Published in J Pharm Biomed Anal on February 23, 2010
MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells. Sci Rep (2015) 0.81
MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling. World J Gastroenterol (2016) 0.80
I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs. Nat Prod Rep (2016) 0.80
Medicinal history of North American Veratrum. Phytochem Rev (2014) 0.80
Cyclopamine analogs bearing exocyclic methylenes are highly potent and acid-stable inhibitors of hedgehog signaling. Beilstein J Org Chem (2013) 0.78
C-H-Functionalization logic guides the synthesis of a carbacyclopamine analog. Beilstein J Org Chem (2014) 0.77
Cyclopamine bioactivity by extraction method from Veratrum californicum. Bioorg Med Chem (2016) 0.75
Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors. Tetrahedron (2011) 0.75
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem (2004) 4.86
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature (2003) 4.80
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab (2006) 2.37
Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat Neurosci (2004) 2.31
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab (2006) 2.25
Indolizine 1-sulfonates as potent inhibitors of 15-lipoxygenase from soybeans. Bioorg Med Chem (2005) 2.23
N-cadherin mediates cortical organization in the mouse brain. Dev Biol (2006) 2.19
Representation facilitates reasoning: what natural frequencies are and what they are not. Cognition (2002) 2.18
The conjunction fallacy and the many meanings of and. Cognition (2008) 1.81
Zebra sign: cerebellar bleeding pattern characteristic of cerebrospinal fluid loss. Case report. J Neurosurg (2005) 1.80
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. Clin Exp Metastasis (2009) 1.71
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res (2012) 1.70
A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus. Dev Biol (2007) 1.69
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol (2005) 1.66
Tankyrases as drug targets. FEBS J (2013) 1.55
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res (2011) 1.38
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res (2013) 1.38
COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex (2007) 1.33
Indolizines as novel potent inhibitors of 15-lipoxygenase. Bioorg Med Chem (2003) 1.32
Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends. J Gene Med (2005) 1.29
Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases. DNA Repair (Amst) (2008) 1.26
Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography. Proc Natl Acad Sci U S A (2012) 1.24
Synthesis of indolizine derivatives with selective antibacterial activity against Mycobacterium tuberculosis. Eur J Pharm Sci (2006) 1.22
Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis (2007) 1.22
Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain. Brain Res Dev Brain Res (2004) 1.22
Isolation, structural determination and acute toxicity of pinnatoxins E, F and G. J Agric Food Chem (2010) 1.21
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification. Nat Biotechnol (2009) 1.21
Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5. J Biol Chem (2006) 1.13
Antimycobacterial activity of 1-substituted indolizines. Arch Pharm (Weinheim) (2003) 1.07
PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. PLoS One (2009) 1.04
Tankyrases: structure, function and therapeutic implications in cancer. Curr Pharm Des (2014) 1.01
Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor. J Med Chem (2013) 1.00
Expression patterns of Neil3 during embryonic brain development and neoplasia. BMC Neurosci (2009) 0.99
Metabolic changes in urine during and after pregnancy in a large, multiethnic population-based cohort study of gestational diabetes. PLoS One (2012) 0.98
Specific modification of peptide-bound citrulline residues. Anal Biochem (2006) 0.98
High sensitivity measurements of active oxysterols with automated filtration/filter backflush-solid phase extraction-liquid chromatography-mass spectrometry. J Chromatogr A (2012) 0.98
Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool. Dev Dyn (2008) 0.97
Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells. Clin Cancer Res (2008) 0.96
Insulin receptor substrate 2 is a negative regulator of memory formation. Learn Mem (2011) 0.94
Complete asymptomatic thrombosis and resorption of a congenital giant intracranial aneurysm. J Neurosurg (2002) 0.94
Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand. Toxicon (2006) 0.94
Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album. J Pharm Biomed Anal (2010) 0.91
Brain metabolism of exogenous pyruvate. J Neurochem (2005) 0.90
Extraction of microalgal toxins by large-scale pumping of seawater in Spain and Norway, and isolation of okadaic acid and dinophysistoxin-2. Toxicon (2007) 0.90
The cellular fate of cortical progenitors is not maintained in neurosphere cultures. Mol Cell Neurosci (2005) 0.89
Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction. BMC Mol Biol (2010) 0.89
3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors. Bioorg Med Chem Lett (2006) 0.89
A novel pectenotoxin, PTX-12, in Dinophysis spp. and shellfish from Norway. Chem Res Toxicol (2004) 0.89
Why do the heavy-atom analogues of acetylene E2H2 (E = Si-Pb) exhibit unusual structures? J Am Chem Soc (2005) 0.88
Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells. Arthritis Rheum (2003) 0.88
The implications of symmetry of the external potential on bond paths. Chemistry (2008) 0.87
Influence of endohedral confinement on the electronic interaction between He atoms: a He2@C20H20 case study. Chemistry (2009) 0.87
Thiol derivatization for LC-MS identification of microcystins in complex matrices. Environ Sci Technol (2012) 0.86
Template-directed supramolecular assembly of a new type of nanoporous peptide-based material. J Pept Sci (2008) 0.86
Clarification of the C-35 stereochemistries of dinophysistoxin-1 and dinophysistoxin-2 and its consequences for binding to protein phosphatase. Chem Res Toxicol (2007) 0.86
Inhibition of canonical Wnt signaling promotes gliogenesis in P0-NSCs. Biochem Biophys Res Commun (2009) 0.86
The mouse enhancer element D6 directs Cre recombinase activity in the neocortex and the hippocampus. Mech Dev (2002) 0.86
Direct estimate of the conjugative and hyperconjugative stabilization in diynes, dienes, and related compounds. Angew Chem Int Ed Engl (2005) 0.86
Limbic and frontal cortical degeneration is associated with psychiatric symptoms in PINK1 mutation carriers. Biol Psychiatry (2008) 0.85
An immunomodulating pectic polymer from Glinus oppositifolius. Phytochemistry (2007) 0.85
A structural basis for the reduced toxicity of dinophysistoxin-2. Chem Res Toxicol (2009) 0.85
Structures and structure-activity relationships of three mitogenic and complement fixing pectic arabinogalactans from the malian antiulcer plants Cochlospermum tinctorium A. Rich and Vernonia kotschyana Sch. Bip. ex Walp. Biomacromolecules (2006) 0.84
In vitro differentiation of mouse embryonic stem cells into neurons of the dorsal forebrain. Cell Mol Neurobiol (2011) 0.84
Mouse Tcf3 represses canonical Wnt signaling by either competing for β-catenin binding or through occupation of DNA-binding sites. Mol Cell Biochem (2012) 0.84
Luciferase assay to study the activity of a cloned promoter DNA fragment. Methods Mol Biol (2013) 0.84
Preserving and using germplasm and dissociated embryonic cells for conserving Caribbean and Pacific coral. PLoS One (2012) 0.83
A technique for the specific enrichment of citrulline-containing peptides. Anal Biochem (2010) 0.83
The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. Cancer Med (2013) 0.83
Identification of fatty acid esters of pectenotoxin-2 seco acid in blue mussels (Mytilus edulis) from Ireland. J Agric Food Chem (2006) 0.83
Lactam ergot alkaloids (ergopeptams) as predominant alkaloids in sclerotia of Claviceps purpurea from Norwegian wild grasses. Toxicon (2008) 0.82
Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia. J Neurochem (2007) 0.82
Identification of major metal complexing compounds in Blepharis aspera. Anal Chim Acta (2007) 0.82
Correlating chest surface motion to motion of the liver using epsilon-SVR--a porcine study. Med Image Comput Comput Assist Interv (2009) 0.82
2-Amino-14,16-dimethyloctadecan-3-ol, a new sphingosine analogue toxin in the fungal genus Fusarium. Toxicon (2005) 0.82
Variational and robust density fitting of four-center two-electron integrals in local metrics. J Chem Phys (2008) 0.82
Biophysical modeling of brain tumor progression: from unconditionally stable explicit time integration to an inverse problem with parabolic PDE constraints for model calibration. Med Phys (2012) 0.82
Unicorns in the world of chemical bonding models. J Comput Chem (2007) 0.82
Electronic structure of CO--an exercise in modern chemical bonding theory. J Comput Chem (2007) 0.81
Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines. Bioorg Med Chem Lett (2003) 0.81
Bonding analysis of metal-metal multiple bonds in R3M-M'R3 (M, M' = Cr, Mo, W; R = Cl, NMe2). Inorg Chem (2011) 0.81
Targeted disruption of mouse Dach1 results in postnatal lethality. Dev Dyn (2003) 0.81
Structural studies on minor enniatins from Fusarium sp. VI 03441: novel N-methyl-threonine containing enniatins. Toxicon (2009) 0.80
Structural characterization of new microcystins containing tryptophan and oxidized tryptophan residues. Mar Drugs (2013) 0.80
New bonding modes of carbon and heavier group 14 atoms Si-Pb. Chem Soc Rev (2014) 0.80
Modulation of cerebellar activation by predictive and non-predictive sequential finger movements. Cerebellum (2003) 0.80
Epimers of azaspiracids: Isolation, structural elucidation, relative LC-MS response, and in vitro toxicity of 37-epi-azaspiracid-1. Chem Res Toxicol (2014) 0.80
Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene. Mol Cell Biochem (2011) 0.80
Uptake and metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro. J Neurochem (2015) 0.80