MicroRNAs: target recognition and regulatory functions.

Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature (2010) 22.04

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell (2010) 17.87

RNA-guided genetic silencing systems in bacteria and archaea. Nature (2012) 17.12

The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature (2010) 13.82

Genome regulation by long noncoding RNAs. Annu Rev Biochem (2012) 11.70

Molecular mechanisms of long noncoding RNAs. Mol Cell (2011) 11.44

Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51

A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell (2011) 10.50

Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell (2009) 10.50

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature (2009) 10.26

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell (2009) 10.09

Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet (2011) 9.79

Natural RNA circles function as efficient microRNA sponges. Nature (2013) 8.93

Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54

Modular regulatory principles of large non-coding RNAs. Nature (2012) 7.42

The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol (2012) 7.32

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol (2010) 7.15

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev (2010) 7.14

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell (2011) 7.02

MiR-33 contributes to the regulation of cholesterol homeostasis. Science (2010) 6.93

MicroRNAs in stress signaling and human disease. Cell (2012) 6.93

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence. Proc Natl Acad Sci U S A (2011) 6.89

Control of the embryonic stem cell state. Cell (2011) 6.89

lincRNAs: genomics, evolution, and mechanisms. Cell (2013) 6.50

The functional role of long non-coding RNA in human carcinomas. Mol Cancer (2011) 6.37

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37

Roles for microRNAs in conferring robustness to biological processes. Cell (2012) 6.32

Pervasive roles of microRNAs in cardiovascular biology. Nature (2011) 6.08

Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov (2010) 6.07

miRNAs in human cancer. J Pathol (2010) 6.02

A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (2010) 5.84

MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science (2010) 5.77

MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74

STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell (2010) 5.67

Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol (2011) 5.57

lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature (2011) 5.42

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet (2012) 5.38

RNA processing and its regulation: global insights into biological networks. Nat Rev Genet (2010) 5.34

miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22

In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell (2011) 5.19

Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. Proc Natl Acad Sci U S A (2009) 5.13

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol (2012) 5.12

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat Biotechnol (2014) 5.07

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A (2012) 5.07

miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95

Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81

Regulation by small RNAs in bacteria: expanding frontiers. Mol Cell (2011) 4.68

Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish. Science (2012) 4.61

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proc Natl Acad Sci U S A (2011) 4.58

TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support. Nucleic Acids Res (2011) 4.54

The microcosmos of cancer. Nature (2012) 4.50

MicroRNA functions in stress responses. Mol Cell (2010) 4.46

miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science (2012) 4.44

Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev (2009) 4.43

HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev (2009) 4.41

Functional screening identifies miRNAs inducing cardiac regeneration. Nature (2012) 4.39

A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature (2010) 4.39

Predicting effective microRNA target sites in mammalian mRNAs. Elife (2015) 4.30

Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding. Cell (2013) 4.28

Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov (2010) 4.25

Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nat Struct Mol Biol (2010) 4.22

Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell (2010) 4.20

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev (2009) 4.15

miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell (2010) 4.07

Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol (2011) 4.06

miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development. Nat Genet (2010) 4.06

TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol (2009) 4.05

The crystal structure of human Argonaute2. Science (2012) 4.03

miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci U S A (2010) 3.99

starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res (2010) 3.99

Target RNA-directed trimming and tailing of small silencing RNAs. Science (2010) 3.98

MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91

LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87

Desperately seeking microRNA targets. Nat Struct Mol Biol (2010) 3.85

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82

Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis. Genome Res (2011) 3.81

Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 3.80

MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol (2012) 3.78

DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways. Nucleic Acids Res (2012) 3.67

MicroRNAs in cancer. Annu Rev Pathol (2013) 3.50

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol (2009) 3.48

A continuum model for tumour suppression. Nature (2011) 3.48

Ending the message: poly(A) signals then and now. Genes Dev (2011) 3.47

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol (2012) 3.42

Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron (2010) 3.37

Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet (2011) 3.36

Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci U S A (2011) 3.35

MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov (2013) 3.33

The landscape of C. elegans 3'UTRs. Science (2010) 3.32

Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature (2014) 3.31

Viruses, microRNAs, and host interactions. Annu Rev Microbiol (2010) 3.30

The role of RNAi and microRNAs in animal virus replication and antiviral immunity. Genes Dev (2009) 3.30

Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29

Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron (2009) 3.27

The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell (2013) 3.27

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27

MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62

Prediction of mammalian microRNA targets. Cell (2003) 53.70

Combinatorial microRNA target predictions. Nat Genet (2005) 50.48

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95

Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16

A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31

miRBase: tools for microRNA genomics. Nucleic Acids Res (2007) 38.61

MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell (2007) 38.42

Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2008) 37.16

The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49

Human MicroRNA targets. PLoS Biol (2004) 34.51

An extensive class of small RNAs in Caenorhabditis elegans. Science (2001) 34.17

A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell (1993) 33.79

Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56

The impact of microRNAs on protein output. Nature (2008) 32.39

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet (2008) 32.08

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60

Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell (2001) 25.86

Principles of microRNA-target recognition. PLoS Biol (2005) 23.70

MicroRNA targets in Drosophila. Genome Biol (2003) 23.59

A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36

The UCSC Genome Browser Database: 2008 update. Nucleic Acids Res (2007) 23.13

Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev (2002) 19.24

Prediction of plant microRNA targets. Cell (2002) 19.20

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature (2000) 19.15

The role of site accessibility in microRNA target recognition. Nat Genet (2007) 18.52

MicroRNA-directed cleavage of HOXB8 mRNA. Science (2004) 18.33

Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science (2006) 18.14

The microRNAs of Caenorhabditis elegans. Genes Dev (2003) 17.70

Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet (2002) 17.20

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature (2005) 17.17

Switching from repression to activation: microRNAs can up-regulate translation. Science (2007) 17.00

The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26

Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24

siRNAs can function as miRNAs. Genes Dev (2003) 16.08

MicroRNA expression in zebrafish embryonic development. Science (2005) 15.52

Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Cell (2005) 15.38

Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell (2005) 15.26

Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell (2006) 15.12

A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02

A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell (2006) 14.70

MicroRNAS and their regulatory roles in plants. Annu Rev Plant Biol (2006) 14.44

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet (2004) 12.97

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature (2003) 12.93

The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell (1997) 12.87

Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell (2006) 12.73

Identification of Drosophila MicroRNA targets. PLoS Biol (2003) 12.72

Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48

Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science (2007) 12.42

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66

Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (2008) 11.33

A genome-wide map of conserved microRNA targets in C. elegans. Curr Biol (2006) 10.14

MicroRNAs and other tiny endogenous RNAs in C. elegans. Curr Biol (2003) 9.90

A combined computational-experimental approach predicts human microRNA targets. Genes Dev (2004) 9.82

Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61

The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36

MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33

Potent effect of target structure on microRNA function. Nat Struct Mol Biol (2007) 8.92

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev (2004) 8.42

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nat Genet (2006) 8.37

Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science (2005) 8.20

Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR. Proc Natl Acad Sci U S A (2007) 7.93

Kinetic analysis of the RNAi enzyme complex. Nat Struct Mol Biol (2004) 7.26

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12

Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A (2006) 7.11

RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell (2007) 7.06

The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Dev Cell (2003) 6.86

microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77

Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA (2007) 6.44

MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev (2006) 6.30

MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. EMBO J (2004) 6.27

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature (2005) 6.23

Inference of miRNA targets using evolutionary conservation and pathway analysis. BMC Bioinformatics (2007) 6.21

Small RNAs correspond to centromere heterochromatic repeats. Science (2002) 5.96

The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90

Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes Dev (2005) 5.78

Incorporating structure to predict microRNA targets. Proc Natl Acad Sci U S A (2005) 5.68

Isolation of microRNA targets by miRNP immunopurification. RNA (2007) 5.50

Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33

Multiplex detection of RNA expression in Drosophila embryos. Science (2004) 5.27

A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03

Spatial preferences of microRNA targets in 3' untranslated regions. BMC Genomics (2007) 4.99

Identification of human microRNA targets from isolated argonaute protein complexes. RNA Biol (2007) 4.96

Distance constraints between microRNA target sites dictate efficacy and cooperativity. Nucleic Acids Res (2007) 4.91

Reliable prediction of regulator targets using 12 Drosophila genomes. Genome Res (2007) 4.89

Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science (2007) 4.72

MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59

A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell (2005) 4.54

Concern Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic Acids Res (2004) 4.50

Molecular basis for target RNA recognition and cleavage by human RISC. Cell (2007) 4.40

LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Science (2005) 4.28