Published in Infect Immun on March 15, 2010
Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. J Clin Invest (2011) 1.24
Monocyte chemoattractant protein 1 regulates pulmonary host defense via neutrophil recruitment during Escherichia coli infection. Infect Immun (2011) 1.16
Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice. J Immunol (2012) 1.14
Obesity and respiratory infections: does excess adiposity weigh down host defense? Pulm Pharmacol Ther (2012) 1.08
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med (2013) 1.05
A 24-48 h fed Amblyomma americanum tick saliva immuno-proteome. BMC Genomics (2014) 1.03
Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood (2010) 1.02
Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. J Immunol (2010) 0.94
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. J Immunol (2012) 0.94
Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity. J Biol Chem (2011) 0.92
An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. PLoS One (2013) 0.90
Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes. J Immunol (2013) 0.88
E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae. Prostaglandins Other Lipid Mediat (2012) 0.85
Protective role of 5-lipoxigenase during Leishmania infantum infection is associated with Th17 subset. Biomed Res Int (2014) 0.80
The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. PLoS Negl Trop Dis (2013) 0.80
Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection. Nat Commun (2015) 0.78
Obesity: impact of infections and response to vaccines. Eur J Clin Microbiol Infect Dis (2015) 0.77
Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality. Nat Commun (2016) 0.77
Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. Am J Physiol Lung Cell Mol Physiol (2016) 0.76
Macrophage LTB4 drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2. J Lipid Res (2017) 0.75
Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection. PLoS One (2017) 0.75
Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis (2007) 24.91
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature (1980) 9.25
Leukotrienes. N Engl J Med (2007) 5.00
Acute lower respiratory tract infection. N Engl J Med (2008) 3.70
Lung infection--a public health priority. PLoS Med (2006) 3.34
Activation and assembly of the NADPH oxidase: a structural perspective. Biochem J (2005) 3.02
Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature (1994) 2.37
Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol (2002) 2.27
Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler Thromb Vasc Biol (2002) 2.24
Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J Clin Invest (1989) 2.09
Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med (2005) 1.97
Leukotrienes: underappreciated mediators of innate immune responses. J Immunol (2005) 1.89
Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4. J Immunol (1999) 1.85
Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J Immunol (1996) 1.75
Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood (2005) 1.62
5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. Infect Immun (1998) 1.49
Expression and regulation of chemokines in bacterial pneumonia. J Leukoc Biol (1996) 1.45
Infectious disease hospitalizations in the United States. Clin Infect Dis (2009) 1.43
Macrophage Turnover Kinetics in the Lungs of Mice Infected with Streptococcus pneumoniae. Am J Respir Cell Mol Biol (2007) 1.42
Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. J Immunol (2007) 1.41
Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae. J Immunol (2009) 1.27
Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae. Infect Immun (2001) 1.20
Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis. Infect Immun (2004) 1.19
Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility. J Immunol (2006) 1.18
Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. Blood (1999) 1.15
Role of peroxide in phagocytic killing of pneumococci. Infect Immun (1974) 1.15
Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis. Microbes Infect (2007) 1.13
The release of leukotrienes in the respiratory tract during infection with respiratory syncytial virus: role in obstructive airway disease. Pediatr Res (1988) 1.12
E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J Immunol (2009) 1.10
Different patterns of arachidonate metabolism in autologous human blood monocytes and alveolar macrophages. J Immunol (1989) 1.05
Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. J Immunol (2007) 1.03
Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils. J Leukoc Biol (2005) 1.02
Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. J Immunol (2008) 1.01
Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. Infect Immun (2002) 1.01
Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia. J Immunol (2001) 0.99
Phagocytosis and bactericidal action of mouse peritoneal macrophages treated with leukotriene B4. Int J Immunopharmacol (1989) 0.96
Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation. Am J Physiol Lung Cell Mol Physiol (2008) 0.95
Leukotriene B4 stimulates human polymorphonuclear leukocytes to synthesize and release interleukin-8 in vitro. Am J Respir Cell Mol Biol (1994) 0.93
Leukotrienes are involved in leukocyte recruitment induced by live Histoplasma capsulatum or by the beta-glucan present in their cell wall. Br J Pharmacol (1999) 0.90
Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents. J Immunol (2007) 0.89
Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone. Toxicology (1996) 0.89
Bacterial community-acquired pneumonia in older patients. Clin Geriatr Med (2007) 0.86
Decreased leukotriene B4 synthesis by polymorphonuclear leukocytes from male patients with diabetes mellitus. Prostaglandins Leukot Med (1984) 0.85
The effect of inhaled leukotriene B4 in normal and in asthmatic subjects. Am J Respir Crit Care Med (1997) 0.83
New immunosuppressive strategies and the risk of infection. Transpl Infect Dis (2008) 0.82
Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages rrom 1,25-dihydroxyvitamin D3-deficient rats. Prostaglandins (1994) 0.82
Leukotriene B4 up-regulates IL-6 rather than IL-1 synthesis in human monocytes. Agents Actions (1991) 0.81
Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. J Intern Med (2000) 0.79
Cyclophosphamide stimulates lung fibroblasts to release neutrophil and monocyte chemoattractants. Am J Physiol Lung Cell Mol Physiol (2001) 0.77
Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. J Exp Med (2002) 3.86
Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP. J Immunol (2004) 2.51
Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol (2002) 2.27
Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation. Am J Respir Cell Mol Biol (2003) 2.14
Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1. J Immunol (2005) 2.01
Cyclic AMP: master regulator of innate immune cell function. Am J Respir Cell Mol Biol (2008) 2.00
Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med (2005) 1.97
Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts. J Clin Invest (2007) 1.87
Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii. J Immunol (2008) 1.74
Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling. J Exp Med (2009) 1.74
Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling. Am J Physiol Lung Cell Mol Physiol (2006) 1.66
Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood (2005) 1.62
Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation. J Immunol (2006) 1.56
Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase. Am J Respir Cell Mol Biol (2007) 1.52
Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J Allergy Clin Immunol (2003) 1.52
Prostaglandin E2 as an inhibitory modulator of fibrogenesis in human lung allografts. Am J Respir Crit Care Med (2012) 1.47
Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent. Am J Respir Cell Mol Biol (2002) 1.47
Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity. Am J Respir Cell Mol Biol (2004) 1.47
Prostaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1. Am J Respir Cell Mol Biol (2008) 1.45
Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol (2008) 1.42
Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways. FASEB J (2009) 1.41
Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2. Am J Physiol Lung Cell Mol Physiol (2002) 1.33
Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2. J Immunol (2005) 1.33
Variable prostaglandin E2 resistance in fibroblasts from patients with usual interstitial pneumonia. Am J Respir Crit Care Med (2007) 1.29
The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice. J Clin Invest (2010) 1.27
Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. J Clin Invest (2011) 1.24
Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice. Am J Pathol (2010) 1.23
Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities. J Immunol (2007) 1.23
Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae. Infect Immun (2009) 1.22
Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: implications for fibroproliferation. Am J Physiol Lung Cell Mol Physiol (2003) 1.20
PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling. Am J Physiol Lung Cell Mol Physiol (2007) 1.19
Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility. J Immunol (2006) 1.18
Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res (2006) 1.16
Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity. Proc Natl Acad Sci U S A (2003) 1.15
Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function. J Immunol (2007) 1.14
Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem (2010) 1.14
Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis. Microbes Infect (2007) 1.13
Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol (2008) 1.11
E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J Immunol (2009) 1.10
Resident tissue-specific mesenchymal progenitor cells contribute to fibrogenesis in human lung allografts. Am J Pathol (2011) 1.07
Prostaglandin E₂ increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression. FASEB J (2012) 1.07
Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression. Am J Physiol Lung Cell Mol Physiol (2004) 1.05
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med (2013) 1.05
Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages. J Biol Chem (2011) 1.04
Eicosanoid lipid mediators in fibrotic lung diseases: ready for prime time? Chest (2008) 1.04
Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase. J Biol Chem (2005) 1.03
Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. J Immunol (2007) 1.03
Syk activation is a leukotriene B4-regulated event involved in macrophage phagocytosis of IgG-coated targets but not apoptotic cells. Blood (2003) 1.02
Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils. J Leukoc Biol (2005) 1.02
Cysteinyl leukotriene levels in esophageal mucosal biopsies of children with eosinophilic inflammation: are they all the same? Am J Gastroenterol (2006) 0.99
Prognostic value of bronchiolitis obliterans syndrome stage 0-p in single-lung transplant recipients. Am J Respir Crit Care Med (2005) 0.98
Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells. Am J Respir Cell Mol Biol (2011) 0.98
FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood (2009) 0.98
Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages. J Immunol (2007) 0.98
Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol (2011) 0.96
Eicosanoids: mediators and therapeutic targets in fibrotic lung disease. Clin Sci (Lond) (2005) 0.96
Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages. J Leukoc Biol (2006) 0.96
Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. J Biol Chem (2004) 0.95
Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation. Am J Physiol Lung Cell Mol Physiol (2008) 0.95
Leukotriene B4 mediates gammadelta T lymphocyte migration in response to diverse stimuli. J Leukoc Biol (2009) 0.94
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. J Immunol (2012) 0.94
Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. J Immunol (2010) 0.94
Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling. Blood (2012) 0.93
Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity. J Biol Chem (2011) 0.92
PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi. Sci Signal (2012) 0.92
Prolonged lipopolysaccharide inhibits leukotriene synthesis in peritoneal macrophages: mediation by nitric oxide and prostaglandins. Prostaglandins Other Lipid Mediat (2003) 0.91
Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. J Immunol (2009) 0.91
Leukotriene B4 mediates neutrophil migration induced by heme. J Immunol (2011) 0.91
Induction of inducible nitric oxide synthase by lipopolysaccharide/interferon gamma and sepsis down-regulates 5-lipoxygenase metabolism in murine alveolar macrophages. Exp Lung Res (2004) 0.90
Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism. FASEB J (2002) 0.90
PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis. J Immunol (2014) 0.90
Role of leukotrienes in killing of Mycobacterium bovis by neutrophils. Prostaglandins Leukot Essent Fatty Acids (2004) 0.90
Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier. Infect Immun (2010) 0.90
Reversal of myofibroblast differentiation by prostaglandin E(2). Am J Respir Cell Mol Biol (2013) 0.90
Activation and regulation of cellular eicosanoid biosynthesis. ScientificWorldJournal (2007) 0.89
Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. J Biol Chem (2009) 0.89
Murine colitis is mediated by vimentin. Sci Rep (2013) 0.89
Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis. J Immunol (2005) 0.88
5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection. PLoS One (2012) 0.88
Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2. J Leukoc Biol (2012) 0.88
Leukotrienes and airway inflammation. Biochim Biophys Acta (2011) 0.88
Antileukotriene agents for the treatment of lung disease. Am J Respir Crit Care Med (2013) 0.87
Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. J Immunol (2008) 0.87
The effects of leptin on airway smooth muscle responses. Am J Respir Cell Mol Biol (2008) 0.87
Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation. J Immunol (2014) 0.87
Identification of two novel nuclear import sequences on the 5-lipoxygenase protein. J Biol Chem (2003) 0.86
E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae. Prostaglandins Other Lipid Mediat (2012) 0.85
Intrauterine group A streptococcal infections are exacerbated by prostaglandin E2. J Immunol (2013) 0.85
Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. J Biol Chem (2008) 0.85
Open mind, open airways: broadening the paradigm of prostaglandins and allergic airway inflammation. Am J Respir Crit Care Med (2002) 0.85