Published in J Immunol on March 12, 2010
Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nat Immunol (2011) 1.45
Immunoproteasomes: structure, function, and antigen presentation. Prog Mol Biol Transl Sci (2012) 1.36
The role of the proteasome in the generation of MHC class I ligands and immune responses. Cell Mol Life Sci (2011) 1.35
The immunoproteasomes regulate LPS-induced TRIF/TRAM signaling pathway in murine macrophages. Cell Biochem Biophys (2011) 0.96
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO Mol Med (2014) 0.95
Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases. J Immunol (2011) 0.93
Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis. PLoS Pathog (2011) 0.92
Mixed proteasomes function to increase viral peptide diversity and broaden antiviral CD8+ T cell responses. J Immunol (2013) 0.92
Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity. FASEB J (2015) 0.90
The immunoproteasome and viral infection: a complex regulator of inflammation. Front Microbiol (2015) 0.86
Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. PLoS One (2013) 0.84
Revisiting the role of the immunoproteasome in the activation of the canonical NF-κB pathway. Mol Biosyst (2012) 0.83
A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes. Pharmacology (2012) 0.83
New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells. J Immunol Res (2015) 0.82
Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice. Clin Exp Immunol (2012) 0.82
A FRET-based approach for identification of proteasome catalytic subunit composition. Mol Biosyst (2014) 0.79
Proteasome subtypes and regulators in the processing of antigenic peptides presented by class I molecules of the major histocompatibility complex. Biomolecules (2014) 0.79
Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages. Cell Death Differ (2016) 0.79
Expression of vascular endothelial growth factor and transcription factors HIF-1, NF-kB expression in squamous cell carcinoma of head and neck; association with proteasome and calpain activities. J Cancer Res Clin Oncol (2012) 0.78
Enhanced inflammatory potential of CD4+ T-cells that lack proteasome immunosubunit expression, in a T-cell transfer-based colitis model. PLoS One (2014) 0.77
Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7. Oncotarget (2017) 0.77
Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS One (2016) 0.76
Editorial: Proteostenosis: cancer's Achilles heel? J Leukoc Biol (2012) 0.75
Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection. Virology (2016) 0.75
Dysregulation of the (immuno)proteasome pathway in malformations of cortical development. J Neuroinflammation (2016) 0.75
Elucidating the catalytic subunit composition of distinct proteasome subtypes: a crosslinking approach employing bifunctional activity-based probes. Chembiochem (2014) 0.75
Emerging role of immunoproteasomes in pathophysiology. Immunol Cell Biol (2016) 0.75
Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit. ACS Med Chem Lett (2017) 0.75
Low Neurotoxicity of ONX-0914 Supports the Idea of Specific Immunoproteasome Inhibition as a Side-Effect-Limiting, Therapeutic Strategy. Eur J Microbiol Immunol (Bp) (2017) 0.75
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution. Science (1995) 12.94
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell (1994) 11.73
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell (1994) 11.62
Protein degradation and protection against misfolded or damaged proteins. Nature (2003) 10.19
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol (2001) 8.31
Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity (2001) 5.04
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity (2003) 4.93
Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell (2000) 3.97
Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway. Nature (1991) 3.26
Functional analysis of influenza-specific helper T cell clones in vivo. T cells specific for internal viral proteins provide cognate help for B cell responses to hemagglutinin. J Exp Med (1986) 2.89
Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity (1994) 2.39
Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits. J Exp Med (1998) 2.32
The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation. J Biol Chem (1999) 2.29
Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J Exp Med (2001) 2.28
Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol (2004) 2.27
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide. EMBO J (2001) 2.09
The MHC class I ligand-generating system: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28. Immunol Rev (1998) 1.94
Neuronal induction of the immunoproteasome in Huntington's disease. J Neurosci (2003) 1.83
CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection. J Immunol (2005) 1.77
Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liver. J Immunol (2001) 1.66
The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome. Proc Natl Acad Sci U S A (1997) 1.64
Different proteasome subtypes in a single tissue exhibit different enzymatic properties. J Mol Biol (2000) 1.52
Managing and exploiting stress in the antibody factory. FEBS Lett (2007) 1.48
Induction of CD4(+) T-cell-independent immunoglobulin responses by inactivated influenza virus. J Virol (2000) 1.44
NOD mice are defective in proteasome production and activation of NF-kappaB. Mol Cell Biol (1999) 1.41
Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol Cell Proteomics (2007) 1.41
An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions. J Exp Med (2003) 1.40
Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes. J Virol (2003) 1.39
T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens. J Immunol (2006) 1.23
The seven dirty little secrets of major histocompatibility complex class I antigen processing. Immunol Rev (2005) 1.23
Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination. J Immunol (2005) 1.23
Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation. Eur J Immunol (1999) 1.20
Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency. FASEB J (2008) 1.14
Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses. J Immunol (2006) 1.14
Role of proteasomes modified by interferon-gamma in antigen processing. J Leukoc Biol (1994) 1.06
LMP2 knock-out mice have reduced proteasome activities and increased levels of oxidatively damaged proteins. Antioxid Redox Signal (2006) 1.00
Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus. J Virol (2006) 0.98
The proteasome immunosubunit multicatalytic endopeptidase complex-like 1 is a T-cell-intrinsic factor influencing homeostatic expansion. Infect Immun (2007) 0.96
Dampening Ab responses using proteasome inhibitors following in vivo B cell activation. Eur J Immunol (2008) 0.95
LMP2 expression and proteasome activity in NOD mice. Nat Med (2000) 0.88
Inhibition of apoptosis in acute promyelocytic leukemia cells leads to increases in levels of oxidized protein and LMP2 immunoproteasome. Proc Natl Acad Sci U S A (2004) 0.88
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72
Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe (2007) 5.46
Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift. Science (2009) 3.88
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J Exp Med (2004) 3.43
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proc Natl Acad Sci U S A (2012) 3.27
Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo. Nat Immunol (2002) 3.22
Quantitating protein synthesis, degradation, and endogenous antigen processing. Immunity (2003) 3.14
Immune recognition of a human renal cancer antigen through post-translational protein splicing. Nature (2004) 2.84
RNAdb--a comprehensive mammalian noncoding RNA database. Nucleic Acids Res (2005) 2.84
Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans. Proc Natl Acad Sci U S A (2004) 2.80
The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function. J Virol (2003) 2.76
MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. Sci Transl Med (2011) 2.75
Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes. Nat Immunol (2008) 2.52
CD8+ T cell cross-priming via transfer of proteasome substrates. Science (2004) 2.51
Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature (2009) 2.50
HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation. Proc Natl Acad Sci U S A (2005) 2.11
A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies. Proc Natl Acad Sci U S A (2006) 2.00
Cutting edge: intravascular staining redefines lung CD8 T cell responses. J Immunol (2012) 1.99
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med (2011) 1.95
Nuclear translation visualized by ribosome-bound nascent chain puromycylation. J Cell Biol (2012) 1.93
Heterosubtypic immunity to influenza A virus: where do we stand? Microbes Infect (2008) 1.88
HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products. J Immunol (2005) 1.75
Genome-wide identification of long noncoding RNAs in CD8+ T cells. J Immunol (2009) 1.73
Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins. J Cell Biol (2004) 1.69
Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice. J Virol (2006) 1.66
The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells. Cancer Res (2008) 1.64
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin. Cell Host Microbe (2013) 1.62
Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control. J Biol Chem (2005) 1.62
NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells. Nat Immunol (2012) 1.62
Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain. PLoS Pathog (2010) 1.57
Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis. Arthritis Rheum (2009) 1.56
Influenza A virus hemagglutinin trimerization completes monomer folding and antigenicity. J Virol (2013) 1.56
Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. J Immunol (2005) 1.54
Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery. Blood (2004) 1.54
Regulatory T-cell-mediated attenuation of T-cell responses to the NY-ESO-1 ISCOMATRIX vaccine in patients with advanced malignant melanoma. Clin Cancer Res (2009) 1.52
Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells. J Immunol (2002) 1.51
RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes. J Biol Chem (2011) 1.41
Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy. Proc Natl Acad Sci U S A (2011) 1.40
MEK inhibition, alone or in combination with BRAF inhibition, affects multiple functions of isolated normal human lymphocytes and dendritic cells. Cancer Immunol Res (2014) 1.40
The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. Immunity (2008) 1.30
Beta 2 subunit propeptides influence cooperative proteasome assembly. J Biol Chem (2002) 1.28
Reversal in the immunodominance hierarchy in secondary CD8+ T cell responses to influenza A virus: roles for cross-presentation and lysis-independent immunodomination. J Immunol (2004) 1.28
Tight linkage between translation and MHC class I peptide ligand generation implies specialized antigen processing for defective ribosomal products. J Immunol (2006) 1.27
Comment on "Large-scale sequence analysis of avian influenza isolates". Science (2006) 1.25
Fusion proteins with COOH-terminal ubiquitin are stable and maintain dual functionality in vivo. J Biol Chem (2002) 1.25
Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action. Proc Natl Acad Sci U S A (2010) 1.25
Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance. PLoS One (2011) 1.24
T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens. J Immunol (2006) 1.23
A survival game of hide and seek: cytomegaloviruses and MHC class I antigen presentation pathways. Viral Immunol (2003) 1.21
Reactivation of stalled polyribosomes in synaptic plasticity. Proc Natl Acad Sci U S A (2013) 1.18
Sympathetic nervous system control of anti-influenza CD8+ T cell responses. Proc Natl Acad Sci U S A (2009) 1.17
Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies. Proc Natl Acad Sci U S A (2013) 1.17
Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus. J Virol (2002) 1.17
The early expression of glycoprotein B from herpes simplex virus can be detected by antigen-specific CD8+ T cells. J Virol (2003) 1.16