PubRank

Joan S Brugge

Author PubWeight™ 196.81‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003 18.51
2 Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 2005 8.70
3 Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A 2006 8.01
4 The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 2002 7.35
5 Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet 2011 6.89
6 Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009 5.32
7 Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 2005 5.07
8 Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 2005 5.00
9 Mutant p53 drives invasion by promoting integrin recycling. Cell 2009 4.75
10 Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 2003 4.25
11 Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol 2002 4.22
12 Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A 2003 4.03
13 A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 2007 3.97
14 Engineering tumors with 3D scaffolds. Nat Methods 2007 3.96
15 Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol 2008 3.72
16 p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol 2006 3.37
17 The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell 2003 3.36
18 YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol 2009 3.26
19 A non-genetic route to aneuploidy in human cancers. Nat Cell Biol 2011 3.25
20 Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol 2002 2.92
21 Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci U S A 2004 2.81
22 Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron 2005 2.72
23 Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell 2012 2.71
24 BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell 2007 2.60
25 Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity 2006 2.57
26 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A 2004 2.56
27 Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature 2012 2.40
28 Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol 2003 2.38
29 Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol 2012 2.33
30 IL-6 involvement in epithelial cancers. J Clin Invest 2007 2.29
31 MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A 2010 2.21
32 Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev 2011 2.20
33 Common effector processing mediates cell-specific responses to stimuli. Nature 2007 2.20
34 Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol 2005 2.20
35 Overview of the Alliance for Cellular Signaling. Nature 2002 2.15
36 Identifying single-cell molecular programs by stochastic profiling. Nat Methods 2010 2.11
37 Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell 2012 2.11
38 Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A 2010 2.10
39 The cell biology of cell-in-cell structures. Nat Rev Mol Cell Biol 2008 1.96
40 Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov 2011 1.88
41 Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol 2004 1.87
42 Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc Natl Acad Sci U S A 2007 1.83
43 Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis. J Mammary Gland Biol Neoplasia 2004 1.71
44 Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. J Proteome Res 2006 1.66
45 Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle 2007 1.62
46 Novel role for PDEF in epithelial cell migration and invasion. Cancer Res 2005 1.57
47 Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol 2004 1.56
48 Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol 2004 1.40
49 G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression. Mol Cell Biol 2005 1.35
50 Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell 2012 1.26
51 Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proc Natl Acad Sci U S A 2011 1.26
52 PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One 2010 1.15
53 Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival. Cancer Res 2009 1.15
54 Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. Sci Signal 2012 1.14
55 Chaperone-mediated autophagy degrades mutant p53. Genes Dev 2013 1.11
56 A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene 2004 1.11
57 Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Curr Biol 2008 1.10
58 Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance. J Clin Invest 2014 1.05
59 Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene 2005 1.04
60 ErbB2 and TGF-beta: a cooperative role in mammary tumor progression? Cell Cycle 2004 1.03
61 PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells. Cancer Cell 2013 1.01
62 A stiff blow from the stroma: collagen crosslinking drives tumor progression. Cancer Cell 2009 1.01
63 Tumor self-seeding: bidirectional flow of tumor cells. Cell 2009 0.94
64 Tensins: a new switch in cell migration. Dev Cell 2007 0.91
65 ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. J Biol Chem 2010 0.89
66 Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev 2011 0.89
67 p63, cell adhesion and survival. Cell Cycle 2007 0.88
68 Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis. Mol Biol Cell 2010 0.88
69 Uncovering a tumor suppressor for triple-negative breast cancers. Cell 2011 0.86
70 Transcriptional regulation of metastatic [Id]entity by KLF17. Genome Biol 2009 0.85
71 Circulating colony stimulating factor-1 and breast cancer risk. Cancer Res 2008 0.85
72 In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis. J Vis Exp 2012 0.84
73 Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res 2013 0.83
74 YB-1 translational control of epithelial-mesenchyme transition. Cancer Cell 2009 0.82
75 An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand. Cell Commun Signal 2006 0.81
76 The myosin-II-responsive focal adhesion proteome: a tour de force? Nat Cell Biol 2011 0.80
77 Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. PLoS One 2010 0.80
78 SePARating polarity and proliferation in ErbB2 oncogenesis. Nat Cell Biol 2006 0.77
79 [Entosis, a cell death process related to cell cannibalism between tumor cells]. Med Sci (Paris) 2008 0.76
80 Mechanistic biology in the next quarter century. Mol Biol Cell 2010 0.76
81 Direct phosphorylation of focal adhesion kinase by c-Src: evidence using a modified nucleotide pocket kinase and ATP analog. Biochem Biophys Res Commun 2002 0.76
82 Correction: Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters. Elife 2015 0.75
83 Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues. Nano Lett 2017 0.75
84 Corrigendum: Chaperone-mediated autophagy degrades mutant p53. Genes Dev 2016 0.75