transcription factors in glioblastoma multiforme. Biochim Biophys Acta (2016) 0.76
A single-nucleotide polymorphism in serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor for multiple sclerosis. ASN Neuro (2015) 0.76
MicroRNA and extracellular vesicles in glioblastoma: small but powerful. Brain Tumor Pathol (2016) 0.76
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med (2005) 74.55
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
On the origin of cancer cells. Science (1956) 49.55
Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47
Identification of human brain tumour initiating cells. Nature (2004) 38.87
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
The diverse functions of microRNAs in animal development and disease. Dev Cell (2006) 15.62
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J (2004) 10.82
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell (2009) 8.14
Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol (2002) 8.04
The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell (2004) 7.77
Cancer's molecular sweet tooth and the Warburg effect. Cancer Res (2006) 7.24
Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev (2009) 6.46
Cost of migration: invasion of malignant gliomas and implications for treatment. J Clin Oncol (2003) 5.28
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol (2008) 5.21
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev (2007) 5.16
Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res (2008) 4.64
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell (2008) 4.57
Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med (1987) 4.55
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell (2004) 3.87
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J (2003) 3.77
The regulation of AMP-activated protein kinase by phosphorylation. Biochem J (2000) 3.76
Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature (2007) 3.71
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J Biol Chem (1995) 3.46
mTOR and cancer therapy. Oncogene (2006) 3.07
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature (2008) 2.96
microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells. Clin Cancer Res (2009) 2.80
The role of myosin II in glioma invasion of the brain. Mol Biol Cell (2008) 2.20
MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun (2008) 2.15
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem (2007) 2.12
Polarity proteins in migration and invasion. Oncogene (2008) 2.11
LKB1; linking cell structure and tumor suppression. Oncogene (2008) 1.96
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells. Biochem Biophys Res Commun (2008) 1.85
Adult glioma incidence trends in the United States, 1977-2000. Cancer (2004) 1.78
LKB1 and AMPK in cell polarity and division. Trends Cell Biol (2008) 1.72
CD133 is a marker of bioenergetic stress in human glioma. PLoS One (2008) 1.63
Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3. Neuro Oncol (2008) 1.47
Emerging functions of microRNAs in glioblastoma. J Neurooncol (2009) 1.44
Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors. Mol Biol Cell (2006) 1.31
Association between hyperglycemia and survival in patients with newly diagnosed glioblastoma. J Clin Oncol (2009) 1.30
LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning. J Neurosci (2007) 1.22
Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas. Neurosurgery (2008) 1.17
Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration. J Neurosci (2008) 1.16
Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes. FEBS Lett (2008) 0.93
A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. Brain Res (2007) 0.88
microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res (2008) 4.81
Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation (2009) 4.71
Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res (2008) 4.64
miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell (2009) 4.48
Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21
A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood (2002) 4.06
Extra-embryonic function of Rb is essential for embryonic development and viability. Nature (2003) 3.92
Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res (2008) 3.41
MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. J Biol Chem (2009) 3.16
Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem (2008) 3.00
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med (2011) 2.93
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A (2006) 2.72
Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature (2008) 2.71
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue. Immunity (2010) 2.67
Reprogramming of miRNA networks in cancer and leukemia. Genome Res (2010) 2.65
miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res (2012) 2.52
Degos disease: a C5b-9/interferon-α-mediated endotheliopathy syndrome. Am J Clin Pathol (2011) 2.50
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat Med (2011) 2.46
Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy. J Natl Cancer Inst (2007) 2.46
Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res (2006) 2.42
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest (2008) 2.29
Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology (2009) 2.29
Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR Am J Neuroradiol (2004) 2.21
Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22. Blood (2009) 2.18
Genomic alterations in tumor stroma. Cancer Res (2009) 2.18
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood (2006) 2.18
Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood (2009) 2.17
Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med (2013) 2.16
Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA. Proc Natl Acad Sci U S A (2012) 2.07
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer. J Natl Cancer Inst (2010) 1.94
The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci (2009) 1.85
Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells. Mol Ther (2003) 1.78
Evidence for a stepwise program of extrathymic T cell development within the human tonsil. J Clin Invest (2012) 1.72
Karyotype-specific microRNA signature in chronic lymphocytic leukemia. Blood (2009) 1.70
An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. Cancer Res (2005) 1.63
Gene expression networks in COPD: microRNA and mRNA regulation. Thorax (2011) 1.62
Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis. Mol Cell Biol (2002) 1.60
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res (2007) 1.60
Histone deacetylase inhibitors augment antitumor efficacy of herpes-based oncolytic viruses. Mol Ther (2008) 1.59
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. J Biol Chem (2002) 1.59
MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation. J Biol Chem (2007) 1.53
REO-10: a phase I study of intravenous reovirus and docetaxel in patients with advanced cancer. Clin Cancer Res (2010) 1.53
Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res (2009) 1.52
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med (2012) 1.52
Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis. Gene Ther (2004) 1.51
Glioma virotherapy: effects of innate immune suppression and increased viral replication capacity. Cancer Res (2006) 1.47
Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3. Neuro Oncol (2008) 1.47
Emerging functions of microRNAs in glioblastoma. J Neurooncol (2009) 1.44
Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors. Mol Cell Biol (2007) 1.43
ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis. Oncogene (2005) 1.42
Human herpesvirus 6-related fulminant myocarditis and hepatitis in an immunocompetent adult with fatal outcome. Hum Pathol (2009) 1.42
Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell (2003) 1.42
Bovine leukemia virus DNA in human breast tissue. Emerg Infect Dis (2014) 1.41
microRNA-451: A conditional switch controlling glioma cell proliferation and migration. Cell Cycle (2010) 1.40
An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. Cancer Res (2010) 1.39
Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance. Clin Cancer Res (2013) 1.35
ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis. Inflamm Bowel Dis (2006) 1.32
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther (2006) 1.32
e-Science, caGrid, and Translational Biomedical Research. Computer (Long Beach Calif) (2008) 1.32
Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors. Mol Biol Cell (2006) 1.31
The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol (2004) 1.31
Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells. Cancer Res (2008) 1.30
Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61. Mol Ther (2008) 1.28
TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. PLoS One (2010) 1.28
Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter. J Biol Chem (2003) 1.27
Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity. Brain (2011) 1.27
Cyclophosphamide allows for in vivo dose reduction of a potent oncolytic virus. Cancer Res (2005) 1.26
Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis. PLoS One (2009) 1.26
Anti-microRNA-222 (anti-miR-222) and -181B suppress growth of tamoxifen-resistant xenografts in mouse by targeting TIMP3 protein and modulating mitogenic signal. J Biol Chem (2011) 1.24
Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLoS Genet (2013) 1.24
BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells. DNA Repair (Amst) (2005) 1.23
GAMES identifies and annotates mutations in next-generation sequencing projects. Bioinformatics (2010) 1.21
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse. Cancer Res (2006) 1.20
MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol (2013) 1.20
"Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment. Curr Gene Ther (2009) 1.20
Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia (2011) 1.19
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase. J Biol Chem (2004) 1.18
MicroRNA expression profiling in human Barrett's carcinogenesis. Int J Cancer (2011) 1.17
Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes. Clin Cancer Res (2010) 1.17
Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumors. Mol Ther (2005) 1.16
Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1. Mol Ther (2009) 1.16
Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression. J Biol Chem (2003) 1.14
The complement response against an oncolytic virus is species-specific in its activation pathways. Mol Ther (2002) 1.14
Comparison of microRNA deep sequencing of matched formalin-fixed paraffin-embedded and fresh frozen cancer tissues. PLoS One (2013) 1.14