PubRank

Mel Greaves

Author PubWeight™ 91.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Signatures of mutational processes in human cancer. Nature 2013 21.63
2 Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 2010 8.48
3 Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 2009 4.47
4 Acute lymphoblastic leukaemia. Lancet 2013 3.44
5 Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 2008 3.38
6 Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci U S A 2002 2.58
7 Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. Nat Genet 2010 2.47
8 Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia. Blood 2008 2.41
9 Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia. Blood 2010 2.38
10 Single-cell mutational profiling and clonal phylogeny in cancer. Genome Res 2013 2.10
11 In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 2002 1.71
12 TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia. Clin Cancer Res 2004 1.70
13 Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood. Blood 2009 1.64
14 MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia. Blood 2010 1.62
15 Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. Blood 2013 1.45
16 The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem 2003 1.32
17 Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia. Blood 2011 1.31
18 Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood. Genes Chromosomes Cancer 2004 1.27
19 Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia. Blood 2011 1.25
20 Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice. Proc Natl Acad Sci U S A 2004 1.23
21 Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia. Oncogene 2004 1.23
22 The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells. J Clin Invest 2009 1.15
23 NOTCH1 mutation can be an early, prenatal genetic event in T-ALL. Blood 2007 1.15
24 Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia. Genes Chromosomes Cancer 2008 1.14
25 Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model. Oncogene 2005 1.10
26 Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia. Haematologica 2011 1.07
27 Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia. Blood 2011 1.07
28 Immunologically silent cancer clone transmission from mother to offspring. Proc Natl Acad Sci U S A 2009 1.07
29 The role of the MLL gene in infant leukemia. Int J Hematol 2003 1.04
30 Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk. Blood 2010 1.02
31 Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201. Hum Mol Genet 2002 1.02
32 Molecular pathogenesis of MLL-associated leukemias. Int J Hematol 2005 1.01
33 ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor. Blood 2011 1.00
34 Allergy and risk of childhood leukaemia: results from the UKCCS. Int J Cancer 2007 0.98
35 The association of a distinctive allele of NAD(P)H:quinone oxidoreductase with pediatric acute lymphoblastic leukemias with MLL fusion genes in Japan. Haematologica 2005 0.96
36 Protracted postnatal natural histories in childhood leukemia. Genes Chromosomes Cancer 2004 0.93
37 Cancer stem cells renew their impact. Nat Med 2011 0.92
38 Developmental timing of mutations revealed by whole-genome sequencing of twins with acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 2013 0.92
39 Backtracking of leukemic clones to birth. Methods Mol Biol 2009 0.90
40 MLL chimeric protein activation renders cells vulnerable to chromosomal damage: an explanation for the very short latency of infant leukemia. Genes Chromosomes Cancer 2006 0.88
41 The small oligomerization domain of gephyrin converts MLL to an oncogene. Blood 2004 0.84
42 Fusion genes in cord blood. Blood 2011 0.83
43 Pre-natal, clonal origin of acute lymphoblastic leukaemia in triplets. Leuk Lymphoma 2003 0.81
44 Covert preleukemia driven by MLL gene fusion. Genes Chromosomes Cancer 2009 0.81
45 HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention. Cancer Immunol Immunother 2007 0.81
46 Directing oncogenic fusion genes into stem cells via an SCL enhancer. Proc Natl Acad Sci U S A 2005 0.78
47 Prenatal chromosomal diversification of leukemia in monozygotic twins. Genes Chromosomes Cancer 2003 0.77
48 Tyrosine kinase inhibitor insensitivity of non-cycling CD34+ human acute myeloid leukaemia cells with FMS-like tyrosine kinase 3 mutations. Br J Haematol 2011 0.77
49 Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis. Exp Hematol 2007 0.75
50 Developmental impact of leukemic fusion genes on stem cell fate. Ann N Y Acad Sci 2005 0.75